Syllabus B.Pharm(Hons) NUB MANIK

B.Pharm Syllabus
Northern University Bangladesh
De ve l oped b y: Ma h ab u r R a hma n She i kh & M ahm ud ur R ah man
Assistant Professors, Department of Pharmacy, Northern University Bangladesh
1
Submitted by:
Table of Content
Offered by
Department of Pharmacy
Submitted to:
Pharmacy Council of Bangladesh
Rahat Tower, (4th Floor) 14 Link Road. West Banglamotor, Dhaka-1000, Bangladesh
93, Kazi Nazrul Islam Avenue, Karwan Bazar, Dhaka-1215, Tel.:9146278, 9110231,
9110716, Fax: 9135562, Email: info@nub.ac.bd, website: www.nub.ac.bd

B.Pharm Syllabus
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Serial No. Content Page No.
Bachelor of Pharmacy (Honours) --------------------------------------- 3
1) Objectives --------------------------------------- 4
2) Eligibility of Student for Admission --------------------------------------- 5
3) Number of Seats per Semester --------------------------------------- 5
4) Academic Calendar --------------------------------------- 5
5) Assessment System --------------------------------------- 5
6) Assessment Procedure --------------------------------------- 6-7
7) Credit Hour per Course --------------------------------------- 7
8) Course Structure --------------------------------------- 7
9) Fees Structure --------------------------------------- 8
10) Graduation --------------------------------------- 8
11) Examination --------------------------------------- 8
12) Promotion --------------------------------------- 8
13) Practical Training --------------------------------------- 8
14) Project/ Thesis --------------------------------------- 8
Course Distribution --------------------------------------- 9
Prerequisites --------------------------------------- 10-11
Course outline for B. Pharm. Part-I (Semester-1) --------------------------------------- 12-14
Course outline for B. Pharm. Part-I (Semester-2) --------------------------------------- 15-19
Course outline for B. Pharm. Part-II(Semester-3) --------------------------------------- 20-23
Course outline for B. Pharm. Part-II (Semester-4) --------------------------------------- 24-28
Course outline for B. Pharm. Part-III (Semester-5) --------------------------------------- 29-35
Course outline for B. Pharm. Part-III (Semester-6) --------------------------------------- 36-40
Course outline for B. Pharm. Part-IV (Semester-7) --------------------------------------- 41-44
Course outline for B. Pharm. Part-IV (Semester-8) --------------------------------------- 45-48

B.Pharm Syllabus
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Bachelor of Pharmacy (Honours)
Offered by
Faculty of Health Science
93, Kazi Nazrul Islam Avenue, Karwan Bazar, Dhaka-1215

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Bachelorof Pharmacy (Honors)
(4 Years Honours Course consists of 8 Semesters)
1. Objectives
i) 4 years Bachelor of Pharmacy (Honors) Program aims to provide in depth education in
Pharmacy and relevant subjects. This program aims in-
 Developing students with a wide range of Pharmacy relevant education
and their application in practice.
 Preparing students to accept the challenges of twenty first century in the
field of Pharmaceutical breakthrough.
 Getting students trained to be competent for the job market of wide range
of Pharmaceutical fields.
ii) Students shall have wide range of options to begin their profession after earning their
4 years B.Pharm (Honors) degree.The options are-
 Work in Pharmaceutical Industries as Production Pharmacist, Quality
Control Analyst, Quality Assurance Personnel and other relevant
administrative officials.
 Work for Government in different Health care, Hygiene and Immunization
programs.
 Work for corporate bodies of varied nature, especially in Pharmaceutical
marketing.
 To work as clinical research associates to assist is drug clinical trialsl
 To involve in hospital setting Pharmacists are to compound & dispense
medicines, councel patients and manufacture of specialized medicine in
small –scale and handle overall drug supply management.
 To engage in community practice for dispense medicines, advise patients
on correct & rational use of medicines and cosmetics, councel people on
health care workers for appropriate help and to play central leadership
roles in the communities they serve.
 To pursue a carrer as academician that involves teaching in universities or
other institutions and research on relevant issues for the further
development and progress of the profession.
iii) Students shall be encouraged in undergoing the study of Pharmacy in a congenial
atmosphere with state of the art laboratories. They shall be trained to be keen and
analytical, concerning the contradictions and consistencies in theory and practice of
Pharmacy.
iv) Regularly seminars and workshops shall be arranged. Through seminars and
workshops students shall receive new ideas and guidance, which helps in facing the
real life problems in relevant Pharmaceutical fields.
v) There shall be both theory and practical examinations at the end of semesters for all
the subjects. Class tests, assignments etc. carried out during the semester shall also be
considered in making overall assessment. A satisfactory class record will also be
required at each stage.
2. Eligibility of students for admission
The admission criteria are set by Pharmacy Council of Bangladesh. The students must pass HSC,
A- Level or recognized equivalents with any one of the following two combinations for the
subjects:

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(a) Chemistry, Physics and Biology (with Mathematics as an optional subject)
(b) Chemistry, Physics and Mathematics (with Biology as an optional subject)
A student must secure at least two B grades in the above mentioned subjects to qualify for
admission. Admission in the department should be based on competitive written test evaluations.
In addition for further sorting of the better candidates oral test may be taken.
3. Number of seats per semester
The number of seats per semester is 50. The number has been set based on our laboratory
facilities for practical works.
4. Academic Calendar
An academic year will consist of 02 (two) semesters of 6 months duration each (25 weeks).
Semesters shall be divided in the following manner.
Semester: Description: Duration:
A
Semester I Spring January - June
Semester II Fall July - December
Time fragmentation of the semester duration:
i) Admission & Registration for semester 01 week
ii) Theory and practical work 16 weeks
iii) Mid term Examination & result publish 02 weeks
iv) Semester Final Examination & result publish 04 weeks
v) Semester break and other holidays 02 weeks __
Total-25 weeks
5. Assessment System (Letter Grade & CGPA)
Assessment will be as follows:
Marks Range
Letter Grade Credit Grade Point Average
(CGPA) Assessment
90 –100 A+ 4.0 Outstanding
85 – 89 A 3.75 Excellent
80 – 84 A- 3.50 Very Good
75 – 79 B+ 3.25 Good
70 – 74 B 3.0 Satisfactory
65 – 69 B- 2.75 Above Average
60 –64 C+ 2.50 Average
55 – 59 C 2.25 Below Average
50 – 54 D 2.00 Pass
00 – 49 F 0.0 Fail
I Incomplete
W Withdraw
X Absent in exam

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6. Assessment Procedure
1) Theory paper:
The time and the number distribution for the theory paper of the midterm examination as
well as final examination have been fixed as follows.
The total mark for the course theory paper will have marks 100 with following segmentation.
Continuous assessment marks 20
Mid term examination marks 30
Final examination marks 50
Total- marks 100
Continuous assessment (Detailing is given below.)
Attendance marks 05
Class assessment marks 10
Overall class performance marks 05
Total- marks 20
Class assessment can be done in the form of evaluation through class tests, quiz, cards,
assignments or even suitable projects. Respective course teacher will enjoy the freedom in this
very issue. However the overall class performance shall totally depend on the course
teachers. S/he would look on many aspects (e.g. timely arrival, interpersonal communication,
punctuality, active participation in the class, precision in work etc.) before assessing a student.
Teachers are advised not to be biased.
Mid term examination
Multiple choice questions marks 06 10 minutes 12 questions
Descriptive type questions marks 24 01 hour 20 minutes 03 questions out of 04
Total- marks 30 01 hour 30 minutes
Final examination
Multiple choice questions marks 10 15 minutes 20 questions
Descriptive type questions marks 40 02 hour 15 minutes 05 questions out of 06
Total- marks 50 02 hours 30 minutes
2) Practical paper:
The time and the number distribution for the practical paper of the midterm examination
as well as final examination are as follows:
Continuous assessment marks 20
Mid term examination marks 30
Final examination marks 50
Total- marks 100 (Detailing is given below.)

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Continuous assessment
Attendance marks 05
Note book marks 10
Overall lab performance marks 05
Total- marks 20
However the overall lab performance shall totally depend on the course teachers. S/ he
would look on (e.g. timely arrival, interpersonal communication, punctuality, active
participation, precision in work, proper record keeping etc.) many aspects before assessing a
student. Teachers are advised not to be biased.
Mid term practical examination
Short test on the topics of experiments marks 25 20 minutes
Viva voce marks 05 max 05 minutes for each examinee
Total- marks 30
The short test should preferably be in the form of short questions but less commonly the
MCQs.
Final practical examination
Experiment report writing marks 20
Data collection, Result and conclusion marks 20
Viva voce marks 10 max 05 minutes for each examinee
Total- marks 50
7. Credit Hour per Course
NUB follows the Credit Hour System in its academic programs of having involvement of 25
Weeks of Instruction in each Semester. Courses may have different credit hours depending
on the course length and weight in the curriculum.
A Pharmacy theory course of 3 credit hours comprise 42 hours (3 credits  14 hours) of
instruction and this is covered within a number of 42 Theory Classes (each class has duration
of 1 hour).
A Pharmacy practical course of 2 credit hours means 2 Practical Classes (each of practical class
has duration of 3 hours) per week.
8. Course Structure
The 4 years Bachelor of Pharmacy (Honors) consists of
Types of Courses No. of
Courses
Credit Hours
1. Core Courses:
A. Pharmacy Courses: Pharm
1. Theory & Practical
2. Training Report
3. Project / Thesis
57
2
2
139
2
3
2. Mathematics & Biostatistics: STAT 1 3
3. Computer: CIT 1 3
4. Arts and Humanities Courses: HUM 1 2
5. Basic English Courses: ENG 2 6
6. General Education Courses: GED 1 2
Total 67 160
9. Fees Structure
 Admission fees : 10,000.00

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 Tuition fees : 2,72,000.00 (Fees 1700.00 per credit  160)
 Semester fees : 24,000.00 (Fees 3000.00 per semester  08)
 Practical fees : 4,000.00 (Fees 1000.00 per year  4)
Total fees : 3,10,000.00 (in BDT)
10. Graduation
To obtain the Bachelor (Hons.) degree in Pharmacy, a student shall have to complete a minimum
of 160 Credit Hours with a minimum CGPA of 2.00. If a student fails in any course he/she will get
the opportunity to improve the grade by re-taking the same in the subsequent semesters along
with regular students.
11. Examination
Students will appear in the Mid Term Examination after 10 weeks of semester and Semester Final
Examination at the end of the semester. Examination covers both theory and practical as
mentioned in the curriculum. Assessment will be made in each Academic year on the basis of
total marks obtained in two consecutive semesters.
12. Promotion
A student who fails to pass any one of the Part (e.g. Part-I, Part-II etc.) of B. Pharm. in two
consecutive chances whether availed of or not, shall be debarred from continuing his/ her study
in Pharmacy. However in case of any logical ground, student might take a re-admission on
special consideration from the side of authority.
13. Practical Training
(a) Every student of B. Pharm. (Hons.) will complete a four (4) weeks Practical Training in a
Compounding Pharmacy in Hospital or Retail Pharmacy.
(b) Every student of B. Pharm. (Hons.) shall be required to undergo an In-Plant Training of
four (4) weeks at the end of his Part-IV of study in a Pharmaceutical Industry arranged by
the authority.
Students shall keep a record of all the work done during their Practical Training and a Report to
be submitted countersigned by the Teacher In-charge and Official of the Hospital/
Pharmaceutical Industry at the time of Fourth Year Second Semester Examination.
14. Project
Every student of B. Pharm. Part-IV has to submit a dissertation on a selected topic having
importance in Pharmacy at the end of second semester of fourth year.
----------------==---__________-------------------

