In a welcome move, the Pharmacy Council of India has recently re-structured the syllabus of the
Bachelor of Pharmacy course. In the effort to make the content more relevant to the practice of
pharmacy in its current form, we now find new, important subjects introduced, and Pharmaceutical
Quality Assurance is one of them.
Brucellosis is caused by bacteria of the genus Brucella and is a major zoonotic disease transmitted from animals to humans. It causes flu-like symptoms such as fever, sweats, and joint pain in humans. The disease is widespread globally in areas where infection is common in livestock like sheep, goats and cattle. Diagnosis involves serological tests to detect antibodies and culturing Brucella from blood or tissues. Treatment requires prolonged antibiotic therapy. Vaccination of livestock and pasteurization of dairy products are important for control and prevention.
A review of Staphylococcus aureus prevalence from raw.pptxRajadr
This document reviews the prevalence of Staphylococcus aureus in raw milk. It discusses how raw milk is an excellent medium for bacterial growth and S. aureus in particular. Milk can become contaminated with S. aureus during the milking process if the udder is not properly cleaned. S. aureus is a common cause of bovine mastitis worldwide and consumption of raw milk from infected cows can lead to food poisoning in humans. Pasteurization kills harmful bacteria in milk and has significantly reduced illness from contaminated milk. The conclusion emphasizes that S. aureus is difficult to eliminate from dairy animals and prompt treatment is needed before it can form biofilms.
This document summarizes key information about Brucellosis, including:
- Brucellosis is a zoonotic disease caused by bacteria of the genus Brucella that can be transmitted from animals to humans. It causes undulant fever in humans and remains endemic in parts of the world.
- Clinical manifestations in humans include intermittent fever, loss of weight, and nausea. Laboratory diagnosis involves blood culture, serological tests like SAT and ELISA to detect antibodies, and PCR to detect bacterial DNA.
- Treatment consists of a combination of doxycycline and streptomycin for several weeks to prevent relapse of the infection. Adhering to food safety practices and avoiding direct contact with infected animals helps
- Shigellosis is caused by Shigella bacteria and is transmitted through the fecal-oral route, especially in conditions of poor sanitation and hygiene.
- It causes acute diarrhea which can range from mild to severe dysentery accompanied by fever, abdominal pain, and bloody stools. Complications can occasionally occur outside the GI tract.
- Diagnosis is usually made clinically or through stool culture. Treatment involves rehydration and appropriate antibiotics like ciprofloxacin.
- Prevention relies on improved sanitation, access to clean water, and hand washing to reduce transmission in areas where it is endemic.
This document discusses food-borne zoonotic diseases. It begins by introducing zoonotic diseases and their origins in animals. It then classifies zoonotic diseases and lists those most at risk. Several bacterial, viral, and parasitic food-borne zoonoses are described along with their symptoms. The document highlights issues in Pakistan and strategies to mitigate food-borne pathogens from farm to processing. It emphasizes the role of prevention through good practices and hygiene. In conclusion, the global threat of food-borne diseases to public health is noted and a One Health approach is recommended.
Food borne diseases can be caused by bacteria, viruses, parasites, or toxins in contaminated food. Common foodborne illnesses include salmonellosis, campylobacteriosis, E. coli infection, shigellosis, cholera, and listeriosis. These pathogens often contaminate foods of animal origin like meat, eggs, and dairy if they are not properly refrigerated, cooked, or handled. Symptoms range from diarrhea to life-threatening conditions. Proper hygiene, sanitation, and food handling can help reduce the risk of contracting a foodborne illness.
This document provides an overview of Brucella, the bacteria that causes brucellosis. It discusses the taxonomy of Brucella, describing the nine recognized species. It covers the pathogenesis of Brucellosis, noting that it is a zoonotic disease transmitted from animals to humans. The clinical manifestations of both acute and chronic Brucellosis are explained. The document also summarizes methods for laboratory diagnosis of Brucellosis, including culture, serology, PCR and skin tests. Treatment involves a combination of tetracycline and doxycycline antibiotics. Prevention strategies include pasteurizing milk, vaccinating animals and slaughtering infected herds.
This document discusses various foodborne illnesses and their causes. It provides information on common disease vectors like Salmonella, E. coli, C. botulinum, and Hepatitis A. Symptoms, food sources, and treatments are described for each. Proper food handling and sanitation are key to preventing contamination and spoilage. Common preservation methods like drying, cooling, freezing, boiling and sugaring can help extend the safe storage time of foods by inhibiting microbial growth.
Brucellosis is caused by bacteria of the genus Brucella and is a major zoonotic disease transmitted from animals to humans. It causes flu-like symptoms such as fever, sweats, and joint pain in humans. The disease is widespread globally in areas where infection is common in livestock like sheep, goats and cattle. Diagnosis involves serological tests to detect antibodies and culturing Brucella from blood or tissues. Treatment requires prolonged antibiotic therapy. Vaccination of livestock and pasteurization of dairy products are important for control and prevention.
A review of Staphylococcus aureus prevalence from raw.pptxRajadr
This document reviews the prevalence of Staphylococcus aureus in raw milk. It discusses how raw milk is an excellent medium for bacterial growth and S. aureus in particular. Milk can become contaminated with S. aureus during the milking process if the udder is not properly cleaned. S. aureus is a common cause of bovine mastitis worldwide and consumption of raw milk from infected cows can lead to food poisoning in humans. Pasteurization kills harmful bacteria in milk and has significantly reduced illness from contaminated milk. The conclusion emphasizes that S. aureus is difficult to eliminate from dairy animals and prompt treatment is needed before it can form biofilms.
This document summarizes key information about Brucellosis, including:
- Brucellosis is a zoonotic disease caused by bacteria of the genus Brucella that can be transmitted from animals to humans. It causes undulant fever in humans and remains endemic in parts of the world.
- Clinical manifestations in humans include intermittent fever, loss of weight, and nausea. Laboratory diagnosis involves blood culture, serological tests like SAT and ELISA to detect antibodies, and PCR to detect bacterial DNA.
- Treatment consists of a combination of doxycycline and streptomycin for several weeks to prevent relapse of the infection. Adhering to food safety practices and avoiding direct contact with infected animals helps
- Shigellosis is caused by Shigella bacteria and is transmitted through the fecal-oral route, especially in conditions of poor sanitation and hygiene.
- It causes acute diarrhea which can range from mild to severe dysentery accompanied by fever, abdominal pain, and bloody stools. Complications can occasionally occur outside the GI tract.
- Diagnosis is usually made clinically or through stool culture. Treatment involves rehydration and appropriate antibiotics like ciprofloxacin.
