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Skin/eye decontamination
   Past and Present



                      Eileen Segal
                      Segal Consults
                      Easton, PA 18045
                      ebsegal@aol.com
Past


 Present


Case Study
Past

• History of organized first aid goes back 120 years

• Training in first aid began in 1903

• Clara Bow, President of the American Red Cross
Exception to the rule

In 1998

“First aid for a unique acid: HF”

Limit flush to 5 minutes
Past

• K.I.S.S.

Keep It Simple and
Straightforward
Past

Many treatments recommended in the past are
 simply based on practical experience and the
 consensus of experts.
Present

In 2000 the American Heart Association in
  collaboration with the International Liaison
  Committee on Resuscitation began the first
  step to evaluate guidelines in first aid.
NFASAB

In 2004, the American Heart Association and the
  American Red Cross co-founded the

National First Aid Science Advisory Board

(NFASAB) to review and evaluate the scientific
  literature on first aid to develop “evidence-
  based medicine”.
Evidenced-Based Medicine


   A movement to apply the scientific
   method to the practice of medicine,
   especially to long-established practices
   that never have been subjected to
   adequate scientific study
NFASAB Organizations


•   American Academy of               •   Australian Resuscitation Council
    Orthopaedic Surgeons              •   Canadian Red Cross
•   American Academy of Pediatrics    •   International Association of Fire
•   American Association of Poison        Chiefs
    Control Centers                   •   International Association of Fire
•   American Burn Association             Fighters
•   American College of Emergency     •   Medic First Aid International
    Physicians                        •   Military Training Network
•   American College of               •   National Association of EMS
    Occupational and Environmental        Educators
    Medicine                          •   National Association EMS
•   American College of Surgeons          Physicians
•   American Heart Association        •   National Association of EMTs
•   The American Pediatric Surgical   •   National Safety Council
    Association                       •   Occupational Safety and Health
•   American Red Cross                    Administration
•   American Safety and Health        •   Save a Life Foundation
    Institute
•   Army Medical Command
Goals of NFASAB

Goals are to analyze the scientific data and answer the
  following questions:

• 1. What are the most common emergency conditions
  that lead to significant morbidity and mortality?

• 2. In which of these emergency conditions can
  morbidity or mortality be reduced by the intervention
  of a first-aid provider?

• 3. How strong is the scientific evidence that
  interventions performed by a first-aid provider are
  safe, effective, and feasible?
NFASAB

• NFASAB considered a wide range of
  emergencies, e.g.

• Allergic reactions, contusions, fractures, how to
  position a victim, oxygen delivery, seizures, severe
  bleeding, snake bites, spinal injuries, sprains, etc.,
  as well as chemical and thermal burns.
An example

• Emergency treatment of poisoning:

• Syrup of ipecac

NFASAB new guidelines state:
Do NOT give water, milk, or syrup of ipecac to
 someone who has ingested poison.
Important References


• (1) A special supplement to Circulation [Dec. 12, 2005]
  Part 14: First Aid, 2005, 112, IV-196—IV-203, freely available at
http://www.circulationaha.org
or

http://www.redcross.org/static/file_cont4913_lang0_1727.pdf


(2) The Canadian Centre for Occupational Health and Safety, “The
   MSDS—A Practical Guide for First Aid.” CCOHS encourages the
   widest possible distribution. Call 1-800-668-4284 or visit
http://www.ccohs.ca/products/publications/firstaid/
NFASAB statement for chemical burns

In their review of the science behind first-aid
  practices, the American Heart Association
  advises flushing chemical burns with large
  amounts of cool running water and to continue
  flushing until EMS personnel arrive.
N.B.

• This recommendation does not address the
  question of how long flushing should continue.

• However, it makes sense to tailor the duration
  of flushing to the known effects of the
  chemical or product.
○Adequate irrigation is difficult to define and
depends on the amount of exposure and the
agent involved.

○The first priority in treatment is to ensure
complete removal of the offending agent.
New Guidelines

• Flushing should start immediately following skin or
  eye contact with a chemical.

• Longer flushing is required for corrosive chemicals:
     60 min for strong alkalies
     30 min for other corrosives

• A moderate or severe irritant requires 15-20 min.

• A mild irritant needs only 5 min.
Some considerations

• Using litmus paper to measure the pH of
  the affected area or the irrigating solution is
  helpful.

• Tap water is adequate for irrigation.

• Low-pressure irrigation is desired; high
  pressure may exacerbate the tissue injury.

• It is preferable that complete
  decontamination of the skin and eyes occur
  on site.
More considerations

• Each emergency is unique.

• First-aid provider must be trained.

• It is important to know the physical and reactivity
  properties of the chemicals involved.

