This document provides an introduction and overview to a proposed book on the topic of "Supervenience" which will explore how emergent minds and money can seize power over matter. It outlines 19 potential chapter topics and serves as a "where I'm at" for sharing the author's work in complex systems and emergence. Short sections give insights on various related concepts including multiple paths to emergence, the roles of order and chaos, constraints and degrees of freedom, the inside view, urban hydrology, birds and music, language as a tool and its limitations, dystopian utopias, and accepting cosmological responsibility.
The Sale of 'Open Content' - Recognizing & Negotiating the Philosophical Quan...Rolin Moe
Slides from a presentation at the Open Education 2015 conference in Vancouver, BC, Canada. 12 years into the Open Education Conference (and nearly 20 years since Open Content was first used as a term to represent the availability of specific media), this presentation uses postmodern theory as a critical lens to look at how the discourse around defining characteristics of the movement may hamper the ability for the Open Education movement to evolve beyond the recent successes of free/low-cost textbooks.
Second of four presentations exploring a hydrology-first view of accelerating Earth Systems Crises, this particularly focused on separating understanding of "knowledge" from the words we have long assumed to be essential to it, while remaining dependent on words for communication.
Collective learning sets humans apart from all other species, and language magnifies the impact of that learning.
Register to explore the whole course here: https://school.bighistoryproject.com/bhplive?WT.mc_id=Slideshare12202017
The Sale of 'Open Content' - Recognizing & Negotiating the Philosophical Quan...Rolin Moe
Slides from a presentation at the Open Education 2015 conference in Vancouver, BC, Canada. 12 years into the Open Education Conference (and nearly 20 years since Open Content was first used as a term to represent the availability of specific media), this presentation uses postmodern theory as a critical lens to look at how the discourse around defining characteristics of the movement may hamper the ability for the Open Education movement to evolve beyond the recent successes of free/low-cost textbooks.
Second of four presentations exploring a hydrology-first view of accelerating Earth Systems Crises, this particularly focused on separating understanding of "knowledge" from the words we have long assumed to be essential to it, while remaining dependent on words for communication.
Collective learning sets humans apart from all other species, and language magnifies the impact of that learning.
Register to explore the whole course here: https://school.bighistoryproject.com/bhplive?WT.mc_id=Slideshare12202017
Due date Saturday March 21, 2015.Answers for each question sho.docxjacksnathalie
Due date Saturday March 21, 2015.
Answers for each question should be at least 100 words.
1. Exam Questions:
Topic #3 – Economic Actors
1. Explain Myrdal’s concept of cumulative and circular causation and compare and contrast it to Veblen’s concept of cumulative causation.
2. Explain Robert Montgomery’s theory of how institutional practices come about and come to be thought of and practiced over time.
3. What is Montgomery’s theorized relationship between technological change and cultural change and give (articulate) an example outside of the Montgomery reading.
Reading:
1. Montgomery: Historical Fact
2. Myrdal: Institutional Economics
4. Exam Questions:
Topic #9 – Money
1. How does the standard story of the invention of money differ from the Institutionalist/Post Keynesian theory?
2. What does the Institutionalist/Post Keynesian theory of money says about the financial constraints on an economy to provisioning for the elderly?
Reading:
Wray: An irreverent overview of the history of money from the beginning of the beginning through to the present.
Question 1
a) The law that will be applied. . . .
b) The court will decide the effect of the the purported acceptance in the following way: . . .
c) The additional terms . . .
Question 2
a) She was only joking:
The offeror would argue that . . .
b) She didn't know that an offer was being made:
The offeror would argue that . . .
c) She knew she was signing an offer but he didn't read all of the terms:
The offeror would argue that . . .
d) She did not understand some of the terms and conditions:
The offeror would argue that . . .
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
An irreverent overview of the history of money from the beginning of the begi...
L Randall Wray
Journal of Post Keynesian Economics; Summer 1999; 21, 4; ABI/INFORM Global
pg. 679
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with p ...