- Prevention relies on improved sanitation, access to clean water, and hand washing to reduce transmission in areas where it is endemic.
This document discusses food-borne zoonotic diseases. It begins by introducing zoonotic diseases and their origins in animals. It then classifies zoonotic diseases and lists those most at risk. Several bacterial, viral, and parasitic food-borne zoonoses are described along with their symptoms. The document highlights issues in Pakistan and strategies to mitigate food-borne pathogens from farm to processing. It emphasizes the role of prevention through good practices and hygiene. In conclusion, the global threat of food-borne diseases to public health is noted and a One Health approach is recommended.
Food borne diseases can be caused by bacteria, viruses, parasites, or toxins in contaminated food. Common foodborne illnesses include salmonellosis, campylobacteriosis, E. coli infection, shigellosis, cholera, and listeriosis. These pathogens often contaminate foods of animal origin like meat, eggs, and dairy if they are not properly refrigerated, cooked, or handled. Symptoms range from diarrhea to life-threatening conditions. Proper hygiene, sanitation, and food handling can help reduce the risk of contracting a foodborne illness.
This document provides an overview of Brucella, the bacteria that causes brucellosis. It discusses the taxonomy of Brucella, describing the nine recognized species. It covers the pathogenesis of Brucellosis, noting that it is a zoonotic disease transmitted from animals to humans. The clinical manifestations of both acute and chronic Brucellosis are explained. The document also summarizes methods for laboratory diagnosis of Brucellosis, including culture, serology, PCR and skin tests. Treatment involves a combination of tetracycline and doxycycline antibiotics. Prevention strategies include pasteurizing milk, vaccinating animals and slaughtering infected herds.
This document discusses various foodborne illnesses and their causes. It provides information on common disease vectors like Salmonella, E. coli, C. botulinum, and Hepatitis A. Symptoms, food sources, and treatments are described for each. Proper food handling and sanitation are key to preventing contamination and spoilage. Common preservation methods like drying, cooling, freezing, boiling and sugaring can help extend the safe storage time of foods by inhibiting microbial growth.
The document discusses food hygiene and safety. It defines food hygiene as sanitary science that aims to produce safe, good quality food. The primary goal of food hygiene is to prevent food poisoning and illnesses. It explains that food can become contaminated during various stages from production to consumption. Proper hygiene of milk, meat, fish, eggs and fruits and vegetables is important to prevent diseases. Good hygiene practices during food preparation, processing, storage and consumption are also discussed.
This document discusses food safety and food hygiene. It covers:
1) The importance of food hygiene in preventing foodborne illness from contamination at any point during food production and handling.
2) Classification of common foodborne illnesses caused by bacteria, viruses, parasites, and chemicals.
3) Diseases that can be transmitted through milk due to contamination and the importance of clean milk production practices.
4) Pasteurization as a method to destroy pathogens in milk without compromising quality, involving specific time and temperature standards.
Studying described bacterial toxins , types , mode of action, contaminant foods that sources of bacteria causes diseases , types of infections , methods of toxins detection and elimination of bacterial toxin from body .
Yersinia enterocolitica is a pathogenic Gram-negative bacterium. It is commonly found in the intestines of pigs and can be transmitted to humans through contaminated food, especially undercooked pork. In humans, it causes gastrointestinal illness known as yersiniosis. Symptoms include diarrhea, fever, and abdominal pain. While usually self-limiting, it can occasionally lead to complications affecting the joints, heart, or thyroid. Proper food handling and cooking pork thoroughly can help prevent yersiniosis.
Brucellosis is a bacterial zoonotic disease caused by the Brucella genus. It is a major public health problem in Nepal, where it is commonly transmitted from infected animals like cattle, sheep, and goats to humans through the ingestion of raw milk or close contact. Symptoms in humans include fever, joint pain, and weakness. Prevention focuses on vaccination programs for animals and pasteurization of milk, while treatment involves prolonged antibiotic therapy.
This document provides information on various foodborne diseases. It discusses foodborne infections and intoxications. Specific bacterial infections covered include salmonellosis, cholera, shigellosis, campylobacteriosis, E. coli, and vibrio parahemolyticus. Key points about transmission, clinical symptoms, diagnosis, and control measures are provided for each disease. Salmonellosis is discussed in particularly depth due to its prevalence and importance as a food poisoning pathogen.
The term food borne diseases or food-borne illnesses or more commonly food poisoning are used to denote gastrointestinal complications that occur following recent consumption of a particular food or drink.
Each year around one-third of the world population is affected by food-borne pathogens especially in developing countries. Even in developed nation like US, billions are spent in treatment of foodborne diseases caused by major pathogens. Each year 48 million people are affected in US with foodborne illness
Food borne diseases are caused by pathogens or toxins entering the body through contaminated food. They are classified as infections or intoxications. Salmonellosis is a common food borne infection caused by Salmonella bacteria. Symptoms include diarrhea, fever and abdominal cramps. It is often associated with eating contaminated poultry, eggs or meat. Prevention involves proper cooking and refrigeration of foods. Cholera is a severe infection of the small intestine caused by the Vibrio cholerae bacterium, often transmitted through contaminated water or seafood. It causes profuse watery diarrhea and dehydration.
This document discusses various biological hazards in food including Escherichia coli, Listeria monocytogenes, hepatitis A virus, Norovirus, and various foodborne parasites. E. coli O157:H7 is highlighted as an important pathogenic strain of E. coli that can cause serious illness, especially in infants. Listeria monocytogenes is noted as a pathogen that can grow at refrigeration temperatures. Hepatitis A virus is described as having a long incubation period of 10-45 days, making the food source difficult to identify. Control methods like proper cooking, temperature control, cleaning and sanitation are recommended to prevent illness from biological hazards in food.
Brucellosis is a systemic bacterial disease caused by Brucella bacteria, with symptoms including irregular fever, sweating, joint pain, and fatigue. It is most commonly transmitted from infected animals like cattle, goats, and pigs to humans through direct contact or consumption of unpasteurized dairy. While rarely fatal, it can cause long-term joint or reproductive organ complications if untreated. Control relies on vaccination and testing of livestock with elimination of infected herds to prevent transmission.
Food poisoning can be caused by foodborne infections or intoxications. Foodborne infections are due to ingestion of pathogenic microorganisms like bacteria, viruses or parasites. Symptoms include fever and diarrhea. Common bacterial causes are Salmonella, Campylobacter, E. coli, Shigella, Vibrio species and Yersinia. Viral causes include hepatitis A and norovirus. Foodborne intoxications occur when preformed toxins produced by bacteria like Staphylococcus, Bacillus, Clostridium species are ingested, causing short incubation illnesses without fever.
