الإستخدام الدوائي الثانوي خارج المفعول الأساسي للدواء

1. ‫التسمية‬ ‫خارج‬ ‫الدوائي‬ ‫اإلستخدام‬
Dr. Firas Kassab Page 1
َ‫اإلٍزقلا‬ٟ‫اٌلٚائ‬‫فبهط‬
‫اٌزَّ١خ‬
Off-Label Drugs Use
‫وَبة‬ ً‫فوا‬ .‫ك‬

2. ‫التسمية‬ ‫خارج‬ ‫الدوائي‬ ‫اإلستخدام‬
Dr. Firas Kassab Page 2
‫اٌزَّ١خ‬ ‫فبهط‬ ٟ‫اٌلٚائ‬ َ‫اإلٍزقلا‬
Off-Label Drugs Use
ِٓ ‫لبئّخ‬ ٓ١‫اٌجبؽض‬ ِٓ ‫ِغّٛػخ‬ ‫ٚػغ‬‫أكٚ٠خ‬ ‫ػلح‬‫ٚاٍغ‬ ‫ٔطبق‬ ٍٝ‫ػ‬ ‫ِٛطٛفخ‬‫رؼزجو‬ ٟ‫اٌز‬ ٚ‫األوضو‬‫إ‬‫ٌؾبؽب‬ٚ
‫ث‬‫ٌزؾل٠ل‬ ‫إػبف١خ‬ ‫كهاٍخ‬ ٌٝ‫إ‬ ‫ؾبعخ‬ٚ ‫فؼبٌ١خ‬ ٜ‫ِل‬ْ‫أِب‬‫ا‬‫إل‬‫اٌزَّ١خ‬ ‫فبهط‬ َ‫ٍزقلا‬(off-label uses).
‫رؼزجو‬ ٚٚ ‫االوزئبة‬ ‫ِؼبكاد‬ْ‫اٌن٘ب‬ ‫ِؼبكاد‬ِٓٚ ،‫اٌمبئّخ‬ ٍٝ‫ػ‬ ‫األكٚ٠خ‬ ‫فئبد‬ ‫أثوى‬ٗ‫ٚع‬ ٍٝ‫ػ‬ ‫رَزٙلف‬ ٟ‫اٌز‬
ِٓ ‫ػبٌ١خ‬ ‫َِزٛ٠بد‬ ‫ٌل٠ٙب‬ ٟ‫اٌز‬ ‫األكٚ٠خ‬ ‫اٌزؾل٠ل‬‫اإل‬.‫ع١ل‬ ٍّٟ‫ػ‬ ُ‫كػ‬ ْٚ‫ك‬ ‫اٌزَّ١خ‬ ‫فبهط‬ َ‫ٍزقلا‬
"ٖ‫٘ن‬‫اٌمبئّخ‬ِٓ‫األكٚ٠خ‬‫ماد‬‫األٌٚٛ٠خ‬‫لل‬ْٛ‫رى‬‫ثلا٠خ‬‫ٌّٛاعٙخ‬‫ِشىٍخ‬َ‫اإلٍزقلا‬‫فبهط‬‫اٌزَّ١خ‬‫ِغ‬‫أكٌخ‬
‫ِؾلٚكح‬."Randall Stafford, MD, PhD, associate professor of medicine at the Stanford Prevention Research Center
‫ٚلل‬‫أظٙود‬‫اٌلهاٍبد‬‫إرَبع‬‫اٌلٚائ١خ‬ ‫اٌٛطفبد‬‫فبهط‬, ‫اٌزَّ١خ‬‫ٚٚعلد‬‫كهاٍخ‬َ‫ػب‬5=<9ْ‫أ‬ِٓٓ١‫ث‬
‫اإلٍزقلاِبد‬‫األوضو‬‫ش١ٛػب‬511ِٓ‫األكٚ٠خ‬، ‫اٌَّٛلخ‬75ِٓ‫رٍه‬‫اإلٍزقلاِبد‬ٌُٓ‫٠ى‬ٗ٠‫ٌل‬‫ِٛافمخ‬ِٓ
‫إكاهح‬‫األغن٠خ‬‫ٚاٌؼمبل١و‬(FDA).ٚ‫أظٙود‬‫كهاٍخ‬‫أعوا٘ب‬Randall Staffordٟ‫ف‬َ‫ػب‬611:ْ‫أ‬‫ِب‬ٗ‫َٔجز‬65
ٟ‫ف‬‫اٌّبئخ‬ِٓ‫إٍزقلاِبد‬‫األكٚ٠خ‬‫غ١و‬‫اٌَّغٍخ‬ٟ‫ف‬َ‫ػب‬6115،ًٌُ‫٠ؾظ‬ٍٝ‫ػ‬;7ٟ‫ف‬‫اٌّبئخ‬ُِٓ‫اٌلػ‬
ٍّٟ‫اٌؼ‬ٞٛ‫اٌم‬
‫اي‬58ٌٝٚ‫األ‬ ‫كٚاء‬‫ٔشو‬ ‫ِمبي‬ ِٓ ‫ثَ١ؾ‬ ‫ثزظوف‬ ‫ٔمٍٙب‬ ُ‫ر‬ْ‫ثؼٕٛا‬>
Off-Label Use of Gastrointestinal Medications in the Intensive Care Unit
Journal of Intensive Care Medicine, vol. 30, 4: pp. 217-225. , First Published December 20, 2013.
ٚ‫أ‬ ‫ػّٕٙب‬ ‫اٌّظٕفخ‬ ٚ ‫األٍبٍ١خ‬ ‫ثفبػٍ١زٙب‬ ‫ٍٛاء‬ ‫اإلٍزؼّبي‬ ‫شبئؼخ‬ ‫رؼزجو‬ ‫أكٚ٠خ‬ ٟٙ‫ف‬ ‫اٌمبئّخ‬ ِٓ ٟ‫رجم‬ ‫ِب‬ ‫أِب‬
‫اٌزَّ١خ‬ ‫فبهط‬ ‫ثفبػٍ١زٙب‬

3. ‫التسمية‬ ‫خارج‬ ‫الدوائي‬ ‫اإلستخدام‬
Dr. Firas Kassab Page 3
ٞٛٔ‫صب‬ ‫إٍزطجبة‬ ٍٟ‫أٍب‬ ‫إٍزطجبة‬ ‫اٌلٚائ١خ‬ ‫اٌيِوح‬ ‫ا‬‫ألٍّبء‬
٠‫اٌزغبه‬‫خ‬
‫اإلفزظبه‬
ٍّٟ‫اٌؼ‬
Bipolar, maintenance Schizophreniaٚ‫أ‬ ) َ‫اٌفظب‬ (
‫اٌشقظ١خ‬ َ‫ثئٔفظب‬ ‫٠ؼوف‬ ‫ِب‬
Antipsychotics 2nd
generation
Antimaniac Agent
Seroquel Quetiapine
Rheumatic Valve Disease
atrial fibrillation
Systolic LV Dysfunction
Antiphospholipid Antibody
Syndrome
Venous Thrombosis
Stroke & Thromboembolism
Anticoagulants Coumadin Warfarin
)*Bipolarٛ٘ >‫اال‬‫إ‬‫ػطواة‬َٟ‫إٌف‬
ٚ‫م‬‫اإل‬ٓ١٘‫رغب‬ٚ‫أ‬‫اإل‬‫ػطواة‬ٟٔ‫اٌٛعلا‬
ٟ‫صٕبئ‬‫اٌمطت‬ٚ‫أ‬ًٌٛٙ‫ا‬ٟ‫االوزئبث‬
‫ٔفَ١خ‬ ‫ؽبٌخ‬ ٟ٘ ٚ‫ف١ٙب‬ ٟٔ‫٠ؼب‬