Beyond Flesh and Code: Exploring The Future of Humanity and AIthoughtango
If you enjoy our books, you may like this: https://youtu.be/Tn3fg_EPlhU?si=L7RX_8wlD4A5MmJe
Beyond Flesh and Code is a captivating book that explores the possibilities and consequences of humans transcending biological limitations through technology. It takes readers on an imaginative journey that merges science fiction with profound philosophical and ethical questions about the nature of existence.
The book is structured in two sections, each unraveling thought-provoking ideas about the future evolution of humanity. The first section, "Synthesis: The Evolution Beyond Human," delves into the concept of transferring human consciousness into synthetic or digital forms to eliminate suffering and limitations. It examines the potential benefits of synthetic humans, including virtual immortality, enhanced cognition, the eradication of disease, greater collaboration to solve global issues, and an elevated state of consciousness.
However, this visionary future also raises challenging ethical dilemmas about identity, mortality, the sanctity of life, and what it means to be human. The author explores philosophical, moral, and practical concerns surrounding synthetic existence. For instance, how would personhood and individuality be defined? What criteria would determine who gets to transcend biology? Could this divide humanity further between the privileged synthetic elite and ordinary humans? How would fundamental human experiences like birth, aging, and death be transformed?
These philosophical musings are grounded in scientific possibilities, describing how advanced technologies like artificial intelligence, neural networks, and complex simulations of consciousness might enable the creation of synthetic humans. Intriguing parallels are drawn with religious ideas of transcendence and transhumanist visions of using technology to overcome physical limitations.
The second section, "The Illusion: Simulation, Programming, Limits," ventures into more speculative territory, contemplating the notion that our perceived reality is an artificial construct subject to deliberate constraints and manipulation. Humans are portrayed as programmed entities in a simulated existence, but some individuals begin to see beyond this veil and realize the illusory nature of their lives.
The book explores the premise that humanity lives in a controlled environment created by an advanced intelligence. Our senses are limited, our cognition is constrained, and our collective history shaped by intentional interventions. Phenomena such as déjà vu, synchronicities, UFO sightings and spiritual experiences are analyzed as possible glitches in the simulation, providing fleeting glimpses behind the veil.
A look at a few lifelike systems that share the essential characteristics of being Self-organisaing and Adaptive as context for ongoing series of Water and Words presentations.
Includes links to other parts of the deeper understanding building around this plus additional reading .
OverFlow Chart Introduction and Application to Gateway DrugsTony Smith
Presentation Slides from Melbourne Emergence Meetup 11 November 2021 examining three emergence-superveience relationships centred around the Accelerating Abstraction of humans from Industrialised Apex Predator in the biosphere to ever more Documented Consumable in the map of legal fictions.
Essays About Cell Phones. Reflection Essay: Persuasive essay on cell phone us...davih0fytav3
Mobile Phones Essay Free Essay Example. Essay describing a cellphone. Cell phones should be banned in schools essay in 2021 School essay .... Essay on use and abuse of mobile phones - bookcritic.x.fc2.com. Essay about the cell phones. Essay About Cell Phone. Should cell phones be allowed at school? - GCSE English - Marked by .... Mobile Phones Essay Essay on Mobile Phones for Students and Children .... Argumentative Essay Practice- Students Use of Cell Phones in School. 004 Cell Phone Usage In Schools Essayerm Paper Academic Writing Phones .... Essay on harmful effects of mobile phones on students. Harmful .... Argumentative Essay on Cell Phones: Should They Be Allowed in School .... Calaméo - Essay on Cell Phones: Great and Excellent Tips for Students. Mobile Phone Essay - IMobile Cool. mobile phones essay - GCSE English - Marked by Teachers.com. Persuasive essay cell phones. Mobile Phones and Drivi
Reading the Tea Leaves: Global Trends and Opportunities for Tomorrow's MuseumsRobert J. Stein
A presentation to the 2014 Communicating the Museum conference in Sydney, Australia.