Disinfection of Mycotic Species Isolated from Cases of Bovine Mastitis Showin...CrimsonpublishersCJMI
Disinfection of Mycotic Species Isolated from Cases of Bovine Mastitis Showing Antifungal Resistance by Elaine Meade in Cohesive Journal of Microbiology & Infectious Disease
This document discusses vaccines used to control diseases in various animal species in the UK. It provides lists of the specific diseases controlled by vaccines in cattle, sheep, pigs, poultry, and fish. It then discusses how vaccines work to produce an animal's own defenses without causing disease. The document also covers how vaccine safety and effectiveness are regulated. Several case studies are presented on the use of vaccines for diseases such as clostridial disease in sheep, Aujeszky's disease in pigs, Newcastle disease in poultry, and others. Vaccination protocols are also summarized for dogs, cats, and rabbits.
This document discusses various food borne diseases including their classification, causative agents, modes of transmission, symptoms, and prevention methods. It focuses on salmonellosis, describing the salmonella bacteria and serotypes that commonly cause food poisoning in humans. Symptoms of salmonellosis include abdominal pain, diarrhea, fever and vomiting. Foods of animal origin like meat, eggs and dairy are often vehicles of transmission. Proper cooking and hygiene are recommended for prevention.
This document provides an overview of meat-borne diseases. It discusses zoonotic, foodborne, and meat-borne diseases and outlines their significance to public health. Historical outbreaks of diseases like E. coli and salmonellosis transmitted through meat are described. Key bacterial diseases transmitted by meat consumption including E. coli, salmonellosis, campylobacteriosis, and listeriosis are summarized. The document also discusses factors that influence microbial growth on meat and points of contamination.
Presentation on Safe Milk Production for Public HealthRafiqul Islam
Milk is a complete food that provides many essential nutrients. It is considered safe when it comes from healthy animals in hygienic environments and contains low bacteria levels. Several factors are important for producing clean and safe milk, including maintaining animal health, clean udders and farm premises, and controlling contamination. Dirty milk can transmit diseases from animals to humans like tuberculosis, brucellosis, and e.coli infections. Proper hygiene and sanitation at all stages of milk production and processing are necessary to ensure milk safety.
This document provides information on the enteric bacilli Salmonella typhi. It describes S. typhi as a gram-negative facultative anaerobe that causes the systemic disease typhoid fever. The document outlines the clinical symptoms of typhoid fever such as sustained fever, headache and abdominal issues. It discusses the virulence factors that allow S. typhi to cause disease, including its ability to invade non-phagocytic cells and inhibit the immune response. Prevention is focused on proper sanitation and hygiene to avoid contamination of food and water from human feces carrying the bacteria.
The ICH guidelines for stability testing define what information must be provided at the
time of applying to register a new drug molecule. These guidelines were first adopted in
1993. After revision and updation, the current version in use called Q1A(R2) has been
adopted since 2003. This guideline harmonizes the drug registration process for all drugs in
the USA, Japan, and the EU. This means a drug registered in one of these regions will not
require repeated stability testing when to be sold in any of the other two regions.
Stability testing is important because drug products must be stable when administered
to patients. If an unstable product degrades into toxic metabolites, or if the activity of the
drug reduces below 85% of the label claim, there can be serious therapy failures that may
even result in death. Stability testing also provides data to choose the formulation
parameters, excipients, and the right container-closure system to ensure safe and effective
quality products that retain activity throughout the shelf life.
In a welcome move, the Pharmacy Council of India has recently re-structured the syllabus of the
Bachelor of Pharmacy course. In the effort to make the content more relevant to the practice of
pharmacy in its current form, we now find new, important subjects introduced, and Pharmaceutical
Quality Assurance is one of them.
The document discusses food hygiene and safety. It defines food hygiene as sanitary science that aims to produce safe, good quality food. The primary goal of food hygiene is to prevent food poisoning and illnesses. It explains that food can become contaminated during various stages from production to consumption. Proper hygiene of milk, meat, fish, eggs and fruits and vegetables is important to prevent diseases. Good hygiene practices during food preparation, processing, storage and consumption are also discussed.
This document discusses food safety and food hygiene. It covers:
1) The importance of food hygiene in preventing foodborne illness from contamination at any point during food production and handling.
2) Classification of common foodborne illnesses caused by bacteria, viruses, parasites, and chemicals.
3) Diseases that can be transmitted through milk due to contamination and the importance of clean milk production practices.
4) Pasteurization as a method to destroy pathogens in milk without compromising quality, involving specific time and temperature standards.
Studying described bacterial toxins , types , mode of action, contaminant foods that sources of bacteria causes diseases , types of infections , methods of toxins detection and elimination of bacterial toxin from body .
Yersinia enterocolitica is a pathogenic Gram-negative bacterium. It is commonly found in the intestines of pigs and can be transmitted to humans through contaminated food, especially undercooked pork. In humans, it causes gastrointestinal illness known as yersiniosis. Symptoms include diarrhea, fever, and abdominal pain. While usually self-limiting, it can occasionally lead to complications affecting the joints, heart, or thyroid. Proper food handling and cooking pork thoroughly can help prevent yersiniosis.
Brucellosis is a bacterial zoonotic disease caused by the Brucella genus. It is a major public health problem in Nepal, where it is commonly transmitted from infected animals like cattle, sheep, and goats to humans through the ingestion of raw milk or close contact. Symptoms in humans include fever, joint pain, and weakness. Prevention focuses on vaccination programs for animals and pasteurization of milk, while treatment involves prolonged antibiotic therapy.
This document provides information on various foodborne diseases. It discusses foodborne infections and intoxications. Specific bacterial infections covered include salmonellosis, cholera, shigellosis, campylobacteriosis, E. coli, and vibrio parahemolyticus. Key points about transmission, clinical symptoms, diagnosis, and control measures are provided for each disease. Salmonellosis is discussed in particularly depth due to its prevalence and importance as a food poisoning pathogen.
The term food borne diseases or food-borne illnesses or more commonly food poisoning are used to denote gastrointestinal complications that occur following recent consumption of a particular food or drink.
Each year around one-third of the world population is affected by food-borne pathogens especially in developing countries. Even in developed nation like US, billions are spent in treatment of foodborne diseases caused by major pathogens. Each year 48 million people are affected in US with foodborne illness
Food borne diseases are caused by pathogens or toxins entering the body through contaminated food. They are classified as infections or intoxications. Salmonellosis is a common food borne infection caused by Salmonella bacteria. Symptoms include diarrhea, fever and abdominal cramps. It is often associated with eating contaminated poultry, eggs or meat. Prevention involves proper cooking and refrigeration of foods. Cholera is a severe infection of the small intestine caused by the Vibrio cholerae bacterium, often transmitted through contaminated water or seafood. It causes profuse watery diarrhea and dehydration.