‫اٌّو٠غ‬‫رغ١واد‬‫شل٠لح‬ٟ‫ف‬‫اٌّياط‬
‫ِغ‬‫ٔٛثبد‬١ٌ‫ػب‬‫خ‬‫ِٕقفؼ‬ ٚ‫أ‬‫خ‬‫اٌّياط‬
‫ثظٛهح‬‫غ١و‬‫إ‬‫ػز١بك٠خ‬
)*ٞ‫اٌمٙو‬ ً‫اٌٍٛٛا‬
)*ٌَٕٛ‫ا‬ ‫لٍخ‬
)*‫اٌٛػبئ١خ‬ ‫اٌؾوو١خ‬ ‫إػطواثبد‬
ً‫اإل٠ب‬ َٓ‫ث‬ ‫اٌّورجطخ‬
Depression Antidepressants
SSRIs
Lexapro Escitalopram
)*Tourette Syndrome
)*‫ٌٍوع‬ ٌٟ‫اٌزب‬ ‫اٌمٍك‬ ‫إػطواة‬
Schizophrenia Antipsychotics 2nd
generation
Risperdal Risperidone
COPD ( Chronic Obstructive
Pulmonary Disease )
Asthma Leukotreine Receptor
Antagonists
Singulair Montelukast
ADHD
(Attention-deficit/hyperactivity
disorder)
‫لظٛه‬ٖ‫االٔزجب‬‫ٚفوؽ‬‫اٌؾووخ‬
Depression Antidepressants
Dopamine Reuptake
Inhibitors
Smoking Cessation
Aids
Wellbutrin
Zyban
Buproban
Bupropion
Pruritus‫اٌؾىخ‬ Depression Antidepressants
SSRIs
(selective serotonin
reuptake inhibitors )
Zoloft Sertraline

4. ‫التسمية‬ ‫خارج‬ ‫الدوائي‬ ‫اإلستخدام‬
Dr. Firas Kassab Page 4
)*Hot Flashes Due to Hormonal
Chemotherapy‫اٌٙجبد‬‫اٌَبفٕخ‬
‫ثَجت‬‫اٌؼالط‬ٟ‫اٌى١ّ١بئ‬ِٟٔٛ‫اٌٙو‬
)*Neuropathic Painٟ‫اٌؼظج‬ ٌُ‫األ‬
Depression Antidepressants
SNRIs
(Serotonin–
norepinephrine
reuptake inhibitors )
Effexor Venlafaxine
)*Fibromatosis‫اٌٍ١ف١خ‬ َ‫األٚها‬
Familial Adenomatous Polyposis
)*ٍٟ‫اٌؼبئ‬ ِٟٚ‫اٌغل‬ ً‫اٌَالئ‬ ‫كاء‬
Acute Pain & Primary
Dysmenorrhea
Ankylosing Spondylitis
Osteoarthritis
Rheumatoid Arthritis
NSAIDs Celebrex Celecoxib
Coronary artery disease‫ِضجطبد‬
ACEًٍ‫رم‬ِٓ‫ؽبعخ‬‫اٌمٍت‬ٚ
‫اٌلِٛ٠خ‬ ‫األٚػ١خ‬remodling‫اٌّورجطخ‬
‫ثئ‬‫هرفبع‬‫ػغؾ‬َ‫اٌل‬ِٓ‫اٌّي‬،ًٚ‫فش‬
،‫اٌمٍت‬ٚ‫إ‬‫ؽزشبء‬‫ػؼٍخ‬‫اٌمٍت‬
Hypertension ACE Inhibitor Prinivil
Zestril
Lisinopril
Anxiety Depression Antidepressants
SNRIs
Fibromyalgia Agents
Cymbalta Duloxetine
ٌَٕٛ‫ا‬ ً‫ِشبو‬ ‫ػالط‬ ٟ‫ف‬ ‫٠َزطت‬
Depression Antidepressants Desyrel
Oleptro
Trazodone
Depression Schizophrenia Antipsychotics 2nd
generation
Antimaniac agent
) ًٛ٘ ‫ِؼبك‬ (
Zyprexa Olanzapine
Anemia of chronic disease٠ >‫ؾل‬
ِٓ‫اٌؾبعخ‬ً‫ٌٕم‬‫فال٠ب‬َ‫اٌل‬‫اٌؾّواء‬
ٟ‫ف‬ٝ‫اٌّوػ‬ٓ٠‫اٌن‬ْٛٔ‫٠ؼب‬ِٓ‫ِوع‬
ٍٝ‫اٌى‬ِٓ‫اٌّي‬
Chronic renal failure
Hemopoietic Growth
Factors
Recombinant Human
Erythropoietins
Erythroiesis-
Simulating Agents
Procrit
Epogen
Eprex
Epoetin alfa
‫اٌمنف‬ ‫ٍوػخ‬ ‫ػالط‬ ‫إوزئبة‬ ‫ِؼبك‬ Tricyclic
Antidepressant
Anafranil Clomipramine
َ‫٠َزقل‬‫ؽبٌ١ب‬ٝ‫ف‬‫ػالط‬‫ا‬‫ٌغوٚػ‬ٚ
‫إٌّبؽك‬ٗ‫اٌّزموؽ‬
‫ٌٍَّبػلح‬ٍٝ‫ػ‬‫اإل‬َ‫ٌزئب‬wound)
(healingٓ‫ػ‬‫ؽو٠ك‬(stimulation of
fibroblast proliferation, facilitation of
collagen deposition)
‫أ‬‫كٚ٠خ‬‫اٌظوع‬epilepsy Antidysrhythmics
Anticonvulsants
Healosol
Dilantin
Phenytek
Phenytoin