• The MSDS is only a starting point for developing a
  work-site first-aid program.
Physical Properties


• Is the chemical involved a solid, liquid, or gas?
   This information helps determine which exposure routes
  and first-aid measures are relevant for a particular
  substance. E.g., first aid for a solid particle in the eye
  may not be the same as for a liquid in the eye.

• Is the involved chemical soluble in water?
   Substances that are not water soluble should be quickly
  blotted or brushed from the skin before flushing with
  water.
Reactivity Data


• Does the substance react with water to produce heat
  or a more toxic substance?
   This information allows modification of the
  recommendation to reduce contact of the chemical
  with water by quickly blotting or brushing the chemical
  away, prior to flushing.

• Is the substance an oxidizer?
    Oxidizers create a fire hazard. Care must be taken
  with contaminated clothing.

Knowledge of the properties of chemicals involved
  determines the first-aid intervention.
MSDSs

• The MSDS should not exclusively describe first- aid
  recommendations written for the "worst case"
  exposure imaginable.

• Usually, first aid is given for mild to moderate
  exposures. If the MSDS places too much emphasis
  on extreme exposures, which rarely occur, the first-aid
  procedures will be overstated.

• Inappropriate first aid could further harm the victim.
Because of their properties, the following
chemicals need special consideration.

• Hydrofluoric Acid*
  Because HF can penetrate tissues deeply and can
  cause fatal systemic toxicity even in small burns,
  exposures need special attention.
• Flushing with water should be limited to no more
  than 5 min. Then treatment with benzalkonium
  chloride or calcium gluconate gel should begin.
• For eye contact: Immediately flush the contaminated
  eye(s) with lukewarm, gently flowing water for 15-20
  min., while holding the eyelid(s) open. Do NOT use
  benzalkonium chloride (Zephiran®) for eye contact.
• *Details can be found in the updated “Recommended Medical
  Treatment for Hydrofluoric Acid Exposure.”
Phenol

• Phenol is not water-soluble and is difficult to remove
  with water alone. Dilution of phenol with water may
  enhance skin absorption .

• If available, immediately and repeatedly wipe the
  affected area with a 50% water solution of PEG 300
  or PEG 400 (polyethylene glycol of average molecular
  weight 300 or 400). If PEG is not available, quickly
  blot or brush away excess chemical. Then flush
  affected area with lukewarm water at a high flow rate
  for at least 30 min. Quickly transport victim to an
  emergency care facility.
Sodium and Potassium

• These metals can ignite spontaneously on contact
  with moisture and react with water to form very
  corrosive sodium and potassium hydroxides.

•   Do NOT flush with water. Use forceps to carefully remove any
    metal fragments embedded in the skin and submerse them in
    mineral oil. If all particles cannot be removed, cover affected
    area with nontoxic mineral oil or cooking oil (Na) / tert-butyl
    alcohol (K) and transport victim to an emergency care facility. If
    all particles have been removed, flush the affected area with
    lukewarm, gently flowing water for at least 30 min. Then,
    immediately transport victim to an emergency care facility
White Phosphorus

• White phosphorus is spontaneously oxidized in air to
  P2O5 which reacts violently with water to evolve heat.

• Keep the area immersed in water and manually
  remove any P particles seen.
Are other flushing solutions effective?

Four eye-irrigating solutions were evaluated for comfort
  as flushing solutions:
• normal saline
• lactated Ringer’s
• normal saline with bicarbonate, and
• Balanced Saline Solution Plus

• Diphoterine

• Neutralizing agents
Neutralization

• Neutralization of a chemical on the skin seems logical;
• e.g., treat an acid with a base or a base with an acid.
  There are, however, consequences which could increase
  the injury:

• a delay in flushing while first-aid personnel search for
  neutralizing agents

• thermal burns from the heat of reaction of the chemicals
  involved

• further injury due to contact with the neutralizing agent
Evidence-based medicine

• The conclusion is that there is no clear benefit in
  using neutralizing agents instead of water following
  exposure to acids or bases.
An Admonition

• Delays of even seconds can dramatically affect the
  outcome following contact with a corrosive chemical.
  There is no justification for waiting for another solution
  if water is the first available agent.
Help is available

• Decision trees: decision-making processes presented
  in flowcharts, one for each route of exposure.

• Use of the decision trees allows a step-by-step
  determination or evaluation of first-aid
  recommendations for a specific product.

• A worksheet is provided to gather the information
  required for making first-aid decisions.
Decision Tree
NFASAB Statement

• NFASAB strongly believes that education in
  first aid should be universal; everyone can
  and should learn first aid.
Next Step


• Every major national and international training
  organization is in the process of developing evidence-
  based training materials to reflect the new treatment
  recommendations.

• Training material revision, publication, and rollout are
  expected to continue to the end of the year.
Conclusion


Very little research on first aid for chemical exposure is
  being done

Thus, there is a lack of evidence-based medicine on
  skin/eye first aid

Extrapolations by health professionals are being made

More research must be undertaken
Conclusion

• However, what we do learn as scientific fact should
  be accepted.

