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Kevin Esteban Duque Duque
3rd semester
Universidad Pontificia Bolivariana
Streptococcus pneumoniae, commonly known as
pneumococcus, is a gram-positive bacterium responsable
for various illnesses ranging from mild infections like otitis
media to severe conditions such as pneumonia, meningitis,
and septicemia.
Streptococcus pneumoniae
Its ability to produce polysaccharide capsules enhances
virulence, making prevention through vaccination and
appropriate antibiotic use critical in combating its
potentially life-threatening effects.
Influenza A virus is a type of RNA virus that
infects humans, causing seasonal flu
outbreaks. It's categorized into subtypes
based on its surface proteins. Transmission
occurs through respiratory droplets, and
symptoms range from mild to severe
respiratory complications, especially in
high-risk groups.
Influenza A Virus
Examine how NEDD4 Regulated Pyroptosis
Occurred from Co‐infection between
Influenza A Virus and Streptococcus
pneumoniae
OBJECTIVE
MÉTODOS
Establecimiento de un modelo de coinfección
en BALB/c ratones.
Se administra una dosis infecciosa a los 20
ratones BALB/c, con el fin de tener el modelo de
coinfección para establecer la tasa de
mortalidad y supervivencia para el desarrollo de
la investigación.
Modelo de construcción de coinfección celular
A549.
Utilizar un modelo de coinfección con las celulas
A549 que son células epiteliales basales
alveolares humanas, usadas para investigar la
patología molecular de las células epiteliales de
las vias respiratorias en respuesta a infecciones
virales.
MÉTODOS
Western Blot.
Se usa para detectar la presencia de proteínas
específicas en una muestra de tejido o extracto
celular, usado en el estudio para detectar la
presencia de varios anticuerpos.
SiRNA de interferencia con NEDD4.
Se usa el RNA de interferencia para regular la
expresión génica, usado en este estudio para el
gen NEDD4.
RESULTS
RESULTS
Agree or disagree
Agree or disagree
Author
Author
DISCUSSION
What did they say?
What did they say?
“Our developed co-infection model accurately
captures the excess mortality caused by co-
infection, thereby validating the success of our
approach (...).”
(Bao et al., 2020)
“The airway epithelium is now considered to be central to the
orchestration of pulmonary inflammatory and immune
responses, and is also key to tissue remodelling. It acts as the
first barrier in the defense against pathogen challenges, and is
critically involved in the regulation of both innate and adaptive
immune responses to these challenges”.
(Negash et al., 2013;
Peeters et al., 2013;
Russier et al., 2020)
“Establishing a co-infection model of influenza virus and Strep-
tococcus pneumoniae using A549 cells contributes to a deeper
understanding of the potential molecular mechanisms underlying co-
infections. Numerous studies have reported individual infections of
human lung tissue cells with influenza virus or Streptococcus
pneumoniae, both domestically and internationally”.
(Han et al., 2012; Julkunen
et al., 2000; Schmeck et
al., 2004, 2006).
CONCLUSIONS
1.
The study of viral co-infection
and its effects on cellular
resistance provides valuable
information on the processes
of cell death and
inflammation, being of great
importance for these studies
the evidence and the
progress of molecular biology.
2.
It has been shown that the
interaction between virus and host
cells can trigger inflammatory
responses and programmed cell
death mechanisms, such as
pyroptosis, which can significantly
influence the pathogenicity and
progression of infection, these
findings highlight the importance of
understanding at the molecular level
the processes behind viral co-
infection.
MAPA CONCEPTUAL

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Seminario biología molecular Kevin Duque

  • 1. Kevin Esteban Duque Duque 3rd semester Universidad Pontificia Bolivariana
  • 2. Streptococcus pneumoniae, commonly known as pneumococcus, is a gram-positive bacterium responsable for various illnesses ranging from mild infections like otitis media to severe conditions such as pneumonia, meningitis, and septicemia. Streptococcus pneumoniae Its ability to produce polysaccharide capsules enhances virulence, making prevention through vaccination and appropriate antibiotic use critical in combating its potentially life-threatening effects.
  • 3. Influenza A virus is a type of RNA virus that infects humans, causing seasonal flu outbreaks. It's categorized into subtypes based on its surface proteins. Transmission occurs through respiratory droplets, and symptoms range from mild to severe respiratory complications, especially in high-risk groups. Influenza A Virus
  • 4. Examine how NEDD4 Regulated Pyroptosis Occurred from Co‐infection between Influenza A Virus and Streptococcus pneumoniae OBJECTIVE
  • 5. MÉTODOS Establecimiento de un modelo de coinfección en BALB/c ratones. Se administra una dosis infecciosa a los 20 ratones BALB/c, con el fin de tener el modelo de coinfección para establecer la tasa de mortalidad y supervivencia para el desarrollo de la investigación. Modelo de construcción de coinfección celular A549. Utilizar un modelo de coinfección con las celulas A549 que son células epiteliales basales alveolares humanas, usadas para investigar la patología molecular de las células epiteliales de las vias respiratorias en respuesta a infecciones virales.
  • 6. MÉTODOS Western Blot. Se usa para detectar la presencia de proteínas específicas en una muestra de tejido o extracto celular, usado en el estudio para detectar la presencia de varios anticuerpos. SiRNA de interferencia con NEDD4. Se usa el RNA de interferencia para regular la expresión génica, usado en este estudio para el gen NEDD4.
  • 9. Agree or disagree Agree or disagree Author Author DISCUSSION What did they say? What did they say? “Our developed co-infection model accurately captures the excess mortality caused by co- infection, thereby validating the success of our approach (...).” (Bao et al., 2020) “The airway epithelium is now considered to be central to the orchestration of pulmonary inflammatory and immune responses, and is also key to tissue remodelling. It acts as the first barrier in the defense against pathogen challenges, and is critically involved in the regulation of both innate and adaptive immune responses to these challenges”. (Negash et al., 2013; Peeters et al., 2013; Russier et al., 2020) “Establishing a co-infection model of influenza virus and Strep- tococcus pneumoniae using A549 cells contributes to a deeper understanding of the potential molecular mechanisms underlying co- infections. Numerous studies have reported individual infections of human lung tissue cells with influenza virus or Streptococcus pneumoniae, both domestically and internationally”. (Han et al., 2012; Julkunen et al., 2000; Schmeck et al., 2004, 2006).
  • 10. CONCLUSIONS 1. The study of viral co-infection and its effects on cellular resistance provides valuable information on the processes of cell death and inflammation, being of great importance for these studies the evidence and the progress of molecular biology. 2. It has been shown that the interaction between virus and host cells can trigger inflammatory responses and programmed cell death mechanisms, such as pyroptosis, which can significantly influence the pathogenicity and progression of infection, these findings highlight the importance of understanding at the molecular level the processes behind viral co- infection.