SBW is a Finnish-Indian research and services corporation with expertise in drug discovery, functional foods, and chemical safety industries. It provides contract research services for pharmaceutical and biotech customers across discovery, preclinical, and clinical trial phases. SBW has over 600 projects for 120+ customers in over 20 countries, with offices and laboratories in Finland, Sweden, UK, and India. It offers a range of business models including fee-for-service, risk sharing, outsourcing, and joint R&D collaboration.

1. SBW
Discovering
Success
Cascading
service
models
with
SBW
-­‐
a
Finnish-­‐Indian
research-­‐service
corpora<on
with
comprehensive
exper<se
in
drug-­‐discovery,
func<onal
foods
and
chemical
safety
industries

2. SBW in a nutshell
• Contract Research Services for Pharmaceutical and Biotech customers
• Headquarter in Helsinki, Finland, offices / laboratories in total 7 cities in
Finland, Sweden, UK and India
• Discovery informatics: bioinformatics, chemoinformatics, structural / SBD
informatics
• Discovery biology; biomarker analytics and discovery
• Early and preclinical toxicology
• In vivo pharmacology
• ADME / DMPK
• Biostatistics, clinical data management and data warehousing
• 140+ pharma/biotech customers in more than 20 countries. Organic
revenue increase 2007-2008 around 50%. More than 60 professionals.
• Owned by Helsinki University Funds and Tooltech Pvt Ltd (Indian CAD/CAM
and engineering simulations, offices in 7 European countries, India and US)

3. SBW Solutions for Drug Research
Regulatory/
Indica'on
Target
Screen
Hit
Lead
Candidate
IND
Phase
0
Phase
1
Phase
2
Phase
3
SBW-­‐α
SBW-­‐η
SBW-­‐β
SBW-­‐ε
SBW-­‐γ
SBW-­‐δ
SBW-­‐α
SBW-­‐γ
SBW-­‐δ
SBW-­‐η
• Whole
genome
transcriptomics
and
• In
silico
bioac'vity,
adverse
effect
• In
vitro
metabolism
• Sample
size
es'ma'ons
and
power
gemomics
and
toxicity
predic'on
• CYP
iden'fica'on
and
inhibi'on
analysis
• Proteomics
• Scaffold
hopping
and
op'miza'on
• M etabolite
iden'fica'on,
MIST,
• Randomiza'on
• Biomarker
discovery
and
valida'on
• Experimental
logP,
logD,
logS,
pKa
different
species
• CRF
design
• Genome-­‐wide
bioinforma'cs
and
analysis
• PAMPA,
Caco-­‐2,
MDCK
permeability
• Database
design,
data
entry
and
computa'onal
systems
biology
• Plasma
protein
binding
• In
vitro
cytotoxicity,
prolifera'on,
valida'on
• PAMPA
permeability
membrane
integrity
• Sta's'cal
analysis
and
repor'ng
• Metabolic
stability
• In
vivo
pharmacokine'cs
• Medical
wri'ng
• In
vivo
disease
models
• Safety
pharmacology
• In
vivo
toxicology
SBW-­‐β
SBW-­‐ε
• Virtual
HTS,
ligand,
target,
and
• GLP
in
vivo
toxicity
reverse
docking
• GLP
in
vivo
safety,
ICH
Core
Ba^ery
•
Library
design
etc
• In
silico
ADME
models
• In
vitro
assay
development

4. What suites you best?
Fee
for
service
Risk
sharing
model
Consulta've
model
Collabora've
model
Protocol
based
Milestone
based
Your
preference
Price
/
study
Fixed
price
/
project
Based
on
your
need
Personal
customer
care

5. Levels Of Engagement
Close co-work, possibly in-site, Level 4
possibly external funding applied, Complete Drug Discovery / Development project
involving risk-sharing partnership
SBW involvement in focused
areas of discovery, like LI, LO
etc. Involvement of multiple
Level 3
Managed project involving many types of expertise in
units from SBW, sharing of
combination with sponsor’s expertise
related project data
Master agreement with
SBW, confidentiality and
Level 2
Utilization and coordination of services from multiple
expertise from multiple units
units
Level 1 Master agreement for
Repeated utilization of services from individial unit repeated services
Level 0 Individual service(s), NDA &
Outsourcing of individual analytics - internal capactiy agreement with the
extension and internally unavailable tasks corresponding unit

