The document outlines a senior design project to quantify the therapeutic effects of using an AmTryke for rehabilitation. The goals are to perform an initial study using kinematic data and develop force sensors to gather kinetic data. A multi-disciplinary team will analyze kinematic data, develop simplified musculoskeletal models, and design force sensors to measure handlebar forces. The project will provide data to understand the benefits of AmTryke exercise and develop tools to improve mobility for people with disabilities.
This document discusses two studies that examined how the valuation of EQ-5D-5L health states is affected by:
1) The ordering of the five dimensions in time trade-off (TTO) and discrete choice experiment (DCE) tasks. The studies found the dimension ordering had a small but statistically significant impact on TTO values.
2) Whether the TTO tasks used "full health" or the best possible health state "11111" as the comparator state. While most respondents considered the descriptions different and preferred "full health", there were no significant differences in mean TTO values between study arms that used different comparators.
- The document describes the BENEFIT-ALS clinical trial which evaluated the safety and efficacy of tirasemtiv in people with ALS.
- The trial involved over 680 patients across 8 countries who received open-label tirasemtiv followed by 12 weeks of double-blind treatment with escalating doses of tirasemtiv or placebo.
- Preliminary results show tirasemtiv was generally well tolerated. While changes from baseline on efficacy measures were small, the direction of effects on respiratory and muscle function were consistent with a potential benefit of tirasemtiv compared to an expected rate of decline in ALS.
This document provides census data and statistics for the orthopedics department of JPNATC, AIIMS from 2013-2016. Some key figures include:
- Total patients seen in the emergency department increased from 67044 in 2015 to 69551 in 2016.
- Orthopedic consultations in the emergency department increased from 25337 in 2015 to 26376 in 2016.
- Total surgeries decreased slightly from 1826 in 2015 to 1745 in 2016, with the proportion of routine to emergency cases remaining similar.
- Common procedures included long bone fractures of the femur and tibia, pelvi-acetabular fractures, and spine surgeries.
This study examined the prevalence and risk factors of postpartum depression among 1,379 Arab women in Qatar within 6 months of delivery. The Edinburgh Postnatal Depression Scale was used to screen participants. The prevalence of postpartum depression was found to be 17.6%. Mothers who were older, less educated, housewives, had lower incomes, maternal/infant complications, poor family/marital support, financial difficulties, prematurity, and dissatisfaction in marriage had higher rates of postpartum depression.
This document provides an audit summary of the Neurosurgery Department from 2013-2016. Key points include:
- Clinical workload including OPD visits, admissions, surgeries and beds remained steady from 2013-2016. Staffing included junior residents, senior residents and consultants.
- Mortality rates from head and spinal injuries generally decreased from 2013-2016, especially for severe head injuries.
- Average hospital stay durations for head and spinal injury patients varied depending on injury severity but were typically longest for severe injuries.
- Common surgeries included craniotomies, ventriculoperitoneal/ventriculoatrial shunts, cranioplasties and tracheostomies.
Top Laser Surgery Expert Dr. David RobinsonDavid Robinson
Dr. David Robinson is a well-trained, qualified and experienced corneal and cataract surgeon; not just a standard eye surgeon doing cataracts. He has skill and experience in his field. He uses latest technology and equipment’s in their treatment procedure.
The Dow Chemical Company is a leading global supplier of industrial materials including epoxy products. Dow has invested in expanding its epoxy production capacity and acquiring curing agent companies to strengthen its position in the epoxy industry. Recent innovations in Dow's epoxy product line include developments that enable lower viscosity, faster curing, increased flexibility, and higher temperature performance compared to previous products. These new epoxy products address evolving customer needs in composite applications.
This document discusses two studies that examined how the valuation of EQ-5D-5L health states is affected by:
1) The ordering of the five dimensions in time trade-off (TTO) and discrete choice experiment (DCE) tasks. The studies found the dimension ordering had a small but statistically significant impact on TTO values.
2) Whether the TTO tasks used "full health" or the best possible health state "11111" as the comparator state. While most respondents considered the descriptions different and preferred "full health", there were no significant differences in mean TTO values between study arms that used different comparators.
- The document describes the BENEFIT-ALS clinical trial which evaluated the safety and efficacy of tirasemtiv in people with ALS.
- The trial involved over 680 patients across 8 countries who received open-label tirasemtiv followed by 12 weeks of double-blind treatment with escalating doses of tirasemtiv or placebo.
- Preliminary results show tirasemtiv was generally well tolerated. While changes from baseline on efficacy measures were small, the direction of effects on respiratory and muscle function were consistent with a potential benefit of tirasemtiv compared to an expected rate of decline in ALS.