• Life would be much simpler if the K.I.S.S. principle
  were in effect,

• Our world is not simple

• NFASAB strongly believes that education in first aid
  should be universal; everyone can and should learn
  first aid.
•

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Segal

  • 1. Skin/eye decontamination Past and Present Eileen Segal Segal Consults Easton, PA 18045 ebsegal@aol.com
  • 3. Past • History of organized first aid goes back 120 years • Training in first aid began in 1903 • Clara Bow, President of the American Red Cross
  • 4. Exception to the rule In 1998 “First aid for a unique acid: HF” Limit flush to 5 minutes
  • 5. Past • K.I.S.S. Keep It Simple and Straightforward
  • 6. Past Many treatments recommended in the past are simply based on practical experience and the consensus of experts.
  • 7. Present In 2000 the American Heart Association in collaboration with the International Liaison Committee on Resuscitation began the first step to evaluate guidelines in first aid.
  • 8. NFASAB In 2004, the American Heart Association and the American Red Cross co-founded the National First Aid Science Advisory Board (NFASAB) to review and evaluate the scientific literature on first aid to develop “evidence- based medicine”.
  • 9. Evidenced-Based Medicine A movement to apply the scientific method to the practice of medicine, especially to long-established practices that never have been subjected to adequate scientific study
  • 10. NFASAB Organizations • American Academy of • Australian Resuscitation Council Orthopaedic Surgeons • Canadian Red Cross • American Academy of Pediatrics • International Association of Fire • American Association of Poison Chiefs Control Centers • International Association of Fire • American Burn Association Fighters • American College of Emergency • Medic First Aid International Physicians • Military Training Network • American College of • National Association of EMS Occupational and Environmental Educators Medicine • National Association EMS • American College of Surgeons Physicians • American Heart Association • National Association of EMTs • The American Pediatric Surgical • National Safety Council Association • Occupational Safety and Health • American Red Cross Administration • American Safety and Health • Save a Life Foundation Institute • Army Medical Command
  • 11. Goals of NFASAB Goals are to analyze the scientific data and answer the following questions: • 1. What are the most common emergency conditions that lead to significant morbidity and mortality? • 2. In which of these emergency conditions can morbidity or mortality be reduced by the intervention of a first-aid provider? • 3. How strong is the scientific evidence that interventions performed by a first-aid provider are safe, effective, and feasible?
  • 12. NFASAB • NFASAB considered a wide range of emergencies, e.g. • Allergic reactions, contusions, fractures, how to position a victim, oxygen delivery, seizures, severe bleeding, snake bites, spinal injuries, sprains, etc., as well as chemical and thermal burns.
  • 13. An example • Emergency treatment of poisoning: • Syrup of ipecac NFASAB new guidelines state: Do NOT give water, milk, or syrup of ipecac to someone who has ingested poison.
  • 14. Important References • (1) A special supplement to Circulation [Dec. 12, 2005] Part 14: First Aid, 2005, 112, IV-196—IV-203, freely available at http://www.circulationaha.org or http://www.redcross.org/static/file_cont4913_lang0_1727.pdf (2) The Canadian Centre for Occupational Health and Safety, “The MSDS—A Practical Guide for First Aid.” CCOHS encourages the widest possible distribution. Call 1-800-668-4284 or visit http://www.ccohs.ca/products/publications/firstaid/
  • 15. NFASAB statement for chemical burns In their review of the science behind first-aid practices, the American Heart Association advises flushing chemical burns with large amounts of cool running water and to continue flushing until EMS personnel arrive.
  • 16. N.B. • This recommendation does not address the question of how long flushing should continue. • However, it makes sense to tailor the duration of flushing to the known effects of the chemical or product.
  • 17. ○Adequate irrigation is difficult to define and depends on the amount of exposure and the agent involved. ○The first priority in treatment is to ensure complete removal of the offending agent.
  • 18. New Guidelines • Flushing should start immediately following skin or eye contact with a chemical. • Longer flushing is required for corrosive chemicals: 60 min for strong alkalies 30 min for other corrosives • A moderate or severe irritant requires 15-20 min. • A mild irritant needs only 5 min.
  • 19. Some considerations • Using litmus paper to measure the pH of the affected area or the irrigating solution is helpful. • Tap water is adequate for irrigation. • Low-pressure irrigation is desired; high pressure may exacerbate the tissue injury. • It is preferable that complete decontamination of the skin and eyes occur on site.
  • 20. More considerations • Each emergency is unique. • First-aid provider must be trained. • It is important to know the physical and reactivity properties of the chemicals involved. • The MSDS is only a starting point for developing a work-site first-aid program.
  • 21. Physical Properties • Is the chemical involved a solid, liquid, or gas? This information helps determine which exposure routes and first-aid measures are relevant for a particular substance. E.g., first aid for a solid particle in the eye may not be the same as for a liquid in the eye. • Is the involved chemical soluble in water? Substances that are not water soluble should be quickly blotted or brushed from the skin before flushing with water.
