Key documents found in the Opioid Industry Documents Archive. The Industry Documents Library collects and preserves the internal documents of opioid manufacturers and distributors which document the development, sale, promotion, marketing, and compliance related to prescription opioids and the opioid epidemic.
CRITICAL APPRAISAL OF THE EVIDENCE REGARDING EFFICACY/EFFECTIVENESS AND SAFETY OF COVID-19 VACCINES – METHODOLOGICAL LIMITATIONS OF THE COVID-19 VACCINES CLINICAL TRIALS
Pedro Morago, 21st January 2022
AZT: How an abandoned drug found new life as an important AIDS/HIV treatmentFirhan Malik
In the 1960's, a drug that inhibited the replication of viruses was discovered. Researchers hoped this could be a therapy for cancer caused by retroviruses. Unfortunately, the drug failed in animal models, and was abandoned. In the early 1980's, the HIV virus was found to be the cause of AIDS, a devastating and fatal disease. This document by Mark Yarchoan explains how the abandoned drug AZT found new life as an important treatment for patients with AIDS. AZT changed the very nature of the diagnosis and health of these patients.
The Status of the Regulatory and Economic Landscape for Innovation in Big Pha...Lindsay Meyer
The purpose of engaging this topic is to: examine the current regulatory environment for new drugs, gain an understanding of breakthrough innovation in pharmaceuticals, evaluate the efforts of key players, and make projections about the future of this industry. As therapeutics has evolved away from their theistic origins, natural products, synthetic chemistry, and biopharmaceuticals have emerged. Yet many difficulties remain for this specialized industry. The approval process for a new drug can take upwards of eight years and cost $800 million. The progression from test tube to commercial distribution includes preclinical trials followed by three phases of clinical (human) trials, marked by ongoing dialogue between the Food and Drug Administration (“FDA”). Five of largest American pharmaceutical companies have intensified their efforts in Research and Development (“R&D”) in recent years. But in a space marked with competition from generic manufacturers and maturing biotech companies, understanding the dynamics of this highly scrutinized market requires an awareness of the political and economic climate these key players face. Where this industry is headed is much less clear than where it is coming from. Careful analysis is one lens through which to examine all of these intricate elements and is the focus of this research paper.
CRITICAL APPRAISAL OF THE EVIDENCE REGARDING EFFICACY/EFFECTIVENESS AND SAFETY OF COVID-19 VACCINES – METHODOLOGICAL LIMITATIONS OF THE COVID-19 VACCINES CLINICAL TRIALS
Pedro Morago, 21st January 2022
AZT: How an abandoned drug found new life as an important AIDS/HIV treatmentFirhan Malik
In the 1960's, a drug that inhibited the replication of viruses was discovered. Researchers hoped this could be a therapy for cancer caused by retroviruses. Unfortunately, the drug failed in animal models, and was abandoned. In the early 1980's, the HIV virus was found to be the cause of AIDS, a devastating and fatal disease. This document by Mark Yarchoan explains how the abandoned drug AZT found new life as an important treatment for patients with AIDS. AZT changed the very nature of the diagnosis and health of these patients.
The Status of the Regulatory and Economic Landscape for Innovation in Big Pha...Lindsay Meyer
The purpose of engaging this topic is to: examine the current regulatory environment for new drugs, gain an understanding of breakthrough innovation in pharmaceuticals, evaluate the efforts of key players, and make projections about the future of this industry. As therapeutics has evolved away from their theistic origins, natural products, synthetic chemistry, and biopharmaceuticals have emerged. Yet many difficulties remain for this specialized industry. The approval process for a new drug can take upwards of eight years and cost $800 million. The progression from test tube to commercial distribution includes preclinical trials followed by three phases of clinical (human) trials, marked by ongoing dialogue between the Food and Drug Administration (“FDA”). Five of largest American pharmaceutical companies have intensified their efforts in Research and Development (“R&D”) in recent years. But in a space marked with competition from generic manufacturers and maturing biotech companies, understanding the dynamics of this highly scrutinized market requires an awareness of the political and economic climate these key players face. Where this industry is headed is much less clear than where it is coming from. Careful analysis is one lens through which to examine all of these intricate elements and is the focus of this research paper.
Lesson 3 Separation of Fact From FictionObjectives· Define .docxSHIVA101531
Lesson 3: Separation of Fact From Fiction
Objectives
· Define peer review
· List the characteristics of an intelligent consumer
· Explain why people are vulnerable to quackery
· Explain how the scientific method is used to determine health-related facts
· Explain how to evaluate sources of health information
· Explain and analyze the issue of conflict of interest in clinical research
It is difficult to be an informed consumer in today's world with all the sources of information that bombard us daily. The first two chapters of our text, Barrett,
Jarvis, Kroger and London (2007) review some of the major issues and list some
characteristics of an intelligent consumer. Test your consumer IQ and take the
consumer health profile on page 13. You may post your comments about these assessments on the discussion board.