This document provides census data and statistics for the orthopedics department of JPNATC, AIIMS from 2013-2016. Some key figures include:
- Total patients seen in the emergency department increased from 67044 in 2015 to 69551 in 2016.
- Orthopedic consultations in the emergency department increased from 25337 in 2015 to 26376 in 2016.
- Total surgeries decreased slightly from 1826 in 2015 to 1745 in 2016, with the proportion of routine to emergency cases remaining similar.
- Common procedures included long bone fractures of the femur and tibia, pelvi-acetabular fractures, and spine surgeries.
This study examined the prevalence and risk factors of postpartum depression among 1,379 Arab women in Qatar within 6 months of delivery. The Edinburgh Postnatal Depression Scale was used to screen participants. The prevalence of postpartum depression was found to be 17.6%. Mothers who were older, less educated, housewives, had lower incomes, maternal/infant complications, poor family/marital support, financial difficulties, prematurity, and dissatisfaction in marriage had higher rates of postpartum depression.
This document provides an audit summary of the Neurosurgery Department from 2013-2016. Key points include:
- Clinical workload including OPD visits, admissions, surgeries and beds remained steady from 2013-2016. Staffing included junior residents, senior residents and consultants.
- Mortality rates from head and spinal injuries generally decreased from 2013-2016, especially for severe head injuries.
- Average hospital stay durations for head and spinal injury patients varied depending on injury severity but were typically longest for severe injuries.
- Common surgeries included craniotomies, ventriculoperitoneal/ventriculoatrial shunts, cranioplasties and tracheostomies.
Top Laser Surgery Expert Dr. David RobinsonDavid Robinson
Dr. David Robinson is a well-trained, qualified and experienced corneal and cataract surgeon; not just a standard eye surgeon doing cataracts. He has skill and experience in his field. He uses latest technology and equipment’s in their treatment procedure.
The Dow Chemical Company is a leading global supplier of industrial materials including epoxy products. Dow has invested in expanding its epoxy production capacity and acquiring curing agent companies to strengthen its position in the epoxy industry. Recent innovations in Dow's epoxy product line include developments that enable lower viscosity, faster curing, increased flexibility, and higher temperature performance compared to previous products. These new epoxy products address evolving customer needs in composite applications.
Presentation of Hexoskin Validation for KHealth's Dementia Project
The paper is available at: http://www.knoesis.org/library/resource.php?id=2155
Citation for the paper: T. Banerjee, P. Anantharam, W. L. Romine, L. Lawhorne, A. Sheth, 'Evaluating a Potential Commercial Tool for Healthcare Application for People with Dementia' in Proc. of the Intl Conf on Health Informatics and Medical Systems (HIMS), Las Vegas, July 27-30, 2015.
AI techniques are being explored to derive real-world evidence from routine medical imaging and reports. Image segmentation algorithms can identify tumors and organs in medical images. Natural language processing of radiology reports containing over 700,000 structured records dating back to 2009 has mapped patterns of metastatic disease and generated real-time survival curves for different cancers using only the uncurated data. Further development aims to uncover true response rates, map cancers of unknown primary back in time, and generate hypotheses for clinical trials to potentially expedite research. Addressing issues around data biases, identity, and social justice will be important to responsibly develop these techniques.
THESIS-STUDY OF EPIDEMIOLOGY AND TREATMENT OUTCOME USING BARTHEL’S INDEX IN M...Kanhu Charan
This study analyzed the epidemiology and treatment outcomes of 51 patients with metastatic brain tumors treated with radiotherapy. It found that brain metastases most commonly occurred in the 6th decade of life from primary lung cancer. The most common symptom was headache. Whole brain radiation improved symptoms in 70-90% of patients based on the Barthel Index scale. For multiple brain metastases, a shorter radiation regimen of 20Gy in 5 fractions was found to have equal efficacy as 30Gy in 10 fractions, based on median survival times.
Early benefits and impacts of Electronic Patient Record implementation: Findings from the UK. Presented by Steven Shaha, Center for Policy & Public Administration, UK, at HINZ 2014, 11 November 2014, 12pm, Marlborough Room 3
This study assessed the feasibility of using a portable optical coherence tomography (OCT) device to measure retinal parameters in multiple sclerosis (MS) patients both with and without a history of optic neuritis (ON). OCT scans of 137 eyes from 71 MS patients found thinning of the retinal nerve fiber layer, ganglion cell complex, and macular thickness in eyes with a history of ON compared to those without. Contrast sensitivity scores using the Pelli-Robson test also correlated with retinal thinning. The semi-automated OCT device provided detailed retinal measurements within clinical care and could stratify patients based on prior ON history.