As our society becomes increasingly more intertwined, it is evident that global trends that once seemed remote are having a deep impact on our local communities. These same trends play out in museums around the globe as we reflect our communities both past and present. The museum audience is inherently submerged in this current of cultural change. Without pretending to predict the entire future, there are strong signals that a few important global trends will persist. What are those trends and how can museums begin to take advantage of those likely shifts to promote, advocate, and enhance their relevance to a global audience?
Dissipating Gradients & Sinks (Supervenience)Tony Smith
Annotated image-rich presentation of material selected for Exploiting a Dissipating Gradient component of Supervenience Project, with supporting focus on flow aggregation and natural resistance to rapid equilibrating.
References Geoffery West's Scale, Donna Haraway's Chthulucene, David Graeber's structural violence, and 20 years earlier Conversation Piece.
How to Write Your Hero Essay. Batman is a fictional superhero - Free Essay Example | PapersOwl.com. 003 Essay Example My Hero Essays On Heroes Examples Good Writing The ....
Academic Essay Examples - 18+ in PDF | Examples. Essay Example Apa essay format paper sample writing research example .... Sample Term Paper About Education - example papers. Argumentative Essay Topics for College Assignments - Blog BuyEssayClub.com. Essay Topic Example – Sketsa. Thesis Statement Position Paper Examples - Writing A Thesis Statement .... College Sample Scholarship Essays | Master of Template Document. 32 College Essay Format Templates & Examples - TemplateArchive. Business paper: Sample essay paper. essay write my marketing research paper. MLA Format: Everything You Need to Know Here. Top Blc Sharp Essay Examples The Latest - scholarship. Writing a essay paper. Sample Apa Essay Paper – APA Style Essay: Formatting Rules. College Essay Examples - 13+ in PDF | Examples. Business Paper: Sample argument essay. 003 Critique Essay Example Of Research Paper 131380 ~ Thatsnotus. Quick Way To Write Essay - Anna Blog. Essay Writing Template – emmamcintyrephotography.com. Essay writing template free online printable sheets.
The Period of Enlightenment Free Essay Example. The Age of Enlightenment: [Essay Example], 710 words | EssayPay. The Enlightenment. Question about the enlightenment for essay - qualityassignments.x.fc2.com.
Slide deck for the third of ongoing series of presentations looking at water's planet-shaping role and barriers to its recognition within knowledge systems submerged in human language.
Presentation using a pair of books to expand possibilities inherent in chemical and electromagnetic interaction leading to some wider speculation about the role the rich structure of H₂O has had and continues to have in shaping Life of this planet. Consequent linkage to persistent themes within our Supervenience project and wider orbit.
More Related Content
Similar to Supervenience: how emergent minds and money seize power over matter
Due date Saturday March 21, 2015.Answers for each question sho.docxjacksnathalie
Due date Saturday March 21, 2015.
Answers for each question should be at least 100 words.
1. Exam Questions:
Topic #3 – Economic Actors
1. Explain Myrdal’s concept of cumulative and circular causation and compare and contrast it to Veblen’s concept of cumulative causation.
2. Explain Robert Montgomery’s theory of how institutional practices come about and come to be thought of and practiced over time.
3. What is Montgomery’s theorized relationship between technological change and cultural change and give (articulate) an example outside of the Montgomery reading.
Reading:
1. Montgomery: Historical Fact
2. Myrdal: Institutional Economics
4. Exam Questions:
Topic #9 – Money
1. How does the standard story of the invention of money differ from the Institutionalist/Post Keynesian theory?
2. What does the Institutionalist/Post Keynesian theory of money says about the financial constraints on an economy to provisioning for the elderly?
Reading:
Wray: An irreverent overview of the history of money from the beginning of the beginning through to the present.
Question 1
a) The law that will be applied. . . .
b) The court will decide the effect of the the purported acceptance in the following way: . . .
c) The additional terms . . .