The Scientific Method
In Chapter 2 there is a discussion about how to find reliable sources of health
information. The authors have rated some popular magazines and other periodicals.
Also in Chapter 2 there is an important discussion about the scientific method. This course is based on the assumption that the scientific method is valid. In the area of consumer health, services and products must be studied by following the scientific method in order to know if they are of any use. Health services and products must be subject to scientific scrutiny.
An understanding of the scientific method is crucial in so many ways. It helps us
separate fact from fiction. It can also give us an approach to problem solving and therefore, critical thinking. It helps us to ask questions about new treatments and products. It gives us a skeptical, or should I say, questioning view about what we are told. Knowing about the scientific method makes us want to see the proof before we accept a statement.
In epidemiology we learn about various ways to go about studying the relationship
between a factor (like cigarette smoking) and a disease (like lung cancer). When scientists begin to study a relationship like this they need to have a "wait and see" attitude about the findings. They need to go into the research with no bias or at least put aside that bias. When the cigarette companies funded the research they found no relationship between cigarettes and lung cancer. When the government began to fund the studies they found a very strong relationship. It is important to know where the funding is coming from in the various studies. The most reputable journals have a policy on conflict of interest stating that authors must disclose any
conflict of interest that might taint the study. That is also why articles are peer reviewed; so that other scientists can check their colleagues' work.
Conflict of Interest in Health Research
There has been a great deal of discussion about the effect of corporate funding of health research lately. The reason being that since the mid-70's government funding for health research declined and private funding increased. (Blumentha ...
The Fauci/COVID-19 Dossier
This work was supported, in part, by a fund-raising effort in which approximately 330 persons contributed funds in support
of the New Earth technology team and Urban Global Health Alliance. It is released under a Creative Commons license CCBY-NC-SA
IN THIS SUMMARY
The United States Food and Drug Administration (FDA) has significant reach in the American economy, ranging from medicines and medical devices to items on the grocery store shelves. Since its inception in 1906, the agency has faced a variety of technical and political challenges. Looking ahead, the FDA faces many new demands that could enlarge the agency’s already expansive mandate. New responsibilities may include the cost of medicine, consumers’ pursuit of perfection through drugs, consumer lifestyles, tobacco, and counterterrorism. As the nature of public health changes over time, it is inevitable that the FDA’s scope and responsibilities will change as well. In Inside the FDA, Fran Hawthorne explains the history of the FDA, how its processes work, and what the future may hold for this government agency.
SUBSCRIBE TODAY
http://www.bizsum.com/summaries/inside-fda
A white paper authored by Energy in Depth that lays bare the corruption of New York State's Dept. of Health in the cherry-picked anti-drilling-backed reports used to disparage fracking--a report that eventually led to a ban in the state. This report by EID exposes the fraud of the so-called science used by State Health Commissioner Howard Zucker.
Financial Disclosure –Duties and Strategies for Clinical StudiesMichael Swit
Financial disclosure requirements for clinical studies are explored with a particular emphasis on how the requirement for tracking "Significant Payments of Other Sorts" -- or SPOOS -- present challenges in clinical study compliance.
Network of corruption the cdc who and big pharmaKaye Beach
Unfortunately it is very profitable for the drug industry to get the medical profession to promote vaccines to the general population. Drug companies are corporations and they do not have a duty to "do no harm". Their only duty is to make money and "mitigate" any liability the company might be forced to deal with in a court of law. It is important the public doesn't forget this as it is very unlikely your physician or anyone who works for public health will remind you of this reality.
Here are the major signs of government and/or medical industry corruption:
1. Fraud and/or Misrepresentation
2. Conflict of interest
3. Bribery
4. Lack of transparency (concealment or deception)
Documents from the tobacco industry archives that highlight their strategies to address issues surrounding secondhand smoke or "environmental tobacco smoke" (ETS). These strategies include formation of scientific organizations and coalitions to disseminate research information and involvement in national ventilation standards and regulations surrounding indoor air quality.