Cardiff University Healthy Ageing Conference & Public Lecture
The importance of a healthy lifestyle
A Conference and a Public Lecture
Thursday 30th October 2014
http://medicine.cardiff.ac.uk/event/healthy-ageing-conference-public-lecture/
Esophageal Cancer: Artificial Intelligence, Synergetics, Complex System Analy...Oleg Kshivets
5-year survival of ECP after radical procedures significantly depended on: 1) PT “early-invasive cancer”; 2) PT N0--N12; 3) Cell Ratio Factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) EC cell dynamics; 9) EC characteristics; 10) tumor localization; 11) anthropometric data; 12) surgery type. Optimal diagnosis and treatment strategies for EC are: 1) screening and early detection of EC; 2) availability of experienced thoracoabdominal surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for ECP with unfavorable prognosis.
This study investigates the prevalence and causes of upper extremity dysfunction (UED) after transradial percutaneous coronary intervention (TRPCI). Preliminary results found that 63% of patients experienced UED up to 6 months post-procedure. At 2 weeks, positive family history of coronary artery disease and radial artery occlusion were associated with UED. By 6 months, reduced wrist flexion and increased symptom scores were drivers of UED. Approximately 11% of patients were referred for hand specialist care. The study aims to further analyze causes of long-term UED after TRPCI.
A Physical Strength Measurement and Analysis System for Elderly People Using ...Kawai (Sun) Akira (Weihua)
The fiscal burden of increasing social security ex- penses for the elderly is a major issue in Japan. The elderly lose physical fitness as they age. In particular, degradation in walking ability leads to falling accidents which pose a risk of serious wounds such as fractures that may resign one to a life in bed. In this study, we propose a system that is capable of measuring and analyzing an elderly person’s walking ability. The proposed system, using Kinect motion sensor and written in the programming language Scratch, can measure an elderly person’s gait accurately and be operated simply without specialist knowledge. Through real experiments with 16 subjects, some potential problems in walking were easily found by analyzing the measured data.
This study examined the relationship between neurological function and mobility in older adults using data from the Baltimore Longitudinal Study of Aging. Various neurological tests were assessed, including finger tapping, reflexes, and nerve conduction tests. Finger tapping ability strongly predicted mobility measures like gait speed and chair stands, while nerve conduction tests showed weaker relationships. Pathological reflexes were found to predict future decline in mobility. The study concluded that basic neurological exams including finger tapping should be included in geriatric assessments, while more expensive tests like nerve conduction may not be necessary.
The document demonstrates various statistical software packages for analyzing a dataset on brain size and intelligence. It shows how to calculate descriptive statistics, conduct t-tests, and make plots and graphs using Calc, R, and PSPP. Descriptive statistics include means, standard deviations, and summaries. T-tests and correlation analyses are used to examine relationships between variables like gender and IQ or weight and height.
Pranešimas VII Lietuvos jaunųjų mokslininkų konferencijoje „Operacijų tyrimas ir taikymai“
„Kompiuterininkų dienos – 2015“, Panevėžyje, KTU PTVF 2013-09-18
Chapter 9
Multivariable Methods
Objectives
• Define and provide examples of dependent and
independent variables in a study of a public
health problem
• Explain the principle of statistical adjustment
to a lay audience
• Organize data for regression analysis
Objectives
• Define and provide an example of confounding
• Define and provide an example of effect
modification
• Interpret coefficients in multiple linear and
multiple logistic regression analysis
Definitions
• Confounding – the distortion of the effect of a
risk factor on an outcome
• Effect Modification – a different relationship
between the risk factor and an outcome
depending on the level of another variable
Confounding
• A confounder is related to the risk factor and
also to the outcome
• Assessing confounding
– Formal tests of hypothesis
– Clinically meaningful associations
Example 9.1.
Confounding
We wish to assess the association between obesity and
incident cardiovascular disease.
Incident
CVD
No
CVD
Total
Obese 46 254 300
Not
Obese
60 640 700
Total 106 894 1000
1.78
0.086
0.153
60/700
46/300
RR
CVD
Example 9.1.
Confounding
Is age a confounder?
Age
< 50
CVD No
CVD
Total Age
50+
CVD No
CVD
Total
Obese 10 90 100 Obese 36 164 200
Not
Obese
35 465 500 Not
Obese
25 175 200
Total 45 555 600 Total 65 335 400
1.44
0.13
0.18
RR and 1.43
0.07
0.10
RR
50 Age|CVD50Age|CVD
Example 9.2.