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Revised Syllabus of Bachelor of Pharmacy
Semester Wise Distribution of Courses
Course Name Code Cr. Hr. Course Name Code Cr. Hr.
1st
year: Semester-1: 1st
year: Semester-2:
English I ENG 1103 3 Mathematics & Biostatistics STAT 1203 3
Introduction to Computers CIT 1101 3 English II ENG 1204 3
Inorganic Pharmacy I PHARM 1101 3 Physical Pharmacy I PHARM 1205 3
Organic Pharmacy I PHARM 1102 3 Physical Pharmacy I Lab PHARM 1206 2
Pharmacognosy I PHARM 1103 3 Physiology & Anatomy I PHARM 1207 3
Pharmacognosy I Lab PHARM 1104 2 Physiology & Anatomy I Lab PHARM 1208 2
Organic Pharmacy II PHARM 1209 3
Organic Pharmacy II lab PHARM 1210 2
Viva Voce I PHARM 1200 1
Total = 17 Total = 22
2nd
year: Semester-3: 2nd
year: Semester-4:
Pharmaceutical Microbiology PHARM 2111 3 Economics HUM 1301 2
Pharma. Microbiology Lab PHARM 2112 2 Socio economic study of BD GED 2204 2
Inorganic Pharmacy II PHARM 2113 3 Physical Pharmacy II PHARM 2219 3
Inorganic Pharmacy II lab PHARM 2114 2 Physical Pharmacy II Lab PHARM 2220 2
Biomolecular Pharmacy PHARM 2115 3 Pharmacognosy II PHARM 2221 3
Biomolecular Pharmacy Lab PHARM 2116 2 Pharmacognosy II Lab PHARM 2222 2
Physiology & Anatomy II PHARM 2117 3 Pharmacology I PHARM 2223 3
Physiology & Anatomy II Lab PHARM 2118 2 Pharmaceutical Analysis-I PHARM 2224 3
Viva Voce II PHARM 2200 1
3rd
year: Semester-5: 3rd
year: Semester-6:
Pharmaceutical Tech. I PHARM 3125 3 Biopharmaceutics I PHARM 3233 3
Pharmaceutical Tech. I Lab PHARM 3126 2 Biopharmaceutics I Lab PHARM 3234 2
Medicinal Chemistry I PHARM 3127 3 Pharmaceutical analysis II PHARM 3235 3
Medicinal Chemistry I Lab PHARM 3128 2 Pharmaceutical analysis II LabPHARM 3236 2
Pharmacology II PHARM 3129 3 Pharmaceutical Tech. II PHARM 3237 3
Pharmacology II Lab PHARM 3130 2 Pharmaceutical Tech. II Lab PHARM 3238 2
Forensic Pharmacy&
Toxicology
PHARM 3131 3 Pharmaceutical engineering PHARM 3239 3
Hospital Pharmacy PHARM 3132 3 Community Pharmacy & Regu.PHARM 3240 2
Viva Voce III PHARM 3200 1
4th
year: Semester-7: 4th
year: Semester-8:
Pharmacology III PHARM 4141 3 Bio-Pharmaceutics II PHARM 4249 2
Pharmacology III Lab PHARM 4142 2 Bio-Pharmaceutics II Lab PHARM 4250 1
Medicinal Chemistry II PHARM 4143 3 Pharmaceutical Analysis III PHARM 4251 3
Medicinal Chemistry II Lab PHARM 4144 2 Pharma. Analysis III Lab PHARM 4252 2
Cosmetology PHARM 4145 3 Pharmaceutical Biotechnology PHARM 4253 3
Cosmetology Lab PHARM 4146 1 Clinical Pharmacy PHARM 4254 2
Pharmaceutical Tech. III PHARM 4147 3 Pharma. Manage. & MarketingPHARM 4255 3
Training in Hospital Pharmacy PHARM 4148 1 In-Plant Training PHARM 4256 1
Project PHARM 4200 2
Viva Voce IV PHARM 4258 1
Total credit hours=160 (Core cr:144)

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Course code Course Title Prerequisite*
Part-I (Semester-1)
ENG 1103 English I
CIT 1101 Introduction to computers
PHARM 1101 Inorganic Pharmacy I
PHARM 1102 Organic Pharmacy I
PHARM 1103 Pharmacognosy I
PHARM 1104 Pharmacognosy I Lab
Part-I (Semester-2)
ENG 1204 English II ENG 1103
MATH 1202 Mathematics & Biostatistics
PHARM 1205 Physical Pharmacy I PHARM 1102
PHARM 1206 Physical Pharmacy I Lab PHARM 1205
PHARM 1207 Physiology & Anatomy I
PHARM 1208 Physiology & Anatomy I Lab PHARM 1207
PHARM 1209 Organic Pharmacy II PHARM 1102
PHARM 1210 Organic Pharmacy II Lab PHARM 1209
PHARM 1200 Viva Voce I
Part-II(Semester-3)
PHARM 2111 Pharmaceutical Microbiology
PHARM 2112 Pharmaceutical Microbiology Lab
PHARM 2113 Inorganic Pharmacy II PHARM 1101
PHARM 2114 Inorganic Pharmacy II Lab PHARM 2111
PHARM 2115 Biomolecular Pharmacy PHARM 1102
PHARM 2116 Biomolecular Pharmacy Lab PHARM 2115
PHARM 2117 Physiology & Anatomy II PHARM 1207
PHARM 2118 Physiology & Anatomy II Lab PHARM 2117
Part-II (Semester-4)
HUM 1301 Economics
GED 2204 Socio economic study of BD
PHARM 2219 Physical Pharmacy II PHARM 1205
PHARM 2220 Physical Pharmacy II Lab PHARM 2219
PHARM 2221 Pharmacognosy II PHARM 1103
PHARM 2222 Pharmacognosy II Lab PHARM 2221
PHARM 2223 Pharmacology-I PHARM 2117
PHARM 2224 Pharmaceutical analysis-I PHARM 2219
PHARM 2200 Viva Voce II
Part-III (Semester-5)
PHARM 3125 Pharmaceutical Technology-I PHARM 2219
PHARM 3126 Pharmaceutical Technology-I Lab PHARM 3125
PHARM 3127 Medicinal Chemistry I PHARM 1209
PHARM 3128 Medicinal Chemistry I Lab PHARM 3127
PHARM 3129 Pharmacology II PHARM 2223
PHARM 3130 Pharmacology II Lab PHARM 3129
PHARM 3131 Forensic Pharmacy & Toxicology PHARM 3129
PHARM 3132 Hospital Pharmacy
Part-III (Semester-6)
PHARM 3233 Biopharmaceutics I PHARM 3129
PHARM 3234 Biopharmaceutics I Lab PHARM 3233

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PHARM 3235 Pharmaceutical Analysis-II PHARM 2224
PHARM 3236 Pharmaceutical Analysis-II Lab PHARM 3235
PHARM 3237 Pharmaceutical Technology-II PHARM 3125
PHARM 3238 Pharmaceutical Technology-II Lab PHARM 3237
PHARM 3239 Pharmaceutical Engineering PHARM 3125
PHARM 3240 Community Pharmacy and Regulatory Affairs PHARM 3129
PHARM 3200 Viva Voce III
Part-IV (Semester-7)
PHARM 4141 Pharmacology-III PHARM 3129
PHARM 4142 Pharmacology-III Lab PHARM 4141
PHARM 4143 Medicinal Chemistry-II PHARM 3127
PHARM 4144 Medicinal Chemistry-II Lab PHARM 4143
PHARM 4145 Cosmetology PHARM 3125
PHARM 4146 Cosmetology Lab PHARM 4145
PHARM 4147 Pharmaceutical Technology-III PHARM 3237
PHARM 4148 Training in Hospital Pharmacy
Part-IV (Semester-8)
PHARM 4249 Biopharmaceutics II PHARM 3233
PHARM 4250 Biopharmaceutics II Lab PHARM 4249
PHARM 4251 Pharmaceutical Analysis-III PHARM 3235
PHARM 4252 Pharmaceutical Analysis-III Lab PHARM 4251
PHARM 4253 Pharmaceutical Biotechnology I PHARM 2219
PHARM 4254 Clinical Pharmacy PHARM 2223
PHARM 4255 Pharmaceutical Management and Marketing
PHARM 4256 In-Plant Training
PHARM 4200 Project
* Theory & Lab course of same subject may be taken simultaneously or later on.

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Semester-1
English-I (ENG 1103)
1. A quick brush up english grammar
2. Writing on selected topics relevant to the courses and current affairs
3. Common mistakes in writing
4. Styles in presentation
5. Differences in oral and written english
6. Essays, paragraphs, letters & applications of various types
Introduction to Computer (CIT 1101)
1. History and General information:
Historical background of computers and computing, classification and application of computers
according to size and function, computer logic and computer architecture-a general review of
INPUT/OUTPUT media and devices. Functional parts and organization of central processing
unit, memory and memory organizations, storage device, general review of micro-processor,
number systems, binary, hexadecimal etc. hardware, software, batch processing, RAM, ROM
etc.
2. Programming languages:
Introduction to machine language, interpreter, compiler, assembler language, high level
language-BASIC, C, FORTRAN, PASCAL etc. algorithm, flowchart, decision table, basic idea of
programming, data file and database.
3. Software:
Operating system: Introduction to Windows, Mac OS and DOS and its commands. Application
Software’s: Introduction to word processing software’s (MS Word etc.) Analytical software’s
SPS etc.)
4. Computer and communication:
Computer networking (LAN, MAN, WAN), internet working, basic principle, gateway and bridge,
internet protocol (IP), protocol translation and computer network.
Practical
1. Word processing: Microsoft Word
2. Spread sheet analysis: Microsoft Excel
3. Database management: Microsoft Access
4. Multimedia projection: Microsoft PowerPoint
5. Statistical data analysis package: SPSS
6. Use of internet.

