Focused Chemical/Microbiological technician highly effective at following USP methods and GMP practices with pharmaceutical and medical device experience.
Chemist accomplished in GC, HPLC, analytical and assay methods used on raw material and finished products to assure the quality and purity of products. Certified in Clinical Trials and Drug Development and worked side by side a chemical formulator R&D chemist for 3 years. Coordinated process validation procedures, stability program, chemical waste management system, calibration program, laboratory set up, ordering and SOP procedural writing.
Versed Microbiological surface and air quality testing, process validation, microbiological identification, trending, tracking, gram staining techniques and microbiological morphology. Certified in Pharmaceutical Microbiology.
BOC Sciences Updated Its Product Catalog of Pharmaceutical Impurity Reference...BOC Sciences
BOC Sciences recently updated its product list of pharmaceutical impurity reference standards to better serve pharmaceutical companies, scientific research units, testing institutions and universities. Visit https://www.bocsci.com/products/impurities-8.html for more information.
Cell & Gene Therapy enterprise development solutions to reduce scientific, regulatory and commercial risks, and accelerate development wherever you are in your product's development.
Boolean Search Fundamentals For Recruiters - GuideProminence
This printable guide was produced to complement the deskside cheat sheets. The guide goes into far more detail on Boolean Logic, including several real life examples.
BOC Sciences Updated Its Product Catalog of Pharmaceutical Impurity Reference...BOC Sciences
BOC Sciences recently updated its product list of pharmaceutical impurity reference standards to better serve pharmaceutical companies, scientific research units, testing institutions and universities. Visit https://www.bocsci.com/products/impurities-8.html for more information.
Cell & Gene Therapy enterprise development solutions to reduce scientific, regulatory and commercial risks, and accelerate development wherever you are in your product's development.
Boolean Search Fundamentals For Recruiters - GuideProminence
This printable guide was produced to complement the deskside cheat sheets. The guide goes into far more detail on Boolean Logic, including several real life examples.
Become a Ninja Recruiter: Advanced Boolean Search | Talent Connect London 2014LinkedIn Talent Solutions
Learn from Glen Cathey, author of the Boolean Black Belt blog, to extract maximum value from LinkedIn's massive professional network. Learn human capital data retrieval concepts and best practices, expose hidden talent pools within LinkedIn, and explore the five levels of LinkedIn Talent Mining.
Continue your talent acquisition transformation at Talent Connect 365: http://linkd.in/1z8YEaf
Position Summary:
Responsible for developing, implementing and managing systems to mitigate the risk of experiencing unacceptable levels of bioburden in products. This includes establishing best practices, process controls and environmental monitoring programs that reduce the potential for microbial product contamination. Also responsible for training manufacturing associates on aseptic technique and monitoring and coaching production associates at their work stations.
Key Responsibilities:
•Microbial sampling, identification & bioburden mapping of production facilities.
•Bioburden challenge studies for existing and new product formulations.
•Bioburden risk assessment and validation for new product development process.
•Aseptic process development and process control.
•Environmental and water monitoring of Rockford and Wisconsin sites.
•Interpret test results and initiate corrective actions as needed.
•Assist with equipment and process cleaning validations.
•Clean room management inclusive of mentoring and supervising 23 clean room associates.
•Microbial test-method development as per USP test method suitability.
•Contamination investigations & implementation of corrective actions.
•Prepare reports and present data with conclusions.
•Maintain microbiology laboratory equipment and supplies.
Also efficiently performed Preservative Efficacy Challenge Tests, Environmental monitoring, LAL Endotoxin testing (Kinetic & Gel Clot methods), Microbial Ingress Integrity Testing (both Dye Penetration & Bacterial Challenge testing), Microbial Identification using Biolog, Mycoplasma testing of products using Luminometer, Bioburden & Water testing.
A detail-oriented, sincere and hardworking individual with a Master of Science and Over Fourteen years of GLP/GMP work experience
Expert in Audit trails review in Empower, Lab solutions, Tiamo and other softwares.
Experience in theoretical and practical knowledge in calibration, preventive maintenance, troubleshooting and problem solving of critical equipment like HPLC, GC, Auto Titrator,DR and UV-Spectrophotometer etc.
I am in quest of senior level assignments as Functional Lead - Quality Control/ Quality Assurance with an organization of repute in Denmark or nearby Schengen countries.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
1. Sarah Knopp
1007 GoldenGrove Ln. Florence,KY41042 (859)-445-1391 Knopps6980@hotmail.com
Summary
Focused Chemical/Microbiological technician highly effective at following USP methods and GMP
practices with pharmaceutical and medical device experience.
Chemist accomplished in GC, HPLC, analytical and assay methods used on raw material and finished
products to assure the quality and purity of products. Certified in Clinical Trials and Drug Development
and worked side by side a chemical formulator R&D chemist for 3 years. Coordinated process validation
procedures, stability program, chemical waste management system, calibration program, laboratory set
up, ordering and SOP procedural writing.