Effect Modification
A clinical trial is run to assess the efficacy of a new drug
to increase HDL cholesterol.
N Mean Std Dev
New drug 50 40.16 4.46
Placebo 50 39.21 3.91
H0: m1m2 versus H1:m1≠m2
Z=-1.13 is not statistically significant
Example 9.2.
Effect Modification
Is there effect modification by gender?
Women N Mean Std Dev
New drug 40 38.88 3.97
Placebo 41 39.24 4.21
Men N Mean Std Dev
New drug 10 45.25 1.89
Placebo 9 39.06 2.22
Effect Modification
34
36
38
40
42
44
46
Women Men
M
e
a
n
H
D
L
Gender
Placebo
New Drug
Cochran-Mantel-Haenszel Method
• Technique to estimate association between risk
factor and outcome accounting for
confounding
• Data are organized into stratum and
associations are estimated in each stratum and
combined
Correlation and Simple Linear Regression
Analysis
• Two continuous variables
– Y= dependent, outcome variable
– X=independent, predictor variable
Relationship between age and SBP, number of
hours of exercise and percent body fat, caffeine
consumption and blood sugar level.
Correlation and Simple Linear Regression
• Correlation – nature and strength of linear
association between variables
• Regression – equation that best describes
relationship between variables
Scatter Diagram
0
5
10
15
20
25
0 5 10 15 20 25 30 35 40 45
X
Y
Correlation Coefficient
• Population correlation r
• Sample correlation r, -1 < r < +1
• Sign indicates nature of relationship (positive
or direct, negative o.
How to acheive NABH Standards in PHC & CHC Part 4 4Dr Jitu Lal Meena
This document provides guidance on achieving NABH "Output" standards in Primary Health Centers (PHCs) in India. It discusses several objective elements that PHCs should meet including: recording and analyzing utilization of services, maintaining statistics on key health indicators, reporting births and deaths to local authorities, conducting medical record audits, measuring patient and employee satisfaction, and utilizing a web-based health information system. The document contains many examples and templates for PHCs to use to collect and report data required to meet the national standards.
The study had two specific goals: 1) Determine the impact of a simulated reduced dose rendering on the detection of skeletal fractures in children, and 2) Evaluate the effect of enhanced skeletal processing on the same detection task. The methodology and results of this study were on display at RSNA 2015. Read the blog at http://www.carestream.com/blog/2016/04/12/carestream-pediatric-fracture-detection-study-and-potential-dose-reduction/#more-7700 or visit www.carestream.com/medical
Technology Driving the Mind-Body Connection by Dr. WilkersonMarcelo Aller CSCS
1. The document discusses how brain processes generate rapid responses to changing environmental conditions through factors like reaction time and muscle activation patterns.
2. It describes how injuries like ACL tears and concussions can impact brain function by decreasing proprioception and altering activity in areas of the brain involved in movement.
3. Several studies presented show increased risk of lower extremity musculoskeletal injuries in athletes with a history of concussion compared to those without.
Knee Osteoarthritis Classification System Examination on Wearable Daily-Use I...sugiuralab
This document proposes using inertial measurement units (IMUs) embedded in daily objects to screen for knee osteoarthritis (OA). It tests different IMU placements and machine learning classifiers to find the optimal configuration. The best performance was achieved using a decision tree classifier with IMUs on the right lower arm, left lower arm, and right foot, achieving an AUC of 0.81 with 83% sensitivity and 78% specificity. While promising, the study had limitations with a small dataset and number of IMU sensors tested. Further work is needed with more sensors, data, and algorithms to develop an effective daily-use knee OA screening system.
This document provides an overview of key statistical concepts for non-statisticians. It defines different types of data and variables, different ways of displaying and summarizing data, measures of central tendency and dispersion, normal and non-normal distributions, and different types of clinical research studies. The goal is to introduce basic statistical concepts in an accessible way for those without a statistics background.
Presentation of Hexoskin Validation for KHealth's Dementia Project
The paper is available at: http://www.knoesis.org/library/resource.php?id=2155
Citation for the paper: T. Banerjee, P. Anantharam, W. L. Romine, L. Lawhorne, A. Sheth, 'Evaluating a Potential Commercial Tool for Healthcare Application for People with Dementia' in Proc. of the Intl Conf on Health Informatics and Medical Systems (HIMS), Las Vegas, July 27-30, 2015.