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Inorganic Pharmacy-I (PHARM 1101)
1. Structure of the Atom: An elementary treatment of theories of atomic structure. Quantum
numbers. Pauli’s Exclusion Principle, origin of spectral lines.
2. The chemical Bond: Electronic concept of valency. Different types of chemical bond e.g. ionic,
covalent, coordinate covalent metallic, dipole, hydrogen bond etc. Theories of covalent bonding
and hybridization.
3. Classification of Elements: The electronic structure of the atom and the Modern Periodic Table
and Periodic Law. Variation of properties within period and groups. Usefulness and limitations of
Periodic Table.
4. Chemistry of alkali and alkaline earth metals and halogen compounds including their
Pharmaceutical applications.
5. The chemistry of Co-ordination compounds and chelating agents including their structures and
isomerism.
6. The atmosphere and the inert gases.
Organic Pharmacy-I (PHARM 1102)
1. Introduction:
Introduction to pharmacy, chemistry, classification of chemistry, organic chemistry, melting point,
boiling point, solubility, acid, base, polarity, ions, carbonium ion, carbanions, hydrides, free radicals,
hydrogen bonds, Vander Waal forces, nucleophile, electrophile.
2. Organic Compounds of Individual Groups:
Hydrocarbon: Alkanes, alkenes, alkynes: Occurrence, nomenclature, structure, physical properties,
preparation and importance
Aldehydes & ketones: Occurrence, nomenclature, structure, physical properties, preparation and
importance
Alcohols, ethers, epoxides: Occurrence, nomenclature, structure, physical properties, preparation
and importance
Carboxylic acids, amines: Occurrence, nomenclature, structure, physical properties, preparation and
importance
3. Dienes & Aromatic Compounds:
Types, properties, resonance, 1, 2 additions and 1, 4-addition reactions of Dienes, Aromaticity,
characteristic properties of aromatic compounds, Pharmaceutical importance of aromatic and
substituted aromatic compounds
4. Principles of Various Types of Bonding:
Addition reaction, substitutions reaction, elimination reaction and rearrangement reactions

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Pharmacognosy-I (PHARM 1103)
1. Definition and scope of Pharmacognosy, its historical developments.
2. Drug literature and publications: Pharmacopoeia, Codex, Formulary, Dispensatory and Index
etc. Official, Non-official, Un-official drugs.
3. Structure of the cell as a unit: Its function and form. Introduction to general structure of the
morphological parts of plants.
4. Crude drugs: A general view of their origin, distributions, cultivation, collection, drying and
storage, commerce and quality control.
a) Classification of drugs.
b) Preparation of drugs for commercial market
c) Evaluation of crude drugs.
d) Drug adulteration.
5. Plant analysis: Extraction, separation, chromatography, types of plant constituents,
comparative phytochemistry and chemotaxonomy.
6. Phytochemistry and pharmaceutical uses of the following plant constituents along with
consideration of some important drugs of each group.
a. Lipids: Castor oil, linseed oil, coconut oil, olive oil, peanut oil, chaulmoogra oil and bees
wax.
b. Carbohydrate and related compounds: Sugars and sugar containing drugs. Sucrose,
dextrose, glucose, fructose etc. Polysaccharides and polysaccharide containing drugs,
Starches, dextrins etc. Gums and mucilages, tragacanth, acacia, sterculia, sodium
alginate, agar and cellulose.
c. Alkaloids: Distribution, properties, tests, extraction, structural types and classification.
7. Plants in complimentary and traditional systems of medicine: Introduction-different types of
alternative systems of treatments (e.g. Ayurvedic, Unani and Homeopathic medicine). Contribution
of traditional drugs to modern medicines. Details of some common indigenous traditional drugs:
Punarnava, Vashaka, Anantamul, Arjuna, Chirata, Picrorhiga, Kalomegh, Amla, Asoka, Bahera,
Haritaki, Tulsi, Neem, Betel nut, Joan, Karela, Shajna, Carrot, Bael, Garlic, Jam and Madar.
8. Vitamins and vitamin containing few selected animal drugs: Cod liver oil, shark liver oil, hilsha
fish/liver oil etc.
9. Surgical dressings and fibres.

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Pharmacognosy-I Lab (PHARM 1104)
A. The Cell, cell contents and cell types:
1) The Cell: Some cellular organisms e.g. chalk & diatomite
2) Cell contents:
a. Starches and derivatives
b. Calcium oxalate crystals
3) Cell types:
a. Parenchyma and modifications: Colocynth. Nux-vomica, endosperm, cinnamon powder,
tea.
b. Parenchyma-Pericyelic fibres: jute.
B. Epidermal cells and associated structures (trichomes, stomata etc.) Leaves of stramonium,
mentha, senna, digitalis etc. Seed trichomes Cotton and nux-vomica seeds.
C. Study of some groups of unorganised white and off white powder and whole drugs:
i) General tests for carbohydrates
ii) Preparation and extraction of starches and related products
iii) Examination of gums: Acacia, tragacanth and alginates
D. Examination of fibres and surgical dressings.
E. Study of some medicinal plants of Bangladesh: Both fresh and dride crude drugs.
F. Examination of prepared proprietary drug produgs.

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Semester-2
Mathematics & Biostatistics (STAT 1203)
Mathematics
1. Graphs and gradients:
a) Rectangular co-ordinates. Curve fitting using first degree equation in both variables.
b) Determination of slope and intercept and point of intersection
c) Equation of first degree in both x and y (circle, ellipse, rectangular hyperbola etc.)
d) Exponential and logarithmic curves, graphical solution of equation, graphical solution of
simultaneous equations
e) Arithmetic progression, geometric progression, permutation-combination, binomial
theorem, exponential theorem and e
f) Application of curve fitting method in expressing degradation of drugs
2.Calculus:
a) Rate process, rules of differentiation, successive and partial differentiation,
differentiation of a function of a function, relation between the derivatives of inverse
functions
b) Rules of integration, integration as a summation, area under curve, integration by
partial fraction, graphical integration, indefinite and definite integrals.
3.Matrices:
Addition. Subtraction and multiplication of matrices, unit matrix, row transformation,
determinants, inverse of matrix and solution of equations by matrix
Biostatistics
1. Graphical and diagrammatic representation: graphs and diagrams.
2. Measures of central tendency: arithmetic mean, geometric mean, harmonic mean,
median and mode.
3. Measures of dispersion: range, mean deviation, variance, coefficient of variation,
standard deviation.
4. Moments, skewness and kurtosis.
5. Probability distribution: the normal, binomial and poisson distribution. Derivation,
means and variances.
6. The basic idea of significance text: simple significance tests based on the normal
distribution, comparison with a known standard, comparison of means of two large
samples. The use of ‘t’ tests for small samples, importance of small sample comparison
of sample mean with a standard, comparison of means of two small samples (unknown
variances-assumed equal, not assumed equal), confidence limits.
X2
-tests of goodness of fit and homogeneity introduction to general idea, testing the fit
of a whole frequency distribution to data, tests of homogeneity, variance ratio tests.
7. The correlation of measurement: general notion of correlation, calculation of
correlation coefficient.

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8. Regression analysis: basic idea of regression. Calculation of regression coefficient,
standard error and significance test. Partial correlation and multiple regression with two
and more than two independent variables.
9. Simple experimental design and the analysis of variances: introduction, completely
randomised design, randomised block design testing the homogeneity of variances.
10. Introduction to factorial experiments: principles of basic ideas notation in 2nd factorial,
scope of more advanced designs.
11. Random samples and random numbers: their need and use. Representative samples.
Practical
1. Means and variances: Basic calculation.
2. Estimation: Standard errors and confidence limit.
3. Simple significance test.
4. The use of t tests.
5. X2
tests of goodness-of-fit and homogeneity.
6. Calculation of correlation coefficient significance tests for correlation coefficients.
7. Calculation of regression coefficient. Standard errors & significant test.
8. Simple experimental design and analysis of variance (testing the homogeneity of
variances).
9. Analysis of variance.
Application of statistics in Pharmacy
1. Studies of rates of chemical & biological reactions.
2. Sampling Random sample representative sample.
3. Test for uniformity of tables.
4. Qualitative test on samples.
5. Limits for content of active ingredient of tables.
6. Probability of a batch passing or falling to pass a test.
7. Dispensing error: Dispensing of liquids, dispensing of solids.
8. Analysis of variance in studying the results obtained in the development of an assay.
9. Biological assay: Threshold dose assay, toxicity tests, Bacteriological counts (Poisson
distribution).

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English-II (ENG 1204)
1. New words, antonyms, synonyms
2. Speech preparation
3. Practice speech on selected topics
4. Style development in public speaking
5. Business letters
6. Project proposals
7. Information compilation
Physical Pharmacy-I (PHARM 1205)
1. Properties of gases: gas laws, ideal gas equation, dalton’s law of partial pressure,
diffusion of gases, kinetic theory of gases, mean free path, deviation from ideal gas
behavior, vander wails equation, critical constants, liquefaction of gases, determination
of molecular weights, law of corresponding states and heat capacity
2. Chemical equilibrium: law of mass action, determination of equilibrium constant,
heterogeneous equilibrium and homogenous equilibrium, le chateliar principle and vant
hoff equation
3. Chemical thermodynamics: introduction, the first law of thermodynamics, work, energy
and heat. Work of expansion, internal energy, determination of internal energy, heat
change at constant volume and constant pressure. Thermodynamic reversibility. Work
in isothermal reversible expansion of gases, the maximum work under the isothermal
expansion of a gas. Heat capacities, difference between molar heats. Adiabatic
process. Joule-thomson experiment.
Thermochemistry and thermochemical laws, hess’s law. Second law of
thermodynamics. Carnot’s cycle and efficiency of a perfect engine, the concept of
entropy and entropy changes for an ideal gas expansion. Entropy changes of materials
under various conditions. Free energy and work functions. Gibbs-helmholtz equation,
free energy changes under equilibrium. The clausius clapyeron equation.
4. Phase equilibria: phase, components and degrees of freedom. The phase rule and its
thermodynamic derivation. The phase diagrams of water and sulphur systems, partially
miscible liquid pairs: the phenol and water and nicotine-water systems. Completely
miscible liquid pairs and their separation by fractional distillation. Freeze drying
(lyophilization).
5. Solutions: types and properties of solutions. Units of concentration, ideal and real
solutions. Henry’s law, distribution of solids between two immiscible liquids, distribution
law. Partition coefficient and solvent extraction.
6. Colligative properties of dilute solutions: lowering of vapour pressure, elevation of
boiling point, depression of freezing point and osmotic pressure including necessary
thermodynamic derivations.

B.Pharm Syllabus
19
7. Ionic equilibria: ph, determination of ph of different acids and bases, salt solutions and
buffers. Titration curves of acids and bases and indicators.
8. Buffer capacity: preparation of buffers, buffers and isotonic systems. Methods for
adjustment of tonicity of solutions. Buffers in pharmaceutical and biological systems.
Physical Pharmacy-I lab (PHARM 1206)
1. Standardization of Acids and bases.
2. Determination of pKa and pKb values
3. Preparation of solutions of different pH & buffer capacities.
4. Determination of phase diagram of binary systems.
5. Determination of distribution coefficients.
6. Determination of molecular weight by Victor Meyer’s Method.
7. Determination of heats of solutions by measuring solubility as a function of
temperature (Van’t Hoff equation.)