This document discusses various biological hazards in food including Escherichia coli, Listeria monocytogenes, hepatitis A virus, Norovirus, and various foodborne parasites. E. coli O157:H7 is highlighted as an important pathogenic strain of E. coli that can cause serious illness, especially in infants. Listeria monocytogenes is noted as a pathogen that can grow at refrigeration temperatures. Hepatitis A virus is described as having a long incubation period of 10-45 days, making the food source difficult to identify. Control methods like proper cooking, temperature control, cleaning and sanitation are recommended to prevent illness from biological hazards in food.
Brucellosis is a systemic bacterial disease caused by Brucella bacteria, with symptoms including irregular fever, sweating, joint pain, and fatigue. It is most commonly transmitted from infected animals like cattle, goats, and pigs to humans through direct contact or consumption of unpasteurized dairy. While rarely fatal, it can cause long-term joint or reproductive organ complications if untreated. Control relies on vaccination and testing of livestock with elimination of infected herds to prevent transmission.
Food poisoning can be caused by foodborne infections or intoxications. Foodborne infections are due to ingestion of pathogenic microorganisms like bacteria, viruses or parasites. Symptoms include fever and diarrhea. Common bacterial causes are Salmonella, Campylobacter, E. coli, Shigella, Vibrio species and Yersinia. Viral causes include hepatitis A and norovirus. Foodborne intoxications occur when preformed toxins produced by bacteria like Staphylococcus, Bacillus, Clostridium species are ingested, causing short incubation illnesses without fever.
Disinfection of Mycotic Species Isolated from Cases of Bovine Mastitis Showin...CrimsonpublishersCJMI
Disinfection of Mycotic Species Isolated from Cases of Bovine Mastitis Showing Antifungal Resistance by Elaine Meade in Cohesive Journal of Microbiology & Infectious Disease
This document discusses vaccines used to control diseases in various animal species in the UK. It provides lists of the specific diseases controlled by vaccines in cattle, sheep, pigs, poultry, and fish. It then discusses how vaccines work to produce an animal's own defenses without causing disease. The document also covers how vaccine safety and effectiveness are regulated. Several case studies are presented on the use of vaccines for diseases such as clostridial disease in sheep, Aujeszky's disease in pigs, Newcastle disease in poultry, and others. Vaccination protocols are also summarized for dogs, cats, and rabbits.
This document discusses various food borne diseases including their classification, causative agents, modes of transmission, symptoms, and prevention methods. It focuses on salmonellosis, describing the salmonella bacteria and serotypes that commonly cause food poisoning in humans. Symptoms of salmonellosis include abdominal pain, diarrhea, fever and vomiting. Foods of animal origin like meat, eggs and dairy are often vehicles of transmission. Proper cooking and hygiene are recommended for prevention.
This document provides an overview of meat-borne diseases. It discusses zoonotic, foodborne, and meat-borne diseases and outlines their significance to public health. Historical outbreaks of diseases like E. coli and salmonellosis transmitted through meat are described. Key bacterial diseases transmitted by meat consumption including E. coli, salmonellosis, campylobacteriosis, and listeriosis are summarized. The document also discusses factors that influence microbial growth on meat and points of contamination.
Presentation on Safe Milk Production for Public HealthRafiqul Islam
Milk is a complete food that provides many essential nutrients. It is considered safe when it comes from healthy animals in hygienic environments and contains low bacteria levels. Several factors are important for producing clean and safe milk, including maintaining animal health, clean udders and farm premises, and controlling contamination. Dirty milk can transmit diseases from animals to humans like tuberculosis, brucellosis, and e.coli infections. Proper hygiene and sanitation at all stages of milk production and processing are necessary to ensure milk safety.
This document provides information on the enteric bacilli Salmonella typhi. It describes S. typhi as a gram-negative facultative anaerobe that causes the systemic disease typhoid fever. The document outlines the clinical symptoms of typhoid fever such as sustained fever, headache and abdominal issues. It discusses the virulence factors that allow S. typhi to cause disease, including its ability to invade non-phagocytic cells and inhibit the immune response. Prevention is focused on proper sanitation and hygiene to avoid contamination of food and water from human feces carrying the bacteria.
The ICH guidelines for stability testing define what information must be provided at the
time of applying to register a new drug molecule. These guidelines were first adopted in
1993. After revision and updation, the current version in use called Q1A(R2) has been
adopted since 2003. This guideline harmonizes the drug registration process for all drugs in
the USA, Japan, and the EU. This means a drug registered in one of these regions will not
require repeated stability testing when to be sold in any of the other two regions.
Stability testing is important because drug products must be stable when administered
to patients. If an unstable product degrades into toxic metabolites, or if the activity of the
drug reduces below 85% of the label claim, there can be serious therapy failures that may
even result in death. Stability testing also provides data to choose the formulation
parameters, excipients, and the right container-closure system to ensure safe and effective
quality products that retain activity throughout the shelf life.
In a welcome move, the Pharmacy Council of India has recently re-structured the syllabus of the
Bachelor of Pharmacy course. In the effort to make the content more relevant to the practice of
pharmacy in its current form, we now find new, important subjects introduced, and Pharmaceutical
Quality Assurance is one of them.
In a welcome move, the Pharmacy Council of India has recently re-structured the syllabus of the
Bachelor of Pharmacy course. In the effort to make the content more relevant to the practice of
pharmacy in its current form, we now find new, important subjects introduced, and Pharmaceutical
Quality Assurance is one of them.
In a welcome move, the Pharmacy Council of India has recently re-structured the syllabus of the
Bachelor of Pharmacy course. In the effort to make the content more relevant to the practice of
pharmacy in its current form, we now find new, important subjects introduced, and Pharmaceutical
Quality Assurance is one of them.
In a welcome move, the Pharmacy Council of India has recently re-structured the syllabus of the
Bachelor of Pharmacy course. In the effort to make the content more relevant to the practice of
pharmacy in its current form, we now find new, important subjects introduced, and Pharmaceutical
Quality Assurance is one of them.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise boosts blood flow and levels of serotonin and endorphins which elevate mood and may help prevent mental illness.