5. ‫التسمية‬ ‫خارج‬ ‫الدوائي‬ ‫اإلستخدام‬
Dr. Firas Kassab Page 5
َ‫٠َزقل‬ٝ‫ف‬‫ػالط‬
(pulmonary hypertension)
ٌ‫ثٕف‬٢‫ا‬‫ٌ١خ‬‫فبطخ‬‫ف‬ٟ
(right –sided heart failure)
*)‫رّٕغ‬ُ٠‫أي‬
phosphodiestraseٌٚ‫ا‬ٞ‫ن‬
٠ُ‫ؾط‬‫ِبكح‬cGMPٌَّ‫ا‬‫ؤ‬‫ٌٚخ‬
ٓ‫ػ‬‫إ‬‫رَبع‬‫األ‬‫ٚػ١خ‬‫اٌلِٛ٠خ‬
*)‫ػالط‬
(Erectile dysfunction)
ٗٔ‫أ‬ ‫إم‬ٟ‫ف‬ ‫٠َبػل‬
(blood supply to penis)
Phosphodiesterase-5
Enzyme inhibitors
Viagra
Revatio
Sildenafil
‫فبط١خ‬ ‫٠ّزٍه‬
(Anti androgenic effect)
ٌٚ‫ا‬‫ز‬ُٝ٘‫رَب‬ٝ‫ف‬‫ػالط‬‫اٌظٍغ‬
‫إٌبرظ‬ٓ‫ػ‬‫ى٠بكح‬‫اٌٙوِٛٔبد‬‫اٌنوو٠خ‬
*)‫كٚاء‬ٍّٗ‫٠َزؼ‬ُ‫ِؼظ‬
ٝ‫ِوػ‬‫اٌؼغؾ‬ٌٝ‫إ‬ ‫ثبإلػبفخ‬
‫ِلهاد‬ٜ‫أفو‬ ‫ثٌٛ١خ‬thiazide
*)‫رقفغ‬ٜٛ‫َِز‬َٛ١ٍ‫اٌجٛرب‬
َُِٓ‫اٌغ‬,ٌٚٝ‫ثبٌزب‬
ٝ٘‫ِطٍٛثخ‬‫إل‬‫ػبكح‬‫إ‬‫ِزظبص‬
َٛ١ٍ‫اٌجٛرب‬ِٓٗ١ٍ‫اٌى‬‫ٌٍؾفبظ‬
ٍٝ‫ػ‬ٗ‫َٔجز‬ٝ‫ف‬َُ‫اٌغ‬
Aldosterone
Antagonists
Diuretics , Potassium-
sparing
Aldactone Spironolactone
)*‫اإل‬َ‫ٍزقلا‬٢‫ا‬‫فو‬ٝ‫ف‬‫ؽبٌخ‬ٌ‫ا‬ًّ‫ؾ‬
‫فبهط‬ٌ‫ا‬ُ‫وؽ‬(Ectopic pregnancy)
‫٠َزٙلف‬ ْ‫أ‬ ‫ثّب‬ ٚ‫اٌقال٠ب‬‫ٍو٠ؼخ‬
‫اإل‬َ‫ٔمَب‬ٚ‫ِٕٙب‬‫فال٠ب‬ٓ١ٕ‫اٌغ‬ٚ
‫فبطخ‬ٝ‫ف‬‫األ‬‫ٍبث١غ‬‫األ‬ٌٝٚ,ٚ
ٌٟ‫ثبٌزب‬‫ا٠مبف‬ّٛٔٓ١ٕ‫اٌغ‬‫ثبٌلٚاء‬
ٗ‫٠زجؼ‬ً‫رلف‬ٝ‫عواؽ‬‫ٌزٕظ١ف‬ُ‫اٌوؽ‬
*)‫ػالط‬ْ‫اٌَوؽب‬
*)‫األػؼبء‬ ‫ىهع‬
Immunosuppressants
Antineoplastics
Antimetabolite
Immunomodulators
Methotrexate
Trexall
Otrexup
Rasuvo
Methotrexate
‫إ‬‫ٍزقلا‬ِٗٛ٘‫ن‬Prokinetic
‫٠َوع‬ِٓ‫رفو٠غ‬‫اٌّؼلح‬ٚ‫ِب‬‫٠ٍ١ٙب‬
ٝ‫ف‬‫ػالط‬‫اٌزوع١غ‬‫أ‬ٚ‫إ‬‫هرغبع‬‫اٌّوا‬
١ِٚ‫اال٠و٠ضو‬ٓ١َٛ٘‫اٚي‬‫كٚاء‬ُ‫ر‬
ٗ‫اوزشبف‬ِٓ‫ِغّٛػخ‬
Macrolides
ٝ٘ٚ‫ِغّٛػخ‬ِٓ‫اٌّؼبكاد‬
‫اٌؾ١ٛ٠خ‬ٌ‫ا‬‫ز‬ٌٝ‫ٙب‬‫رؤص١و‬ٍٝ‫ػ‬
‫اٌجىزو٠ب‬G+َٚ‫٠َزقل‬ً٠‫وجل‬
ٓ١ٍ١َٕ‫ٌٍج‬ٝ‫ف‬‫ؽبالد‬
‫اٌؾَبٍ١خ‬
Macrolides Erythrocine Erythromycin

6. ‫التسمية‬ ‫خارج‬ ‫الدوائي‬ ‫اإلستخدام‬
Dr. Firas Kassab Page 6
ًٍ‫٠م‬ٓ١ِ‫اٌلٚثب‬‫ف١ي٠ل‬
ٓ١‫اٌجوٚالوز‬‫ف١يٚك‬‫إ‬‫فواى‬َ‫األ‬ ‫ؽٍ١ت‬ٚ
ٌ‫اٌؼى‬‫طؾ١ؼ‬
‫ثؼ١لا‬ٓ‫ػ‬‫أ‬ٗٔ‫كٚاء‬َ‫٠َزقل‬ٝ‫ف‬
‫اٌزوع١غ‬‫أ‬ٚ‫إ‬‫هرغبع‬‫اٌّوا‬ٓ‫ػ‬
‫ؽو٠ك‬ٗٔ‫ا‬Dopamine
antagonist
‫فمؾ‬ ‫ٌٍّؼٍِٛخ‬ٓ١ِ‫اٌلٚثب‬ٌ‫ػى‬
ٓ١‫اٌجوٚالوز‬)ِْٛ‫٘و‬
َ‫األ‬ ‫ؽٍ١ت‬(
Dopamine
Antagonists
Vasodilator
Corlopam Fenoldopam
ِٗ‫٠َزقل‬‫ا‬‫ٌوعبي‬‫أ‬‫٠ؼب‬ٝ‫ف‬‫ؽبٌخ‬
ُ‫اٌؼم‬ٓ‫ػ‬ ‫إٌبرغخ‬(Hyopgonadism)
ٟٚ٘‫ؽبٌخ‬‫ٔبرغخ‬ٓ‫ػ‬‫ٔمض‬
ْٚ‫اٌزَزٍٛز١و‬
‫افواى‬hypothalamusِْٛٚ‫ٌٙو‬LH
‫٠ؾفي‬‫اٌقظ١خ‬ٍٝ‫ػ‬‫ػـ‬ِْٛٚ‫٘و‬
ْٚ‫اٌزَزٍٛز١و‬‫ٌجلء‬‫أزبط‬‫اٌؾ١ٛأبد‬
‫إٌّٛ٠خ‬‫ثٕبءا‬ٍٝ‫ػ‬‫رؾو٠غ‬
Hypothalamusٝ‫ؽز‬ُ‫٠ز‬‫أزبط‬
‫اٌىّ١خ‬‫اٌىبف١خ‬,ً‫ٚط‬ ‫ؽبي‬ ٟ‫ف‬
ُ‫٠ز‬ ‫اٌّطٍٛة‬ ‫ٌٍؾل‬ ٌّٕٞٛ‫ا‬ ‫اإلٔزبط‬
‫إٔزبط‬ ‫ٌٛلف‬ ٟ‫ٍٍج‬ ‫هاعغ‬ ُ١‫رٍم‬
ِْٛ‫٘و‬LH‫رؾو٠غ‬ ِٓ ٌٟ‫ثبٌزب‬ ‫ٌٍؾل‬
‫اٌقظ١خ‬
‫إٍزؼّبي‬ ‫ؽبي‬ ٟ‫ف‬Clomiphene
ً‫رؼط‬‫َِزمجالد‬ٓ١‫االٍزوٚع‬ٚ
ٌٝ‫ثبٌزب‬‫االشبهح‬‫إٌٙبئ١خ‬‫اٌٛاهكح‬ًٌ