Question 2
a) She was only joking:
The offeror would argue that . . .
b) She didn't know that an offer was being made:
The offeror would argue that . . .
c) She knew she was signing an offer but he didn't read all of the terms:
The offeror would argue that . . .
d) She did not understand some of the terms and conditions:
The offeror would argue that . . .
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
An irreverent overview of the history of money from the beginning of the begi...
L Randall Wray
Journal of Post Keynesian Economics; Summer 1999; 21, 4; ABI/INFORM Global
pg. 679
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Reproduced with p ...
Beyond Flesh and Code: Exploring The Future of Humanity and AIthoughtango
If you enjoy our books, you may like this: https://youtu.be/Tn3fg_EPlhU?si=L7RX_8wlD4A5MmJe
Beyond Flesh and Code is a captivating book that explores the possibilities and consequences of humans transcending biological limitations through technology. It takes readers on an imaginative journey that merges science fiction with profound philosophical and ethical questions about the nature of existence.
The book is structured in two sections, each unraveling thought-provoking ideas about the future evolution of humanity. The first section, "Synthesis: The Evolution Beyond Human," delves into the concept of transferring human consciousness into synthetic or digital forms to eliminate suffering and limitations. It examines the potential benefits of synthetic humans, including virtual immortality, enhanced cognition, the eradication of disease, greater collaboration to solve global issues, and an elevated state of consciousness.
However, this visionary future also raises challenging ethical dilemmas about identity, mortality, the sanctity of life, and what it means to be human. The author explores philosophical, moral, and practical concerns surrounding synthetic existence. For instance, how would personhood and individuality be defined? What criteria would determine who gets to transcend biology? Could this divide humanity further between the privileged synthetic elite and ordinary humans? How would fundamental human experiences like birth, aging, and death be transformed?
These philosophical musings are grounded in scientific possibilities, describing how advanced technologies like artificial intelligence, neural networks, and complex simulations of consciousness might enable the creation of synthetic humans. Intriguing parallels are drawn with religious ideas of transcendence and transhumanist visions of using technology to overcome physical limitations.
The second section, "The Illusion: Simulation, Programming, Limits," ventures into more speculative territory, contemplating the notion that our perceived reality is an artificial construct subject to deliberate constraints and manipulation. Humans are portrayed as programmed entities in a simulated existence, but some individuals begin to see beyond this veil and realize the illusory nature of their lives.
The book explores the premise that humanity lives in a controlled environment created by an advanced intelligence. Our senses are limited, our cognition is constrained, and our collective history shaped by intentional interventions. Phenomena such as déjà vu, synchronicities, UFO sightings and spiritual experiences are analyzed as possible glitches in the simulation, providing fleeting glimpses behind the veil.
A look at a few lifelike systems that share the essential characteristics of being Self-organisaing and Adaptive as context for ongoing series of Water and Words presentations.
Includes links to other parts of the deeper understanding building around this plus additional reading .
OverFlow Chart Introduction and Application to Gateway DrugsTony Smith
Presentation Slides from Melbourne Emergence Meetup 11 November 2021 examining three emergence-superveience relationships centred around the Accelerating Abstraction of humans from Industrialised Apex Predator in the biosphere to ever more Documented Consumable in the map of legal fictions.
Essays About Cell Phones. Reflection Essay: Persuasive essay on cell phone us...davih0fytav3
Mobile Phones Essay Free Essay Example. Essay describing a cellphone. Cell phones should be banned in schools essay in 2021 School essay .... Essay on use and abuse of mobile phones - bookcritic.x.fc2.com. Essay about the cell phones. Essay About Cell Phone. Should cell phones be allowed at school? - GCSE English - Marked by .... Mobile Phones Essay Essay on Mobile Phones for Students and Children .... Argumentative Essay Practice- Students Use of Cell Phones in School. 004 Cell Phone Usage In Schools Essayerm Paper Academic Writing Phones .... Essay on harmful effects of mobile phones on students. Harmful .... Argumentative Essay on Cell Phones: Should They Be Allowed in School .... Calaméo - Essay on Cell Phones: Great and Excellent Tips for Students. Mobile Phone Essay - IMobile Cool. mobile phones essay - GCSE English - Marked by Teachers.com. Persuasive essay cell phones. Mobile Phones and Drivi
Reading the Tea Leaves: Global Trends and Opportunities for Tomorrow's MuseumsRobert J. Stein
A presentation to the 2014 Communicating the Museum conference in Sydney, Australia.
