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そつけんぷろでゅーす
This document appears to be an agenda or outline for a presentation. It lists several bullet points including monitoring tools, ping, 404 errors, and the monitoring platforms Nagios and Zabbix. It also includes a link to an article on a Japanese website related to the presentation topics.
My life!!! (utan transition)
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Recommended
A User-Centered Design Methodology for Academic Libraries
This is a presentation I gave on the annual meeting of Academic Libraries of Indiana (ALI), on May 9th, 2013, in Indianapolis, Indiana.
Designing an engagement strategy for private social networks
The document provides guidance on designing an engagement strategy for a private social network. It recommends defining why engagement is important for both the organization and members by outlining what constitutes a "win" for each. It also suggests identifying who the target audience is, where they are located, what actions you want them to take, how to implement engagement activities, and setting a timeline. An example for a nonprofit scientific organization (NPC) is given to illustrate how to determine the audience, their location, desired actions, and scheduling posts and events to maximize engagement. The key is to make resources easy to access, use thought leaders, promote events, and assign moderators to facilitate discussion and sharing of information.
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Pizza Hut is considering expanding their menu globally to include pizzas from different world cuisines like Indian curry pizza, Korean shrimp pizza, and Japanese seafood pizza as part of a "Go Global" strategy to attract more customers and markets in a safe marketing strategy. They recognize budgets are critical to consider for this project.
そつけんぷろでゅーす
This document appears to be an agenda or outline for a presentation. It lists several bullet points including monitoring tools, ping, 404 errors, and the monitoring platforms Nagios and Zabbix. It also includes a link to an article on a Japanese website related to the presentation topics.
My life!!! (utan transition)
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Vuaxaydung
CHƯƠNG VI
VỮA XÂY DỰNG
6.1. Khái niệm chung
Vữa xây dựng là một loại vật liệu đá nhân tạo thành phần bao gồm chất kết dính, nước, cốt liệu nhỏ và phụ gia. Các thành phần này được nhào trộn theo tỷ lệ thích hợp, khi mới nhào trộn hỗn hợp có tính dẻo gọi là hỗn hợp vữa, sau khi cứng rắn có khả năng chịu lực gọi là vữa. Phụ gia có tác dụng cải thiện tính chất của hỗn hợp vữa và vữa.
Đặc điểm của vữa là chỉ có cốt liệu nhỏ, khi xây và trát phải trải thành lớp mỏng, diện tích tiếp xúc với nền xây, với mặt trát và với không khí khá lớn, nước dễ bị mất đi, do đó lượng nước nhào trộn vữa cần lớn hơn so với bê tông. Do không có cốt liệu lớn nên cường độ chịu lực của vữa thấp hơn so với bê tông khi sử dụng cùng lượng và cùng loại chất kết dính.
Vữa xây dựng được thường được phân loại theo loại chất kết dính, theo khối lượng thể tích và theo công dụng của vữa.
Theo chất kết dính: chia ra vữa xi măng, vữa vôi, vữa thạch cao và vữa hỗn hợp (xi măng - vôi; xi măng - đất sét).
Theo khối lượng thể tích: chia ra vữa nặng ρv > 1500 kg/m3, vữa nhẹ ρv ≤1500 kg/m3.
Theo công dụng: chia ra vữa xây, vữa trát, vữa láng, lát, ốp, vữa trang trí v.v... để hoàn thiện công trình, vữa đặc biệt như vữa giếng khoan, vữa chèn mối nối, vữa chống thấm v.v...
6.2. Vật liệu chế tạo vữa
6.2.1. Chất kết dính
Để chế tạo vữa thường dùng chất kết dính vô cơ như xi măng pooclăng, xi măng pooclăng hỗn hợp, xi măng pooclăng xỉ hạt lò cao, xi măng pooclăng puzolan, vôi không khí, vôi thủy, thạch cao xây dựng v.v...
Việc lựa chọn sử dụng loại chất kết dính phải đảm bảo cho vữa có cường độ và độ ổn định trong điều kiện cụ thể.
Trong môi trường khô nên dùng vữa vôi mác 4. Để đảm bảo cường độ và độ dẻo nếu không có yêu cầu gì đặc biệt nên dùng vữa hỗn hợp mác 10 - 75. Trong môi trường ẩm ướt nên dùng vữa xi măng mác 100 - 150. Vôi rắn trong không khí thường được dùng ở dạng vôi nhuyễn hoặc bột vôi sống. Nếu dùng vôi nhuyễn phải lọc sạch các hạt sạn. Thạch cao thường được sử dụng để chế tạo vữa trang trí, vì có độ mịn và bóng cao.
6.2.2. Cốt liệu
Cốt liệu cát là bộ xương chịu lực cho vữa đồng thời cát còn có tác dụng chống co ngót cho vữa và làm tăng sản lượng vữa.
Để chế tạo vữa có thể sử dụng cát thiên nhiên hoặc cát nhân tạo nghiền từ các loại đá đặc hoặc đá rỗng. Chất lượng cát có ảnh hưởng nhiều đến cường độ của vữa. Cát phải đảm bảo các yêu cầu chủ yếu theo bảng 6 - 1.
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Gsc profile pdf
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Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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Vuaxaydung
CHƯƠNG VI
VỮA XÂY DỰNG
6.1. Khái niệm chung
Vữa xây dựng là một loại vật liệu đá nhân tạo thành phần bao gồm chất kết dính, nước, cốt liệu nhỏ và phụ gia. Các thành phần này được nhào trộn theo tỷ lệ thích hợp, khi mới nhào trộn hỗn hợp có tính dẻo gọi là hỗn hợp vữa, sau khi cứng rắn có khả năng chịu lực gọi là vữa. Phụ gia có tác dụng cải thiện tính chất của hỗn hợp vữa và vữa.
