Apuntes quimico descriptivo de somatomamotrofinas

2. e ,V'- ~ !r~ C.¡ o.~clc.
..
1
't" ~o~l'<U ~
~~
.
, ___ ,
. '"
.,.
- ¡-
--t ·" -
~f~ctt'fO : ~n
cr&~ .. ~

3. ~,"u~. rt~:~-r: ;:;;.t ,o":;t~tl ;{eM .~a ' .Cf ~ 3o ~)
~¿_sr' ~ prolaci.~0a. y l~ ~ ·t ¡·E.ste. ~(~l''l~o(O pu-e.d2 estd.,élloCA..~
k-.! o ti o p.._ ,"
e!.r
1J(
tnhtbc(;>'r
'Y'U.l.Y fe_~-tl'j}~¡ ,.
clwe~~)' ~(meQ.Q. Co('(l,O ~'td?<:)('~1-~.r
dof~rt1'~r__q,co~ .) 'f-&'f~~~s ~lh-c;~.n+~
dd htfo-~T~mo o ~Q.J~ !<f ~p~-h~' ~- ~~
Cot
1'{+Q"fe.( e.0 _ Qo~ Id ~ ~~}:'1ac..t.b ( d;e..': e
~~~') tle h~~ f'oac~nq_ F ' k PR-tH /
~fCt{01 cLS~.?
fe
Cv(f
,1~~ .~<?VC)S'B'UJ,.,e(.te.._. ,
¿:a.tmet'to
"JR..K . y_ -e üsq" ~- ~"{1·. ­
coYC.eP.t'l 0.S Of~. es. Lo.r· fv..m.o. ~f
.SeCfQ...tO e J de. p~ a c+LVÓ S'cvt. ót~
e~~ y ~V: h;Jcef~c:. ~"~~~'.~~
~ por ~o_{ac..--urea_, ~rneno,cea. '!) · ~~h?.f' hda:~~ . .J~.sto~ ~iumésíeJ 9lw_ c.o~.s-~b -~y~~
r-#ncmef
~~~ 12*~(ai:~~ Bo~/. Ole_ t~rn p9 f:.•~ F 'oS ·~~~t t~~~r- 1fo"" ~ 're<> el. '+~-c.{. () V.J
}
~~~~..t<d'c:.c~9 ~U:l r~rg"t c·a_. ~
-9f c.c~ ca~e n
lc2{
_fc.,rmat.olo~,c.oJ'. ' G..ta.Vd.o ,.. }~f' fo.~oreJ
so~ ~'tro ade~om~ · (o asou~d.QJ' t-e(
··
r
1
G )(t-e (~16" s,..q~ ~~-~~o a. lb-e.·,-.~~ ~ ~~- ;
e:.~~ l1~ud..t. l~rst6"' ~~'(rrvac.olá-::
~ tc.d &e_ d ~c:n?c.t.h 4 ~~ ~:l~ tY'la ~/'
ed~c-L" a ~l - pko e. ~~, ~._oSct ~·-e~da.
~-?-· Su,,:p.sesto'l' de. ~LE_,~_l?ctor~~ ~-0~
, d~ J 1 ~ clo'Y d~_ fe::.'1 uáo_;~~- · ~~~ . ~ k
A ~:t
,~~ a~~ toe e .c..JY"' 'f.'e.SJ Q cLJ r v~'n ..,bJ~
t~&.-uros -~~~r+f! i~~ .~ ra~deh~ '~~~~di­
Y'tfe" te ~ v,e.g-o ~e. 'l~e te1 r'~f'<"'~~ ta rt?J'
?~ . c5lge.~4e. Se 'ncl.r ob~r"'i~o ntsu.(~-?d~
c[l t1~ •c;os.. M.á) ~ ·.:r•-o m •So no~ f. c. o lt. (;) r
dQnJ-2Cbf &1 üJ<Ve.~eo ck( C.Q t+en~ .
c
...

4. ..A~u~os- ck. es.-ib~ e<>mfOe&tJi tVh.bR.~ }d Se.c.met""On
dQ f;odti-1'~ JI'! ~tvo j e<'- _fe.~ e1~ ck. - ~ 1 -.:· • "'
f',sts cl.tS ~dor 'f J ,t-roJ estoJ · Q_ ~Lf-os
~" a<t~~(~~cl()f ~-t e.l kaop€nJ.ol!:.~l
éV con~<:.ueocl~, ~~ r~b~ ~e. lQr
ak:~lotder de c:or't'~~e1o c.leJ C..el"-.fetto !