Hypothalamusٞ‫اٌن‬ٍ‫١َزّو‬ٝ‫ف‬
‫إ‬‫فواى‬LH‫ف‬‫١َزّو‬‫إ‬‫ٔزبط‬
ْٚ‫اٌزَزٍٛز١و‬ِٓ‫اٌقظ١خ‬ٞ‫اٌن‬
ٟ‫ف‬ ٖ‫ثلٚه‬ ُ٘‫٠َب‬‫ػالط‬‫ؽبٌخ‬ُ‫اٌؼم‬
‫اٌّزٛاعلح‬
ٝ‫٠ؼط‬ٝ‫ف‬‫ؽبالد‬ُ‫م‬ُ‫ػ‬
‫اٌَ١لاد‬‫أل‬ٗٔ‫٠ي‬٠‫ل‬ِٓٗ‫َٔج‬
‫األ‬ٚٓ١‫ٍزوٚع‬ٝ‫ف‬َ‫اٌل‬ٌٚ‫ا‬‫ن‬ٜ
ٖ‫ثلٚه‬‫٠ؾفي‬ٚ‫٠ٕشؾ‬‫اٌّجب٠غ‬
(‫ِبكح‬ٓ١‫اٌىٍِٛ١ف‬
(Selective estrogen
receptorModulator
(SERM))
‫رضجؾ‬‫َِزمجالد‬‫األ‬ٚٓ١‫ٍزوٚع‬
ٍٝ‫ػ‬ٜٛ‫َِز‬Hypothalamus
ٌٝ‫ٚثبٌزب‬‫٠ضجؾ‬–ve feedback
ٍٝ‫ػ‬ُٖ‫افواى‬ٚ‫٠َزّو‬
‫افواى‬‫األ‬ٚٓ١‫ٍزوٚع‬
Selective Estrogen
Receptor Modulator
Clomid
Serophene
Clomiphene
‫إ‬ِ‫ٍزقلا‬ٗ٢‫ا‬‫فو‬ٝ‫ف‬ٌ‫اٌوعب‬‫خ‬
( Anorgasmia )ٟٚ٘‫ثجَبؽخ‬‫ؽلٚس‬
‫اٌوعبي‬ ٜ‫ٌل‬ ‫اٌمنف‬ ‫رؤفو‬
‫اٌؾبٌخ‬‫ٌٙب‬‫أ‬‫ٍجبة‬‫وز١و‬‫إٍزٙالن‬ ‫ِٕٙب‬
ٌ‫ا‬‫ّقلهاد‬‫أ‬ٚ‫ِو٠غ‬‫ٍىو‬ٞ‫أ‬ٚ
ٍّٟ‫َِزؼ‬SSRIٟ‫اٌز‬‫ر‬‫ؤفو‬‫ػٍّ١خ‬
‫اٌمنف‬
‫َِزقلِخ‬‫إل‬‫٠مبف‬‫اٌوػبػخ‬,
ٓ١ِ‫اٌلٚثب‬ٌ‫ػى‬ٓ١‫اٌجوٚالوز‬
)ِْٛٚ‫٘و‬ٓ‫اٌٍج‬(
Hyperprolactinemia Dostinex
Elonda
Cabergoline

7. ‫التسمية‬ ‫خارج‬ ‫الدوائي‬ ‫اإلستخدام‬
Dr. Firas Kassab Page 7
‫اإل‬‫لالع‬ٓ‫ػ‬ٓ١‫اٌزلف‬ٌٗ‫ؽوق‬‫وز١و‬
ٗ١َ‫ٔف‬ٚ‫ػالع١خ‬ٚ‫اٌفىوح‬‫ٕ٘ب‬
ْ‫ا‬‫اٌّو٠غ‬ٝ‫ف‬‫االٚي‬ٝٔ‫٠ؼب‬ِٓ
‫أ‬‫ػواع‬‫ٍؾت‬ٓ١‫إٌ١ىٛر‬‫و‬‫بٌمٍك‬
‫اٌَّزّو‬ٌٚ‫ا‬‫زٛرو‬ٌٚٝ‫ثبٌزب‬ٖ‫٘ن‬
‫اٌّبكح‬‫رؼجؾ‬‫ِٛاك‬‫اٌَؼبكح‬ٚ‫اإل‬ْ‫ريا‬
َٝ‫إٌف‬ٌ‫ا‬َ‫غ‬ٞ‫ل‬
ٝ٘‫أ‬‫ؽل‬‫اٌّٛاك‬ِٗ‫اٌَّزقل‬
ٝ‫ف‬‫ػالط‬‫اإل‬‫وزئبة‬ٚ‫رؼزجو‬‫ن‬
ًّ‫رؼ‬‫ن‬
Weak serotonin and
Noradrenalin reuptake
inhibitor‫األكٚ٠خ‬ ٖ‫٘ن‬ ْ‫أ‬ ‫إال‬
‫لل‬‫رَجت‬epilepsyٌٝ‫ٚثبٌزب‬
ًّ‫رَزؼ‬‫رؾذ‬‫ِوالجخ‬
Antidepressants
Dopamine Reuptake
Inhibitor
Wellbutrine
Zyban
Budeprion
Aplenzin
Forfivo XL
Bupropion
)*‫إ‬ِ‫ٍزقلا‬ٙ‫ب‬‫االفو‬ٝ‫ف‬‫ؽبٌخ‬
َُّ‫اٌز‬‫ثبٌجبهاٍ١زبِٛي‬ٌ‫ا‬‫ز‬ٌٝٙ‫ب‬
‫رؤص١و‬‫ِلِو‬ٍٝ‫ػ‬ٞ‫اٌىجل‬ ‫إٌَ١ظ‬
‫ِبكح‬NAC‫٠طٍك‬‫ػٍ١ٙب‬
(Paracetamol antidote)
ُ‫٠ز‬‫اػطبئٙب‬‫ٍٛاء‬‫ٚه٠ل٠ب‬ ٚ‫أ‬ ‫فّٛ٠ب‬
‫الػبكح‬ٓ٠ٛ‫رى‬‫ِبكح‬Glutathioneٝ‫ف‬
‫اٌىجل‬ٌٚ‫ا‬‫ز‬ٝ‫رورجؾ‬
‫ة‬‫اإلٍزمالث١خ‬ ٌََّٛ‫ا‬‫إٌبرظ‬ٓ‫ػ‬
‫اٌجبهاٍ١زبِٛي‬ٌٚ‫ا‬‫ز‬ٝ‫ر‬َّٝ
NAPQI
)*‫ٕ٘بن‬َ‫اٍزقلا‬‫آ‬‫فو‬ٚٛ٘ٝ‫ف‬
ٌ‫ؽب‬‫ى٠بكح‬ ‫خ‬‫ٌيٚعخ‬ً‫اٌَبئ‬ٌّٜٕٛ‫ا‬
ٝ‫اٌز‬‫ؼ١ك‬ُ‫ر‬‫ؽووخ‬‫ٚٚطٛي‬‫اٌؾ١ٛأبد‬
‫إٌّٛ٠خ‬‫ٌٍجٛ٠ؼخ‬
N-acetyl l-cysteine (NAC)
‫اإل‬َ‫ٍزقلا‬‫اٌشبئغ‬ٛ٘‫وّن٠ت‬
ُ‫ٌٍجٍغ‬ٝ‫ف‬‫طٛهح‬‫ؽج١جبد‬‫فٛهاح‬
ٓ‫ػ‬‫ؽو٠ك‬ُ١‫رؾط‬Disulfide
linkageٌ‫ا‬‫ّٛعٛكح‬ٓ١‫ث‬‫اي‬
Mucous
Expectorative
Mucolysis
N-Acetyl
cysteine
Mucomyst
Acetylcysteine
‫إ‬ِٗ‫ٍزقلا‬٢‫ا‬‫فو‬‫فمل‬ ‫ؽبالد‬ ٟ‫ف‬
ٌ‫ا‬‫شٙ١خ‬َٚٓ‫٠ؾ‬ِٓٗ‫ؽبٌز‬
ٗ١‫اٌّياع‬
‫ؽبالد‬‫اٌؾَبٍ١خ‬ Antihistamines , 1er
Generation
Triactin
Benadryl
Cyproheptadine
‫إ‬ِ‫ٍزقلا‬ٗ٢‫ا‬‫فو‬ٝ‫ف‬‫ؽظٛاد‬ٍُٝ‫ى‬ٌ‫ا‬
ًّ‫٠ؼ‬ ٗٔ‫أ‬ ‫إم‬ٍٝ‫ػ‬Alpha receptor
‫اٌّٛعٛكح‬ٝ‫ف‬‫اٌؾبٌت‬ٚٗ١‫٠وف‬‫ِّب‬
ًَٙ٠‫فوٚعٙب‬
Alpha 1 blocker drug