AI techniques are being explored to derive real-world evidence from routine medical imaging and reports. Image segmentation algorithms can identify tumors and organs in medical images. Natural language processing of radiology reports containing over 700,000 structured records dating back to 2009 has mapped patterns of metastatic disease and generated real-time survival curves for different cancers using only the uncurated data. Further development aims to uncover true response rates, map cancers of unknown primary back in time, and generate hypotheses for clinical trials to potentially expedite research. Addressing issues around data biases, identity, and social justice will be important to responsibly develop these techniques.
THESIS-STUDY OF EPIDEMIOLOGY AND TREATMENT OUTCOME USING BARTHEL’S INDEX IN M...Kanhu Charan
This study analyzed the epidemiology and treatment outcomes of 51 patients with metastatic brain tumors treated with radiotherapy. It found that brain metastases most commonly occurred in the 6th decade of life from primary lung cancer. The most common symptom was headache. Whole brain radiation improved symptoms in 70-90% of patients based on the Barthel Index scale. For multiple brain metastases, a shorter radiation regimen of 20Gy in 5 fractions was found to have equal efficacy as 30Gy in 10 fractions, based on median survival times.
Early benefits and impacts of Electronic Patient Record implementation: Findings from the UK. Presented by Steven Shaha, Center for Policy & Public Administration, UK, at HINZ 2014, 11 November 2014, 12pm, Marlborough Room 3
This study assessed the feasibility of using a portable optical coherence tomography (OCT) device to measure retinal parameters in multiple sclerosis (MS) patients both with and without a history of optic neuritis (ON). OCT scans of 137 eyes from 71 MS patients found thinning of the retinal nerve fiber layer, ganglion cell complex, and macular thickness in eyes with a history of ON compared to those without. Contrast sensitivity scores using the Pelli-Robson test also correlated with retinal thinning. The semi-automated OCT device provided detailed retinal measurements within clinical care and could stratify patients based on prior ON history.
Cardiff University Healthy Ageing Conference & Public Lecture
The importance of a healthy lifestyle
A Conference and a Public Lecture
Thursday 30th October 2014
http://medicine.cardiff.ac.uk/event/healthy-ageing-conference-public-lecture/
Esophageal Cancer: Artificial Intelligence, Synergetics, Complex System Analy...Oleg Kshivets
5-year survival of ECP after radical procedures significantly depended on: 1) PT “early-invasive cancer”; 2) PT N0--N12; 3) Cell Ratio Factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) EC cell dynamics; 9) EC characteristics; 10) tumor localization; 11) anthropometric data; 12) surgery type. Optimal diagnosis and treatment strategies for EC are: 1) screening and early detection of EC; 2) availability of experienced thoracoabdominal surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for ECP with unfavorable prognosis.
This study investigates the prevalence and causes of upper extremity dysfunction (UED) after transradial percutaneous coronary intervention (TRPCI). Preliminary results found that 63% of patients experienced UED up to 6 months post-procedure. At 2 weeks, positive family history of coronary artery disease and radial artery occlusion were associated with UED. By 6 months, reduced wrist flexion and increased symptom scores were drivers of UED. Approximately 11% of patients were referred for hand specialist care. The study aims to further analyze causes of long-term UED after TRPCI.
A Physical Strength Measurement and Analysis System for Elderly People Using ...Kawai (Sun) Akira (Weihua)
The fiscal burden of increasing social security ex- penses for the elderly is a major issue in Japan. The elderly lose physical fitness as they age. In particular, degradation in walking ability leads to falling accidents which pose a risk of serious wounds such as fractures that may resign one to a life in bed. In this study, we propose a system that is capable of measuring and analyzing an elderly person’s walking ability. The proposed system, using Kinect motion sensor and written in the programming language Scratch, can measure an elderly person’s gait accurately and be operated simply without specialist knowledge. Through real experiments with 16 subjects, some potential problems in walking were easily found by analyzing the measured data.
This study examined the relationship between neurological function and mobility in older adults using data from the Baltimore Longitudinal Study of Aging. Various neurological tests were assessed, including finger tapping, reflexes, and nerve conduction tests. Finger tapping ability strongly predicted mobility measures like gait speed and chair stands, while nerve conduction tests showed weaker relationships. Pathological reflexes were found to predict future decline in mobility. The study concluded that basic neurological exams including finger tapping should be included in geriatric assessments, while more expensive tests like nerve conduction may not be necessary.