achle~ lor fece.r~c~r dopertHléf~(_oj'
lo5- ·~..unoref'_ ~<..U~( ~~Vlck ~ ~)~
'~ b'f'D m o~( r""'OQ
(
"''ro
~
~""
,~ l ~iro cl~ tJ ~~cm~ ~la ~no_ ¡e cteO~~,~
~,..e~ ~t. ~ m~ctda ~' '2 -fhc'r>Y'eJ'i n_,~Taomltof
i,.c. 1-tofnt())~ Lt.kCt~'(C.. dJ... l6 ~0(1<:lt"'Q ~ Sl'euntlt~tii
' (6:HR-) i Íd.. H.,"monct ''"~'h&r~tk ~tt o :'ru~.' <fJL ~
'ofO'~~ . de CteC:¡rt'~~<'1t:> (~m~-fos~-61"'-) , k .f."'<> f''"Jad
~~C4t..~ ~ lGt ~t.c..r~O·~l- ltt MI'',"'Or1C ~~ are U.~
.J:
<;l.ue
t
f"'c.~n '~ 1 b~h~t..L6C e~ -p:--o~~fn~
~~ 1 =
r- ,
~0'f'»e.l-k mi~ U 6l e_J ~~ b'IU n10(.rÍ
·h~ 1 tuyy d~s., f~~~t.U> r y. e fecb:d· S~
~~Y d~W..tl:c..o €'terlor~ente..e()V n:.Q- rn1eCT~ &a~.- lCJ-Jtheretui-' ep•~J~~CA ~~n~rú·"'<.cA
CV;)V ~ ~ ~rnfeo eh c~~~~Q..
~ -esh1 ~ctttdcre.s .t 0wa~r f"C::.r'"'u.0>J, fl.~ro t~_,'ifl)h
ÜJ.~nd.o ~ Oromo~nph~a ~ ~~re~ ~'(~ sc.~S,mttob<:~kt~D/ rcirof eJt:fl'u.L;J ~t+er~v' Svr'mr ~ Sa~CLoY' cl~ p~ol~~+~~e ~ )"'- s~c.r~c..t~~" <k. te:-- -'o,·N~tc.t. cid c._íeu''1::C.W 1
.por :1.1.mo'f~ f _.fAV(..Ul'anteJ 1 ~ <:(~ ~c..'U) .- .(r~·h.
.t4"~ Sbb~""'e. h' ~Ott:.~ "''"<:> (_ ~ fec~'<.Íro ~
're<-
~(
~ meYorre~ usu.d.meffe C@I~n .~~u~:H' ~ GHR-f y de s-t:::mo..tosi:-c.t~,~~~
u..0a~ ~~t ~~W~t' y e; /'~do le ~+ ~ I:;n-le e.llqJ S'e. e:"'UJ..e'" 'é.ro..,' (q_ dof~'Yq''-..;
y
!
~~ eh'~fa~.
e-+ lQ.. ~~ld<~~'~¡;-pl:-an"tfu.. (:~-KT)_ y f'-F
_tV' e~tos ~c~t' loJ' ~N" 'o~'(~~)' y 1a ='*= ct~"t~S o< . . o..J,~e!Sic.cJ / ~ erf~l~tdw' c.M. __ _
t>;ope-"''e. h~n S~ VtOa-m~l~ 1 .per.;:, se
' . ,'tc-rMú. a..gu~. l"'-. ~" ~ ~ ',0(!'"o i(Á. d.t:J
rcc.ohte<"~ta ~us~dsu ~~ h....omoe:r-~p,'i..2 l cceCtmlei"W"'={,. u'htbtUC( d..< lt~re..c.t.6." f>veh
d.,u.~Y.te
a
~~st ii}C..6n.
.
-t~r-t-
~~ ~1er~., ~ ?.al~ ~tone~, l d
·
.;}~'fOt"f'e..¿ y O este~ .ld~ ~Cu.'("f'e~
""-'"' a pa"'-e( ~e oo ~es.al'.+€ cu~nd.o
~ ~q,e.fcl.t.. e.
rvn aoo '"
._. .
.fé
~ f~ ü~c'l'tot' , ~t=-o._dreterjtc..qJ
-Av. ~f~ L,'tb6C; 1_ táF-:~. -f fe,- ["' r:1 pu:>.. hur,TOt;_c.