َ‫٠َزقل‬‫ؽبالد‬ ٟ‫ف‬ُ‫رؼق‬
‫اٌجوٍٚزبرب‬‫اٌؾّ١ل‬ٟٚ‫اٌز‬
ٌَٓ‫ا‬ ‫وجبه‬ ‫ػٕل‬ ‫رشب٘ل‬
‫اٌجوٍٚزبد‬ ‫ػقبِخ‬‫رغٍك‬ ٚ‫أ‬ ‫رؼ١ك‬
‫اٌجٛي‬ ٜ‫ِغو‬ٌٚٝ‫ثبٌزب‬‫كٚه‬‫اٌلٚاء‬
‫ٕ٘ب‬ٝ‫٠وف‬‫ٕك‬ُ‫ػ‬ٗٔ‫اٌّضب‬‫٠َّؼ‬ ٚ
‫ثبٌزجٛي‬
Alpha Blockers Flomax
Omnic Ocas
Tamsulosin

8. ‫التسمية‬ ‫خارج‬ ‫الدوائي‬ ‫اإلستخدام‬
Dr. Firas Kassab Page 8
)*‫اإل‬َ‫ٍزقلا‬٢‫ا‬‫فو‬ٝ‫ف‬ٌ١َ‫اٌزق‬
ٌ‫ثٕف‬٢‫ا‬‫ٌ١خ‬ٚ‫اٌغوػبد‬‫ؽجؼب‬ُ‫٠ز‬
‫رؾل٠ل٘ب‬‫ؽَت‬‫اٌؾبٌخ‬َ‫٠َزقل‬
)*‫ؽبٌخ‬‫رى١َبد‬‫اٌّجب٠غ‬
‫اٌّظؾٛثخ‬‫ث‬‫ئ‬‫ػطواة‬ٝ‫ف‬‫اٌٙوِٛٔبد‬ٚ
‫ى٠بكح‬ٗ‫َٔج‬ْٚ‫اٌزَزٍٛز١و‬ٌٚ‫ا‬‫ز‬ٝ
‫رَجت‬ٍٗ‫ِشى‬‫أ‬ٜ‫فو‬‫ػٕل‬‫اإل‬‫ٔبس‬ٚ
ٟ٘‫ؽت‬‫اٌشجبة‬‫ٔز١غخ‬
Hyperandrogenismٌٚٝ‫ثبٌزب‬
‫إ‬‫ٍزؼّبي‬ٓ١ِ‫اٌّ١زفٛه‬ٝ‫ف‬‫ؽت‬
‫اٌشجبة‬‫ث١مزظو‬ٍٝ‫ػ‬ٖ‫٘ن‬‫اٌؾبٌخ‬>
Hormonal imbalance induced
acne
)*ٟٔ‫اٌضب‬ ‫إٌّؾ‬ ٞ‫اٌَىو‬ٓ‫ػ‬
‫ؽو٠ك‬‫ففغ‬‫اِزظبص‬
‫اٌغٍٛوٛى‬ًٚ١ٍ‫رم‬‫إ‬ٗ‫ٔزبع‬ِٓ
‫اٌىجل‬
)*ٗ‫ثبالػبف‬ٗٔ‫ا‬‫٠ؼبػف‬
‫ؽَبٍ١خ‬‫األ‬ٗ‫َٔغ‬‫ٌأل‬ٓ١ٌَٛٔ
ٚ‫٠َبػل‬‫أ‬‫وزو‬ٝ‫ف‬‫ؽوق‬
‫اٌغٍٛوٛى‬
Antidiabetics
Biguanides
Glugophage
Fortamet
Glumetza
Riomet
Metformin
‫ا‬‫إل‬َ‫ٍزقلا‬٢‫ا‬‫فو‬ٝ‫ف‬ً‫فش‬‫اٌىجل‬
‫إٌبرغخ‬ٓ‫ػ‬‫ى٠بكح‬ammoniaٌٚ‫ا‬ٟ‫ز‬
ٟ‫ف‬ ‫اٌىجل‬ ً‫فش‬ ‫ثَجت‬ ُ‫رزواو‬
ٗ‫ؽبٌز‬ ‫ثَجت‬ ‫ِٕٙب‬ ‫اٌزقٍض‬ٟ‫اٌز‬ ٚ ,
ً‫ِشبو‬ ٌٝ‫إ‬ ٞ‫رؤك‬‫ِٕٙب‬ ‫ػظج١خ‬
‫اٌغ١جٛثخ‬ ٌٝ‫إ‬ ٞ‫رؤك‬ ‫لل‬ ٚ ‫اٌٍٍٙٛخ‬
‫ػٕل‬‫إ‬‫ػطبء‬Lactuloseٍٝ‫ػ‬‫٘١ئخ‬
ٕٗ‫ؽم‬‫شوع١خ‬‫٠ٕشطو‬ٌٝ‫ا‬Lactic
acid‫ٌؾلٚس‬ ٞ‫٠ؤك‬ ٞ‫اٌن‬Acidic
media‫ؼبكي‬ُ‫ر‬ammonia‫ٚرؾٌٛٙب‬
ٌٝ‫ا‬َٛ١ِٔٛ‫ا‬‫ِزؼبكي‬NH3 to NH4ٚ
ٌٝ‫ثبٌزب‬‫٠زٛلف‬‫ػجٛه‬ammoniaِٓ
ٌ‫ا‬‫إ‬ ٌْٛٛ‫م‬ٌَٝ‫اٌل‬ٖ‫٘ن‬ ٟ‫ف‬‫اٌؾبٌخ‬
ٓ‫٠ّى‬‫إػطبء‬Neomycin (Antibiotic)
ًٌ‫مز‬Bacterial floraٟ‫اٌز‬ُ٘‫رَب‬
ٜٝ٘‫االفو‬‫ف‬‫إ‬ ٟ‫ٔزبط‬ammonia
ٜ‫اؽل‬‫ٍ١ٕبد‬ٌُّ‫ا‬ِٗ‫اٌَّزقل‬
ً‫ثشى‬‫وج١و‬ِٚٓ‫آ‬ٜ‫ٌل‬
‫األ‬‫ؽفبي‬ٚ‫اٌىجبه‬ٚٝ‫ؽز‬
ًِ‫اٌؾٛا‬
Laxatives , Osmotic
Ammonium
Detoxicants
Generlac
Constulose
Kristalose
Lactulose
Lactulose
‫اإل‬َ‫ٍزقلا‬ٚ ‫ا٢فو‬‫ثّب‬ٗٔ‫ا‬ًٍ‫٠م‬
ِْٛ‫٘و‬‫اٌنوٛهح‬‫ثبٌّؾظٍخ‬ ٗ٠‫فٍل‬
Anti androgenic effect
ٌٚٝ‫ثبٌزب‬َ‫٠َزقل‬ٝ‫ف‬‫ػالط‬‫اٌظٍغ‬
ٓ‫ٌى‬‫ؽجؼب‬‫ثغوػبد‬‫أ‬ً‫ل‬
Testosterone to
dihydrotestosterone (active
form)
ٌٝ‫ٚثبٌزب‬َ‫٠َزقل‬ٝ‫ف‬‫ػالط‬
ُ‫رؼق‬‫اٌجوٍٚزب‬‫د‬‫إٌبرظ‬ٓ‫ػ‬
‫ى٠بكح‬ِْٛ‫٘و‬‫اٌنوٛهح‬
5-alpha-reductase
inhibitor
Prostec
Proscar
Propecia
Finasteride

9. ‫التسمية‬ ‫خارج‬ ‫الدوائي‬ ‫اإلستخدام‬
Dr. Firas Kassab Page 9
‫ؽبالد‬‫ى٠بكح‬ْ‫اٌٛى‬‫اٌّورجطخ‬
‫ثبإل‬‫وزئبة‬ٌ‫ا‬‫ز‬ٝ‫ث‬ٗ‫ّؼبٌغز‬‫٠وعغ‬
‫اإل‬ْ‫َٔب‬ٗ‫ٌطج١ؼز‬
‫روفغ‬ٗ‫َٔج‬ٌَ‫ا‬ٓ١ٔٛ‫١وٚر‬ٝ‫ف‬
َ‫اٌل‬ٌٚ‫ا‬‫اٌّياط‬ ِٓ َٓ‫رؾ‬ ٟ‫ز‬
‫ثبٌَؼبكح‬ ‫شؼٛها‬ ٟ‫رؼط‬ ٚ َ‫اٌؼب‬
Antidepressants
SSRIs
Paroxetine
Paxil
Brisdelle
Paroxetine
)*‫ري٠ل‬ِٓٓ٠ٛ‫رى‬‫ِبكح‬Surfactant
ً‫كاف‬‫هئخ‬ٓ١ٕ‫اٌغ‬.