As our society becomes increasingly more intertwined, it is evident that global trends that once seemed remote are having a deep impact on our local communities. These same trends play out in museums around the globe as we reflect our communities both past and present. The museum audience is inherently submerged in this current of cultural change. Without pretending to predict the entire future, there are strong signals that a few important global trends will persist. What are those trends and how can museums begin to take advantage of those likely shifts to promote, advocate, and enhance their relevance to a global audience?
Dissipating Gradients & Sinks (Supervenience)Tony Smith
Annotated image-rich presentation of material selected for Exploiting a Dissipating Gradient component of Supervenience Project, with supporting focus on flow aggregation and natural resistance to rapid equilibrating.
References Geoffery West's Scale, Donna Haraway's Chthulucene, David Graeber's structural violence, and 20 years earlier Conversation Piece.
How to Write Your Hero Essay. Batman is a fictional superhero - Free Essay Example | PapersOwl.com. 003 Essay Example My Hero Essays On Heroes Examples Good Writing The ....
Academic Essay Examples - 18+ in PDF | Examples. Essay Example Apa essay format paper sample writing research example .... Sample Term Paper About Education - example papers. Argumentative Essay Topics for College Assignments - Blog BuyEssayClub.com. Essay Topic Example – Sketsa. Thesis Statement Position Paper Examples - Writing A Thesis Statement .... College Sample Scholarship Essays | Master of Template Document. 32 College Essay Format Templates & Examples - TemplateArchive. Business paper: Sample essay paper. essay write my marketing research paper. MLA Format: Everything You Need to Know Here. Top Blc Sharp Essay Examples The Latest - scholarship. Writing a essay paper. Sample Apa Essay Paper – APA Style Essay: Formatting Rules. College Essay Examples - 13+ in PDF | Examples. Business Paper: Sample argument essay. 003 Critique Essay Example Of Research Paper 131380 ~ Thatsnotus. Quick Way To Write Essay - Anna Blog. Essay Writing Template – emmamcintyrephotography.com. Essay writing template free online printable sheets.
The Period of Enlightenment Free Essay Example. The Age of Enlightenment: [Essay Example], 710 words | EssayPay. The Enlightenment. Question about the enlightenment for essay - qualityassignments.x.fc2.com.
Similar to Supervenience: how emergent minds and money seize power over matter (20)
Slide deck for the third of ongoing series of presentations looking at water's planet-shaping role and barriers to its recognition within knowledge systems submerged in human language.
Presentation using a pair of books to expand possibilities inherent in chemical and electromagnetic interaction leading to some wider speculation about the role the rich structure of H₂O has had and continues to have in shaping Life of this planet. Consequent linkage to persistent themes within our Supervenience project and wider orbit.
Images (pics, maps and covers) drawn from Kororoit Institute submission to parliamentary inquiry into Ecosystems Decline in Victoria, with minimal commentary aside from section headings and recommendations, providing context for discussion of where we take this from here, both the global task of insisting on the urgent need for humans to work with rather than against until now dangerously suppressed ecosystems, and the local task of working with structures of our colonial political economy to ensure the tide is well and truly turning.
Experimental presentation using photos of a contested local remnant site as song lines style background to initial contextualisation of the essential ubiquity of habituation and addictions.