Sef
cc~ú f'1en1S . . k . qu.uoS~ p)CV)'nCl.tl~ ~~'V.biPV
e¡ Uf' podJHtlfo m_~.t_W eU. &- %~,'~
(t-. ~tr-L-1 M c:reu '"''tef'"f~¡ ~ ¡,tf:+-c.lif'"-la. Jer..u~-
ctJ
{:)t~Vtof bO'O(f(!J' se t..-re_to(ej' de r,ro~Lrr. .~ " k ~ct_mt ('tsf(a~' Ct:_" f()Jtdt ·~/o rs-:'
d t~ m, r'H•.y ~ t' .su t".a~an o du ~a~ le f~
o bb f c-auJa.S mc.l;..Lu_ a"'-l... r~p·c~ e(R.va.ú-0{ k <.¿,__
a d ~~ '{~-t("~c.ú)"' <iR.. bmmou- p-t,--~~1 d~J Co ' ~' ~rt:t-W'II i ~0<tt (,,.j~ ttA-ert<.U dJ... k ~,~~Jo~ 1~("..
tOc((.cJ.o~ el m~.a~~mo d.t
"---'-----
(!U.
QSt,a ~~íe.t~'Y (o. Qtdt~' c1t l-. ~f4 cuAJó. ltt10..{'TA.... yl,"'''"''':8. €-f,),1~<--~
_ . . _______ ___· -...!.t~-!~Fei"-<.JClQ.( ~ctl..., {" tVscdf>Ol, cil. a114 <.A,,,J&( n ~

6. ~f eon~r~uones ele.J~c:{.~, IQ ~~"?'Ya ~c..+.'Jcl
lo~ f(!cer~or~.r v~cu ~re.l alfo;>_,- ~drené'S>c1U
<....y pos~ h..e':'e"~ tn rt.amfef'rtc..os), ~~~wtdo
"'BS<>Co'Csn.ec.l-6-n • t<'"'~ C..on~cu.e..nci a , C.U;)Vd.o ~
o.tilt<e dopaYYHYo Q" esi:&!cr d~ ~~bct-k <t~
a Yne.~a<a" ~ 'Cdd., ~~ tl.Qbe_ efe~h.t.~r u.n_ CX)a'td
~~~d~'> ~ la p-res~on orter~. 'j la
~"~ t fe ~. el~
· ? f t-
t- t
11E"<>.aucl ·'!lf'~~
1
n ' · -- ~ t · '.·
A
w·+-
~ ~~- ~
· ~~ _t :--·--
1
lf~-f'.:>S
s-vb-edvsi
fea"'to 1a. mí na.
·r -.
f' c~~V
~l m~ h~ e')(c e.Snta ( ~u~9-t.~ e tcmb 1éYl fu.c!ck..
se'("" a re~ !lÁes1a o s~cck ~ eY"'1~~u) Pú..eck.
haat"~ Y~u~aS:) "'~,"t~t~s- , {.a2olt.ca~'a 1 d..oo("
t
- .
Y2Soc.ci'~r~.~cl6~
c)..ufa'11e.
a "'-'~rte.YS•ÓA ~
~~ O~s ,()" ck doyam11a
~de ~USL 1~ cl:c~a ttene Ul2 "'da m ~eL~
~~~ f'C~ i;,ca
(X)( to. 1 esbr- ~fectas n<~d:u d. . . .
me.. V ·h~ ~~~2f'e<:eY ro'1.1E ~!¡ ~ J,~ I'YII nu.'{~ ~ _ _
_.,
e' ~ t lV v .dA.., ~ t"n flt 'S' o 1. o -s-e ''{ te n-o m f>t. ~ tZ.:l f i ..
muy
~<. -r-'-~~ r(~9i}~;~r~
b~- at~ 0.J · ~~p.
e. ~se~ O,t" d.<?~n·hc bo9u~tn
b~~e c.omJ ..Peo'.Qiclrn,na '
Jq
pc2"'de) ca('tid~<ks
d~fd"''t¿). d..t.h~"+~ d . ·,, ~'!,¿n r.~.J .-Q.d~
La e>c+c<l.a.sao..c'l
.w, ros··s : '~""'é""''~~ :.'.f. ~~s:fa.c.lo.,
.
d..ct
í
~
i(
~ (t-•J ;1~ton
a cko¿o , :S ( T." ··.ste.r)
'
tnstd::..ur .A~~
,nfdtc~~tiS" A_opa' ~ a- 'f~t5" ce~
~~ner~me"te ao" ~t(i ~ble.r ~ 2 ';)ct,'ftdQd
a~~'~oso, a.rrtM.as•.. s_ef~
eJ.¡;-¿
l,
' '
~.t'd¡ -;~ a ~ d
ame.th.~4a~,-s~ de-be
r,oc t1"ens fusión ok ~n~re ~tt~(¿. ~ 1~s-m2 o
i'UJ.lclo' ca r~~dos .. Se ~~ C:o'í1-~oaY ~-
~-;).c.t~+e. como ~ '"cl',to a n-~ ~ lor ef~~-h~y
..2-
o fes
ptol~0~de
K?-~t~ ,·c'0~J · LklV~~- ~' ~ ~ ~(l~~~"!.d'{Ft~!'