More Related Content
Similar to Selected Documents from the UCSF-JHU Opioid Industry Documents Archive
Lesson 3 Separation of Fact From FictionObjectives· Define .docxSHIVA101531
Lesson 3: Separation of Fact From Fiction
Objectives
· Define peer review
· List the characteristics of an intelligent consumer
· Explain why people are vulnerable to quackery
· Explain how the scientific method is used to determine health-related facts
· Explain how to evaluate sources of health information
· Explain and analyze the issue of conflict of interest in clinical research
It is difficult to be an informed consumer in today's world with all the sources of information that bombard us daily. The first two chapters of our text, Barrett,
Jarvis, Kroger and London (2007) review some of the major issues and list some
characteristics of an intelligent consumer. Test your consumer IQ and take the
consumer health profile on page 13. You may post your comments about these assessments on the discussion board.
The Scientific Method
In Chapter 2 there is a discussion about how to find reliable sources of health
information. The authors have rated some popular magazines and other periodicals.
Also in Chapter 2 there is an important discussion about the scientific method. This course is based on the assumption that the scientific method is valid. In the area of consumer health, services and products must be studied by following the scientific method in order to know if they are of any use. Health services and products must be subject to scientific scrutiny.
An understanding of the scientific method is crucial in so many ways. It helps us
separate fact from fiction. It can also give us an approach to problem solving and therefore, critical thinking. It helps us to ask questions about new treatments and products. It gives us a skeptical, or should I say, questioning view about what we are told. Knowing about the scientific method makes us want to see the proof before we accept a statement.
In epidemiology we learn about various ways to go about studying the relationship
between a factor (like cigarette smoking) and a disease (like lung cancer). When scientists begin to study a relationship like this they need to have a "wait and see" attitude about the findings. They need to go into the research with no bias or at least put aside that bias. When the cigarette companies funded the research they found no relationship between cigarettes and lung cancer. When the government began to fund the studies they found a very strong relationship. It is important to know where the funding is coming from in the various studies. The most reputable journals have a policy on conflict of interest stating that authors must disclose any
conflict of interest that might taint the study. That is also why articles are peer reviewed; so that other scientists can check their colleagues' work.
Conflict of Interest in Health Research
There has been a great deal of discussion about the effect of corporate funding of health research lately. The reason being that since the mid-70's government funding for health research declined and private funding increased. (Blumentha ...
The Fauci/COVID-19 Dossier
This work was supported, in part, by a fund-raising effort in which approximately 330 persons contributed funds in support
of the New Earth technology team and Urban Global Health Alliance. It is released under a Creative Commons license CCBY-NC-SA
IN THIS SUMMARY
The United States Food and Drug Administration (FDA) has significant reach in the American economy, ranging from medicines and medical devices to items on the grocery store shelves. Since its inception in 1906, the agency has faced a variety of technical and political challenges. Looking ahead, the FDA faces many new demands that could enlarge the agency’s already expansive mandate. New responsibilities may include the cost of medicine, consumers’ pursuit of perfection through drugs, consumer lifestyles, tobacco, and counterterrorism. As the nature of public health changes over time, it is inevitable that the FDA’s scope and responsibilities will change as well. In Inside the FDA, Fran Hawthorne explains the history of the FDA, how its processes work, and what the future may hold for this government agency.
SUBSCRIBE TODAY
http://www.bizsum.com/summaries/inside-fda
A white paper authored by Energy in Depth that lays bare the corruption of New York State's Dept. of Health in the cherry-picked anti-drilling-backed reports used to disparage fracking--a report that eventually led to a ban in the state. This report by EID exposes the fraud of the so-called science used by State Health Commissioner Howard Zucker.
Financial Disclosure –Duties and Strategies for Clinical StudiesMichael Swit
Financial disclosure requirements for clinical studies are explored with a particular emphasis on how the requirement for tracking "Significant Payments of Other Sorts" -- or SPOOS -- present challenges in clinical study compliance.
Network of corruption the cdc who and big pharmaKaye Beach
Unfortunately it is very profitable for the drug industry to get the medical profession to promote vaccines to the general population. Drug companies are corporations and they do not have a duty to "do no harm". Their only duty is to make money and "mitigate" any liability the company might be forced to deal with in a court of law. It is important the public doesn't forget this as it is very unlikely your physician or anyone who works for public health will remind you of this reality.
Here are the major signs of government and/or medical industry corruption:
1. Fraud and/or Misrepresentation
2. Conflict of interest
3. Bribery
4. Lack of transparency (concealment or deception)
Documents from the tobacco industry archives that highlight their strategies to address issues surrounding secondhand smoke or "environmental tobacco smoke" (ETS). These strategies include formation of scientific organizations and coalitions to disseminate research information and involvement in national ventilation standards and regulations surrounding indoor air quality.