B.Pharm Syllabus
20
Physiology & Anatomy-I (PHARM 1207)
1. Cell: structure and functions. Cell inclusion. Division of cell.
Tissue: definition and classification, epithelial tissue, connective tissue, muscle tissue,
blood, bone & cartilage, nerve tissue, functions of various tissues & their minute
structure.
2. Blood: composition & function.
Plasma: electrolytes, proteins & other organic constituents.
Blood cells: their formation & destruction cell count, functions of different blood cells.
Haemoglobin: structure, properties & function.
Anaemia: causes & classification.
Blood coagulation: blood groups. Blood transfusion.
Lymph: composition, formation, circulation & function, lymph nodes & lymphatic.
3. Circulatory system:
Heart: structure, heart muscles, conduction system of heart, origin and transmission of
cardiac impulse, ecg, control and requirements for the normal heart beat, cardiac
cycle, cardiac output, nervous regulation of heart, cardiac reflexes.
Blood vessels: types of blood vessels & their functions.
Blood pressure: measurements and regulation of blood pressure, nervous control and
chemical control.
Arterial pulse: definition & clinical study, recording of arterial pulse.
Capillary circulation: importance & functions.
Regional blood circulation: pulmonary circulation, hepatic circulation, renal circulation
and cerebral circulation.
4. Respiratory system:
Mechanism of respiration, pulmonary ventilation, ventilation volumes, gaseous
interchange through lungs: carriage of o2 & co2
Regulation of respiration: nervous and chemical regulation.
Hypoxia: causes & classification, abnormal breathing, cheyne stokes breathing,
kussmal breathing, breathing at high altitude.
5. Alimentary system:
structure of the different parts of the alimentary system, movements of the different
parts of the alimentary tract & their control, swallowing, gastric contractions, intestinal
contractions, defecation secretion of digestive juices, saliva, gastric juice, pancreatic
juice, intestinal juice & bile, mechanism & control of the various secretions and their
functions, digestion of food stuff, absorption of the different digested materials,
structure and functions of liver, formation of bile & its concentration in the gal bladder,
circulation of bile salts & bile pigments, functions of liver.
Physiology & Anatomy-I Lab (PHARM 1208)
1. Study of compound microscope.
2. Microscopical study of blood cells: R.B.C., W.B.C., and platelets.
3. Estimation of Haemoglobin.
4. Total count of R.B.C.

B.Pharm Syllabus
21
5. Total count of W.B.C.
6. Differential count of W.B.C.
7. Determination of clotting and bleeding time.
8. Examination of clot under the microscope.
9. Effect of chemical agents on R.B.C.
10. Fragility test of R.B.C.
11. Determination of erythrocyte sedimentation rate.
12. Examination of Haemin crystals.

B.Pharm Syllabus
22
Organic Pharmacy–II (PHARM 1209)
1. Isomerism:
General discussion, classification and structural isomerism, stereoisomerisms: geometric
and optical isomerism
2. Heterocyclic Chemistry:
5-membered heterocyclic: pyrole, furan, thiophene, thiazole, isothiazole, oxazole,
isooxazole compounds; their preparation, reaction and pharmaceutical importance.
6-membered heterocyclic compounds: pyridine, pyrimidine, pyradizine, pyrazine &
triazine: preparation reaction and importance.
Benzofused 5-member hetero-atomic compounds: indole, benzofuran, benzothiaphene,
and carbazole preparation reaction and importance
Benzofused 6-member hetero-atomic compounds: quinoline, iosquinoline: their chemistry,
synthesis and pharmaceutical importance.
3. Reaction Mechanism:
Addition reaction: Electrophilic, nucleophilic, free radical, 1,2-addition, 1,4-addition
Substitution: SN1, SN2, stereochemistry, electrophilic and free radical substitution reaction.
Elimination: E1, E2 mechanism and stereochemistry.
Rearrangement: Hoffmann, Claisen, Signatropic & Fries rearrangement.
4. Introduction to common essential drugs:
Introduction, synthesis & uses of paracetamol, aspirin, salicylic acid, benzoic acid, benzyl
benzoate, sulfa drugs, PASA, PABA, isoniazide, hallothane, enfurane, methoxyfurane,
diethyl ether, chloroform, cyclopropane, trichloroethane,
Paper-i: introduction & history of pharmacy
Organic Pharmacy–II Lab (PHARM 1210)
1. Test for elements of organic compounds.
2. Solubility tests of organic compounds.
3. Identification of functional groups from organic compounds/ drug:
(a)–COOH (b) –OH (c) –NH2 (d) –NO2 (e) –CONH2 (f) –COOR (g) >C=O (h) –CHO
(I) –CI (j) –Br (k) –I (l) –SO2 (m) –CONHR (n) –CONR2
Viva voce-I (PHARM 1200)

B.Pharm Syllabus
23
Semester-3
Pharmaceutical Microbiology (PHARM 2111)
1. Introduction to microbiology: microbiology as a field of biology, place of
microorganisms in the living field, procaryotic and eucaryotic protists. Groups of
microorganisms, areas of microbiology, application of microbiology.
2. History and evolution of microbiology: spontaneous generation and biogenesis, germs
theory of diseases, pure culture concept, immunization, widening horizons.
3. Microscopic observations of microorganisms: bright field, dark field, fluorescence and
phase contrast microscopy, electron microscopy, preparations of microscopic
examinations, wet mount and hanging drop techniques, fixed and stained smears,
microbiological stains: simple and differential methods.
4. Bacteria: nomenclature of bacteria, morphology and fine structures, nutritional
requirements, bacteriological media, growth and reproduction, quantitative
measurement of bacterial growth, maintenance and preservation of pure culture of
bacteria.
5. Micro-organisms other than bacteria: (brief study):
a) Yeasts: types, morphology, reproduction and physiology, pathogenic yeasts.
b) Rickettsiae: introduction, characteristics, pathogenic rickettsiae, laboratory
diagnosis of rickettsial diseases.
c) Viruses: history of viruses, classification, Characteristics, reproduction and
culture of viruses, virus inhibition, control of virus infections, bacterial virus or
bacteriophages, morphology and composition, cultivation of bacterial viruses,
reproduction of bacterial viruses.
6. Sterilization by heat: sterilization by dry heat, principles of hot air oven, methods of use
and applications, advantages and disadvantage of sterilization by moist heat, factors
affecting sterilization by moist heat, principles of sterilization by steam under pressure,
autoclave-applications, testing the efficiency of autoclaves, sterilization by heating with
bactericides.
7. Basic concepts of immunology: infections, pathogenicity and virulence immunity.

B.Pharm Syllabus
24
Pharmaceutical Microbiology Lab (PHARM 2112)
1. Identification and characterization of bacteria.
2. Staining of bacterial cells and spores.
3. Preparation of pure bacterial cultures.
4. Preparation of pure culture and its identification.
5. Bacterial counts.
Inorganic Pharmacy-II (PHARM 2113)
Environmental Chemistry and Environmental Science:
a) Definition, causes of environmental pollution, types of pollutants ex-gases
(SO2, SO3, CO2, CO, NO, HCl, NO2, etc.) hydrocarbons, cigarettes, smokes, suspended
particulate, pesticides, gasoline and industrial waste, pharmaceutical food additives,
deleterious effects of pollutants on life cycle, application and importance of
environmental sciences.
b) Heavy metal toxicity: Poisoning caused by Mercury, Arsenic, Lead, Iron and
Copper. Their adverse effects on human life cycle and study of antidotes used in these
poisoning cases.
Principles of Radioactivity and Nuclear Science:
Nature of elements, types of elements that possess radioactive properties; their use in
Pharmaceutical and medical sciences.
Pharmaceutically acceptable glass and glass wares. Intra & extracellular electrolytes (Na, K,
Ca and Cl ions). Electrolytes in acid base therapy. Essential & trace ions & their
preparations (Fe, Cu, Zn, Mn, S, I, Cr) and application in pharmaceutical science.
Gastrointestinal agents:
Antacids (Al, Mg-preparations with application). Protective & adsorbents. Saline
cathartics, their preparations with applications.
Dental Preparation:
Fluorides and other anticaries agents & their preparations with applications.
Topical Agents:
Zinc preparations, iodine preparations, sulfur preparations. Boric acid, selenium,
cadmium sulphides, silver sulphadiazine preparation and their applications.

B.Pharm Syllabus
25
Inorganic Pharmacy-II Lab (PHARM 2114)
A. Qualitative analysis of metal ions and acid radicals:
Na+
, K+
, Ca+2
, Ag+
, Mn+4
, Fe+2
, Fe+3
, Co+2
, Mg+2
, Al+3
, Cu+2
and acid radicals CO3,
halides, Citrate
SO4
-2
, NO3
-
, SO3
-2
, etc.
B. Identification of inorganic drugs in their formulation:
1. Ca+2
, from supplied preparations
2. Fe+2
from supplied preparations
3. Al+3
4. Mg+2
5. K+
from supplied reparations
6. Na+
C. Conversion of different water insoluble or sparingly soluble drugs into water soluble
forms:
1. Na/ K – salicylate from salicylic acid
2. Na/ K – benzoate from benzoic acid
3. Na/ K – citrate from citric acid
D. Manufacturing of inorganic drugs:
1. Manufacturing of aluminum hydroxide gel.
2. Manufacturing of ferrous chloride, ferrous gluconate & ferrous fumerate.
Biomolecular Pharmacy (PHARM 2115)
1. Carbohydrates:
General considerations, chemistry, stereochemistry, classification, aldoses, ketoses,
oxidation, effect of alkali, Kiliani-Fisher synthesis of aldoses. Ruf degradation of optical family,
D-L. R.S. cyclic structures of D (+) glucose, mutarotation, hemiacetal-acetal form of glucose,
ring size determination, disaccharide’s, structure determination of polysaccharides, starch,
cellulose, glycogen; chemical and pharmaceutical importance of carbohydrates, blood sugar,
glycogenesis, glycolysis, TCA cycle, metabolism of carbohydrates.
2. Lipids:
General consideration, chemistry, biosynthesis of fats and fatty acids, catabolism of fat,
fatty acid cycle, B-oxidation, catabolism of unsaturated fatty acids, ketone bodies, ketosis,
ketourea, ketoacidosis, diabetic coma and its treatment, lactic acid and acidosis.
Phosphoglycerides, steroid and bile salts.

B.Pharm Syllabus
26
3. Amino Acids & Proteins:
General considerations, structure of amino acids, acidity and basicity of amino acids,
isoelectric point, preparation and reactions of amino acids, essential amino acid, peptide
synthesis, amino acid sequence determination, metabolism of amino acids, deamination,
transamination, racimization etc.
Classification and functions of protein structure, denaturation of proteins, purification
of proteins, electrophoresis, enzymes as protein, one carbon unit transfer, proteins as drugs.
4. Nucleic Acids:
Chemistry of nucleic acids, bases, nucleosides, nucleotides, polynucleotides,
nucleoproteins, RNA, DNA, Double – Helix theory, replication of DNA, genetic code, codons,
anticodons, polypeptides and protein synthesis, viruses, hereditary diseases, genetic
engineering and its application in pharmaceutical industries.
5. Enzymes and Coenzymes:
Chemical nature, classification, catalytic properties, enzyme specificity, mechanism of enzyme
actions, enzyme catalyzed reactions, enzyme activation and inhibition, competitive inhibition,
allosteric inhibition, irreversible inhibition of poisons and toxins, chemotherapy and enzyme
inhibition, coenzymes, thiamin pyrophosphate, flavin coenzyme, TH4, pentothenic acid, NAD+,
NADH+ H+, pyridoxal pyrophosphate, biotin, vit. B12 coenzymes etc.
Biomolecular Pharmacy Lab (PHARM 2116)
1. Identification of DNA by gel electrophoresis.
2. Identification of Protein by gel electrophoresis.
3. Purification of Protein by different methods.
4. Estimation/Detection of Protein by Bradford method. (UV method)
5. Determination of Protein by Lowry method. (UV method)
6. Estimation of serum protein by using Biurete method.
Physiology & Anatomy-II (PHARM 2117)
1. Nervous system: nerve cells-properties, classification and functions.
Nerve fibres, types of nerve fibres, origin and propagation of nerve impulse across nerve fiber,
action potential, units for the measurement of nerve excitability, synapse: classification and
properties of synapses and their functions.
Reflex action: definition, classification and properties, principal division of the nerve system:
CNS & PNS, different parts of the CNS, principal motor and sensory paths of the CNS, upper
motor neurone and lower motor neurone, sensory nerve endings: different types of sensation.
Muscle tone: definition & regulation, posture & postural reflexes, autonomic nervous system &
its principal division: sympathetic & parasympathetic functions served by the sympathetic &
parasympathetic nerves. Neurotransmitters: definition & functions.