)*‫اي‬Dexamethasoneًٌٗ‫فؼ‬
ٞ‫رآىه‬‫ِغ‬Ondansetron(َٛ‫٠م‬
‫و‬ْ‫ظ‬َ‫ؾ‬‫ث‬(‫إػبلخ‬)‫َِزمجالد‬
ٓ١ٔٛ‫ٍ١وٚر‬(Serotonin)،
)*ًّ‫٠َزؼ‬‫ٌّٕغ‬ْ‫اٌغض١ب‬‫ٚاٌزم١ؤاد‬
‫إٌبرغخ‬ٓ‫ػ‬‫اٌّؼبٌغخ‬‫اٌى١ّ١بئ١خ‬ٚ
ٜٛ‫٠م‬ِٓ‫ِفؼٌٛخ‬ٚ‫غبٌجب‬‫ِب‬
ٜ‫ٌل‬ ًّ‫٠َزؼ‬ٝ‫ِوػ‬َ‫األٚها‬
ٜٛ‫أل‬‫ِؼبك‬‫ٌإل‬‫ٌزٙبة‬ٓ‫ػ‬‫ؽو٠ك‬
‫ِٕغ‬‫أشطبه‬Arachidonic acid
ٚ‫أ‬ ًّ‫٠َزؼ‬‫٠ؼب‬‫ضجؾ‬ُّ‫و‬‫ٌٍّٕبػخ‬
Anti-inflamatory
Agents
Dexa
Decadron
Solurex
Baycadron
Dexamethasone
)*Neuropathic pain‫إٌبرظ‬ٓ‫ػ‬
‫إ‬‫ٌزٙبة‬‫االػظبة‬‫وّب‬ٝ‫ف‬ٝ‫ِوػ‬
‫اٌَىو‬‫اإلطبثبد‬ ٝ‫ِوػ‬ ٚ ٞ
‫اٌؼظّ١خ‬
)*Bipolar disorderٟٚ٘‫ؽٍخ‬
‫٠زؤهعؼ‬‫ف١ٙب‬‫ِياط‬ْ‫االَٔب‬ٓ١‫ث‬
ٓ١‫ؽبٌز‬ٓ١‫ِزٕبلؼز‬‫فوػ‬ْٕٛ‫ثغ‬ٚ
‫إ‬‫وزئ‬‫ب‬‫ة‬"‫"ِّ١ذ‬!
‫كٚه‬‫اٌّبكح‬‫ٕ٘ب‬‫و‬ ٛ٘‫ِياط‬ ‫ّؼلي‬
)*Post herpetic neuralgia
ٌٟٚ٘ٗ‫ؽب‬ْٛ‫٠ى‬‫اٌّو٠غ‬‫ظبة‬ُِ‫ة‬
VZ virus‫ث‬ َّٝ٠ ‫ِب‬ ٚ‫أ‬َ‫بٌؾيا‬
ٜ‫إٌبه‬
ٗ١‫شج‬‫ثّووت‬‫آفو‬‫ِٛعٛك‬ٝ‫ف‬
َُ‫اٌغ‬> ٝ‫٠لػ‬
Gama amino butyric acid
GABA (inhibitory neurotransmitter)
‫اٌلٚاء‬َ‫٠َزقل‬ٝ‫ف‬‫ػالط‬
‫اٌظوع‬ٚ‫اٌزشٕغبد‬ٓ‫ػ‬‫ؽو٠ك‬
‫ى٠بكح‬GABAٍٝ‫ػ‬‫األ‬‫ػظبة‬ٚ
ٌ‫ا‬‫ز‬ٝ‫رّٕغ‬‫أزمبي‬‫إٌجؼبد‬
‫اٌؼظج١خ‬
Anticonvulsants Neurontin
Gralise
Conventin
Gaptin
Gabapentin
‫اٌشو‬‫اٌشك‬ ٚ‫أ‬ ‫ؿ‬ٝ‫اٌشوع‬
Anal fissureِٓ ‫٠ي٠ل‬ ‫ؽ١ش‬
blood supplyٌَٙ‫ز‬١ً‫ػٍّ١خ‬
‫اإل‬َ‫ٌزئب‬
)*ٓ٠‫إٌزوٚعٍ١َو‬Anti
anginaٚca channel blocker
)*َ‫٠َزقل‬‫إهرفبع‬ ٝ‫ِوػ‬ ٜ‫ٌل‬
ٟٔ‫اٌشو٠ب‬ ‫اٌزٛرو‬
)*‫ؽبالد‬‫اٌنثؾخ‬‫اٌظله٠خ‬ٓ‫ػ‬
‫ؽو٠ك‬‫رٍٛ١غ‬‫االٚػ١خ‬‫اٌلِٛ٠خ‬
ً‫ف١م‬‫ػغؾ‬َ‫اٌل‬After and
preload
Nitrates , Angina
Vasodilatator
Ca channel blocker
Nitromak
Nitrostat
Adalat
Nifediac
Nitroglycerin
Nifedipine

10. ‫التسمية‬ ‫خارج‬ ‫الدوائي‬ ‫اإلستخدام‬
Dr. Firas Kassab Page 10
ٜ‫ٌل‬ َ‫٠َزقل‬ )*‫اٌّو٠غ‬ٌ‫ا‬‫ؼوع‬ُّ
‫أ‬ٚٞ‫اٌن‬ٛ‫٠شى‬ً‫ثبٌفؼ‬ِٓ‫عٍطخ‬,
َ‫٠َزقل‬ )*ٜ‫ٌل‬ًِ‫اٌؾٛا‬ٟ‫ف‬
‫اٌشٙٛه‬‫األ‬ٌٝٚ‫األ‬‫وضو‬‫ػوػ‬‫خ‬
‫ٌالعٙبع‬
‫ا٢ٌ١خ‬‫ٕ٘ب‬‫ٚاؽل‬‫ح‬ٟٚ٘‫أ‬ْ‫األ‬ٓ٠‫ٍجو‬
‫٠ّٕغ‬‫رغّغ‬‫اٌظفبئؼ‬‫اٌلِٛ٠خ‬‫َججب‬ُِ
‫ٍ١ٌٛخ‬ٝ‫ف‬َ‫اٌل‬
Potent anti inflammatory ,
analgesic , anti pyretic
‫٠ؼزجو‬ِٜٓٛ‫ال‬‫اي‬NSAIDSٓ‫ػ‬
‫ؽو٠ك‬‫ِٕغ‬
COX 1 , 2 enzymes
ٌٝ‫ٚثبٌزب‬‫ِٕغ‬ٓ٠ٛ‫رى‬
ٓ٠‫اٌجوٍٚزبعالٔل‬
NSAIDs
Antiplatelet Agents
Aspirin
Ascriptin
Acetyl salicylic
acid (aspirin)
)*Phenobarbitalِٓ‫اشٙو‬
enzymes inducer Liver
ً‫ثشى‬ ‫غ‬ّ‫ػ‬ُ‫اٌو‬ ٜ‫ٌل‬ ‫أؽ١بٔب‬ ‫٠ٛطف‬
‫ِووت‬ِٓ‫كٚا‬‫ئ‬ٓ١>
(rbitone)syr
(phenoba) ominalettaS
ٚ‫ٕ٘ب‬ٗ‫َٔج‬‫اٌظفواء‬ْٛ‫رى‬‫ػبٌ١خ‬
‫ثَجت‬‫ِبكح‬Bilirubin‫اٌز‬ ٚٝ‫٠َبػل‬
ٝ‫ف‬‫رىَ١و٘ب‬‫أي٠ّبد‬‫اٌىجل‬ٖ‫في‬َ‫ؾ‬ٌُّ‫ا‬
( long Acting Barbiturate)
