The document discusses how modern lifestyles have shifted away from exposure to microbes and dirt, which may upregulate the immune system. It suggests that increased sterilization has changed our immune response. It then describes how the innate immune system acts as our first line of defense through physical barriers and cells like neutrophils and macrophages that attack invaders. It highlights the yeast derivative Wellmune as a supplement that may support the innate immune system by fueling these immune cells and promoting a healthy response through beta glucan components.

1. Supporting Your Innate Immunity
Mark Lange, PhD

2. Disclaimer
These statements have not been
evaluated by the Food and Drug
Administration. This product is not
intended to diagnose, treat, cure or
prevent any disease.

3. The Hygiene Hypothesis
▪The shift from dirty to sterile has
changed our immune response.
▪The idea that sterile is good, sterile is
healthy, is being questioned.

4. Our Urban Lifestyle Attempts to
Eliminate Naturally-Occurring
Microbes, Yeasts and Molds

5. Exposure to Dirt/Microbes Might
Actually Upregulate Immune
Response
▪Children going to daycare have fewer asthma
and allergies as they grow up.
▪Children living on farms less likely to have
asthma and allergies.
▪Growing up in large family gives exposure to
viruses and microbes.
▪Breast-fed babies have fewer allergies than
bottle-fed.

6. Is Getting Dirty the Best Way to
Support Natural Immune
Response?

7. How Your Immune System Works
▪Creates a barrier that prevents bacteria and
viruses from entering body.
▪Your innate (meaning “present from birth”)
immune system detects and destroys without
needing to be trained to identify the intruders.
(FAST)
▪Your adaptive immune system learns.
(SLOWER)

8. Cells of the Innate Immune System
▪Neutrophils are very abundant.
▪Attack in large numbers.
▪They are the first responders; within minutes.
▪Survive only 1-2 days.

9. Cells of the Innate Immune System
▪Macrophages (“big eaters”)
▪Hang out in lung, gut, mucosal tissue.
▪Either “eat” (phagocytize) invaders or
▪Give an external oxidative burst to kill
invaders.

10. Complement
▪Is like a chemical red flag, marking pathogens
as being “non-self.”
▪Acts as an attractant to innate immune cells,
such as neutrophils.
▪Complement also enhances the binding of the
pathogen for phagocytosis, enhancing the
antimicrobial activities of neutrophils.

11. Supporting a
Healthy Immune System

12. Wellmune®
▪Derived from a proprietary strain of yeast.
▪Generally Recognized as Safe (GRAS) and
non-allergenic.
▪Effectiveness proven in clinical trials.
▪Source of beta glucans, which act as
complement to neutrophils.

13. How Wellmune®
Works
After ingestion, Wellmune is absorbed in the
GI tract through Peyer’s patches.

14. Macrophages Digest Wellmune
Wellmune Wellmune
Active
Fragments
Enzymes
Slowly released

15. Engulfing a Bacterium
Neutrophil
Bacterium
flagged with
complement
Receptor
(CR3)
Beta Glucan
Fragment
Captured Bacterium

16. Two More Immune-Supporting
Ingredients
▪Zinc
▪Phagocytosis
▪Generation of oxidative burst
▪Vitamin C
▪Protects cell membrane from oxidative
burst

18. Wellmune Improves Mood State
▪ S.M. Talbott and J.A. Talbott. Baker's Yeast Beta-Glucan
Supplement Reduces Upper Respiratory Symptoms
and Improves Mood State in Stressed Women J Am Coll
Nutr. August 2012 vol 31 no. 4 pp 295-300.
▪ S.M. Talbott and J.A. Talbott. Effect of BETA 1, 3/1, 6
GLUCAN on upper respiratory tract infection symptoms
and mood state in marathon athletes Journal of Sports
Science and Medicine (2009) 8, pp 509-515.
▪ Placebo controlled studies showing decreased confusion,
fatigue, tension, anger and increased vigor after stress.

20. nutraMetrix®
Immune Benefits
▪Boosts the body’s natural immune response.
▪Clinical trials show Wellmune®
promotes a
healthy immune system.
▪Promotes beneficial activity of macrophages.
▪Promotes healthy energy levels and vitality.
▪Improves mental clarity.