  • 22. Reactivity Data • Does the substance react with water to produce heat or a more toxic substance? This information allows modification of the recommendation to reduce contact of the chemical with water by quickly blotting or brushing the chemical away, prior to flushing. • Is the substance an oxidizer? Oxidizers create a fire hazard. Care must be taken with contaminated clothing. Knowledge of the properties of chemicals involved determines the first-aid intervention.
  • 23. MSDSs • The MSDS should not exclusively describe first- aid recommendations written for the "worst case" exposure imaginable. • Usually, first aid is given for mild to moderate exposures. If the MSDS places too much emphasis on extreme exposures, which rarely occur, the first-aid procedures will be overstated. • Inappropriate first aid could further harm the victim.
  • 24. Because of their properties, the following chemicals need special consideration. • Hydrofluoric Acid* Because HF can penetrate tissues deeply and can cause fatal systemic toxicity even in small burns, exposures need special attention. • Flushing with water should be limited to no more than 5 min. Then treatment with benzalkonium chloride or calcium gluconate gel should begin. • For eye contact: Immediately flush the contaminated eye(s) with lukewarm, gently flowing water for 15-20 min., while holding the eyelid(s) open. Do NOT use benzalkonium chloride (Zephiran®) for eye contact. • *Details can be found in the updated “Recommended Medical Treatment for Hydrofluoric Acid Exposure.”
  • 25. Phenol • Phenol is not water-soluble and is difficult to remove with water alone. Dilution of phenol with water may enhance skin absorption . • If available, immediately and repeatedly wipe the affected area with a 50% water solution of PEG 300 or PEG 400 (polyethylene glycol of average molecular weight 300 or 400). If PEG is not available, quickly blot or brush away excess chemical. Then flush affected area with lukewarm water at a high flow rate for at least 30 min. Quickly transport victim to an emergency care facility.
  • 26. Sodium and Potassium • These metals can ignite spontaneously on contact with moisture and react with water to form very corrosive sodium and potassium hydroxides. • Do NOT flush with water. Use forceps to carefully remove any metal fragments embedded in the skin and submerse them in mineral oil. If all particles cannot be removed, cover affected area with nontoxic mineral oil or cooking oil (Na) / tert-butyl alcohol (K) and transport victim to an emergency care facility. If all particles have been removed, flush the affected area with lukewarm, gently flowing water for at least 30 min. Then, immediately transport victim to an emergency care facility
  • 27. White Phosphorus • White phosphorus is spontaneously oxidized in air to P2O5 which reacts violently with water to evolve heat. • Keep the area immersed in water and manually remove any P particles seen.
  • 28. Are other flushing solutions effective? Four eye-irrigating solutions were evaluated for comfort as flushing solutions: • normal saline • lactated Ringer’s • normal saline with bicarbonate, and • Balanced Saline Solution Plus • Diphoterine • Neutralizing agents
  • 29. Neutralization • Neutralization of a chemical on the skin seems logical; • e.g., treat an acid with a base or a base with an acid. There are, however, consequences which could increase the injury: • a delay in flushing while first-aid personnel search for neutralizing agents • thermal burns from the heat of reaction of the chemicals involved • further injury due to contact with the neutralizing agent
  • 30. Evidence-based medicine • The conclusion is that there is no clear benefit in using neutralizing agents instead of water following exposure to acids or bases.
  • 31. An Admonition • Delays of even seconds can dramatically affect the outcome following contact with a corrosive chemical. There is no justification for waiting for another solution if water is the first available agent.
  • 32. Help is available • Decision trees: decision-making processes presented in flowcharts, one for each route of exposure. • Use of the decision trees allows a step-by-step determination or evaluation of first-aid recommendations for a specific product. • A worksheet is provided to gather the information required for making first-aid decisions.
  • 34. NFASAB Statement • NFASAB strongly believes that education in first aid should be universal; everyone can and should learn first aid.
  • 35. Next Step • Every major national and international training organization is in the process of developing evidence- based training materials to reflect the new treatment recommendations. • Training material revision, publication, and rollout are expected to continue to the end of the year.
  • 36. Conclusion Very little research on first aid for chemical exposure is being done Thus, there is a lack of evidence-based medicine on skin/eye first aid Extrapolations by health professionals are being made More research must be undertaken
  • 37. Conclusion • However, what we do learn as scientific fact should be accepted. • Life would be much simpler if the K.I.S.S. principle were in effect, • Our world is not simple • NFASAB strongly believes that education in first aid should be universal; everyone can and should learn first aid.
  • 38.