In a welcome move, the Pharmacy Council of India has recently re-structured the syllabus of the
Bachelor of Pharmacy course. In the effort to make the content more relevant to the practice of
pharmacy in its current form, we now find new, important subjects introduced, and Pharmaceutical
Quality Assurance is one of them.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise stimulates the production of endorphins in the brain which elevate mood and reduce stress levels.
In a welcome move, the Pharmacy Council of India has recently re-structured the syllabus of the
Bachelor of Pharmacy course. In the effort to make the content more relevant to the practice of
pharmacy in its current form, we now find new, important subjects introduced, and Pharmaceutical
Quality Assurance is one of them.
In a welcome move, the Pharmacy Council of India has recently re-structured the syllabus of the
Bachelor of Pharmacy course. In the effort to make the content more relevant to the practice of
pharmacy in its current form, we now find new, important subjects introduced, and Pharmaceutical
Quality Assurance is one of them.
In a welcome move, the Pharmacy Council of India has recently re-structured the syllabus of the
Bachelor of Pharmacy course. In the effort to make the content more relevant to the practice of
pharmacy in its current form, we now find new, important subjects introduced, and Pharmaceutical
Quality Assurance is one of them.
This document discusses the classification of human parasites. It begins by classifying parasites into unicellular protozoa and multicellular metazoa such as helminthes and arthropods. It then focuses on protozoa, describing their general features such as being single-celled eukaryotes that have structures like a cell membrane, cytoplasm, nucleus and organelles. It discusses the life cycles and forms of protozoa including trophozoites, cysts and various reproductive stages. It classifies protozoan parasites into phyla based on their locomotion organs such as Sarcomastigophora, Ciliophora, Apicomplexa and Microspora. It concludes by classifying protozo
বাংলাদেশের অর্থনৈতিক সমীক্ষা ২০২৪ [Bangladesh Economic Review 2024 Bangla.pdf] কম্পিউটার , ট্যাব ও স্মার্ট ফোন ভার্সন সহ সম্পূর্ণ বাংলা ই-বুক বা pdf বই " সুচিপত্র ...বুকমার্ক মেনু 🔖 ও হাইপার লিংক মেনু 📝👆 যুক্ত ..
আমাদের সবার জন্য খুব খুব গুরুত্বপূর্ণ একটি বই ..বিসিএস, ব্যাংক, ইউনিভার্সিটি ভর্তি ও যে কোন প্রতিযোগিতা মূলক পরীক্ষার জন্য এর খুব ইম্পরট্যান্ট একটি বিষয় ...তাছাড়া বাংলাদেশের সাম্প্রতিক যে কোন ডাটা বা তথ্য এই বইতে পাবেন ...
তাই একজন নাগরিক হিসাবে এই তথ্য গুলো আপনার জানা প্রয়োজন ...।
বিসিএস ও ব্যাংক এর লিখিত পরীক্ষা ...+এছাড়া মাধ্যমিক ও উচ্চমাধ্যমিকের স্টুডেন্টদের জন্য অনেক কাজে আসবে ...
Executive Directors Chat Leveraging AI for Diversity, Equity, and InclusionTechSoup
Let’s explore the intersection of technology and equity in the final session of our DEI series. Discover how AI tools, like ChatGPT, can be used to support and enhance your nonprofit's DEI initiatives. Participants will gain insights into practical AI applications and get tips for leveraging technology to advance their DEI goals.
हिंदी वर्णमाला पीपीटी, hindi alphabet PPT presentation, hindi varnamala PPT, Hindi Varnamala pdf, हिंदी स्वर, हिंदी व्यंजन, sikhiye hindi varnmala, dr. mulla adam ali, hindi language and literature, hindi alphabet with drawing, hindi alphabet pdf, hindi varnamala for childrens, hindi language, hindi varnamala practice for kids, https://www.drmullaadamali.com
A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
How to Setup Warehouse & Location in Odoo 17 InventoryCeline George
In this slide, we'll explore how to set up warehouses and locations in Odoo 17 Inventory. This will help us manage our stock effectively, track inventory levels, and streamline warehouse operations.
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
Walmart Business+ and Spark Good for Nonprofits.pdfTechSoup
"Learn about all the ways Walmart supports nonprofit organizations.
You will hear from Liz Willett, the Head of Nonprofits, and hear about what Walmart is doing to help nonprofits, including Walmart Business and Spark Good. Walmart Business+ is a new offer for nonprofits that offers discounts and also streamlines nonprofits order and expense tracking, saving time and money.
The webinar may also give some examples on how nonprofits can best leverage Walmart Business+.
The event will cover the following::
Walmart Business + (https://business.walmart.com/plus) is a new shopping experience for nonprofits, schools, and local business customers that connects an exclusive online shopping experience to stores. Benefits include free delivery and shipping, a 'Spend Analytics” feature, special discounts, deals and tax-exempt shopping.
Special TechSoup offer for a free 180 days membership, and up to $150 in discounts on eligible orders.
Spark Good (walmart.com/sparkgood) is a charitable platform that enables nonprofits to receive donations directly from customers and associates.
Answers about how you can do more with Walmart!"
The simplified electron and muon model, Oscillating Spacetime: The Foundation...RitikBhardwaj56
Discover the Simplified Electron and Muon Model: A New Wave-Based Approach to Understanding Particles delves into a groundbreaking theory that presents electrons and muons as rotating soliton waves within oscillating spacetime. Geared towards students, researchers, and science buffs, this book breaks down complex ideas into simple explanations. It covers topics such as electron waves, temporal dynamics, and the implications of this model on particle physics. With clear illustrations and easy-to-follow explanations, readers will gain a new outlook on the universe's fundamental nature.
How to Manage Your Lost Opportunities in Odoo 17 CRMCeline George
Odoo 17 CRM allows us to track why we lose sales opportunities with "Lost Reasons." This helps analyze our sales process and identify areas for improvement. Here's how to configure lost reasons in Odoo 17 CRM
How to Fix the Import Error in the Odoo 17Celine George
An import error occurs when a program fails to import a module or library, disrupting its execution. In languages like Python, this issue arises when the specified module cannot be found or accessed, hindering the program's functionality. Resolving import errors is crucial for maintaining smooth software operation and uninterrupted development processes.
2. Pathogens of special relevance
Prions
• A prion is a proteinaceous infectious agent or an infectious particle
that transmits a disease from one cell to another and from one
animal to another.
• Prions entered the public’s consciousness during the mad cow
epidemic that hit England in 1986.
• Prions enter brain cells and there convert the normal cell protein
PrPC to the prion form of the protein, called PrPSC.
• Prion-bloated brain cells die and release prions into the tissue.