The Deep Stack of Existence: Seeing Life and its Substrates as Richly Connect...Tony Smith
A key point summary of deep history through a complex systems lens with emphasis on connectivity and contingency, within the context of our Supervenience Project's envisaged chapters Towards Healthy General Knowledge and Life on an Active Planet, with late focus on recent neurological research confirming the breadth of common heritage of mobile animals.
Debate authorising Inquiry into Ecosystem Decline in VictoriaTony Smith
Referral to Environment and Planning Committee.
Extracted as background reading for Ecosystem Decline (KI) Group.
Moved by Samantha Ratnam and widely supported but ultimately opposed by the opposition after their proposed amendment wasn't accepted.
Not my usual kind of slide show but essential to production of the next couple.
Presentation to Melbourne Emergence Meetup with placeholder for short video: https://vimeo.com/388799004 and vertically scrolling portrait orientation view from hand back to Cumbo replaced by start, mid and end stages.
December 2019 presentation to Melbourne Emergence Meetup in the scope of ongoing Supervenience project series and as corollary to November's presentation re human infrastructure projects the group has taken an interest in. Includes pictures from recent visits to Stony Creek toxic fire site and Mud Island.
Reflections on Kororoit Institute’s and friends’ planning interventions in light of Supervenience project and where to from here, presented at Melbourne Emergence Meetup 14 November 2019.
Contains main text and images of a submission to the Australian Infrastructure Audit 2019, save for the Supervenience Project principles which are developed in other presentations and with the introductory background of that submission expanded into a longer account of the history of Kororoit Institute's interest in infrastructure. That history also draws on text of submission to VEAC re Coastal Reserves to provide a shortish explanation of the Nepean Bay Bar proposal.
Many people are aware of something of particular interest to them which conventional wisdom gets badly wrong but assume that one thing is all that really needs to be fixed while the status quo is otherwise fine. Once you escape your silo and start seriously looking around, it becomes obvious that most things you take for granted are pretty much stuffed too. This presentation to CVAF highlights a few of them and argues that adversary systems are no longer fit for purpose.
Presentation to Melbourne Emergence Meetup 12 September 2019 providing further context for Supervenience Project, interleaving four decades of awareness development with one of local activism and digital photography. Doesn't quite achieve declared aims of bridging Too Funny for Words with Accepting Cosmological Responsibility, but useful starting point nonetheless.
Slide 9 is a montage of frames from two minute video of the first of Josie Taylor's two reports cited on Slide 8, as a placeholder for the actual video.
Presentation within the Supervenience Project series made to Melbourne Emergence Meetup Group August 2019 illustrating topic of Bak et al's 1987 paper which defined the topic.
Presentation to Friends of Stony Creek 1 July 2019 re the historic tributaries above the site of the August 2018 West Footscray toxic chemical storage fire. Updates earlier presentations and separates downstream section.
Stony Creek in context of Waterways of the WestTony Smith
Update on presentation given twice in recent months with ever increasing photo coverage of the length of Stony Creek and historic diversions, wrapped in contextual commentary re pollution event from industrial fire and establishment of Waterways of the West Ministerial Advisory Committee.
Supervenience Update on Commonalities, Coding, AdministrationTony Smith
Presentation to Melbourne Emergence Meetup 12 February 2019 with run of mostly shortish video clips and interspersed stills consolidated into a single external 18:44 video.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
3. This is a first step towards a needed “book”
on Supervenience that will briefly introduce
nineteen candidate “chapters” in quest of
early input into the eventual structure.
It will tie together a few earlier topics from
Melbourne Emergence, though far from all,
and go beyond.
It is in part a “where I’m up to” on complex
systems and emergence that has motivated
the more recent half of my life and needs to
be better shared.
SUPERVENIENCE
how emergent minds and money
seize power over matter
4. Too Funny for Words
Australian Fur Seal
Entertaining Diver
Henty Reef, Marengo
5. Too Funny for Words
Sharing a story
with occasional
reference to
mathematical
concepts aiming to
convince you that
cultural reliance on
words and numbers
both facilitates and
impedes our
experience of the
world and our
capacity to act.
