Scientists screened 18 novel compounds for their ability to kill cancer cells. Several compounds showed potent cytotoxic effects, with IC50 values less than 1 μM on multiple cell lines. Three compounds - TMCOS-3, TMCOS-6, and TMCOS-11 - were found to induce apoptotic cell death through DNA fragmentation and caspase activation. TMCOS-11 was found to specifically inhibit tubulin polymerization and cause cell cycle arrest in the G2/M phase. These findings suggest that some of the compounds may be promising new anti-cancer drugs that work by targeting the microtubule protein tubulin.