These prions then enter, infect and destroy other brain cells. As
clusters of cells die, holes form in the brain, which takes on the
appearance of a sponge.
• The medical term for the prion diseases namely “spongiform
encephalopathies.
• ” Mad cow disease is also known as bovine spongiform
encephalitis (BSE). The disease was subsequently spread through
contaminated meat and bone meal fed to cattle. The disease
transmitted to humans as Creutzfeldt-Jakob disease (CJD).
3. Viruses
• Viruses are obligate intracellular parasites. Having
no intrinsic metabolism, they are dependent on a
living host in order to multiply.
• They can consequently only be transmitted by food
and water and do not replicate in these substrates.
• Virtually all food-borne viruses are transmitted via
the fecal–oral route, with man as the only known
reservoir for calicivirus and Hepatitis A, the two
most important viruses at present associated with
food-borne outbreaks.
• Human enteric viruses can be transmitted by raw-
and under-pasteurized milk.
4. • Subsequent pasteurization treatment was sufficient
to control any viruses that may have contaminated
the raw milk.
• The virus infects dairy animals via the tick vector,
and infected animals shed the virus in their milk,
which, if ingested without pasteurization, may
infect humans.
5. Rickettsiae
• Coxiella burnetti, the causative agent of Q-fever, is a
zoonotic organism that may infect the udder, probably
by the hematogenous route, consumption of, or
contact with, the infected milk can lead to human
infection.
• This organism was found to be more heat-resistant
than Mycobacterium tuberculosis, the vat
pasteurization temperature was raised from 61.7 to
63°C (holding time 30 min) to ensure destruction of the
organism, the current high-temperatures hort-time
(HTST) pasteurization temperature of 72°C for 15 s is
also effective in this regard.
• Milk alkaline phosphatase which serves as an indicator
of pasteurization efficacy for bovine milk is more heat-
resistant than Coxiella burnetti and is destroyed by the
above pasteurization treatments.
6. Protozoa
Cryptosporidium
• Human cryptosporidiosis emerged as an important
gastro-intestinal infection in the 1990s, due to the
ingestion of contaminated water and foodstuffs
containing the protozoan parasite, Cryptosporidium
parvum.
• When ingested, it is capable of causing a high degree of
morbidity in healthy populations. It results in mortality
in vulnerable populations such as immune
compromised persons infected with HIV/AIDS or cancer
patients receiving chemotherapy.
• There is no effective antimicrobial treatment to
eradicate this agent from the gastrointestinal tract of
symptomatic individuals.
7. • Generally, cryptosporidiosis is a self-limiting disease
presenting typically with diarrhea, dehydration,
abdominal cramps, vomiting, weight loss, and
electrolyte imbalance.
• Cryptosporidium cannot survive pasteurization of
milk, and 100% inactivation was achieved by
heating milk to 71.7°C for 5 s.
• It showed 0–5%Iviability after 48 h in ice cream
stored at −20°C, also found that prolonged storage
of contaminated yoghurt for up to 240 h was not
sufficient to destroy Cryptosporidium.
8. Bacteria
1. Brucella
• Brucella abortus and B. melitensis are zoonoses that can cause milk-
borne disease outbreaks in humans and are the causative agents of
brucellosis in cattle.
• Brucellosis eradication programmes in many countries have resulted
in a decrease in outbreaks. In many parts of the world, this
eradication has been so successful that it no longer poses a hazard to
human health.
• Where the disease still occurs, pasteurization of milk has minimized
the number of human outbreaks by these microorganisms.
• Consumption of raw milk and some products made from raw milk
(such as some imported cheese) have been implicated in foodborne
brucellosis. The cells survive for a long time in milk and milk products.
• Symptoms of brucellosis in humans include undulant fever with
irregular rise and fall of temperature, profuse sweats, body aches,
aching joints, chills, and weakness. Symptoms appear in 3 to 21 d
following consumption of a contaminated food.
• Control measures for foodborne brucellosis include pasteurization of milk,
manufacturing of dairy products from pasteurized milk, and proper sanitation to
prevent recontamination of pasteurized products.
9. 2. Mycobacterium
• Mycobacterium bovis is a microorganism of concern to the dairy
industry because it causes tuberculosis in cattle.
• It can also result in milk-borne M. bovis infections of humans.
• Cattle immunization and pasteurization of the milk has limited the
number of tuberculosis cases associated with the consumption of
milk or dairy products.
• Another Mycobacterium species that has generated increasing
interest in latter times is Mycobacterium avium subspecies
paratuberculosis (MAP).
• This organism is the aetiological agent of paratuberculosis or
Johne’s disease, a global disease of ruminants.
• The disease itself is a slow developing colitis in which the intestinal
macrophages are infected. In the process, inflammatory reactions
are induced in the host gut.
• This affects the ability of the gut to absorb protein from the diet
resulting in clinical features that include diarrhoea and chronic
weight loss.
• There are similarities between paratuberculosis and Crohn’s
disease in man.
10. • Milk may be contaminated by the natural shedding of
infected macrophages or by fecal contamination.
• While the infectious dose, is reported to be as low as 1000
organisms.
• The most accurate strategy for controlling MAP at present involves an
approach based on three levels:
-Control of MAP at the herd level – Action to reduce the incidence of
MAP infection in cattle appears to be worth while from the point of
view of herd health as well as ensuring a reduction in the excretion of
the organisms in the raw milk;
-Control during milking – The implementation of hygienic practices
during milking is clearly necessary. While improved hygienic
measures can reduce the risk of milk contamination with pathogenic
bacteria, the risk to the consumer cannot be completely eliminated;
-Control by pasteurization of the milk – normal pasteurization
process at 72°C for 15 s reduced the number of viable MAP cells in
milk by a factor of 104–105. It is believed, therefore, that the presence
of MAP in pasteurized milk should be ascribed to either the failure in
applying the correct heat treatment or postpasteurization
contamination
11. 3. Enterobacteriaceae
• The presence of any member of the
Enterobacteriaceae family is undesirable in
pasteurized dairy products. This is due to:
(1) The inherent spoilage capacity of many genera
in this family.
(2) The fact that the presence of certain genera in
water and foods may be indicative of faecal
contamination.
(3) The presence of the many pathogens in this
family in food or water indicates serious food safety
implications.
12. Salmonella.
• Today, Salmonella and Campylobacter are generally
recognized as the two leading causes of dairy-related food-
borne illness in the United States and Western Europe, with
rates of infection being particularly high in regions where raw
milk is neither pasteurized nor boiled.
• Raw milk can be a source of salmonellae, and 32 of 678
(4.7%) of raw bulk milk samples were reported to test positive
in the United States.