The document demonstrates various statistical software packages for analyzing a dataset on brain size and intelligence. It shows how to calculate descriptive statistics, conduct t-tests, and make plots and graphs using Calc, R, and PSPP. Descriptive statistics include means, standard deviations, and summaries. T-tests and correlation analyses are used to examine relationships between variables like gender and IQ or weight and height.
Pranešimas VII Lietuvos jaunųjų mokslininkų konferencijoje „Operacijų tyrimas ir taikymai“
„Kompiuterininkų dienos – 2015“, Panevėžyje, KTU PTVF 2013-09-18
Chapter 9
Multivariable Methods
Objectives
• Define and provide examples of dependent and
independent variables in a study of a public
health problem
• Explain the principle of statistical adjustment
to a lay audience
• Organize data for regression analysis
Objectives
• Define and provide an example of confounding
• Define and provide an example of effect
modification
• Interpret coefficients in multiple linear and
multiple logistic regression analysis
Definitions
• Confounding – the distortion of the effect of a
risk factor on an outcome
• Effect Modification – a different relationship
between the risk factor and an outcome
depending on the level of another variable
Confounding
• A confounder is related to the risk factor and
also to the outcome
• Assessing confounding
– Formal tests of hypothesis
– Clinically meaningful associations
Example 9.1.
Confounding
We wish to assess the association between obesity and
incident cardiovascular disease.
Incident
CVD
No
CVD
Total
Obese 46 254 300
Not
Obese
60 640 700
Total 106 894 1000
1.78
0.086
0.153
60/700
46/300
RR
CVD
Example 9.1.
Confounding
Is age a confounder?
Age
< 50
CVD No
CVD
Total Age
50+
CVD No
CVD
Total
Obese 10 90 100 Obese 36 164 200
Not
Obese
35 465 500 Not
Obese
25 175 200
Total 45 555 600 Total 65 335 400
1.44
0.13
0.18
RR and 1.43
0.07
0.10
RR
50 Age|CVD50Age|CVD
Example 9.2.
Effect Modification
A clinical trial is run to assess the efficacy of a new drug
to increase HDL cholesterol.
N Mean Std Dev
New drug 50 40.16 4.46
Placebo 50 39.21 3.91
H0: m1m2 versus H1:m1≠m2
Z=-1.13 is not statistically significant
Example 9.2.
Effect Modification
Is there effect modification by gender?
Women N Mean Std Dev
New drug 40 38.88 3.97
Placebo 41 39.24 4.21
Men N Mean Std Dev
New drug 10 45.25 1.89
Placebo 9 39.06 2.22
Effect Modification
34
36
38
40
42
44
46
Women Men
M
e
a
n
H
D
L
Gender
Placebo
New Drug
Cochran-Mantel-Haenszel Method
• Technique to estimate association between risk
factor and outcome accounting for
confounding
• Data are organized into stratum and
associations are estimated in each stratum and
combined
Correlation and Simple Linear Regression
Analysis
• Two continuous variables
– Y= dependent, outcome variable
– X=independent, predictor variable
Relationship between age and SBP, number of
hours of exercise and percent body fat, caffeine
consumption and blood sugar level.
Correlation and Simple Linear Regression
• Correlation – nature and strength of linear
association between variables
• Regression – equation that best describes
relationship between variables
Scatter Diagram
0
5
10
15
20
25
0 5 10 15 20 25 30 35 40 45
X
Y
Correlation Coefficient
• Population correlation r
• Sample correlation r, -1 < r < +1
• Sign indicates nature of relationship (positive
or direct, negative o.
How to acheive NABH Standards in PHC & CHC Part 4 4Dr Jitu Lal Meena
This document provides guidance on achieving NABH "Output" standards in Primary Health Centers (PHCs) in India. It discusses several objective elements that PHCs should meet including: recording and analyzing utilization of services, maintaining statistics on key health indicators, reporting births and deaths to local authorities, conducting medical record audits, measuring patient and employee satisfaction, and utilizing a web-based health information system. The document contains many examples and templates for PHCs to use to collect and report data required to meet the national standards.
The study had two specific goals: 1) Determine the impact of a simulated reduced dose rendering on the detection of skeletal fractures in children, and 2) Evaluate the effect of enhanced skeletal processing on the same detection task. The methodology and results of this study were on display at RSNA 2015. Read the blog at http://www.carestream.com/blog/2016/04/12/carestream-pediatric-fracture-detection-study-and-potential-dose-reduction/#more-7700 or visit www.carestream.com/medical
Technology Driving the Mind-Body Connection by Dr. WilkersonMarcelo Aller CSCS
1. The document discusses how brain processes generate rapid responses to changing environmental conditions through factors like reaction time and muscle activation patterns.
