Marcia Villalba discusses the integration of GraphQL with serverless architecture, emphasizing that GraphQL is a specification for querying data rather than a framework or database. She outlines the benefits of using GraphQL with serverless technologies, specifically mentioning AWS AppSync as a platform that provides real-time support and various data sources. Additionally, the presentation covers important considerations such as potential performance issues when using DynamoDB scans and the latency that can be introduced by calling other services from AWS Lambda.