B.Pharm Syllabus
27
2. Metabolism: fat, carbohydrate, protein and nucleoprotein metabolism. Metabolic pathways of
fat, carbohydrate & proteins. Enzymes, vitamins and hormones regulating various metabolic
steps. Vitamin & minerals, their physiological properties and functions.
3. Excretory system: structure of kidney, nephron and its various parts, renal circulation:
adjustment and regulation of renal blood flow and its measurements, renal clearance and its
use for the measurement of GFR and RPF, counter current hypothesis, role of kidney in acid-
base balance of blood and for the maintenance of plasma volume, properties & composition of
urine, micturition reflex and its control.
4. Endocrine system: structure and functions of pituitary thyroid parathyroid, adrenal glands and
pancreatic islets, hormones secreted by the different endocrine glands and by the
hypothalamus, normal & disordered functions of the different hormones, regulation of the
secretion of different hormones.
5. Reproductive system
Male reproductive system; testis & the accessory of organs, male sex hormone, formation of
spermatozoa & its control by various hormones.
Female reproductive system:
Ovaries, uterus, oviduct etc, menstrual cycle & its control, diagnosis of pregnancy, female sex
hormones: oestrogens & progesterone, pregnancy & lactation & their hormonal control.
6. Temperature control: heat production and heat dissipation, role of hypothalamus and other
nervous factors in body temperature regulation, other functions of hypothalamus.
Physiology & Anatomy-II Lab (PHARM 2118)
1. Recording of normal heart beat in toad.
2. Demonstration of the effects of temperature elevation on toad heart.
3. Demonstration of the effects of stannius ligatures on toad heart.
4. Demonstration of the effects of drugs on toad heart.
5. Demonstration of the effect of electrolytes (Na+
, K+
, Ca+2
) on toad heart.
6. Recording of respiration with stethograph. Effect of physical exercise on B. P. and heart rate.
7. Measurement of B. P. with sphygmomanometer. Effects of physical exercise on B. P. and heart
rate.
8. Biochemical test on saliva: Effect of ptyalin on starch.
9. Collection of gastric Juice. Tests for gastric acidity.
10. Estimation of blood sugar in normal person.

B.Pharm Syllabus
28
Semester-4
Economics (HUM 1301)
1. Basic concepts
2. Microeconomics: supply demand, and product markets
3. Factor markets: labor, land, and capital, applied microeconomics, international trade,
government, and the environment
4. Macroeconomics: the study of economic growth and business cycles, economics growth
and macroeconomic policy, unemployment, inflection, and economic policy
Socioeconomic Study of Bangladesh (GED 2204)
1) GED 1302 Health and Environment: Conducted by course Teacher
2) GED 2103 World History and Civilizations:
1. Introduction to history, culture and civilization, early man.
2. Ancient civilizations: Egyptian civilization.
3. Sumerians: Akkads, Babylonians, Assyrians and Phoenicians.
4. Classical civilizations: ancient Greek and Romans.
5. Early Indians, early American civilizations: Mayan, Aztec and Inca.
6. Middle ages: introduction, Roman Empire in east, Persia, Crusades and
explorations, developments in art, literature, science and music.
7. Revolutions: industrial revolution in England, french revolution. World
wars. Cold war and post cold war movements.
3) GED 2204 Socio-economic Study of Bangladesh
1. Physical aspects of Bangladesh: Physiographic, climate and soil of
Bangladesh.
2. Socio-political foundation of Bangladesh: Partition of Bengal to East
Pakistan and Bangladesh.
3. Sociological aspects of Bangladesh: Population, minority groups, social
class.
4. Economic aspects of Bangladesh: Economic activities, natural
resources, human resources and future economic scenario.
Physical Pharmacy-II (PHARM 2219)
1. Principle & techniques of heat transfer: drying, freeze-drying, evaporation, distillation.
2. Extraction: solvent extraction, solid/liquid separation, filtration, centrifugation.
3. Kinetics:
(a) Physical degradation of pharmaceutical products loss of water, absorption of water,
loss of volatile constituents, polymorphism, colour change.
(b) Chemical degradation: hydrolysis, oxidation, isomerization, polymerization,
decarboxylation. Factors affecting chemical degradation etc.
(c) Definitions, rates & orders of reactions, methods for determination of orders of
reactions. Influence of temperature on rate of reactions, theories of reaction rates,
decomposition of pharmaceutical products, accelerated test for physical, chemical and
photo-chemical stability, stability aspects of formulations, manbeted products and
clinical supplies, shelf life determination.
4. Adsorption and interfacial phenomena: freundlich and Langmuir isotherms, BET equation,
electrical properties of interfaces, electrical double layer, nernst and zeta potential, gibbs

B.Pharm Syllabus
29
equation. Spreading, surface active agents, emulgents, detergents and antifoaming agents,
surfactants and drug activity, surfactants and pharmaceutical products.
5. Rheology and rheology of dispersed systems: Newtonian liquids, non-newtonian materials,
yield value, plastic and pseudoplastic flow, dilatant and thixotropic flow, viscosity of suspending
agents.
6. Colloids: classification, preparation, electrical and optical properties, sedimentation, stoke’s law,
stability of colloidal dispersion, protective colloid, sensitization, dialysis, Donnan membrane
equilibrium, application and uses of colloidal preparations in pharmacy.
7. Electrochemistry: electrical units and their interrelation, faradays laws of electrolysis and
electrochemical equivalents; electrolytic conduction, equivalent conductance and the related
facts, conductometric titration’s, transference numbers & their determination.
8. Electrochemical cells: electrode and cell potentials, energies involved in electrode processes;
reference electrodes, buffer solutions and measurement of ph; potentiometric titration’s and
oxidation reduction systems, concentration cells.
Physical Pharmacy-II Lab (PHARM 2220)
1. (a) Determination of viscosity of pure liquids such as glycerin, alcohol etc.
(b) Determination of viscosity of liquid pharmaceutical preparations – syrup, emulsion,
suspension etc.
(c) Study of variation of viscosity of liquids with temperature using Ostwald or Engler’s
viscometer.
2. Determination of velocity constants of the hydrolysis of methyl/ ethyl acetate catalyzed by HCI/
NaOH.
3. Determination of adsorption isotherm of oxalic (or acetic) acid from aqueous solution by
charcoal and calculation of the constant in Freundlich’s equation.
4. Determination of the equilibrium constant of the reaction Kl + I2 = KI3
5. Determination of solubility of a sparingly soluble salt in water by conductance measurement.
6. Determination of velocity constant for the hydrolysis of an ester in the basic medium by
conductance measurements.
7. Determination of the molecular weight of an organic solid by iboluscopy and cryoscopy.
Pharmacognosy-II (PHARM 2221)
1. Phytochemistry and pharmaceutical uses of the following plant constituents along with
considerations of some important local and foreign drugs of each group.
A. Glycosides and glycoside containing drugs.
Biosynthesis of glycosides: The details of the followings:
i) Cyanogenic: Wild Cherry
ii)Isothiocyanate-Mustard (Black mustard and white mustard).
iii) Cardiac: Digitalis, strophanthus, squill.

B.Pharm Syllabus
30
iv) Saponins: Sarsaparilla, glycyrrhiza, dioscorea.
v)Anthraquinone glycosides: Cascara sagrada, aloe, senna, rhubarb.
vi) Other glycosides and neutral principles: Gentian, quassia, saffron.
B. Alkaloids: The details of the followings:
Biosynthesis of tropane, quinoline, isoquinoline and indole alkaloids.
i) Tropane-Belladona, stramonium, hyoscyamus and lica
ii)Quinoline-Cinchona, Cusparia bark
iii) Isoquinoline-Ipecacs, Opium, sanguinaria, curare
iv) Indole-Rawolfia, Nux vomica, Ergot, Catharanthus
v)Imidazole: Pilocarpine
vi) Steroidal: Veretrum viride, aconite
vii)Lupinea-Lupinus spp
viii) Purine base-Coffee, tea.
C. Volatile oils and related terpenoids-Methods of obtaining volatile oils,
chemistry, their medicinal and commercial uses, biosynthesis of some important
volatile oils used as drugs.
Details of different types of volatile oils.
i) Terpenes or sesquiterpenes: Pinus, Juniper, Cade
ii) Alcohols: Coriander, Sandalwood
iii) Ester; Peppermint, lavender, rosemarry
iv) Aldehydes: Cinnamon bark, eucalyptus, lemon peel, lemon grass.
v) Ketones: Spearmint, Caraway, Dill, Camphor
vi) Phenols: Clove, cinnamon leaf, Ajowan
vii)Ethers: Fennel, nutmeg, eucalyptus, anise, cajuput
viii) Peroxides: Chenopodium
ix) Others: Mustard, wintergreen, bitter almond
D. Phenolic compounds and tannins: Chemical nature and test for tannins some taruin
containing drugs such as nutgall and catechu.
E. Resin and resin combinations: Resin, oleo-resin, oleo-gum resin, tolu balsam and
benzoin.
2. Herb as Health foods: Alfa alfa, apricot, pits, arnica, garlic, onion, ginseng, spirulina,
Fenugreek, Sassafrus, Honey etc.
3. Poisonous plants and natural pesticides: Datura, poison hemlock, water hemlock, foxglove
(digitalis). Ipornoca, tobbaco, poppy, pyrethrum flower, Derris & Ianchocarpus, red squill,
strychnine, etc.
Pharmacognosy-II Lab (PHARM 2222)
1. Pharmacognositic study of a few selected powdered drugs.
2. Chromatographic techniques: analysis of plant extracts by thin layer chromatography.
3. Study of volatile oils and some volatile oil containing drugs: Caraway, clove, cinnamon,
peppermint etc.
4. Detection of adulterants: e.g. cotton seed, sesame-and arachis-oils in olive oil.
5. Examination of cod liver oil and detection of vitamin A in cod liver oil.
6. Extraction and isolation of anthraquinone glycosides from Cascara sagrada, Aloe, Senna
and Rhuburb.
7. Isolation of lycopene form tomato
8. -carotene from carrot.
9. Examination of some saponin containing drugs: Sarsaparilla, Dioscorea, etc.
10. Study of few important cardioactive drugs: Digitalis: Strophanthus and Squill.