Selected documents from the UCSF Truth Tobacco Industry Documents reveal tobacco companies collaboration with the US film industry to push smoking and promote tobacco brands.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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2. Title: Imagine the Possibilities Pain Coalition
Date: 2011 October
Collection: National Prescription Opiate Litigation
https://www.industrydocuments.ucsf.edu/drug/docs/ptff0232
Note: Document reflects a presentation at a
meeting between Janssen and the IPPC, a
coalition designed to raise awareness about
undertreated chronic pain by branding chronic
pain as a "public health problem." The
presentation contains evidence that children
as young as elementary school age were
targeted for inclusion within the pain
management campaign.
3. Title: Affidavit of William T Fannin, MD in Commonwealth of
Kentucky v Purdue Pharma
Date: 2014 July
Collection: Kentucky Opioid Litigation Documents
https://www.industrydocuments.ucsf.edu/drug/docs/qgdf0232
4. Title: re: Oxy 30
Author: Borelli, Victor; Covidien, Mallinckrodt Pharmaceutical
Date: 2009 January 27
Collection: Washington Post Opioid Collection
https://www.industrydocuments.ucsf.edu/drug/docs/khyc0230
Note: Document reflects an email exchange between
Mallinckrodt sales rep Victor Borelli and a KeySource
Medical distributor joking about widespread addiction to
Oxycontin.
5. Title: Tapentadol Team Status - Acute Pain Publications
Date: 2009 June 24
Collection: Oklahoma Opioid Litigation Documents
https://www.industrydocuments.ucsf.edu/drug/docs/jlgg0230
Note: Document contains a list of manuscripts regarding Tapentadol
(Nucynta) with possible authors and steps to publication. The document
suggests that the company was providing the outlines and drafts of articles
then seeking MD and PhD co-authors for the manuscripts, raising concerns
regarding ghost-writing.
6. Title: RE: Conference Call Availability
Author: Dart, Richard; Vorsanger, Gary J; Janssen Scientific
Affairs, LLC; Cicero, Theodore; Washington University
Date: 2012 February 11
Collection: Oklahoma Opioid Litigation Documents
https://www.industrydocuments.ucsf.edu/drug/docs/xhhg0230
Note: Document reflects emails between a healthcare
communications company and authors of a Janssen-funded
study that purported abuse rates of Tapentadol (Nucynta)
were lower than for other opioids.
7. Title: Insys Trial Transcript - Day 7 in US v Kapoor et al.
Author: United States District Court, District of Massachusetts
Date: 2019 January 29
Collection: Insys Litigation Documents
https://www.industrydocuments.ucsf.edu/drug/docs/pfgf0232
p.108
p.129
8. Title: KOL Categorization
Author: Thomas, Heather
Date: 2002 February 18
Collection: Oklahoma Opioid Litigation Documents
https://www.industrydocuments.ucsf.edu/drug/docs/lhgg0230
Notes: Email to Janssen Pharmaceuticals employees
describing the company's approach to ‘Key Opinion Leaders’
and the categorization of physicians as "Opponents",
"Neutrals", or "Advocates" for its Duragesic product.
9. Title: Product Pipeline and Strategy - Very Confidential
Author: Friedman, Michael
Date: 1994 December 29
Collection: Kentucky Opioid Litigation Documents
https://www.industrydocuments.ucsf.edu/drug/docs/fqcf0232
10. Title: 2006 Objectives for External Affairs Group
Author: Purdue Pharma
Date: 2018 December 20
Collection: Oklahoma Opioid Litigation Documents
https://www.industrydocuments.ucsf.edu/drug/docs/pxgg0230
11. Title: 2006 Objectives for External Affairs Group
Author: Purdue Pharma
Collection: Oklahoma Opioid Litigation Documents
https://www.industrydocuments.ucsf.edu/drug/docs/pxgg0230
12. Title: The Epidemic of Pain in America
Author: The American Pain Foundation; Rogers, Mike
Date: 2006 June 13
Collection: Oklahoma Opioid Litigation Documents
https://www.industrydocuments.ucsf.edu/drug/docs/yqgg0230
*A collection of news articles used to brief Congress during a 2006
hearing to raise awareness about an "epidemic" of undertreated
chronic pain in America.
Compiled by the Pain Care Forum, a group of executives from
major pain advocacy groups and pharmaceutical companies, the
materials highlight populations of particular interest to the pain care
industry, including women, veterans, and individuals residing in
minority and low-income communities.
13. Title: Teva payments to Advocacy Groups
Author: Teva Pharmaceuticals
Date: 2017
Collection: Oklahoma Opioid Litigation Documents
https://www.industrydocuments.ucsf.edu/drug/docs/zrgg0230