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SUSANA CANO VANEGAS
3RD SEMESTER- UPB
Gliomas are central nervous system (CNS) tumors that have histologic features similar to normal glial cells
(astrocytes, oligodendrocytes and ependymal cells).
INTRODUCTION
GLIOMA
GLIOBLASTOMA
ASTROCYTOMA,
CNS WHO GRADE 2
Louis, D, & et al. (2023). Classification and pathologic diagnosis of gliomas, glioneuronal tumors, and neuronal tumors. Up To Date.
Amthor F. R, et al. (2020). Essentials of Modern Neuroscience. McGraw-Hill. https://doi.org/978-0-07-184905-0
GLIOBLASTOMA
The World Health Organization (WHO) grading system is based on histologic criteria that are used to
classify tumors as 1 of 4 grades:
Grade I
Grade II
Grade III
Grade IV
Molecular tests:
Molecular characterization.
Pathologic evaluation.
IDH mutational testing.
Testing for 1p/19q codeletion*
CELL TARGET BIOLOGIC ACTIVITY
IL-1 All cells
Upregulates adhesion.
Neutrophil and macrophage emigration,
Mimics shock, fever.
Hepatic acute-phase protein production.
Hematopoiesis.
IL-4
T, B, NK cells.
Monocytes-macrophages.
Neutrophils, eosinophils.
Endothelial cells.
Fibroblasts.
T-cell differentiation and proliferation.
B-cell Ig class switch to IgG1.
IgE anti-inflammatory action on T cells.
Stimulate B-cell maturation.
IL4 & IL1
INTRODUCTION
Joseph Loscalzo, et al. (2022). Harrison’s principles of internal medicine (18a ed.). McGraw-Hill Professional.
Johnston, A., et al. (2019). Immunobiologics: Targeted therapy against cytokines, cytokine receptors, and growth factors in dermatology. McGraw Hill Medical.
IDENTIFY IL4I1 IN M2-LIKE
MACROPHAGE PROMOTES
GLIOMA PROGRESSION AND
AS A PROMISING TARGET
FOR IMMUNOTHERAPY
GENERAL OBJECTIVE
02 QUANTITATIVE REAL TIME PCR
WESTERN BLOT
01
https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.mybiosource.com%2Flearn%2Fwesternblotting&psig=AOvVaw04DFYfsN8Rhcg8J2Yd9_Wv&ust=1708440378570000&source=images&cd=vfe&opi=89978449&ved=0CBIQjRxqFwoTCMDv48DSt4QDFQAAAAAdAAAAABAa
https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41467-020-18611-5&psig=AOvVaw0YQg18P5ZzCFoIB5HB5J6O&ust=1708441048182000&source=images&cd=vfe&opi=89978449&ved=0CBQQjhxqFwoTCODqmoDVt4QDFQAAAAAdAAAAABAS
IMMUNOFLUORESCENCE
IMMUNOHISTOCHEMISTRY
03
04
https://www.google.com/url?sa=i&url=https%3A%2F%2Fibidi.com%2Fcontent%2F364-the-principle-of-immunofluorescence-assays&psig=AOvVaw18uq5o6ozK7Wd--lMm9XM4&ust=1708441326294000&source=images&cd=vfe&opi=89978449&ved=0CBQQjhxqFwoTCJC-4oTWt4QDFQAAAAAdAAAAABAS
https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS0165993616302904&psig=AOvVaw1KlAX-uDJzC_1Zox1skXDk&ust=1708441268395000&source=images&cd=vfe&opi=89978449&ved=0CBQQjhxqFwoTCJDcrOnVt4QDFQAAAAAdAAAAABBo
RESULTS
FIGURE 6
RESULTS
FIGURE 7
FIGURE 8
DISCUSSION
Author discussed yes/no
Miller KD, et al.
“The heterogeneity and complexity of epigenetics of glioma
hamper treatment and diagnoses. Despite tremendous efforts to
reduce recurrence and mortality, this malignancy results in a poor
prognosis”
Zhang Y, et al.
Pan Z, et al.
“Within the TME, infiltrating macrophages predominantly
exhibit the M2 subtype and are known as TAMs, which
contribute critically to promote the proliferation and metastasis of
tumor cells”
Morrissey SM, et al.