B.Pharm Syllabus
31
11. Study of alkaloids and some alkaloid containing drugs: Belladona, strammonium, cinchona,
rauwolfia, tea, coffee, tobacco, ergot, ephedra, nux vomica and areca.
12. Isolation of lactose form cow’s milk.
13. Physical and chemical tests for honey.
14. Study of some important medicinal and poisonous plants of Bangladesh.
Pharmacology-I (PHARM 2223)
1. Pharmacological definitions:
pharmacology, clinical pharmacology, scope of pharmacology, historic development, the
pharmacopoeias, drugs-nomenclature, generic and branded drug, prodrugs, source and nature
of drugs and properties of ideal drugs, ethics, over the counter drugs, prescription drugs,
prescription, different parts of a prescription, prescription incompatibilities, dispensing,
agonistic, antagonists, synergistic, side effects, drug tonicities, drug interaction.
2. Dose, dosage Forms and Routes of Administration of Drugs
Drug absorption–factors affecting the drug absorption, plasma membrane, passage of drugs
across membranes, simple diffusion, filtration, facilitated diffusion, active transport, passive
transport, site of absorption, bioavailability, distribution of drugs, protein binding, accumulation
and storage in adipose tissue of body, drug dilution in body fluids, metabolism of drugs,
excretion: renal, hepato-biliary, pulmonary, mammary, vaginal, gastrointestinal excretion,
sweat.
3. Analgesics and antipyretics: concept of pain and fever, causes of pain and fever, narcotic
analgesics: opium alkaloids, methadone and propoxyphene, morphine antagonists, oxycodeine,
hydrocodeine, dihydrocodeine and dextromethorphan, non narcotic analgesics: aspirin,
salicylates, pyrazolone derivatives, pare aminophenol derivatives, anti-inflammatory agents:
concept of inflammation, indomethacin, sulindac, the fenamates, tolmetin, propionic acid
derivatives, drugs used in the treatment of gout:allopurinol, colchicine etc. Steroidal anti-
inflammatory agents.
4. Gastric antacids: general consideration, chemistry, absorption, distribution and excretion,
action and effects of gastric antacids, mode of action on pH, related adverse effects,
classification of antacids: aluminium hydroxide, aluminum carbonate, mg-hydroxide and oxide,
magnesium carbonate, magaldrate, magnesium trisilicate, sodium bicarbonate, antacid
mixtures, peptic ulcer, colloidal bismuth, H2–receptor antagonists: cimetidine and
ranitidine,proton pump inhibitor(e.g. Omeprazole, Pantoprazole, Lansoprazole) etc.
5. Autacoids:
a) Histamines and antihistamines. Mode of action of histamines on cardiovascular system,
smooth muscle, gastric secretion, anaphylactic stock, histamine releasing drugs.
Allergic disorder, antihistamines: classification, pharmacological action. Action on CNS.
Therapeutic uses, absorption, distributions and excretion. Adverse reactions etc.
b) Serotonine and serotonine antagonists.
c) Occurance, pharmacological action, prostaglandins, prostacyclines and tromboxane.
d) The kinins: kallidins and bradykinin.
6. Drugs acting on the blood and blood forming organs:
a) Haemotinic drugs.
b) Anticoagulants.

B.Pharm Syllabus
32
7. Anaesthetic:
General pharmacology of anaesthetics, general properties, chemistry and SAR, mechanism of
action, local anaesthetics, pregnancy dependence and use of dependence, pharmacological
action, fate of local anaesthetics, examples of anaesthetics-cocaine, procaine, benzocaine,
lidocaine, etc, clinical uses of local anaesthetics, general anaesthetics, inhalation anaesthetics
(examples): halothene, enflurane, methoxyfluranc, nitrous oxide. Diethyl ether, fluroxene,
cyclopropane and ethylene etc, intravenous anaesthetics: barbiturates, opoid analgesics, etc.

B.Pharm Syllabus
33
Pharmaceutical Analysis-I (PHARM 2224)
1. Introduction and techniques of pharmaceutical analysis
 Introduction; objectives and the art and science of pharmaceutical analysis
 Selection of samples, selection of chemicals, choosing the tools, identification of containers,
filtration, ignition of precipitates, drying of samples, recording the results
2. Aqueous acid base titration
Definitions, distribution of acid-base species with pH of the medium, acid-base titrimetry for
determination of weakly acidic and basic pharmaceuticals, indicators (theories) and their
selection, applications.
3. Non-aqueous acid-base titration
Theoretical considerations and principles, bronsted lowery theory of acids and bases, non-
aqueous solvents, titration of weak acids and weak bases, applications and scope of non-
aqueous titrations.
4. Complexometric titration
Introduction to complexometric titration, complexes and chelates, stability of complex ions,
titration based on complex formation, types of complexometric titrations, techniques employed
in complexometric titration, methods of end point detection, titration selectivity and masking
regents.
5. Oxidation reduction titration
Principles and concepts, determination involving potassium permanganate, potassium
dichromate and potassium bromate, iodometric determination, miscellaneous oxidation and
reduction titrations, indicators applications.
6. Potentiometric titration
Introduction, theory & principles, electrochemical cells and half cells, electrodes, measurement
of potential, application of potentiometric titrations.
7. Polarography and amperometric titration
Introduction, theoretical considerations, instrumentation, general polarographic analysis,
amperometric titration using one and two electrodes.
8. Aquametry
Principle and scope, physical methods of water determination, chemical methods of water
determination, karl-fischer procedure: principle, chemistry, methodology, equipment, end point
detection and limitations.
Viva voce-II (PHARM 2200)

B.Pharm Syllabus
34
Semester-5
Pharmaceutical Technology-I (PHARM 3125)
1. Micromeritics:
Importance of particle size determination, different means of expressing particle size, methods
of particle size determination, optical and electron microscope studies. Coulter counter
methods. Laser beam technique, sieve analysis, sedimentation methods, particle shape and
surface area measurement of particle surface area.
2. Pre-formulation:
Preliminary evaluation and molecular optimization, bulk characterization of the material, crystal
nature and polymorphism, thermal properties, hygroscopicity, particle characterization, bulk
density, powder flow properties, solubility analysis, pKa determination, ph solubility profile,
effect of temperature, solubilization, partition coefficient, dissolution, stability analysis. Solution
stability and solid state stability.
4. Chemical and Physical Incompatibility.
5. Pharmaceutical excipients:
Chemistry, physical properties and uses of following excipients: acidifying agents, air
displacement agents, alkalizing agent, antifoaming agents, antimicrobial preservatives, anti
oxidants, buffering agents, chelating agents, colors, complexing agents, emulsifying agents,
flavoring agents and perfumes, humectants, ointment bases, solvents, stiffening agents,
wetting and solubilizing agents.
6. Basic Principles of Compounding and Dispensing:
Weight, measures and units calculation for compounding and dispensing, fundamental
operation in compounding, good manufacturing practice in compounding and dispensing,
containers and closures for dispensed products, responding to the prescription, labeling of
dispensed medications.
7. Liquid dosage forms:
Solution and elixirs, theory of solution, different factors affecting solution process, advantages
and disadvantages, formulation consideration, manufacturing considerations, packaging of
liquids, preservation and stability aspects, quality control systems of liquids.
8. Dispensed Systems:
A) Properties of dispensed systems, theoretical aspects of suspension, emulsion & colloids,
surface char and zeta potential, inter-particle force, crystal growth, wetting, adsorption at solid-
liquid interface, surface and interfacial tension, flocculation and coalescence.
b) Suspensions:
advantage and disadvantages, aggregated and dispersed systems, formulation of suspensions,
manufacturing of suspension, stability of suspension, evaluation and quality analysis of
suspension, rheological considerations, illustrative examples.

B.Pharm Syllabus
35
c)Emulsions:
definitions and applications advantage and disadvantages, theory of emulsion, formation of
emulsion, classification of emulsifying agents, HLB values of surface active agents, formulation
of emulsion, manufacturing of emulsion, stability of emulsion, evaluation and quality analysis of
emulsion, rheological considerations, illustrative examples.
9. Semisolid (Ointments, pastes, gels):
Structure of skin, percutaneous absorption of drugs, definition and classification of semisolid,
classification of ointment bases, formulation of ointments, manufacturing of ointments,
rheological consideration, evaluation and quality analysis of ointment.
10. Suppositories
Drug absorption form colon, classification of suppositories, suppository bases, formulation of
suppositories, manufacturing of suppositories, testing of suppositories.
Pharmaceutical Technology-I Lab (PHARM 3126)
1. Preparation of percent solution and calculation.
2. Preparation of aromatic water.
3. Preparation of syrups.
a) Phenobarbitione-Na syrup.
b) Chlorpheniramine maleate syrup.
c) Promethazine-HCl syrup.
d) Iron syrup.
4. Preparation of suspensions
a) Paracetamol suspension
b) Antacid suspension
c) Chalk powder suspension
5. Preparation of emulsion and identification of type of emulsion
a) Primary emulsion by dry gum method and wet gum method
b) Castor oil emulsion

B.Pharm Syllabus
36
Medicinal Chemistry-I (PHARM 3127)
1. Stereochemistry:
a) Geometric isomerism of alkenes, cyclic compounds: cis-trans and (E)-(Z) system of
nomenclature
b) Conformational isomers: Open chain and cyclic system
c) Chirality of molecules: Enantiomers, diastereomers, racemic modification, Meso
compound, R & S configuration, sequence rule, Optical rotation
d) Asymmetric synthesis: Preparation of enantiomers by asymmetric synthesis & optical
resolution method
e) Stereo selective and stereo specific reaction
f) Pharmaceutical importance of studding stereochemistry
2. Name reactions:
Arndt-Eisterd, Baklelite, Baeyer-Villiger, Birch reduction, Clemenson reduction, Darzens
condensation, Diels Alder, Eschweiler-Clarke, Frielde-Creft, Gabriel Synthesis, Gettermann-Koch
& Sandmayer, Gridnard, Hoffman, Mannich, Miahael, Meerwin-pondorf Verley reduction,
Openaur oxidation, Perkin, Reformatsky, Reimer-timan, Vilsmeir-Haak, Witting and Wolf-
kishner reduction.
3. Natural products and secondary metabolites:
a) Vitamins: clinical aspects of vitamins, and effects of free radicals, synthesis of vitamins:
vit-c, nicotinamide, and mechanism of action of vitamins.
b) Alkaloids: alkaloids as pharmaceutical raw materials, opium and its analogue, synthesis
of ephedrine, clinical comparison of ephedrine and epinephrine.
c) Glycosides: chemical and clinical aspects of digoxin and other digitalis glycosides
4. Mechanism of action of indiviual drugs:
a) Antibiotics and chemotherapeutic agents
b) Hypnotic and sedatives
c) Antihistamines
d) Analgesic & anti-inflammatory agents
e) Cardiovascular drugs
f) Diuretics
Medicinal Chemistry-I Lab (PHARM 3128)
Synthesis of Drug & Drug intermediates
a) Paracetamol b) Benzocaine
c) Aspirin d) Phenacetin
e) PABA (Para Amino benzoic acid) f) Meta Nitro benzaldehyde
g) Ethyl Para hydroxy benzoate h) Para Amino phenol
i) Methyl Salicylate.