• Standard pasteurization destroys expected levels of
salmonellae (<100 cfu ml−1), with a wide margin of safety.
• Inadequate pasteurization and post-process contamination
have occasionally resulted in milk and cream that test positive
for Salmonella, as evidenced by the reported outbreaks.
• Salmonella is not particularly tolerant of heat, refrigeration,
or salt. so the typical hurdles used in the dairy industry are
effective in controlling this organism.
13. Escherichia
• E.coli is currently the best-known indicator of fecal
contamination, primarily of water but also of raw
food products.
• Its recovery from fresh dairy products consequently
suggests that other organisms of faecal origin,
including pathogens, may be present.
• E. coli strains are commonly associated with the
normal facultative anaerobic microflora of the
intestinal tracts of humans and animals.
• These pathogens are responsible for three main
clinical syndromes, namely enteric and diarrhoeal
diseases, urinary tract infections and
sepsis/meningitis.
14. • E. coli 0157:H7 has become a pathogen of major
concern for the food and dairy industries because of its
ability to cause severe ailments such as haemorrhagic
colitis (HC), haemolytic uremic syndrome (HUS), and
thrombocytopenic purpura (TTP).
• The ailments affect all human age groups, and the
pathogen is exceptional in the severe consequences of
infection, its low infectious dose and unusual acid
resistance.
• Cattle are the main reservoir of E. coli 0157:H7, while
the most likely mode of transmission in foods is faecal
contamination. The organism has an oral infectious
dose within the range of 10–100 cells, or even lower in
the case of susceptible groups.
15. • The survival of E. coli 0157:H7 in acidic foods such as yoghurt and its
survival in fermented as well as fermenting dairy foods for long
periods of time makes its hardy nature apparent. Such foods have
been associated with E. coli 0157:H7 outbreaks.
• pH and acidity did not halt the growth of E. coli 0157:H7 during the
manufacture of cottage cheese, the most well-known and popular
acid-curd cheese.
• Given the potential for contamination of milk by E. coli during
milking, consumption of raw milk should be avoided. E. coli 0157:H7
is not heat-resistant and, like most E. coli strains, is readily destroyed
by the pasteurization process.
• If good manufacturing practices are followed, consumption of
pasteurized milk consequently poses little or no risk of containing this
microorganism.
• While the organism is unable to grow at less than 10°C, substantial
growth can occur in temperature-abused milk.
16. Yersinia
• Y.enterocolitica and other yersiniae falling within the Family
Enterobacteriaceae are often referred to as ‘environmental
strains’.
• Yersinia enterocolitica is, nevertheless, a well-established
pathogen of humans, causing acute gastroenteritis, enterocolitis
and mesenteric lymphadenitis, as well as a variety of extra-
intestinal disorders.
• The symptoms of these ailments may be especially severe in
children and individuals with underlying disease.
• Yersinia enterocolitica is regarded as an unusual cause of milk-
borne illness because of the low incidence of human pathogenic
strains in the raw milk supply and the high susceptibility of the
organism to pasteurization.
• Yersiniae may be contaminants of raw milk, and most
contamination is thought to occur through contact with faeces or
polluted water supplies. Raw milk and inadequately pasteurized
milk and dairy products have, nevertheless, been implicated in the
transmission of Y. enterocolitica infections to humans.
17. • First recorded food-associated outbreak of yersiniosis
occurred in New York, where more than 220 individuals
were stricken with acute intestinal illness after
consumption of contaminated milk.
• In addition, epidemiological studies have revealed that
refrigerated food stored over prolonged periods of time
poses an additional risk, since Y. enterocolitica, as a
psychrotrophic microbe, is able to grow at
temperatures as low as 0°C.
• Y. enterocolitica and atypical Yersinia spp. were also
isolated from cheese samples in Turkey.
• Yersinia spp. are more likely to be isolated from foods
with a high level of coliforms than from foods with low
coliform counts. This lends impetus to the feasibility of
the faecal origin of Yersinia contamination of raw milk.
18. Campylobacter jejuni
• Campylobacter jejuni has been recognized since 1909
as an important cause of abortion in cattle and sheep.
Improved isolation strategies have also implicated this
organism as a causative agent of human diarrhea.
• C. jejuni as an important milk-borne pathogen that has
come to rival or even surpass Salmonella as a causative
agent of human gastroenteritis worldwide.
• Campylobacter jejuni can be isolated from the faeces of
cattle infected or colonized with the organism and has
been shown to cause asymptomatic bovine mastitis in
which the organism is excreted directly into the milk of
an infected cow.
19. • There is a significant association between the presence
of E. coli in milk and that of C. jejuni.
• Acquired immunity could be important in preventing
infection or preventing illness after infection.
Nevertheless, immunocompromised people are at risk
of contracting the infection.
• Campylobacter jejuni is killed by proper pasteurization.
• But outbreaks involving inadequately pasteurized milk
have been described in England.
• Failure in the public electricity supply and a faulty
pasteurizer were identified as the causes of the
problem.
• Campylobacter is also acid-sensitive, and this suggests
that the genus will not survive a normal fermentation in
a product such as yoghurt.
20. Staphylococcus aureus
• Staphylococcus aureus is a significant cause of mastitis
in dairy cows throughout the world.
• The bovine mammary gland can be a significant source
of enterotoxigenic strains of S. aureus.
• Enterotoxins produced by enterotoxigenic strains of this
organism are classified according to serotypes into A–H
groups and the so-called ‘toxic shock syndrome toxin’
or TSST.
• S. aureus strains were isolated from milk of cows with
clinical and sub-clinical mastitis and also from farm bulk
tank milk which is implicated as apotential source of
enterotoxigenic S. aureus in milk and milk products,
which may constitute a health hazard to consumers.
21. • Consumption of raw milk generally increases the
chances of direct contact with food pathogens such
as S. aureus and its toxins.
• Workers involved in processing the milk and
manufacturing dairy products can also be a source
of S. aureus in the product, where various surveys
have demonstrated that 4–60% of humans are nasal
carriers of S. aureus and that 5–20% of people carry
the organism as part of the normal skin microflora.
• Staphylococcus aureus was found to be the most
frequent pathogen associated with cheese made
from raw milk.
22. • Staphylococcal enterotoxin production can be
prevented by keeping the raw milk refrigerated until
the milk can be effectively pasteurized.
• While pasteurization procedures will kill the cells of
S. aureus in the milk, they will not destroy
enterotoxin already present.