Versed Microbiological surface and air quality testing, process validation, microbiological identification,
trending, tracking, gram staining techniques and microbiological morphology. Certified in Pharmaceutical
Microbiology.
Enthusiastic scientist eager to pursue career in this industry.
Highlights
HPLC/GC Stability
Pharmaceutical Microbiology Microbiological matrix
cGMP, FDA, EPA/FIFRA, FEMA, CFR Raw material/finished products
Air quality/surface micro testing
LIMS Laboratory Information Management System
experience
Validations
AS400 and Application Extender management
systems experience
Wet, satellite, and bench chemistry experience QC/QA & Regulatory experience
Experience
Wild Flavors / ADM – Erlanger,KY. October 2015 – Current
Regulatory Specialist, Scientific and Regulatory Affairs
Timely managementand completion ofaccurate Regulatorydocumentation to supportWILD customer’s
products entering the marketplace.Review for country regulations and countrycompliancyas necessary.
RepresentRegulatoryin cross-functional Teams and communication with managementto maintain legal
compliance and integrityfor WILD.
Maintain and update internal formulation data (including raw materials and formulations).
Develop and align processes to supportISOstandards throughoutall WILD facilities. Duties and
Responsibilities:
Database maintenance oftechnical data for products manufactured and sold byWILD.
Act as an information resource for both internal and external customers to include education and guidance
to affected departments regarding various regulatorytopics.
Currentuse of AS400 and Application Extender information managementsystems.
Ability to read productspecification sheets including:pH,GC, HPLC, viscosity, Flash point,and other
laboratory analysis data.
KAO Brands – Cincinnati,OH. September 2015 – October 2015
R&D Laboratory Technician
Bench chemical testing on finished skincare products
Submitfinished products for microbiological testing,odor panel and clinical trial testing
Submit,test, maintain stabilitysamples
Viscosity, filling,titration, pH, documentcontrol,record keeping,calibrating
Homeschool Parent – Florence,KY. January 2012 – September 2015
Teacher
Successfullyteaching athome using BrightlyBeaming curriculum
Large focus on science
Teaching several children from ages 6mo - 12yrs
Excellent organization,networking,and communication skills
Expert patience
2. Sarah Knopp
1007 GoldenGrove Ln. Florence,KY41042 (859)-445-1391 Knopps6980@hotmail.com
BestSanitizers Inc. – Walton, KY. May 2012 – January 2012
Biological Designee
Serve as microbiological contact
Surface testing swab,contactplate, autoclave, neutralizing diluents,agars,aseptic technique
Environmental sampling techniques,Stock solutions,buffers,broths,recovery & selective medias,agars,
gram stain,quantitating growth,
Airborne Monitoring/microbial contamination;Sampling sites,frequency,sampling plans,alert/action limits
sampling procedures
Data analysis
Microbiological Water Quality
BestSanitizers Inc. – Walton, KY. November 2009 – May 2012
Analytical Chemist
cGMP, FDA, EPA/FIFRA experienced
HPLC on raw materials and finished products
GC on raw materials and finished products
Titrations,pH, specific gravity, flame test, clean room technology, panel odor,dilutions, calibration and
maintenance
Ordering of laboratory supplies
Chemical waste managementofexpired materials
SOP and technical writing
Stability, Calibrations,Validations
P&G (Contractor) - Cincinnati,OH. January 2004 – December 2006
Laboratory Technician
Satellite Laboratory analysis – FemCare Ananytical Dept.
Prepare samples and preform analysis as defined bythe client.
Structural proteins
Record keeping
Solution preparation and experimentation
Qualify and manage new methods
Troubleshoot,operate,and maintenance ofinstrumentation
Extensive use of LIMS information managementsystem
Education
Bachelor of Arts/Sciences – Liberal Arts & Sciences,Northern Kentucky University, 2008
Minors: Psychology, Political Science,Human Resources/Mental Health,Sociology
Areas of focus:Biology I & II, Biology I & II Lab., ChemistryI & II, ChemistryI and II lab., Microbiology I and
Lab., Systems Biology& Lab., Training group theory and Lab, Anatomy I & II, Anatomy I & II lab., Clinicals
@ St. Luke West (3 yrs).
Accomplishments
First employee given own shift and full management of the laboratory.
Worked directly with R&D/formulation chemist daily
Recipient of the first only company paid class for certification.
- Pharmaceutical microbiology certification
- Elite Microsource
Led the Validation of the first successful ozoneated water purification system.
- Validation of water systems 12 water sample/day extraction and
microbiological testing for a year
- Problem solving and successful solution resolution
- Daily testing, trending, tracking and record keeping of all data
- Organization of all internal and external testing of multiple samples/results
- Creation of SMI/SOP official documentation
Developed classes twice a week for microbiological awareness to all company employees.
- Used weekly data to educate staff how to keep microbial contamination at
the most minimal possible
- Established successful and accepted authoritative leader position
- Resulted in microbial contamination decreases and the first ever 100%
cfu free month.