Words oversimplify.
Words can underpin
inflated expectations.
Numbers more so.
Cognitive dissonance.
Humorous surprises.
Story-based cultures.
Surprise definitive of
complex Emergence.
Plenty to laugh about.
7. Multiple Paths to Emergence
To study Emergence is to look at
things which could not have
reasonably been predicted based
on prior knowledge but which
can subsequently be seen to be
clearly within bounds.
Major mechanisms include:
•synergistic/symbiotic pairings,
•larger population organisation,
•formation of persistent patterns
within a dissipating gradient.
9. Better than Out of Control
Kevin Kelly’s 1993 book
was the first popular
account of growing interest
in Complex Systems.
Misconceptions about the
roles of emergent Order
and Chaos motivated an
unproductive search for a
boundary between,
obscuring the possibility
that they are partners in
creating the universe that
begat life and us.
10. Here Now Succession Process
Traces Time Causation?
Track-edge vegetation
Cumberland River
11. Here Now Succession Process
Traces Time Causation?
While we make productive use of
treating time as a dimension,
this may have been overplayed in
ideas like the Block Universe.
We live in the here and now,
though life developed pattern
recognition based on traces that
persist in condensed matter
which DNA and neuronal
networks dynamically encode.
13. Towards Healthy
General Knowledge
The amount of accessible knowledge is
growing rapidly. It is way beyond an
individual to be across most fields.
We need to respect others’ areas of focus.
We and they also need knowledge grounded
on foundations that stand scrutiny.
I might have wider and deeper knowledge
across the broad sweep of sciences, but only
fragments about popular entertainments.
15. Abstractions, Category Errors,
Epistemic Cuts
Thoughts about something, not even
detailed descriptions, can do no more
than represent that thing incompletely.
Thinking is assisted by recognising what
kind of thing you are thinking about and
not accepting a contestable placement.
Laws governing behaviour emerge with
the entities concerned, enabling focus to
be kept without spurious back reference.
16. Constraints and
Degrees of Freedom
UNDERGROUND
LOOP
FLINDERS
STREET-VIADUCT
UPFIELD
LINE
SYDENHAM LINE
BROADMEADOWS
LINE
MELBOURNE-MURRAY
RIVER
SOUTH
KENSINGTON-WEST
FOO
DOCKLANDS
MELBOURNE
KENSINGTON
NORTH
MELBOURNE
WEST
MELBOURNE
CITY OF
MELBOURNE
J J
Holland
Park
Eades
Park
North Melbourne
Recreation
Reserve
SOUTH
KENSINGTON
STATION
NORTH
MELBOURNE
STATION
Map Projection: Transverse Mercator
Horizontal Datum: GDA 1994
Grid: GDA 1994 MGA Zone 55o Date: 15/05/2017
WEST GATE TUNNEL PROJECT
PROJECT BOUNDARY
Sheet 24 of 31 WDA-WDP-LFWD-0024Data Source:
WDA & CPBJH
0 70 140 210 28035
Metres
Legend
Project Boundary
Proposed Road Alignment
Proposed Other Structures
Property Boundary
Melbourne
Laverton
North
Yarraville
The unfairly maligned West Melbourne lagoon was a salt
lake refreshed by flood waters from the Chain of Ponds
that were modified to form lower Moonee Ponds Creek.
17. Constraints and
Degrees of Freedom
Concepts which are formalised in
mathematics sometimes provide insights
into worldly behaviour.
Too much choice can be as inhibiting as too
little. Given a blank slate, identifying
external constraints can help discover a
productive path.
Mathematically, adding constraints
correspondingly reduces degrees of freedom.
This translates well to physics and to life.
Seek sweet spot.
19. Information,
Maps and Territories
Late modernity is so obsessed with
information technologies that even
serious scientists have proposed that
the world is built on information.