“The infiltration and activation of TAMs are
also well-known factors associated with the prognosis of glioma. For
instance, TAM-associated PGK1 phosphorylation has shown
correlations with glioma grade, patient prognosis, and
tumorigenesis”
CONCLUSIONS
Molecular biology allows us to develop new techniques
for the well being of patients by going to the microscopic
causes and principles, as in this article where an
interleukin is key to help people get diagnosed.
This article is key for new coming discoveries in glioma
pathology, as it allows a more specific approach where
more studies can be made for an early diagnosis or
even, new ways to help with the treatment.
Seminario Biología Molecular - Susana Cano V.pdf

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Seminario Biología Molecular - Susana Cano V.pdf

  • 1. SUSANA CANO VANEGAS 3RD SEMESTER- UPB
  • 2. Gliomas are central nervous system (CNS) tumors that have histologic features similar to normal glial cells (astrocytes, oligodendrocytes and ependymal cells). INTRODUCTION GLIOMA GLIOBLASTOMA ASTROCYTOMA, CNS WHO GRADE 2 Louis, D, & et al. (2023). Classification and pathologic diagnosis of gliomas, glioneuronal tumors, and neuronal tumors. Up To Date. Amthor F. R, et al. (2020). Essentials of Modern Neuroscience. McGraw-Hill. https://doi.org/978-0-07-184905-0 GLIOBLASTOMA The World Health Organization (WHO) grading system is based on histologic criteria that are used to classify tumors as 1 of 4 grades: Grade I Grade II Grade III Grade IV Molecular tests: Molecular characterization. Pathologic evaluation. IDH mutational testing. Testing for 1p/19q codeletion*
  • 3. CELL TARGET BIOLOGIC ACTIVITY IL-1 All cells Upregulates adhesion. Neutrophil and macrophage emigration, Mimics shock, fever. Hepatic acute-phase protein production. Hematopoiesis. IL-4 T, B, NK cells. Monocytes-macrophages. Neutrophils, eosinophils. Endothelial cells. Fibroblasts. T-cell differentiation and proliferation. B-cell Ig class switch to IgG1. IgE anti-inflammatory action on T cells. Stimulate B-cell maturation. IL4 & IL1 INTRODUCTION Joseph Loscalzo, et al. (2022). Harrison’s principles of internal medicine (18a ed.). McGraw-Hill Professional. Johnston, A., et al. (2019). Immunobiologics: Targeted therapy against cytokines, cytokine receptors, and growth factors in dermatology. McGraw Hill Medical.
  • 4. IDENTIFY IL4I1 IN M2-LIKE MACROPHAGE PROMOTES GLIOMA PROGRESSION AND AS A PROMISING TARGET FOR IMMUNOTHERAPY GENERAL OBJECTIVE
  • 5. 02 QUANTITATIVE REAL TIME PCR WESTERN BLOT 01 https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.mybiosource.com%2Flearn%2Fwesternblotting&psig=AOvVaw04DFYfsN8Rhcg8J2Yd9_Wv&ust=1708440378570000&source=images&cd=vfe&opi=89978449&ved=0CBIQjRxqFwoTCMDv48DSt4QDFQAAAAAdAAAAABAa https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41467-020-18611-5&psig=AOvVaw0YQg18P5ZzCFoIB5HB5J6O&ust=1708441048182000&source=images&cd=vfe&opi=89978449&ved=0CBQQjhxqFwoTCODqmoDVt4QDFQAAAAAdAAAAABAS
  • 9. DISCUSSION Author discussed yes/no Miller KD, et al. “The heterogeneity and complexity of epigenetics of glioma hamper treatment and diagnoses. Despite tremendous efforts to reduce recurrence and mortality, this malignancy results in a poor prognosis” Zhang Y, et al. Pan Z, et al. “Within the TME, infiltrating macrophages predominantly exhibit the M2 subtype and are known as TAMs, which contribute critically to promote the proliferation and metastasis of tumor cells” Morrissey SM, et al. “The infiltration and activation of TAMs are also well-known factors associated with the prognosis of glioma. For instance, TAM-associated PGK1 phosphorylation has shown correlations with glioma grade, patient prognosis, and tumorigenesis”
  • 10. CONCLUSIONS Molecular biology allows us to develop new techniques for the well being of patients by going to the microscopic causes and principles, as in this article where an interleukin is key to help people get diagnosed. This article is key for new coming discoveries in glioma pathology, as it allows a more specific approach where more studies can be made for an early diagnosis or even, new ways to help with the treatment.