2. It describes how injuries like ACL tears and concussions can impact brain function by decreasing proprioception and altering activity in areas of the brain involved in movement.
3. Several studies presented show increased risk of lower extremity musculoskeletal injuries in athletes with a history of concussion compared to those without.
Knee Osteoarthritis Classification System Examination on Wearable Daily-Use I...sugiuralab
This document proposes using inertial measurement units (IMUs) embedded in daily objects to screen for knee osteoarthritis (OA). It tests different IMU placements and machine learning classifiers to find the optimal configuration. The best performance was achieved using a decision tree classifier with IMUs on the right lower arm, left lower arm, and right foot, achieving an AUC of 0.81 with 83% sensitivity and 78% specificity. While promising, the study had limitations with a small dataset and number of IMU sensors tested. Further work is needed with more sensors, data, and algorithms to develop an effective daily-use knee OA screening system.
This document provides an overview of key statistical concepts for non-statisticians. It defines different types of data and variables, different ways of displaying and summarizing data, measures of central tendency and dispersion, normal and non-normal distributions, and different types of clinical research studies. The goal is to introduce basic statistical concepts in an accessible way for those without a statistics background.
3. Disability Prevalence
• 1500 children born per year with spina bifida [1]
• 1 in 323 children born with cerebral palsy [2]
• 16.5% of 7-11 year olds have sensory processing
disorder [3]
[1] S. E. Parker et al., “Updated National Birth Prevalence estimates for selected birth defects in the United States,
2004-2006,”
[2] D. Christensen et al., “Prevalence of cerebral palsy, co-occurring autism spectrum disorders, and motor
functioning - Autism and Developmental Disabilities Monitoring Network, USA, 2008,”
[3] A. Ben-Sasson et al., “Sensory Over-Responsivity in Elementary School: Prevalence and Social-Emotional
Correlates,”
3
4. Physical Therapy
• The AmTryke is a hand and foot tricycle
• Therapeutic effects on musculoskeletal control not
quantified
• Methods to quantify musculoskeletal activity using:
• Kinematic data
• Kinetic data
• Electromyographic data
4
INSERT PICTURE
OF AMTRYKE HERE
5. Overall Objective
•Quantify the therapeutic effects of AmTyke exercise:
•Perform initial study using kinematic data and gross motor
function measure (GMFM)
•Improve kinematic measurement process
•Develop force sensors for future use in kinetic data gathering
5
6. High Level Deliverables
Force Sensor Team
• Two working handlebar force sensors
• Documentation, SolidWorks model, and electrical
schematic of the sensor and circuit for future work
BME
• Journal manuscript on the kinematic analysis of
AmTryke rehabilitation
6
7. SMART Members
Data Analysis
• Amerz Chek
• Daniella Guerrero
• Allen Hill (Lead)
• Wei Shu
Modeling
• Alana Alston
• Immanuel Phiri
• Alexia Thomas (Sub-
Lead)
Load Cell
• Ellie Blow (Sub-Lead)
• Aaron Jones
• Johannus Smith 7
8. Functional Diagram
Data Acquisition
Data Processing
Model Scaling
Kinematic
Representation Data Analysis
Processing Team
Modeling Team
Load Cell
Design
Test
Working
Load Cell
Load Cell Team
8
9. Methods: Experiment
• 6 subjects
• Age: 2-7 years old
• Disabilities: Cerebral palsy, spina
bifida, SPD, prenatal drug
exposure
• Before and after motion capture
• 3-month interval
9
17. Experiment Setup
Initial Capture:
•38 markers
•Specifically modeled upper limb movement in a bicycling
motion
Control Inverse Kinematics:
•OpenSim was used to scale and run inverse kinematics
•An average RMS error was calculated for the model as a
whole from the individual markers
22. Marker Removal and IK Generation
Marker Removal:
•Focused on scapula and lateral elbow markers in this
order:
•L&R Scap1, L&R TriSpn, L&R Shoulder, L&R ElbowMed
IK Data Generation:
•New .mot files were generated each time a marker was
removed along with new RMS values.