‫إ‬ِ‫ٍزقلا‬ٗ‫األ‬ٍٝ‫ط‬‫ٙلا‬ُّ‫و‬ٚ
ًَِٕٛ٠ٛ‫ؽ‬ٜ‫اٌّل‬ٝ‫ٚف‬‫ؽبالد‬
‫اٌزشٕظ‬
Anti convulsant , hypnotic
Anticonvulsants Mysoline
Phenobarbita
l
Primidone
Phenobarbital
‫ثؼغ‬‫االؽجبء‬ٝ‫ف‬‫ؽبالد‬‫ٔي٠ف‬‫األ‬‫ٔف‬
‫اٌؾبك‬ٟ‫اٌّٛػؼ‬ ‫اٌزطج١ك‬ ‫ػجو‬
‫أل‬ْٓ١ٌ‫االكه٠ٕب‬ٌ‫ل‬ٗ٠
Potent vasoconstrictor effect
Anaphylactic shock
‫ِضال‬‫ؽَبٍ١خ‬ِٓٓ١ٍ١َٕ‫اٌج‬
‫أ‬ٚ‫اٌٍَفب‬
ٚ‫ونٌه‬ٝ‫ف‬‫ؽبالد‬asthmaٚ
cardiac arrest
Alpha/Beta
Adrenergic Antagonist
Alpha/Beta Antagonist
Epipen
Adrenalin
Adrenaclick
Epinephrine
ACEI (angiotensin converting
enzyme inhibitor ) induced cough
ْ‫فئ‬ ‫ا٢ٌ١خ‬ ُٙ‫ٌف‬ ٚ‫ِٕغ‬‫إ‬٠‫ٔي‬ُ
Angiotensin converting (AC)
ٜ‫اٌن‬ٜ‫٠ؤك‬ُ‫ٌزواو‬‫ِبكح‬Bradykinin
ٝ‫اٌز‬‫ؾفي‬ُ‫ر‬vagal effect‫ثبالػبفخ‬‫إ‬ٌٝ
‫إ‬‫ٔزبط‬Arachidonic acidَُِٚٓ‫ص‬‫إ‬‫ٔزبط‬
ٓ٠‫اٌجوٍٚزبعالٔل‬ٗ‫َجج‬ٌُّ‫ا‬ٌٍ‫َؼبي‬,ٚ
‫ٕ٘ب‬‫كٚه‬NSAIDS‫أ‬‫طجؼ‬ٞ‫اٌن‬‫٠ّٕغ‬
ٓ٠ٛ‫رى‬ٓ٠‫اٌجوٍٚزبعالٔل‬
**‫رؼم١ت‬>ُ‫ِؼظ‬‫األ‬‫ؽجبء‬‫ؽبٌ١ب‬‫ؽبي‬ ٟ‫ف‬ ٚ
‫ٍؼبي‬ ‫ٚعٛك‬‫شل٠لح‬ٍٝ‫ػ‬‫اٌّو٠غ‬ُ‫٠ز‬‫رغ١١و‬
‫اٌلٚاء‬‫رّبِب‬
Shift from ACEI to ARB (angiotensin
receptor blocker )
‫األ‬‫كٚ٠خ‬‫اٌّؼبكح‬‫ٌإل‬‫ٌزٙبة‬ٚ
ٗ‫اٌقبفؼ‬‫ٌٍؾواهح‬ٕٚٗ‫َِى‬
‫ٌأل‬ٌُ
NSAIDs Aspirin
Brufferin
Cataflam
Celocoxib
Felene
Ibuprofen
Indocin
Ketorolac
Mefenamic
Acid
Naproxen
Piroxicam
Relafen
Sulindac
Tolmetin
NSAIDs

11. ‫التسمية‬ ‫خارج‬ ‫الدوائي‬ ‫اإلستخدام‬
Dr. Firas Kassab Page 11
‫أفن‬‫ِٛافمخ‬FDAَ‫ػب‬6156‫رمو٠جب‬
‫ف‬ٟ‫ثزقف١ف‬ ‫اٌّزؼٍمخ‬ ‫اٌّؼبٌغبد‬
ْ‫اٌٛى‬weight loss‫اٌزٕؾ١ف‬ ْ‫أ‬ ‫إال‬
‫ٕ٘ب‬‫ػوع‬ٝ‫عبٔج‬‫ٌٍلٚاء‬Side effect
not effect‫ٚاػؾخ‬ ‫غ١و‬ ‫ا٢ٌ١خ‬ ٚ
‫ِٕن‬ ًّ‫٠َزؼ‬َ‫ػب‬1996ٟ‫ف‬
‫ؽبالد‬‫اٌظلاع‬ٝ‫إٌظف‬
‫ظبؽت‬ٌُّ‫ا‬‫ٌؾبالد‬ْ‫اٌؾي‬ٚ
‫اٌمٍك‬ٚ‫أ‬‫٠ؼب‬‫وؼالط‬‫ٌٍظوع‬ٚ
‫اٌزشٕغبد‬
Anticonvulsants
Antimigraine Agents
Topamax
Trokendi XR
Qudexy XR
Topiramate
‫ٔشبؽ‬ ‫فوؽ‬ ‫ؽبالد‬ ٟ‫ف‬ َ‫٠َزقل‬
‫اٌلهق‬Hyperthyrodism
‫اٌّووت‬ٓ١ٍ‫شى‬ ٍٝ‫ػ‬ ٞٛ‫٠ؾ‬
ٓ١‫ِقزٍف‬(L) and (D) isomer
)+L-propranolol>ٛ٘‫اٌَّئٛي‬
ٓ‫ػ‬Beta blocking activity
)+D-propranolol>‫٠ّٕغ‬‫رؾٛي‬
T4 to T3 (most active form)
ٚ‫ٕ٘ب‬ٖ‫كٚه‬ٝ‫ف‬‫اٌؼالط‬ٍُ‫اٌؼ‬ ‫ِغ‬‫أ‬ٗٔ
‫اٌٛؽ١ل‬ِٓ‫اي‬Beta blockersٜ‫اٌن‬
‫٠ّزٍه‬‫اٌقبط١خ‬ ٖ‫٘ن‬
**‫رؼم‬‫١ت‬>‫األ‬‫طٕبف‬ٌّ‫ا‬‫زٛفوح‬ٝ‫ف‬
‫اٌَٛق‬‫اٌلٚائ١خ‬ِٓ ‫عنه٠خ‬ ‫فالئؾ‬ ٟ٘
‫اٌجوٚثبٌٔٛٛي‬
( Racemic mixture of propranolol )
ً‫ٌفظ‬ ‫اٌّورفؼخ‬ ‫اٌزىبٌ١ف‬ ‫ثَجت‬ ‫مٌه‬ ٚ
‫اي‬isomers‫غ١و‬ْ‫أ‬‫رٛاعل‬ٓ١‫إٌٛػ‬‫ِغ‬
‫ثؼغ‬‫ِف١ل‬ٝ‫ف‬‫رٍه‬‫اٌؾبٌخ‬
Non selective beta blocker
ٝ‫ف‬‫ؽبالد‬‫اٌؼغؾ‬‫اٌّورفغ‬
