- Hansel John Bognot Sambat is seeking employment in information technology and has over 10 years of experience in IT infrastructure support, software and hardware design, and desktop support.
- He currently works as an IT Infrastructure Solutions and Support Team Lead at Resorts World Sentosa, where he provides level 3 support, manages the IT infrastructure and operations, and supervises a team of desktop support technicians.
- Previously he has held roles as a Desktop Support Engineer at CSC PTE LTD and Junior Engineer at Accenture Delivery Center, where he provided technical support, hardware and software maintenance, and assisted with various IT projects.
This document is a resume for Jameson L. Mase that outlines his professional experience and qualifications. He has over 10 years of experience in human resources operations management, most recently as a Service Manager at IBM Global Process Services. Prior to that, he held roles as an Operations Manager and HR Practitioner. Mase has extensive expertise in benefits administration, compensation, payroll, and client management. He is skilled in process change management, people leadership, and ensuring compliance. Mase received a Bachelor's degree in Tourism from the University of the Philippines.
This document is a corporate presentation from Neuroservice, a contract research organization that specializes in testing the effects of compounds on central nervous system tissues using in vitro techniques like patch clamp recording and multi-electrode arrays. The presentation outlines Neuroservice's solutions for drug discovery and safety testing, key focus areas, techniques, commitments to clients, and team of experts available to work with clients.
1) Researchers screened 40,000 compounds and identified TRO19622 as a potential drug candidate for treating amyotrophic lateral sclerosis (ALS).
2) In vitro, TRO19622 promoted motor neuron survival in a dose-dependent manner and rescued motor neurons from death.
3) In animal models of ALS and nerve damage, TRO19622 improved motor performance, delayed disease onset, extended survival, and promoted nerve regeneration.
- Hansel John Bognot Sambat is seeking employment in information technology and has over 10 years of experience in IT infrastructure support, software and hardware design, and desktop support.
- He currently works as an IT Infrastructure Solutions and Support Team Lead at Resorts World Sentosa, where he provides level 3 support, manages the IT infrastructure and operations, and supervises a team of desktop support technicians.
- Previously he has held roles as a Desktop Support Engineer at CSC PTE LTD and Junior Engineer at Accenture Delivery Center, where he provided technical support, hardware and software maintenance, and assisted with various IT projects.
This document is a resume for Jameson L. Mase that outlines his professional experience and qualifications. He has over 10 years of experience in human resources operations management, most recently as a Service Manager at IBM Global Process Services. Prior to that, he held roles as an Operations Manager and HR Practitioner. Mase has extensive expertise in benefits administration, compensation, payroll, and client management. He is skilled in process change management, people leadership, and ensuring compliance. Mase received a Bachelor's degree in Tourism from the University of the Philippines.
This document is a corporate presentation from Neuroservice, a contract research organization that specializes in testing the effects of compounds on central nervous system tissues using in vitro techniques like patch clamp recording and multi-electrode arrays. The presentation outlines Neuroservice's solutions for drug discovery and safety testing, key focus areas, techniques, commitments to clients, and team of experts available to work with clients.
1) Researchers screened 40,000 compounds and identified TRO19622 as a potential drug candidate for treating amyotrophic lateral sclerosis (ALS).
2) In vitro, TRO19622 promoted motor neuron survival in a dose-dependent manner and rescued motor neurons from death.
3) In animal models of ALS and nerve damage, TRO19622 improved motor performance, delayed disease onset, extended survival, and promoted nerve regeneration.
This document examines the effects of various compounds on the human α4β2 neuronal nicotinic acetylcholine receptor (nAChR). It finds that hexamethonium, amantadine, memantine, MK-801, and TMB-8 act as open-channel blockers of the receptor. Hexamethonium inhibition is voltage-dependent and non-competitive. It also blocks the receptor in a use-dependent manner. These compounds rank in order of potency as open-channel blockers: amantadine > memantine ≈ hexamethonium > TMB-8 ≈ MK-801.