Ao~S' de:. ~dm~r,,sk~ . plopem•X'~ ~ - l~r ~~~1't..r
en shock k debe. _~1ret>~ '~ h, :po"CoEomle .
~~e~~es ckb1'cbr
1
_f?B;ra ~"?~,. )~ ~~(? Vl~ ¡d 1rl l 6 r ; ~ctas 1 1~
¡

7. .'f> hh'b~I'Smo J ~ ~~forocne~ ~e rQ¡f~ ent.e. k 1~
~~
<Üó'" u~ . -~-
¿t-1)r-fet- d~"~- éJ.e;~+-- J~tr·,r:·}s~)
' . -~ --~e t;ce~
i -- f .. . ~ -· .
•
Sntre
e ~~t() c.e. or- neurotJ~n~Ml S'oí es
~~oks e"' to~ ~ngltos ~~l~, ~lo _
la ~e:e-hle:o~ na se COfStd·e (C) ~ctu~tttet.IG
4~t ~~~t-ttyaiw}n~J ·~ ~: c~~~c.~s . re~3~~.fS' ¡et' ~ f'?r'af' te: e~ ~ fa{"~ ~ca t~!~ rd ck,l
p~rk~ to nt SiO' O. Uf moclcJ '? YelJ: rnq~ Nl C.V
las · F~a~ de i: q 50 j . l960 ~stubi~Jerpr'l
1~ G~ngho~ ~d~a~:s del
c:ati~f~~ , J:~vf lo~
~~~~~ta ~ pero Út~ l. ;_ de .lrd ~~!n~;.~'0 <;.~lA¡
e~~f'~l~f ji: ~spe~f•t.d~en+e: -e.~ ~'~!~roe_
~~~,o~ ba~es ~t~~: l~ ~. --~ ....
~
dóffrn'"'~~~o YC~ '"oes"tt-'a~ torst~ ~~"'en reoe.~ ina kfYl ( tU~eo ~&do Y.
e SltLo .de. . est6-f ~(d.a.Oe~tc1 ~ - la
l
~t~men ). contlene nÓrmJ. Tent~ .e.(
el'fe.~me.~~~ } de p?-~kr$;)(• ~~~t~ J.( a
es-..ul 'b t·~ (X)mronenter tVh~ q.clo~
d~f''-'e'<'Ú~ r-ro'Cu.nc.acl e e.v:_ ~ 1e (J <ct6 ( d.dpamne~tc.os '/ eXQ r.ddoreyfe:.o 1~r­
~ '" t
-
- -'t -
~opaN'Vere~a -~e lot ~~~etlor ba~ae~
. ~koS' (.~"o's"'" Gó~)
d~btc} • ~ . ~e~ce~r, dcr ~r Ye.uro aS ~ t ~H et" e .' L~ e t"Pe"" me.d~c ~ ~'1" u Vocc.) ,~ad a~:- k' ~~ sus-t~ nC,..a n.e-~<a.
· · · . Son "O etfun ~ t~c-~~ J' ~~~ hW'<onaJ'
LQ}s~~~ r~ rne<tacta~ cl~C - 1~ ~us:f. ~. cd tec-3~~5" e dl~
d.~ e .
c1a ne~rd :~ 'n~rma Me(te u--~~~ '2..dY do~rA~l~ cd:t 'L' do~ d :l ~cm, n é rcfi?'cq ~_.p,-rocl..u.c e co m;)
c.omo ~e.u.tb t(a~~mso{" Se he. cl~tno~{cói:l.U
res~t~do ~o exc~ ~Lf~t'"o d~ '~flj~~
9u.~ 6 ·ye~titda ck e~--c cat@éuam,V{~
·C dS . <:e ·~c-.,e ICdS, t ~ 0.. . t:on~CJ.J.entiqi u ...aa
1
feu.F
"'""'uuó ('
1??'( · lJ! . ~P~V~~f ~· ba-saer ~~rct~ r. at~~ ~gul"da e~ro~í~ taufl(~. "'.:: h"'to "<:al la~ m.a't 'te.rtao:one..r mciocas ~ "Dhfupa leJt 'IYV~C~e. dl't~ rOf") ~'Ca
_
fa_1~~~tfb
1 t · t.- ' "' -t -· -·
·t r
:do r~": ~1S<t''-~rf'O 1
~·e~ l~_ s:'i-1-<?~Pt ~
dro(ec..en ~ aolo "+~"'~ ~~?-_ d~FY~~ ~~-~
S
~ ~a 199~~ El (1?~-?b~c.,f't ~~"tL~- ~ ~~'
t(~ fS N[• ~'lo" db ft_a'('t'(e ,~,~~ "'~d.i~V~e_l. .
