Sean Seshadri discusses managing trades in a volatile environment. He states that entering trades with minimal drawdown to avoid stop losses is key to long term success. Developing patience through appropriate position sizing for one's account is important. For a $25,000 account, risking no more than 1% or $250 per trade is common, as one would need to lose 100 trades to lose the full account. However, risk can be decreased by lowering position sizes to $100 or less to feel more comfortable trading without emotion. Adjusting position sizes allows for better trade management during volatility.