Tujuan utama rumah sakit adalah memberikan perawatan pasien secara terkoordinasi dan terintegrasi melalui berbagai praktisi kesehatan. Integrasi dan koordinasi perawatan pasien diperlukan untuk proses perawatan yang efisien dan hasil perawatan yang lebih baik bagi pasien. Oleh karena itu, pemimpin rumah sakit menerapkan berbagai sarana seperti perawatan tim, kunjungan tim ke pasien, dan rekam medis terpadu.
Downtime occurs when employees are affected by an issue that causes a pause or delay in business. Learn about what downtime is really costing your business.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
This document examines the effects of various compounds on the human α4β2 neuronal nicotinic acetylcholine receptor (nAChR). It finds that hexamethonium, amantadine, memantine, MK-801, and TMB-8 act as open-channel blockers of the receptor. Hexamethonium inhibition is voltage-dependent and non-competitive. It also blocks the receptor in a use-dependent manner. These compounds rank in order of potency as open-channel blockers: amantadine > memantine ≈ hexamethonium > TMB-8 ≈ MK-801.
Tujuan utama rumah sakit adalah memberikan perawatan pasien secara terkoordinasi dan terintegrasi melalui berbagai praktisi kesehatan. Integrasi dan koordinasi perawatan pasien diperlukan untuk proses perawatan yang efisien dan hasil perawatan yang lebih baik bagi pasien. Oleh karena itu, pemimpin rumah sakit menerapkan berbagai sarana seperti perawatan tim, kunjungan tim ke pasien, dan rekam medis terpadu.
Downtime occurs when employees are affected by an issue that causes a pause or delay in business. Learn about what downtime is really costing your business.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
3. Определение
Болезнь Паркинсона (синонимы: идиопатический
синдром паркинсонизма, дрожательный
паралич) — медленно прогрессирующее
хроническое неврологическое заболевание,
характерное для лиц старшей возрастной группы.
Относится к дегенеративным заболеваниям
экстрапирамидной моторной системы. Вызвано
прогрессирующим разрушением и гибелью
нейронов, вырабатывающих нейромедиатор
дофамин, — прежде всего в чёрной субстанции,
а также и в других отделах центральной нервной
системы. Недостаточная выработка дофамина
ведет к активирующему влиянию базальных
ганглиев на кору головного мозга.
4. Этиология
Этиологическими
факторами риска
считаются старение,
генетическая
предрасположенность,
воздействие факторов
окружающей
среды(пестициды,
гербициды, соли тяжёлых
металлов), хроническая
цереброваскулярная
недостаточность или
употребление лекарств,
вызывающих
экстрапирамидные
побочные эффекты.
5. Клиническая картина
Для болезни Паркинсона
характерны 4
двигательных нарушения
(тремор, гипокинезия,
мышечная ригидность,
постуральная
неустойчивость), а также
вегетативные и
психические
расстройства.
Различают несколько
клинических форм
заболевания — ригидно-
брадикинетическую,
дрожательно-ригидную и
дрожательную.
6. Стадии паркинсонизма (Хён и Яр)
Стадия 0 Стадия 1 Стадия 1,5 Стадия 2
нет признаков
заболевания
симптомы
проявляются на
одной из
конечностей
симптомы
проявляются на
одной из
конечностей и
туловище
двусторонние
проявления без
постуральной
неустойчивости
Стадия 2,5 Стадия 3 Стадия 4 Стадия 5
двусторонние
проявления с
постуральной
неустойчивость
ю; больной
способен
преодолевать
инерцию
движения,
вызванную
толчком
двусторонние
проявления с
постуральной
неустойчивость
ю. Больной
способен к
самообслужив
анию
обездвиженност
ь, потребность в
посторонней
помощи. При
этом больной
способен
ходить и/или
стоять без
поддержки.
больной
прикован к
креслу или
кровати.
Тяжёлая
инвалидизация