This document describes a new model for policy change through academic, civic, and community partnerships in San Francisco. The model brings together community groups, civic organizations, and academic experts from UCSF to improve health and reduce health disparities. Key partners include community coalitions, organizations, residents, UCSF institutes and programs, and city departments. The goal is to use academic research and expertise to help community and civic partners design scalable interventions that make a measurable impact on community health. Initial focus areas chosen are alcohol policy, children's oral health, hepatitis B quality improvement, and physical activity and nutrition.