€ m* e~ k, ¡ d;•e~"" S>Js-h:t '1C.. <l S ~ qu.e fe <l...f < t"l ~V ~o_/ res--ta.uca a ~~t.é01 ~9_m~'d
e~ e pa¡' c:lf&'OfIS("(0 y . Cons-b~v'{ e ~ ern~.
f.eg'·~ ce'.b{~ e V ~c.--.c¿YY~Vte to d..-__,y 1
:J!
~1) t fheJ.' ~~ ~a"-u~fir ~ tyo -<~ l't'•e fb el.
~·"- e ,.~e(· 0 c.. J e(c:L
r' ..
~1 :~~r.~n~n·s~~p_J ~rr L~~~~~~~$-i­
-~~ a ctt11 od~cl ~l,~frg'': () ' -~~~Ju~~ -~~~tt;~~
~ re.sta'o,.~der el e1~hb~~-C?;. __' ~e tono
c!b fi1 m '"~tfc.O y c.o (.o é .rg<c O e" ~- 1
A~f~s-t;/?~~ ~fo.-,b,(l.?r:: k(~Aip~o""' s~ S'
¿~ ta 1)''"t'~r-g '~,...
'j ~t.t~?O~lli'b::l.) COllt'-e_f~tC':l"' (1)'UJSC~n­
{,:) m e "te
·v'"C.OS)
..... _
_
•
t

8. EJ c,rü.Jit~ , k · ~;-C;.Tn~l~g hca~;~_sT~~z-tern~ n~~,c~t~"' nume.'(t)~_f · f'ter-ccV')e)C..tot1~
~~+~ptc~m~~~) .for~~ u"' d~ ~~~-~-r~~r. =~t1(~ lo¡ cUl~c-s~ ~~NeftoF ok ~~S'-"~~~
_ ~e: "So~ l~ ~~d~ ~ ~ CX)t-1-e.~.?f,{- t"l o;}~~hos bel~ej f~l~~~s ~,__ {~t cu~kJ
"YY'IO-b(a; est~ a'o opore<--en'-enre
en"'bcf'~O,f 1a_f' '113) 'nle..f lrt'p~COCtrod, los N"ov'm '~"-t-v.r ~e. se radll~Yl : t-=.nt~t · e a pa~<?Q<''e y e
S1"
e" c:.~de
moment-.:::>
~R. pc~far e, _• _ t-~td.mte'fTh ~)a_ ~nfef'm~~~J ~
&~~ma Motor~~.a ~ Nt-v-../. NHento &f~ . ~¡- ~'f'k,nson ~V. ~<!J.~ cone.t.taV ~pi
e" l.lfC.. ~~C}sJªf t -e-+ r. ~ .-f · -·- t--t=· .- L 1U.deo c~ud~cla-it>Jtta men to~ '~
é&te ,~s+e~d ~ ~b t~1~~ un~~ rfY~(~=e.fl(.l<t , r~..::sta.nct.a ne.g~_ ...f _
·~
lar- a Fe(""e"'f:es
d.~c-&.. <SI<>~;<T ~~~1'1-_! 'ª Cn~u~f,j~.-~- bkl ~ ·. ~~ <..onCleYe( ~.P-~mw9. emeff>~ll
--+-- -+~ ~Yw)C ~o19l'~l~~~JH1-<é_J:!~t----'f me~. ~ f~ --~'q- ~~t~ ~ ~ ~~t~~~
~1 ~~~~o r:¿Jl:~~dem~-; 4*á C:,4ft;t :~:¡~~~~ ~:~j~V::J~J ~t:c~:
fufclo
+?{:fYo .t.~~
'lu..st ._.l~ V !4-~!fQ~-i.J ?a~,~~)~
-- T . --·
--
-,_
~~ ~~en_.e.~Te ~ ~ la Cl?4~!f-~e ~ t . ~--~ste~ neu(t)"0~JJ-1o éilYYHV~-f~ C.~
-+-~ ~otof"d,. 1 sensorial _~. cla ~~sCt.&n L.t fe-<_~~Y21 """'f fo8~(.
