This document outlines the structural hierarchy and function of skeletal muscles. It begins with the smallest functional unit, the sarcomere, and describes the organization of actin and myosin myofilaments. It then explains the process of neuromuscular transmission where a motor unit receives an action potential from the central nervous system via the end plate. This causes excitation-contraction coupling and the release of calcium ions which trigger the cross-bridge cycling of actin and myosin to generate muscle contraction.

1. Structural hierarchy of skeletal muscles

2. Sarcomere

3. Myofilaments
• Actin
• Myosin

4. Neuromuscular Transmission
Motor Unit
Action Potential

5. End Plate Potentials

6. Action Potential Propagation
• Transverse Tubules

7. http://www.austincc.edu/apreview/PhysText/Muscle.html

8. Release of Calcium
Figure 1: Muscle
channelopathies and critical
points in functional and genetic
studies
J Clin Invest DOI: 10.1172/JCI25525

9. Excitation-Contraction Coupling

10. https://www.r2library.com/resource/detail/1455770051/ch0007s0136#goto=ch0007s013
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11. Role Of Calcium

12. Cross-bridge Cycle

13. Termination Of Contraction