Antidysrhthmics
Beta-Blockers ,
nonselective
Antianginal Agents
Antimigraine Agents
Inderal
InnoPran XL
Hemangeol
Propranolol
‫اٌيهق‬ ‫ؽبالد‬ ٟ‫ف‬ َ‫٠َزقل‬
((Glaucomaٌٚ‫ا‬ْٛ‫٠ى‬ ٟ‫ز‬‫ف١ٙب‬
‫ػغؾ‬ٓ١‫اٌؼ‬‫ِورفغ‬‫ٔز١غخ‬‫رغّغ‬
Aqueous humorٌٚ‫ا‬‫ز‬ٝ‫ر‬‫ؼغؾ‬
‫ثلٚه٘ب‬ٍٝ‫ػ‬‫اٌؼظت‬ٜ‫اٌجظو‬ٚ‫لل‬
‫ر‬ٜ‫ؤك‬ّٝ‫ٌٍؼ‬‫ٌنٌه‬‫إ‬ ْ‫فئ‬‫فواط‬‫وّ١بد‬
َِٓٛ٠‫اٌظٛك‬ٚ‫اٌج١ىوثٛٔبد‬‫ثٛاٍطخ‬
‫٘نا‬‫اٌلٚاء‬ًٍ‫٠م‬ِٓ‫رغّغ‬‫٘نا‬
ً‫اٌَبئ‬ّٓ‫ػ‬ٓ١‫اٌؼ‬ٚ‫رقف١ف‬ِٓ
ٖ‫ؽل‬‫اٌؾبٌخ‬
**١‫رؼم‬‫ت‬>‫اٌلٚاء‬Sulphonamide
derivativeٌٚٝ‫ثبٌزب‬ٗ‫إػطبئ‬ ‫٠ّٕغ‬
ٌّٓٗ٠‫ٌل‬‫ؽَبٍ١خ‬ِٓ‫اٌٍَفب‬
‫رّٕغ‬‫إ‬ُ٠‫ٔي‬‫إ‬ٍّٗ
Carbonic anhydrase
‫اٌَّئٛي‬ٓ‫ػ‬‫إ‬‫ٔشطبه‬
‫اٌج١ىوثٛٔبد‬‫إ‬ٌٝٝٔ‫صب‬‫أ‬‫وَ١ل‬
ْٛ‫اٌىوث‬ٚ‫ِبء‬‫ف١ي٠ل‬ِٓ‫ِؼلي‬
‫فوٚط‬‫اٌج١ىوثٛٔبد‬ٝ‫ف‬‫اٌجٛي‬
‫ٌنٌه‬َ‫٠َزقل‬‫وّله‬‫ٌٍجٛي‬ٝ‫ف‬
ٝ‫ِوػ‬‫اٌؼغؾ‬ٚ‫ونٌه‬ٝ‫ف‬
‫ؽبالد‬‫اٌٛمِخ‬
Antiglaucoma ,
Carbonic Anhydrase
Inhibitor
Mild diuretic lowering
Nacl and bicarbonate
level
Anticonvulsants
Diamox
Sequels
Cidamex
Acetazolamide

12. ‫التسمية‬ ‫خارج‬ ‫الدوائي‬ ‫اإلستخدام‬
Dr. Firas Kassab Page 12
ٜ‫رؤك‬ً٠ٛ‫ٌزط‬ٚ‫وضبفخ‬ُِٛ‫ه‬ٓ١‫اٌؼ‬ َ‫ي‬ٌ‫ا‬َ‫ه‬‫ق‬(Glaucoma)ٚ‫إ‬‫هرفبع‬
‫ػغؾ‬ٓ١‫اٌؼ‬
Antiglaucoma ,
Prostaglandin
Agonists
Xalatan
Loprost
Latanoprost
‫٠َوع‬ِٓ‫٘غوح‬‫فال٠ب‬‫اٌغٍل‬‫إ‬ٌٝ
ْ‫ِىب‬‫اٌغوػ‬‫ػٍّ١خ‬ ِٓ ‫٠َوع‬ ٚ
َ‫اإلٌزئب‬
‫٘نا‬ ْ‫أ‬ ‫إال‬‫اإل‬َ‫ٍزقلا‬ٕٝ‫ال٠غ‬ٓ‫ػ‬
ٜ‫اٌَىو‬ ٝ‫ٌّوػ‬ َ‫اٌل‬ ‫ٍىو‬ ‫ػجؾ‬
DM type 1ٗ‫اٌزف‬ ٞ‫اٌَىو‬ (
) ‫األٚي‬ ‫إٌٛع‬
Antidiabetics Insuline Insulin
‫رؤص١و‬ٖ‫وج١و‬ٟ‫ف‬‫ػؼالد‬ ‫رمجؼبد‬
ُ‫اٌوؽ‬ُ‫ف١ز‬‫إ‬‫ػطبءح‬‫ثؼل‬‫اٌٛالكح‬‫ٌطوك‬
‫ثمب٠ب‬‫اٌّش١ّخ‬ٚ‫رٕظ١ف‬ُ‫اٌوؽ‬ٚ
‫أ٠ؼب‬ٝ‫ف‬‫ؽبٌخ‬ٟ‫اٌطج‬ ‫اإلعٙبع‬‫ف‬ُ‫١ز‬
‫إ‬ِٗ‫ٍزقلا‬‫وطٍك‬ٝ‫طٕبػ‬ِٓ‫أ‬ً‫ع‬
‫اإل‬‫عٙبع‬
‫ٌنٌه‬‫ف‬‫ؾبٌ١ب‬ٌٗٚ‫رلا‬ٝ‫ف‬‫اٌظ١لٌ١بد‬
‫ثؾنه‬‫شل٠ل‬ٚ‫ٔظبِ١خ‬ ‫ؽج١خ‬ ‫ثٛطفخ‬
‫ِزقظض‬ ‫َٔبء٠خ‬ ‫ؽج١ت‬ ِٓ
‫فٛفب‬ِٓ‫إ‬ِٗ‫ٍزقلا‬ٝ‫ف‬‫أ‬‫غواع‬‫غ١و‬
‫شوػ١خ‬‫أفالل١خ‬ ‫غ١و‬ ٚ
ُ‫ر‬‫إ‬ِٗ‫ٍزقلا‬ٝ‫ف‬‫لوؽخ‬
‫اٌّؼلح‬‫٠وفغ‬ ٗٔ‫أ‬ ‫إم‬ِٓ‫إ‬‫فواى‬
Mucous‫ٌؾّب٠خ‬‫علاه‬‫اٌّؼلح‬
ِٓ( ‫اٌّؼل٠خ‬ ‫اٌؾّٛع‬‫ؽّغ‬
‫اٌٙ١لهٚوٍٛه٠ه‬ٚ‫أ‬‫ؽّغ‬‫وٍٛه‬
‫اٌّبء‬HCl)
Gastrointestinal Agent Cytotec Misopristol
‫ػالط‬‫ٍوػخ‬‫اٌمنف‬‫اٌزؤص١و‬ ‫٘نا‬ ْ‫أ‬ ‫إال‬
‫٠ظٙو‬ ‫ال‬‫اٌؼالط‬ ِٓ ‫ىِٕ١خ‬ ‫فزوح‬ ‫ثؼل‬ ‫إال‬
‫اٌَّزّو‬
‫اي‬Dapoxetine‫٠قزٍف‬‫َٔج١ب‬ٓ‫ػ‬
SSRI‫ٍوػخ‬ ‫ٌؼالط‬ ‫فبػٍ١خ‬ ٟ‫٠ؼط‬ ٚ
‫عوػخ‬ ‫أٚي‬ ِٓ ‫اٌوعبي‬ ٜ‫ٌل‬ ‫اٌمنف‬
‫ػالط‬‫االوزئبة‬ٚ‫اٌمٍك‬ٚ
ً‫اٌٍٛٛا‬
Antidepressants Escitalopram
Dapoxetine
Lexapro
Selective
serotonin
reuptake
inhibitors SSRI