.
t. po>t_cl&L~
d.Q
ros . +~~-~tJt1<2-UCb~¿~ Uc: ~'uc:.eo
-=es t:rdn$port~de~t-?l ~~estraatu..f'<l J ,
-'-nudeo e_~ y ~t~~eV) '/ lltecro i c~t..tl~- ~- pu.tav-nc:n , '"clu.~-a"'~ at
,·a lo~ ot~S' ~1~0'e(lf;oS ct.-. ~) ~·~n'?l1.0j r:t= ~~VdeJ tftec"lell(.')'~f Y0 'eSJ?tnoS'aJ
,ba"S.ees ( ~lob.us j>~l~~, n.uc1eo ~ __1. y 2S 'l'.euronas V"YU:..cti ~"'~ .t ~~rptnu~
~~-tclár'l"<:.u 'j SuS"taVua Ye~~-.;-a)
'¡ Y o t- r f.'IIOJaS "1.
.
e.
.M.<!. eo.n-t-lel'tf.q c
.iock
'Lió.}- c*J.tt:cb:as- e ¡Y'C'.llf~~,
~ l
'~ )(.. o(Y~O~l.Lt--l!lCo (G.ABA). l2r n~.:t0nd
~ h"Q~ ,~ ., ~fofni) d~~~ §l~ _:s'UCj<:! ,= 0~Ké':ji~~f .5~e1 l~ _ tu.~nte pr•~c..,r,~.L
rf¡.
p.r,1'u e~rte~-.fJ~-¡1~
~v:~~ ~~F ~da ··~,, ~. :fr'Y e~fR-" ~4rQ~? o.l~r ~6.ructS t'
GR.~ su~ tino.~l neg r.il h~ti.~ 'r 1.v. c..le..o ~ r ~
e} r~ al m e" t e.c[§'. 1'~.-:s '"'l{ ,'cu ~ d.a
*
sJ¡ ~stanud ~-<a~
~ z.
~S t~ ~mo, ~.sd~ d..chT ~ nfo.~e_.
clQ
.
_
&f er en'tl(lda fn1.ll'V'f'o ~k CJ:)ric-z.¿ . _l~f t)u.CUl'2)' <?AABA- ·~cetc~~ ll;ambte1
fl'otofa y P'Ctora su pemenian~ ~-u rr tiete" u t ~p t-td~ ~~ rno ~l)Sr~n~C P
'-1 luttl( o , . k re~ yeSo • 'f le PJ'>f,'.;;. c,,.·tis~ ~~So m~ tos-t.a b "¿ , _~"' ¿ eY1ce.f'.,..h ~~R.Hn¿
c
~-h>~. : ~ . . .· 1 • • • t ¡ 1 t t. ~ dJ..<)l~f 1'e ..
r,-

9. 1 - ~ ~ r~ r;-~ t ~+ l ~ J . l
5ñ (gQ~enúa, ! e P.~~ . ck_l~ ¡: p-roye+.~J ;s~nio_~~ ¿;¿_ '"P~'~TSO~nno ~-~ÍGr-.c( ,.
.{k:pc-.nni'1)LC:~~ h.ao.~ e cu..u-~ F~~r-~~~ otr~~~"J !J-W- '-?"~t·~ .a er-Thtili- lf.~l:e,ttv.<1
.
®
~':, ~ctJ..f,c:~t l'tJ 0e~~J'
a..
¡,.,~ ~nfe<'~f1>1<'!~
~.0ir""')
c:U
J
ot~r Tf· t~d~ _ S,~~l"'lO)' l ?~~'OJ' b~}-lef CCC't0 S'.tto ~
N~-'.!t"l'·•} .¡1«-?,.:,hcl;. 1 ;;}~"' d..t.. ~+.a lmyoc--1:..:""-t.._ d~f" d-.1.
ÓJt
est.¿ T uifoc1d<~
·
1
r
f~r'l"t'~C..OS,
•
~ coNpCef'~lO" ~ ~u.t eJ ~rk.,o&-brtSm.<l eP
u..r' ,sf"d(brne. ~-- tL~{:,<.tco~~ c:.k ~pc!J'(H(~ y
e• cl.<:rtUbtlfYt.n~ t ~· ~- _l~lodo~ ~ ~ ·~§> e.ttl.Jz
1'Nf.r.Jrta_ntc2, -~~~,X ~t~rt'.lt.Ct~ · _&o_¡_e-r(~
ef'terme..cacl ~~ n 2 ~m,n~~_, u~(~
~ U.i'~ ~r,~ U
OkCY(
~CUHe ( !~S¡!.~
-
lQ_
~JerU~ o,¿ ~F.~'(e. eN.
e e~f~lo J~nt~ r~•
.
(lCp;-=t)
<.0
fU-:<!.