6. Discovering Success together
with SBW
• Program Management Services
– We act as your tactical, logistical and scientific interface with our
drug discovery resources.
– Diverse scientific expertise from Discovery Biology to Preclinical and
Clinical Development.
• Business Models
- We aim to form strategic alliances with our customers, where
entire drug discovery programs are contracted and payment is
based on mutually agreed milestones and success.
• BPO – Business Process Outsourcing
• Joint development
• Academic collaboration
• Indian delivery capabilities
• Risk and Reward sharing models
• EU, Government and competitive funding

7. SBW Organization
SBW
HQ
Helsinki,
Finland
Toxis
Novamass
4Pharma
Biodix
Medachem
Infodix
Finland
Finland
Finland
India
India
India
In
vivo
animal
ADME
Clinical
trials
Discovery
Medicinal
Bioinforma'cs
models
analy'cs
data
biology
and
chemistry
chemoinforma
management
‘omics
'cs
SBW
Finland
SBW
India
SBW
Sweden
SBW
Switzerland

8. Benefits of working with
• Easy access to world-class complimentary research skills SBW
• Access to state of the art infrastructure at a fraction of the price
• Cost efficient Indian delivery capabilities and Nordic work ethics
• More than 600 projects delivered to over 120 customers
• A large service platform for drug discovery & development
• With parallel offering of in silico and in vitro/in vivo based services
• Fixed deliverables, duration and investment
Beginning

9. Joint R & D Collaboration
It is a New
business
concept for collaborating on early
discovery projects, where the parties together share the
ownership, risk and potential reward of the project.
The project is divided into smaller engagements with specific
milestones. The parties agree jointly on the activities, efforts
and duration of each engagement within the project.
SBW will carry portion of the risk by utilising:
Our Mixed-Model delivery capabilities
Where we offer our Indian resources at cost basis
Finnish project management and study directors
Pre-determined deliverables and milestones
Low cost and fast delivery for each engagement

10. Milestone Baseline price estimates
FTE
MSc
/
MONTH
OFFSITE
(India)
700
eur
FTE
PhD
/
MONTH
OFFSITE
(India)
1500
eur
In
silico
tox,
ADME
and
bioac'vity
predic'on
20
eur
Omics
data
analysis
(microarray,
proteomics)
65
eur
In
vitro
Cytotoxicity
(LDH
&
MTT)
20
eur
Maximum
tolerated
dose
in
rat
3000
eur
MALDI-­‐TOF/TOF
(Bruker
Ultraflex)
90
eur
NMRs
(300
MHz
and
400
MHz
Bruker
DPX)
/
hour
20
eur
FTIR
with
IR
microscope
(Perkin-­‐Elmer)
/
1st
scan
20
eur
500
MHz
LC-­‐NMR
request
UHR-­‐Qq-­‐TOF
(Bruker
MaXis)
request
LC-­‐MS/MS
LTQ
XL
Linear
Ion-­‐trap
(Thermo)
request
LC-­‐MS
APCI/ESI
Probe
(Finnigan
Mat)
request
GC
with
capillary
column
headspace
(Shimadzu)
request

11. What can we do for you
• World-­‐class
CRO
services
with
experience
and
excellent
instrumenta'on
• Deliver
Europe
and
India
• Broad
service
plaporm
from
early
discovery
to
marke'ng
authoriza'on.
We
have
been
involved
in
projects
from
target
iden'fica'on
to
successful
drug
registra'on.
• More
than
600
projects
delivered
to
over
120
customers
in
over
20
countries.
Including
companies
form
small
virtual
biotechs
to
global
big
pharma
• Bundled
Services
and
Plaporms
with
overall
project
management
• Business
process
outsourcing
possibility
• Joint
R&D
collabora'on
with
industry
and
academia
• Pay
per
service,
FTE,
milestone
based
and
risk-­‐reward
sharing
business
models

12. SBW Sponsors and
partners
Over 120 pharma and biotech customers in 20 countries