•Ex. 1.mot: Scap1
•Ex. 2.mot: TriSpn
•Ex. 3.mot: Scap1 + TriSpn
23. RMS Values
RMS Values
•A MATLAB program was used to calculated the RMS
errors of the comparison between the base model and
new generated models
Aimed for the following values:
•0 < RMS < 5 degrees – for markers on segments with
rotations
•0 < RMS < 1 cm - for makers on thorax and Pelvis
regions
•Markers were picked based on their RMS value
27. Background Research
•Previous Multiaxial Force Sensors
•Liu’s Model
•Side-centered Support Beams
•7 cm X 7 cm
•20 strain gages
•Kim’s Model
•Corner Support Beams and Central Support Beam
•9 cm X 9 cm
•24 strain gages
28. Selection
•Liu’s Model, and shrink it down to a 4 cm by 4 cm piece
•Reasons
•Easier geometry to produce
•Fewer strain gages to measure the same forces and moments
•Closer to the desired size
29. Prototype
•Made of 7075-T6 Aluminum
•Hand-milled at the MTDL (18 hours)
•Fitted with the Fz Bridge
•5 cm X 5 cm
•Used to develop a testing procedure for
use with the final sensor
•Used to validate linearity of responses
30. Attachment to the AmTryke
•Cut off the original handlebar to retain the threading that
connects to the bicycle
•Slide the baseplate over the cut handlebar and use a nut so
that it freely rotates.
•Use four 4-40 screws to attach the baseplate to the sensor
housing
•Attach the handlebar to the housing using a 7/16-20 bolt
32. Sensor Circuit: Notch Filter
•4 pull notch filter
•Focused at 60 HZ to reduce room noise
•Leads into final gain phase (R9 resistor)
33. Sensor Circuit: Final Amp
•Gain of 5
•Outputs to the Vicon system
•Used to amplify the filtered signal to a level that the
Vicon system can work with
34. Sensor Calibration Testing
•Isolate each force and moment by applying along/around the
respective axis
•Create a input(lbf or lbf*in) vs output(mV) plot to find the
voltage increase per lbf or lbf*in for each bridge for each force
•This results in a 6X6 matrix
35. Sensor Calibration w/ Circuit
•Comparable results with similar linearity
•Proves the response of the circuit tracks with the force
applied
36. Project Budget
Items Expected Actual
Raw Materials $75 $122
Strain Gages $900 $285
Manufacturing $400 $781
Electronics $125 $100
Lab and Testing Supplies $250 $250
Total $1750 $1538
36
37. Key Dates
10/20 12/20 01/21 03/0709/03 04/22
Force Sensor BME
Planning Literature compilation Research
Phase 1 Design Pilot Data
Phase 2 Basic Prototyping/Testing Initial Data
Phase 3 Rescaling/Manufacturing Final Data
Finalization Final Modifications Documentation
Force
Sensor
BME
37
38. References
[1] S. E. Parker, C. T. Mai, M. A. Canfield, R. Rickard, Y. Wang, R. E. Meyer, P.
Anderson, C. A. Mason, J. S. Collins, R. S. Kirby, A. Correa, and National Birth
Defects Prevention Network, “Updated National Birth Prevalence estimates
for selected birth defects in the United States, 2004-2006,” Birth Defects
Res. Part A Clin. Mol. Teratol., vol. 88, no. 12, pp. 1008–1016, Dec. 2010.
[2] D. Christensen, K. Van Naarden Braun, N. S. Doernberg, M. J. Maenner, C.
L. Arneson, M. S. Durkin, R. E. Benedict, R. S. Kirby, M. S. Wingate, R.
Fitzgerald, and M. Yeargin-Allsopp, “Prevalence of cerebral palsy, co-
occurring autism spectrum disorders, and motor functioning - Autism and
Developmental Disabilities Monitoring Network, USA, 2008,” Dev Med Child
Neurol, vol. 56, no. 1, pp. 59–65, Jan. 2014.
[3] A. Ben-Sasson, A. S. Carter, and M. J. Briggs-Gowan, “Sensory Over-
Responsivity in Elementary School: Prevalence and Social-Emotional
Correlates,” J Abnorm Child Psychol, vol. 37, no. 5, pp. 705–716, Jan. 2009.
38
39. References
[4] S. A. Liu and H. L. Tzo, “A Novel Six-Component Force Sensor of Good
Measurement Isotropy and Sensitivities,” Sensors and Actuators A: Physical,
vol. 100, no. 2–3, pp. 223–230, Sep. 2002.
39
45. Future Work
• Four (4) force sensors for kinetic analysis
• Develop interactive app for AmTryke users
45
46. Handlebar Angle Calculations
• PCA on marker data
to extract axis of
rotation
• LMS for outlier
detection
• Inverse tangent to
calculate angle
Y.-S. Liu and K. Ramani, “Robust principal axes
determination for point-based shapes using least median
of squares,” Computer-Aided Design, vol. 41, no. 4, pp.
293–305, Apr. 2009.
46