Cot"-f-'(VYQde
M.ot t.)f·l~J
~'<"" C.~(~J'Yy
~~ne rrfd. mb.~V' ~mo~t~'<'On. 2 ~leuu'V
•_ -~ a~ f~u~t~W~Yl'IS~~.. .pu.t~tl107 pe:»;
.• pk""t~ dl a ~fe.('f'r~~a '/ ~u ~r_Q<:.Ú)t
"/
51!-cuon~das,
. "
u~ cl;..: 'Q.~ F'~«t~f ft.le eJ hall.~z~u t..(rn,~
_
crntCc:.)S
1t
t""rle.cli.~"'-te.- r ~ do~
l~ n"~~~
('
dJ. ~) ~'(c..ent<dcu.J~
r-ee..a<~~ ~ ~?~m,~¿ eA. e QVcéJ~k,
~<.U". e~ CU.Q. ta._
rts~ P'Vl~ 1nw.túa u~ . . VUMa~ pro~C'-W'6 ~ -er-labé" ~?S(~
<:U
co.-n.o ·t.. et'{re .o)' es +u<Wlr
. ·
. .
;:,bo...-atono y
ete:-fu~UAnt1:er-}o •.
oUP-~'1~~~t~ b.~ ~ L~,--- . ~> ~p,c..d~(eJ' ~~'~tlC.dS
_
~~1díb.mR.
. ~.'f"=' ' - PF-r. •_"-'. nS:~Vl.'<:!~"W
.~
~
~fk¿~ ~·' M 'l . -~~~f1)., ~
e
eox-~<lO f f'YIQ.Y"ts_l~, clo~u~~u ~ik ~~r~'~
t~.loe~óe y ~o C.O'r'S~wevu~ a.~o-1~~ l<:)/" ·1 .
.
~~~d,--or ~ S hctYo)(l-;t<p l7YV'"'a
.
cM'S I
!
¡
=
Á-'~c:-li.c.lo~ ~~ 80/ hk {Q do,rr,~2
ck.l:_(¿<cef~1:o·, -'1-J.. f<"~VA) , e rf-..a C'"OVl c-:e~. t~~C? el'- ÍoS' ~.:2of~u~ ~>"asa~J, pYt. OctF.1"'e...íte.... e~ e-l (~deo cd.J.J...c.~olo i
L5- HT) y ~ta.<..oam. ~~ del e2nc~~tR . . t:..~ pv..~Y'e..~ ( k.e.~.po ertr•'~d.o)
la. a.u.rtl~ y_ (2 ~~~ f ~d.u-t~d~f : ~ fQrcoe- ~ ~le nc...t~ J..q_ ~ d<lf~~'Vl2.
~ ~ ~ ~Se.fp'l'Yd ~t ~to'l~S F~" S~ .
s-~ne t.~l { LO~ ó rt'eioJ . ~ lo tOfm-)
f'ele_i-tdas 'F--r ;.~~ admtl'1t~t~~"': ~ t. 1 Q.f' of O~V~l,o'S b~S1aeS ~ p;luef.teJ
f
3 4 dJ-"r,..ch-o"f't-fe-"d- ~an,na (d-Dpa~
, c.o" ~f~o,g~('~ a.F.'"Tó e -e'J •de l"'ua
e t ·;p~c.u..fSOf . :"'eiili6ltc..o, .e!~ 1~ d~ ~"''~"'". fu."d'""'e"'+•L ;E 1 ~cJu.,f c.t... ~Í'"-''7""ía
"
..
~tb Yo
~ 5 - h,~~~ f-npto t~'o_ 1 : . . .. ·. ~S ~be c~~n~ ~Y c. ~ró.Á.c!-a
~~t~<JU,.(S<J( dJ. r~ S-MI., . 1
:_ 1 ~ ~r n~nal ~ <.onheVeV me.~ftiZ.
L':f '"N par ~V te obo~Ylact...oí' ~'V;) JJ ~ ~.~ _:~ 1 .R:a~r- c.d~c~ cLt_ --a ~b.Yu~
~ Q.r ~n.=> t-. ~·:l.H''QS ~YY''oLi" 1"ducen
~r,~ J. e ~~l'~ pa_
to(6"c(,c.o N"if (OnGVió
"e
1
ri
1
r
t
f
¡
t;.-f'..
~
¡
(RY ~"'~Y' Sn'l~
.