More productive to see information
as useful abstraction while allowing
usual philosophical disclaimers.
Don’t confuse maps with territories.
Treat the patient, not the clipboard.
21. Codification and
Communication
Our proliferation of coding
systems are one more variant
on an old trick for collecting
and using knowledge, preceded
by DNA and neuronal nets.
Lynne Kelly explained
monumental transition in oral
memory methods needed to
support agriculture.
Bill Hall explained post literate
growth with climatic impact.
23. Science is casting off its behaviourist
blinkers in important areas but still
averse to doing a lot with subjective
accounts of mental processes.
So for now we are stuck examining
our singular experiences informed
only by general worldly awareness.
Noting our own transitions to and
from sleep and dreams may help.
The Inside View
knowing when you're dreaming
24. Life on an Active Planet
Australian
Reed Warbler
Cumberland River
25. Life on an Active Planet
The idea that ‘Life’ should be
defined at the component level
is challenged by suggestions of
seeing it as whole.
The biosphere interacts with
other planetary systems:
tectonic, cryonic, hydrological,
atmospheric, orbital.
Across many millennia humans
have sought separate validation,
denying interdependence,
ignoring others.
27. Birds and Others
Tim Low in Where Song Began asks re the
Lyrebird as model for the first songbirds:
“How could evolution create the best
musicians first, with thousands of
younger lineages producing simpler and
weaker sounds?”
The answer requires us to abandon the
notion of microevolution as progressive
and accept that most innovation comes
from deletions. The overriding need of
thousands of songbirds was to distinguish
their kind from others.
28. Urban Hydrology out of Sight
Stony Creek diversions
right via Anderson Road
left via Kororoit Street
29. Urban Hydrology out of Sight
Endless recent water, coastal
and waterways policy
development has brought
deeper understanding of the
complexity of urban systems.
Such things rarely penetrate
public awareness because
they are hidden from view
beneath ground or water.
Often the maps and other
records can’t prevent the
need to dig to see.
31. Exploit Dissipating Gradient
creaming, trickle down
Stan Salthe’s rule of thumb says you
can use no more than half of any
dissipating gradient you tap into.
The flow of words in and from our
minds is effectively uncoupled from
energy and material flows,
powering emergence of rules and
regulations.
Similarly flows of money/debt can
be creamed by those close to them.
33. Verbal Blindness
Sensory systems evolve to
meet the needs and
opportunities of a niche.
As humans became more
dependent on mapping
perceptions into words we
lost immediacy and breadth.
We became convinced that
our way was the only/best
way no matter how far
astray that lead us.
35. The Two-edged Sword
Human language has proved to be a tool of
unprecedented power for understanding
and collaboratively changing the world,
and at accelerating pace.
But it has proved to be even more efficient
at spreading nonsense and mischief, yet
abysmally inadequate at spreading
corrections.
Rhetorical performance too often
overwhelms its capabilities for analysis,
negotiation and independent verification.
37. Interweb to Facebook
Are we becoming even more dependent on
digital information and communications
technologies than we have been on words?
Interweb fit the dream behind our Public
Information Communications and Access
(PICA) System effort of the early 1980s,
later Conversation Piece and TransForum.
Facebook is as close as we have got, great
for digital photos but weak at curation.
39. Dystopian Utopias
and Science Fiction
Perfection is the enemy of good.
Imagine there's no heaven.
Your Utopia won't be my Utopia.
The idea that we are on a one way
march of progress is as dangerous
as any. Yes there can be win-win
moves, but accelerating into the
unknown is not recommended.
Science fiction has become a great
testing ground for failed utopias,
even while absolving itself from
inconvenient trappings of reality.
41. Accepting Cosmological
Responsibility
There is no persuasive evidence that
we are not the first space-capable
society in our light cone, or beyond.
We have developed an aspiration to
know all that can be encoded in our
media, collectively not individually.
So we must assume that we are the
metaverse’s best hope of knowing
itself and try harder not to stuff up.