B.Pharm Syllabus
37
Pharmacology-II (PHARM 3129)
1. Modes and Mechanisms of Drug Action:
a) Basic concept of drug Action
b) Physico-chemical Nature of drugs
c) Drug receptors
d) Receptor and Non receptor mechanism of drug action
e) Macromolecular nature of drug receptors
f) Relationship between drug concentration versus response:
Concentration-effect curve and receptor binding of agents, Competitive and irreversible
antagonism, Partial against, Receptor-effectors coupling and spare receptors, other
mechanisms of drug antagonism.
g) Signaling mechanisms and drug action: Regulation of gene expression by intracellular
receptors: Legend regulated trans-membrane enzymes: Legend gated channels: G-
proteins and second messengers: Well-established second messengers such as cyclic-
AMP, calcium and phosphoinositides and cyclic GMP; Interplay among signaling
mechanisms.
h) Receptor classes and drug development
i) Relation between drug dose and clinical response: Graded dose response relations,
Shapes of dose-response curve, Quantal dose-effect curve, Variation in drug
responsiveness, Beneficial versus toxic effects of drugs.
2. Antibacterial and Antifungal Agents:
Introduction, classification, chemistry, mode of action, structure-activity relationship
pharmacokinetics, indications, contraindications, dose, adverse effects and drug interaction of
following individual class of drugs:
a) Drugs which interfere with synthesis and/or action of folate:
(i) Sulfonamides (ii) Trimethoprim
b) -lactum antibiotics:
i) Penicillins (ii) Cepahlosporins (iii) Carbapenems (iv) Monobactams
c) Drugs affecting bacterial protein synthesis:
(i) Tetracyclines (ii) Chloramphenicol (iii) Aminoglycosides (iv)
Macrolides
d) Drugs affecting the enzyme topoisomerase-1: e.g. Fluoroquinolones
e) Miscellaneous antibacterial agents:
(i) Glycopeptides Antibiotics (ii) Polymixin Antibiotics (iii) Bacitracin,
(iv) Nitrofurantoin
f) Antitubercular agents:
(I) Streptomycin (ii) Isoniazid (iii) Rifampicin (iv) Ethambutol
(v) Pyrazinamide (vi) Capreomycin (vii) Thiacetazone
g) Antileprosy drugs:
(I) Dapsone (ii) Rifampicin (iii) Clofazimine
h) Antifungal agents:
(i) Clotrimazole
3. Drugs used in tropical diseases:

B.Pharm Syllabus
38
Introduction, classification, chemistry, mode of action structure-activity relationship,
pharmacokinetics, indications, contraindications, dose, adverse effects and drug interaction of
following individual class of drugs.
a) Anti amoebic Drugs
b) Anti malarial Agents
c) Anthelmentics
d) Drugs used in enteric fever
e) Drugs used in diarrhoea and cholera.
4. Cardiovascular Drugs:
Functioning and disease of the heart, arrhythmia, atheroma, ischemia, angina pectoris,
coronary thrombosis, myocardial infarction, arteriosclerosis, atherosclerosis, hypertension and
congestive heart failure.
Introduction, classification, chemistry, mode of action, structure-activity relationship,
pharmacokineties, indications, contraindications, dose, adverse effects and drug interaction of
following individual class of drugs:
a) Cardiac glycosides.
b) Antihypertensives: -blockers, vasodilators, ca-channel blocking agents, ACE inhibitors.
c) Antiarrhythmic drugs.
d) Diuretics: cardiac anhydrase inhibitors, low and high ceiling diuretics, potassium
sparing diuretics and osmotic diuretics.
5. Anti diabetic drugs:
a) Introduction and classification of diabetes.
b) Hyperglycemia and hypoglycemia.
c) Introduction, classification, chemistry, mode of action, structure-activity relationship
pharmacokinetics, indications, contraindication, dose, adverse effects and drug
interaction of following individual class of drugs:
d) Oral hypoglycemic agents:
a. Sulfonylureas
b. Biguanides
c. Hormone preparations: insulin
e) Management of diabetes mellitus.
Pharmacology-II Lab (PHARM 3130)
1. Study of drugs acting on CNS:
a. CNS stimulant drugs (strychnine, ephedrine, and amphetamine).
b. CNS depressant drugs (barbiturates induced sleeping time)
2. Effect of pilocarpine on saliva secretion of rat.
3. Effect of digitalis, adrenaline, nor-adrenaline, isoprenaline on toad’s heart.
4. Effect of local anaesthetics on rat’s tail.
5. Study of mydriatic & myotic effect on rabbit eye (e.g. pilocarpine, atropine,
physostigmine etc.)
Forensic Pharmacy and Toxicology (PHARM 3131)
Forensic pharmacy
1. Introduction:

B.Pharm Syllabus
39
Definition, branches, aim and scope of forensic pharmacy, pharmaceutical jurisprudence, role
of pharmaceutical jurisprudence, difference between forensic pharmacy and pharmaceutical
jurisprudence
2. Forensic Criminology:
Definition of criminology, crime and criminal, classification of criminals, difficulties in the
detection of crime.
3. Legal procedures in Medico-Legal cases:
Define legal procedure, affidavit, crime, complaint, court, document, defendant, evidence,
exhibit, hurt, injury, investigation, judicial proceeding, oath, offence, perjury, and plaintiff,
summon and warrant.
4. Legal System:
Criminal law, civil law, types of cases, courts of law, description and power of Supreme Court,
high court, session court and magistrate courts.
5. Inquest:
Definition, types of inquest, difference between police inquest and magistrate inquest, chalan,
preparation of inquest report, dying declaration, dying deposition, chalan.
6. Ethics in Forensic Pharmacy:
Pharmaceutical ethics, pharmacy act, codes of medical ethics, medical etiquette, professional
infamous conduct, professional secrecy, professional negligence, professional death sentence
7. Death: Modes and Signs:
Definition of death, phases of death, modes of death, signs of death, brain death, coma,
syncope, asphyxia
8. Identification of living and death:
Definition, types of identification, necessity of identification, race, sex, religion etc.
9. Postmortem Changes:
Early change, late change, algor mortis, post mortem caloricity, post mortem lividity, estimation
of time of death, post mortem staining, rigor mortis, cadaveric spasm, putrefaction,
saponification and mummification.

B.Pharm Syllabus
40
Toxicology
1. Basic concepts in toxicology: A course overview, including the assessment of toxic substances,
their target organs, introduction to toxicology.
2. Toxic responses to drugs and chemicals: Classification of different types of responses according
to the biochemical basis and manifestation of toxic effect, mechanism of genotoxicity and
nongenotoxic carcinogens.
3. The biotransformation of toxins, their inactivation and removal from the body: An introduction to
biotransformation, the cytochrome p450 system-its function, mechanism of action and
regulation; glutathione and glutathione-S-transferase-its function, mechanism of action and
regulation.
4. The mechanism of toxin action: DNA damage and its repair, mutagenicity and carcinogenicity,
cell death and apoptosis, environmental oestrogens, neurotoxicity, risk assessment and toxicity
testing.
5. Environmental pollutants: Gaseous pollutants special emphasis on Cyanide and CO.
6. Study of following classes of toxicants include their sources, chemistry, mode of toxicosis, signs
and symptoms, first aid, treatment, antidotes, precautions, long term care, warning and
awarness, rehabilitation etc.
(a) Heavy metals
Lead, mercury etc.
(b) Non-metals
Arsenic
(c) Pesticides and insecticides
DDT, parathion,
(d) Venoms and sting poison
Cobra, bee’s sting,
(e) Accidental house hold poisoning; solvents and liquids
Acids, alkalies
(f) Drug over dose
Food poisoning Toxicity caused by microorganisms
Botulinum
(g) Poisonous plants
Datura
1. Target organ toxicity: Organs and tissue specific toxicity.

B.Pharm Syllabus
41
Hospital Pharmacy (PHARM 3132)
1. Introduction:
Goals, minimum standards, abilities required for a hospitals pharmacist, hospital as an
organization,
Classification, organizational patterns, management and administration, different department
and services, role of a pharmacist in the hospital.
Hospital pharmacy, organizational and personnel, supportive personnel, pharmacy education,
job descriptions.
2. Pharmacy and therapeutics committee:
Description and purpose, membership and functions, hospital formulary guiding principles, legal
basis, principles for admission or deletion of drugs, selection of text.
Investigational use of drugs, description, principles involved classification, control,
identification, role of a hospital pharmacist, advisory committee.
3. Purchasing and inventory control:
Purchasing agent, purchasing procedure, control on purchases, storage, perishable inventory,
physical inventory, perpetual inventory.
4. Control of special classes of drugs:
Use of samples, in- patient drug orders, out-patient prescriptions, ward stock drugs, label
symbols, narcotics and their control, classes, procurement and execution of order forms,
dispensing, hospital narcotic regulations, new systems.
Floor stock drugs, selection, charge and non charge, labeling, regulations concerning narcotics,
inspection and nursing, drug cabinets.
5. Dispensing to in and out patients:
drug distribution systems, dispensing of charge, non floor stock drugs, mobile
dispensing unit, unit dose dispensing, and new concepts.
Dispensing area, dispensing routine, record keeping, dispensing during off hours, use of
nursing supervision, emergency boxes and night drug cabinets, pharmacist on call, drug
charges in hospital, pricing, break even point pricing.
6. Manufacturing- bulk and sterile:
Control and budget, manufacturing facility and capacity, operating costs, quality control.
7. Drug information center and library:
physical facilities, selections of contents, methods of dissemination, role in educational
and training programs, professional education, internal teaching programs, external teaching
programs.

B.Pharm Syllabus
42
Semester-6
Biopharmaceutics-I (PHARM 3233)
1.Introduction to Pharmaceutics and Biopharmaceutics:
2.Gastrointestinal absorption of drugs:
a) Biologic consideration: membrane physiology; gastrointestinal physiology;
mechanism of absorption etc.
b) Physicochemical consideration: pKa and gastrointestinal absorption: ph-
partition theory and other physicochemical factors.
c) Dosage form consideration: role of different dosage forms like solution,
suspension, tablet, capsule, emulsion etc. on gastrointestinal absorption.
d) Disintegration and dissolution of drugs.
3.Distribution of drugs:
a) Important pharmacokinetic parameters, such as: biological half-life, apparent
volume of distribution, area under the curve, elimination rate constant etc.
b) Interpretation of drug-plasma level curve.
c) Drug-protein interaction: theoretical aspect of protein drug interaction;
methods used for protein binding; identification of drug binding sites; kinetics
of protein binding; determination of binding sites and association constants:
factors affecting protein binding; effects of protein binding on drug
distribution; elimination and pharmacological effects of drugs.
4.Drug clearance:
a) Theoretical aspects of drug elimination, excretion and biotransformation.
b) Renal elimination: glomerular filtration, active tubular secretion, tubular
reabsorption, determination of renal clearance.
c) Hepatic elimination: biotransformation of drugs: drug bio-transformation
reactions; pharmacokinetics of drugs and metabolites (Michelis Menten
equation); first pass effect; liver excretion ratio; relation between absolute
bioavailability and liver excretion; hepatic clearance-relationship between blood
flow, intrinsic clearance and hepatic clearance; hepatic clearance of a protein
bound drug (effect of protein binding on hepatic clearance).
d) Biliary excretion of drugs.
5.Bioavailability and bioequivalence:
definitions of different parameters relative to bioavailability; purpose of
bioavailability; relative and absolute bioavailability; methods of assaying
bioavailability; criteria for bioequivalence studies.
6.Drug product selection on the basis of bioavailability testing.
Biopharmaceutics-I Lab (PHARM 3234)
1.Tablet weight variation test.
2.Tablet hardness test.
3.Tablet friability test.
4.Tablet disintegration test.