,

11. 1
mós
·
t
t- ... -r r ·
~fec.-b'lo ~..u~ b fb'(lrr-~ •

12. br<:<d"~'
r_lg~~f -y~ ;,
b~o
¡ Fr
l t:j,r tr 1:"'~~"'""'
~
Id
oksi o.' le,
te m
r. r
;,r í
""" ¡ YO r},,4'r n<:< 1 ,., 0.. o
Lo. a tenu.c~ón .,c{«f1o~ sí nto_pt~,~ -~~ s· ~~m ror~~-~- LJ_ ,'bof~~~ece(")oL
-=~· - -t .}_~~(:t . = t- ·+ m
t
t
tes Jel ~r.~~n~'illlffDO ~la.t a~~F -~cu'o.~:r-P.f.v-h fk~-' :l~P{;~:t' na ~o. rnb•él od:'JC-1- 'fl os "f€(!e<)'O t6re~
c
una f(QJOnq srem~~~Yt~ :e( k. co..po. ¿da~ · runc:.(or.o.l Uop~yn. nerg, ,c.o& vasc-u.lc.t-res 'j hbe..v-a 1'0CCJCY'e-
~en:....
don_
o.s
lcrs mon;yestacZone.S
mo*o,~~ ~<...u~- ~al'1N~J
~MO l(tf ___.c).tero~ov-1e.) er. ~u €')(.pt~SI~()
~ , ho.'86 j 11a_ escr,{J ro., 1o. {~~lU'-.lOf'
los
· L~ re':>.S.h!nua
faro enso.y~x-
'<aürc¿~} od,~'0éc~Ca~)
d~ J~:p~m-eros1 1~le~Í)~do..-~
lo~ ;> ~fecfost ck. ~os~~- t -bs Jl
fo.~1a
1 .o C€Sf(Cl.~l.Or'l, ~e. Joro.~ pro_~ :C{o·V"l 1t e'Ít ~~ - '.. ' /evoda .p~ scbre el • j=<><l<:'"':,ord~IY0 "'"' ql<>.blo:
. ~~'.
·
.
.
t;=~e dm "Thi'tA<~"'f_._ .__~ - }=! "~~ .f ,, ~n l t J ~
s>' a-' po.e'le a 'J.d. ~ 1:;,."" ' o" lo C pa r "'- ' e n
1
·e::..
.
¡
en
E:~ ffilH:htl~ ?ac_~~l~L~-eu le:<od1Dp~. ? fenuQ u ~m en~) d<;• e-fi~~t:p? ~ ~d ~ ovasc.u!a.te3 ro+;n~o. m-e cl<a
9~=t paf~1 J~~ -?:fruCJ.on~s=f"· el e~Joclo dQc:t(lm~J iox.tco':)~J=e~ . P~y~,ccdt:4-r ,~,~-~~-S'~ü"< j orn-t1
~:c~o:~c ~or~~t::,~~% dfl~toez::r~:~ ~"4~KJ ~f-lts~t~rf"';? ;:ut~': ~~t: f~:¡:r,";'~~
b
me.m-pla:~dC{ fre_sueY~~ f c: ~0~Gfl: ~e1os~~po-e~s)f>X o!f_std.ti ~
a
mo~ e.rb..d.?- Y.0~'nto~Cc~; '-1-= to(c:~_nclo..
~t~
.et..
e-{e.c~~...l~.ff~~~ ~, ~ ~~1"~~~<;S -~~~1'qS
ck._3(_:JL~p',t::-'!'1u :cr~n~~o. it~~ f'!'lc.c:~~~ f-P~r ~1
~1 b l~'LC?ck~ f'Y~ce hlpa~sto n
rp
~f
. _.,.
-bo{a.Y"'&~-t~ .~o~l~h!o l~ro pue~e . V~a~'Jen(' .......~..
l
9c-c:.ton~s :C:.~~t:a.es-. y, perifer-~cn~. . l t - ~ t
las do~1s; ~f<? p~u. ~lso S ~ (e'lodopQ. .p~d.J.ice0
p ~tlfiU to.t.9í. e<;trc:Vosc~ .~e ctc:ci.6l' de o. c:.o
r'1' '':'e ..
~re
a'5:
ra
~~~f~o~' · {3 ~- 9-c:rené~~~os: . E~
a_.l~v.nos-. f~c.1_~nte~ F~~ ?~du..~.r~ ,
UhO.,
"'~--'-"
tocq.ul~r-~lo h-.o.'):S~ol~o. y gf.fCl~ . o.yy-itm~' o~
c.c;.n;ÍO-c.o~ .'j ~~1?~~~ ~ ~ dosis:- a~~~a. de... :cU.· ~;L~d?pa_
1 ·-~ -=· He ._
e<::t~~¡~~f~ J _,
V»e<k cuuYe.'Y"-tu ~~=W= ~f.'tíoc:td id~J Je. ~lo~ard'~
c.u.;c:-a.file 'i a n a t oru :S, "- ~ 'l-'-'~ln¡_ t<>. a 1 <.o"' '"" 10
f
e'
........