Đặc điểm của vữa là chỉ có cốt liệu nhỏ, khi xây và trát phải trải thành lớp mỏng, diện tích tiếp xúc với nền xây, với mặt trát và với không khí khá lớn, nước dễ bị mất đi, do đó lượng nước nhào trộn vữa cần lớn hơn so với bê tông. Do không có cốt liệu lớn nên cường độ chịu lực của vữa thấp hơn so với bê tông khi sử dụng cùng lượng và cùng loại chất kết dính.
Vữa xây dựng được thường được phân loại theo loại chất kết dính, theo khối lượng thể tích và theo công dụng của vữa.
Theo chất kết dính: chia ra vữa xi măng, vữa vôi, vữa thạch cao và vữa hỗn hợp (xi măng - vôi; xi măng - đất sét).
Theo khối lượng thể tích: chia ra vữa nặng ρv > 1500 kg/m3, vữa nhẹ ρv ≤1500 kg/m3.
Theo công dụng: chia ra vữa xây, vữa trát, vữa láng, lát, ốp, vữa trang trí v.v... để hoàn thiện công trình, vữa đặc biệt như vữa giếng khoan, vữa chèn mối nối, vữa chống thấm v.v...
6.2. Vật liệu chế tạo vữa
6.2.1. Chất kết dính
Để chế tạo vữa thường dùng chất kết dính vô cơ như xi măng pooclăng, xi măng pooclăng hỗn hợp, xi măng pooclăng xỉ hạt lò cao, xi măng pooclăng puzolan, vôi không khí, vôi thủy, thạch cao xây dựng v.v...
Việc lựa chọn sử dụng loại chất kết dính phải đảm bảo cho vữa có cường độ và độ ổn định trong điều kiện cụ thể.
Trong môi trường khô nên dùng vữa vôi mác 4. Để đảm bảo cường độ và độ dẻo nếu không có yêu cầu gì đặc biệt nên dùng vữa hỗn hợp mác 10 - 75. Trong môi trường ẩm ướt nên dùng vữa xi măng mác 100 - 150. Vôi rắn trong không khí thường được dùng ở dạng vôi nhuyễn hoặc bột vôi sống. Nếu dùng vôi nhuyễn phải lọc sạch các hạt sạn. Thạch cao thường được sử dụng để chế tạo vữa trang trí, vì có độ mịn và bóng cao.
6.2.2. Cốt liệu
Cốt liệu cát là bộ xương chịu lực cho vữa đồng thời cát còn có tác dụng chống co ngót cho vữa và làm tăng sản lượng vữa.
Để chế tạo vữa có thể sử dụng cát thiên nhiên hoặc cát nhân tạo nghiền từ các loại đá đặc hoặc đá rỗng. Chất lượng cát có ảnh hưởng nhiều đến cường độ của vữa. Cát phải đảm bảo các yêu cầu chủ yếu theo bảng 6 - 1.
Gsc profile pdf
Green Sparkle Consulting provides accounting, consulting, and business support services. It has over 50 years of cumulative experience from its professionals. The company utilizes experienced teams to provide quality, compliant services and allow clients to focus on their core businesses. Some key benefits of outsourcing services to Green Sparkle include gaining access to experienced professionals, complying with regulatory requirements efficiently, and optimizing benefits at a competitive price.
Gsc profile pdf
Green Sparkle Consulting provides accounting, consulting, and business support services. It has over 50 years of experience in finance and administration services. The company is professionally managed by qualified accountants, consultants, and tax experts. Outsourcing to Green Sparkle provides several benefits including access to experienced professionals, optimized processes and technology, and the ability to focus on core business activities while regulatory compliance is handled.
Business rule specificatio1
The document specifies business rules for a leave management system. It outlines that the system will provide leave functionality to employees and organizations. It describes status transitions for leave applications depending on the user role. Finally, it lists the available leave types and number of days allowed per year for permanent and contractual staff.
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2) É sugerido que PMEs foquem em ações de marketing de guerrilha, parcerias estratégicas, formadores de opinião e assessoria de imprensa.
3) Antes de fazer marketing, é importante que as PMEs ten
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O documento discute o empreendedorismo no Brasil, destacando que o país tem o maior número de empresas na América Latina e milhões de pessoas envolvidas em negócios. Aponta que o empreendedorismo no Brasil é motivado tanto por oportunidades quanto por necessidade e que os empreendedores brasileiros têm melhor escolaridade e otimismo. No entanto, são necessárias melhorias em áreas como inovação e internacionalização. Conclui que empreender deve ser inclusivo e acessível a todos independentemente de características
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โดยความร่วมมือ 5 ฝ่าย กรมพัฒนาฝีมือแรงงาน, สอศ., Mittutoyo ,บ.สุมิพล จก.และสถาบันมาตรวิทยาแห่งชาติ
ระดับภาคจัดที่สถาบันพัฒนาฝีมือแรงงารแต่ละภาค รอบชิงชนะเลิศระดับชาติจัดที่สถาบันมาตรวิทยาแห่งชาติ
ระดับภาค
Elements of State
A state is defined as a community of people occupying a definite territory with its own government that the people obey. It has three main elements - people, territory, and government. The people are the population living within the state's demarcated territory. The government is the agency that formulates, expresses, and carries out the will of the state and has sovereignty, or supreme power over the people in its territory as well as freedom from external control by other states.
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Breast cancer: Post menopausal endocrine therapy
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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