B.Pharm Syllabus
43
5.Tablet dissolution test.
6.Leakage test of packaging of tablets/capsules.
7.Capsule weight variation test.
8.Determination of binding’s sites and association constants.
Pharmaceutical Analysis-II (PHARM 3235)
1.Visible and Ultraviolet Spectroscopy:
Introduction, electromagnetic radiation, units, electromagnetic and absorption spectra,
Lambert’s and Beer’s laws, deviations from Lambert’s–Beer’s law, chromophores and
auxochromes, absorption and intensity shift, types of electronic transition, effects of solvents,
electronic transition in polyenes, instrumentation, colorimetry, Woodward-Fieser rules for
calculating absorption maximum, analysis of mixtures, applications of ultraviolet and visible
spectroscopy in quantitative analysis of drugs, use of ultra violet and visible spectroscopy in
structural analysis.
2. Atomic Absorption Spectroscopy:
Introduction, theory, instrumentation, application in quantitative analysis, advantages &
disadvantages
3. Fluorometry:
Introduction, theoretical principle, quantum efficiency of fluorescence, molecular structure of
fluorescence, instrumentation, factors influencing the intensity of fluorescence, comparison of
fluorometry with spectrophotometry, application of fluorometry in pharmaceutical analysis
4. Polarimetry:
Introduction, instrumentation and application, optical isomerism, origin of optical rotation,
molecular requirements for optical rotatory power, specific rotation, calculation of specific
rotation, circular dichroism (CD), optical rotatory dispersion (ORD).
5. Chromatographic Methods:
Introduction, theory, types, basic instrumentation, detection and application of column
chromatography, thin layer chromatography, paper chromatography, ion exchange
chromatography, gel filtration techniques.
6. High Performance Liquid Chromatography:
Introduction and theoretical principles, instrumentation, characteristics of stationary and mobile
phases, reversed phase high performance liquid chromatography, applications.
7. Gas Chromatography:
Introduction, principles, theoretical considerations, column technology, detectors, analytical
application of gas chromatography.
Pharmaceutical Analysis-II Lab (PHARM 3236)
1.Estimation of Acetyl Salicylic Acid in Aspirin tablets.
2.Estimation of Diclofenac Sodium in Diclofenac tablets.

B.Pharm Syllabus
44
3.Estimation of Ethambutol Hydrochloride in Ethambutol tablets.
4.Estimation of Calcium in Calcium Gluconate injection by Complexometric titration.
5.Estimation of Vitamin C in any chewable vitamin C tablets.
6.Estimation of Ferrous Fumerate in Ferrous Fumerate capsules.
Pharmaceutical technology-II (PHARM 3237)
1.Formulation and manufacturing of tablet:
Manufacturing of tablets by wet granulation, dry granulation and by direct compression,
Granulation of powders for Tableting, Advantages and disadvantages of different processes,
Processing machineries used in tablet manufacturing.
2.Common Tableting problems and evaluation of tablets:
Hardness measurements, weight variation test, thickness and diameter, friability, disintegration
time, dissolution time, mechanism of tablet disintegration and dissolution, in process quality
control methods in tablet manufacturing, study of common tableting problems.
3.Tablet coating:
Definition and classification of coating method, advantages and disadvantages of coated
tablets. Sugar coating: different stages of sugar coating, problems of sugar coating. Film
coating: theory of film coating, film formers, plasticizers, solvents, other excipients. Enteric
coating: enteric coating polymer, formulation of enteric coating. Dry coating (compression
coating). Comparison between sugar and film coats. Aqueous film coating techniques. Modern
film coating materials and coating formulation. Problems of organic and aqueous film coating,
coating machines: conventional coating machines, perforated coating machines, fluidized
coating machines.
4.Hard gelatine capsule:
Definition and classification, advantages and limitations of capsule dosage forms, gelatin and
its manufacture, manufacture of hard capsule shells, properties of capsules, formulation of
capsules, capsule filling machines, tools and accessories, problems in capsule manufacturing,
quality control methods of capsules, packaging of capsules.
5.Soft gelatine capsule:
Definition and classification, advantages and limitations, properties of soft capsules, formulation
of soft capsules, problems in soft capsule manufacturing, quality control methods of soft
capsules, packaging of soft capsules.
6.Microencapsulation technology:
Purpose, methods of preparation, evaluation, pharmaceutical and biological applications of
microencapsulation process.
7.Sterilization and sterility testing:
Gas sterilization methods, sterilization by filtration and radiation, sterility testing of
pharmaceutical products.
8. Drug stability:
Principles, accelerated stability testing.

B.Pharm Syllabus
45
Pharmaceutical Technology-II Lab (PHARM 3238)
1.Formulation and compounding of different pharmaceutical lotions.
2.Formulation and compounding of different suppositories.
3.Formulation and compounding of different pharmaceutical creams.
4.Formulation and compounding of different capsules.
5.Formulation and compounding of effervescent granules.
6.Formulation and compounding of dry syrups.
7.Trouble shooting during manufacturing of tablets with a 16-station rotary tablet machine.
8.Filling of ampoules and sterilization by autoclaving.

B.Pharm Syllabus
46
Pharmaceutical Engineering (PHARM 3239)
1.Drying:
Definition. Importance of drying, terminology, theory & fundamental concepts, periods of
drying, constant rate period, falling rate period, critical moisture content, equilibrium moisture
content, classification, direct & indirect radiation, batch and continuous, dielectric, types of
beds: static, moving, fluidized, pneumatic bed systems, different drying equipment,
construction, operation, merits and demerits, tray dryer, through-circulation dryer, pneumatic
conveying dryer, rotary dryer, spray dryer, tunnel dryer, steam tube rotatory dryer, agitated
pan dryer, vacuum rotary dryer, selection of drying equipment, preliminary dryer selection,
drying tests, final selection.
2.Freeze Drying:
Definition, basic principles, basic elements, application.
3.Filtration:
Definition, importance of filtration, difference with expression, sedimentation and drying.
Classification of filters, theory of filtration, filter media, filter aids, filter thickeners, different
filtration equipment, construction, operation, merits, demerits, the gravity Nutsche Delpark
industrial filter, bag filters sand filters, plate and frame press, recessed plate filter press, Eimco-
Burwell plates and frames, Readco short cycle filter vertical pressure leaf filter, horizontal plate
filter, industrial tubular filter, Rodney hunt pressure filter, mire filter, Vacu-flow suction leaf
filter, string discharge filter, clarifying filters, selection of filtration equipment.
4.Centrifuges:
General principles, magnitude of centrifugal force, materials of construction, critical speed.
Sedimentation centrifuges, filtering centrifugals, centrifuge auxiliaries, drive mechanisms, feed
and discharge lines, feed treatment, costs, selection of centrifugal separators.
5.Solid–Solid Mixing:
Importance, fundamentals, batch homogeneity, types of solids-mixing machines, mixing
mechanism and operations, double cone, twin shell, horizontal drum, double-cone revolving
around long axis, ribbon, vertical screw, batch muller, continuous muller, twin rotor,
performance characteristics, selection of machines.
6.Paste Mixing:
Definition, importance, simple blending, dispersion operations, general equipment design.
Standard types of equipment and operations, Change-can mixer, change-can mixer with
planetary motion, change-can mixer with rotating turntable, troy angular mixer, duplex mixer,
stationary-tank mixer, kneaded mullers, three-roll mill, selection of process and mixer.
7.Liquid Mixing:
Definition, importance, mixing equipment, axial and radial flow impellers. Mechanisms, flow
patterns, impellers, flat-blade and curved-blade turbines, spiral turbines, paddles, gate
impellers, anchor impellers, different fixed-mounted and portable positions, shaft lengths,
baffled and unbaffled tarns, vortex formation and its control, costs, selection of impeller.

B.Pharm Syllabus
47
Community Pharmacy & Regulatory Affairs (PHARM 3240)
A. Community Pharmacy:
Definition and scope of community pharmacy , concept of community health care , health needs
of the community, different levels of health care, elements of primary health care, principles of
primary health care, equitable distribution, community participation, inter sectoral coordination,
appropriate technology, health manpower, health care delivery at different levels, components,
prevention and control of communicable diseases, community pharmacy in dealing with
communicable disease problems, nutritional problems and indigenous systems of medicine,
development of community pharmacy infrastructure, participation of non governmental voluntary
health agencies.
Objectives and components of maternal and child health (MCH) care and its progress in
Bangladesh, demographic characteristics of Bangladesh.
Types of drug store and design, legal requirements for establishment of a drug store,
maintenance of records of retail and wholesale.
Patient counseling and guidance in a community; role of pharmacist in community health care
and education i. e. Family planning.
B.Rational Use of Drugs:
Background of rational use of drugs, definition, factors underlying irrational use of drugs:
patients, prescribers, drug supply system, drug regulation and drug promotion, impact of
irrational use of drugs with examples, disease-specific indicators, drug use patterns in developing
countries, changing drug use patterns, factors effecting drug use, strategies to improve
prescribing, experiences with interventions to change drug use in developing countries.
C.Regulatory Affairs:
General Considerations: Definition, scope, maintenance of licensure, legal relationship and
dealings.
Commercial Laws: Business law, laws of contract 1872, regulations and laws governing the
practices of Pharmacy (The Pharmacy Ordinance 1976). Policies, sales, regulation and laws
concerning to the manufacture, distribution, sale of drugs and poisons:
The Drug Act 1940, The Drug Policy 1982, Essential Drug List, The Drug (Control) Ordinance
1982, The Narcotics (Control) Ordinance 1990, The Poisons Act 1919 and related amendments,
Drug Policy 2005 (Amendments).
Control of Drug Advertisements and Prices, patented and trade marketed medicine, Schedules of
drugs and poisons, regulation of cosmetics and poison control.
Professional characteristics and ethical norms, relationship of trust, ethical considerations during
Pharmacy practice, deficiencies and adherences of self regulation, The Pharmacist’s code of
ethics.
Drug administration and Pharmacy Council of Bangladesh, their scope and functions.
Viva voce-III (Pharm 3200)

Syllabus B.Pharm(Hons) NUB MANIK

Syllabus B.Pharm(Hons) NUB MANIK

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