• Identification of human carriers of toxigenic S.
aureus in the processing and manufacturing line, as
well as effective procedures for preventing post-
pasteurization contamination, should further assist
in preventing the incidence of this pathogen in the
final product.
23. Listeria monocytogenes
• Listeria monocytogenes has only recently emerged
as a serious food-borne pathogen that can cause
abortion in pregnant women and meningitis,
encephalitis and septicaemia in newborn infants
and immunocompromised adults.
• Although the disease is rare (i.e. 1–9 cases per
1,000,000 people per year) and accounts for only
about 0.02% of all cases of food-borne illness,
listeriosis accounts for about 28% of the deaths
resulting from food-borne illness.
• This severe mortality rate emphasizes the necessity
to minimize the exposure of the high-risk
individuals referred to above.
24. • Foods that have been implicated in listeriosis have
contained >1000 cfu ml−1 or >1000 cfu g−1.
• The most important property of L. monocytogenes is its
ability to multiply in foods at refrigeration
temperatures, and most foods incriminated in listeriosis
have been held under refrigeration.
• Milk and dairy products have been found to be sources
of food-borne listeriosis, and after outbreaks involving
a large number of cases, L. monocytogenes has become
a pathogen of great concern to the dairy industry.
• Listeria monocytogenes is commonly encountered in
the dairy farm environment. The most likely sources of
the organisms in raw bulk-tank milk are therefore
environmental in nature with faeces/manure playing a
major role.
25. • Contamination from within the udder as a result of shedding due
to bovine listeriosis or listerial mastitis is rare.
• The organism can be transmitted to cows via feeds such as
improperly fermented silage and other feedstuffs, causing
infection in the animal.
• Listeria has been isolated from many dairy products, including ice
cream and various types of cheese.
• In soft ripened cheese, contamination is limited to the first few
millimetres under the rind.
• Hard cheese such as Parmesan does not favour growth, and other
cheeses such as Colby, Swiss, Provolone, Munster, Feta and
Limburger show gradual die-off of the bacteria.
• In Mozzarella cheese, the bacteria will survive the manufacturing
process, but not the stretching temperatures.
• L. monocytogenes will not grow in Cottage cheese but can survive.
• Although the organism has been found to gain access to yoghurt
as a post-pasteurization contaminant, it will not survive at pH
levels below 4.6.
26. • Listeria monocytogenes is quite well adapted to dairy factory
environments. It is generally more common in factories
where conditions tend to be wet and cool with areas of
pooled water or liquid.
• The organic load on the floors and in the drains, if high, can
also contribute to the growth and survival of Listeria.
• The primary source of Listeria spp. in processing plants is
probably floors and floor drains, especially areas around
coolers or places subject to outside contamination.
• Due to the ubiquitous nature of the organism, all raw
materials carried into the packaging area must be suspect.
Cooling waters should also be considered as a possible source
of contamination.
• Work practices of factory personnel and the dispersal of the
organisms in water sprays and aerosols have also been
identified as significant carriers of the organism throughout
the factory.
27. • L. monocytogenes can become established in a food-
processing facility and remain members of the resident
microbial flora for many years.
• Examples of niches in which the organisms can become
established are hollow rollers on conveyors, cracked tubular
support rods on equipment, the space between close-fitting
metal-to-metal or metal-to-plastic parts, worn or cracked
rubber seals around doors, on–off valves and switches for
equipment as well as saturated insulation.
• Listeria monocytogenes can become established on steel and
rubber surfaces in the form of biofilms.
• Under favourable conditions, it even multiplied on stainless
steel. Temperature, relative humidity, soiling and the surface
type affected the behaviour of surfaceassociated L.
monocytogenes.
• In addition, the attachment surface affected the efficacy of
sanitizers.
28. • In terms of prevention or control procedures,
Listeria spp. can contaminate raw milk from many
environmental sources, and it is difficult to entirely
prevent the presence of Listeria in raw milk.
• In most cases, control of raw- milk contamination
should, however, be readily achieved by good
sanitation and milking practices.
29. • In controlling the presence of L. monocytogenes in
the processing area and the product itself, the
following strategies can be followed:
In the first place, steps should be taken to prevent
entry of L. monocytogenes to plant areas: These
steps basically include the isolation of the milk
reception area, and associated personnel, from the
processing and packaging area and prevention of
any raw product from entering the processing area.
Any product and container returns should similarly
not be permitted back into the manufacturing or
packaging area. There should be no unsealed
openings to the manufacturing area from other
areas.
30. Listeriae should be prevented from establishing and
growing in niches or other sites that can lead to
contamination of the processed food. This should
include a thorough check of water in cooling systems,
cracks and crevices in storage tanks and other
equipment components and effective cleaning and
sanitizing. All drains must be properly constructed, and
cleaned and sanitized each day. Floor drains should not
be located under or near filling and packaging
equipment.
Effective pasteurization is the key step to control
Listeria in the processing area. In the case of HTST
pasteurization of milk, a minimum of 72°C for 15 s is
essential. Products containing higher fat or sugar levels,
require higher temperatures to ensure effective
destruction of Listeria spp. It is recommended that all
such products be heated to 75°C for 15 s to be safe.
31. Cleaning and sanitizing programmes are vital in
ensuring that post-pasteurization contamination does
not occur. Absorbent items such as rags and sponges
should be eliminated to reduce potential harbourage
and spreading of the organisms. Separate brushes
should be used for product contact and non-product
contact surfaces.
A sampling programme should be implemented that
can assess in a timely manner whether the food-
processing environment is under control. There should
be a rapid and effective response to each positive
sample obtained.
Finally, there should be verification by follow-up
sampling that the source has been detected and
corrected.
32. Bacillus cereus
• Bacillus cereus is a well-known food-poisoning
organism that may cause illness through the production
of either an emetic (vomit-inducing) toxin or at least
three diarrhoeal toxins or enterotoxins.
• Raw milk appears to be the major source of B. cereus in
the pasteurized milk, and post-pasteurization
contamination along the milk processing line is possibly
only a minor source.
• B. cereus cells attach to stainless steel surfaces and are
capable of forming a biofilm, a situation that can
present a major problem for the food industry. biofilms
on food contact surfaces that can cause serious
problems in cleaning and disinfection operations.
33. • Endospore formers such as Bacillus spp. which have
survived the pasteurization process can cause a
variety of spoilage problems in dairy products, and
B. cereus has been detected in ice creams, milk
powders, fermented milks and pasteurized milks.
• Although B. cereus is able to grow at low
temperatures, pH is a definite hurdle, and pH 5 is
critical for the growth of this organism. It is
expected therefore that growth in fermented dairy
products with a pH lower than 5 will be minimal.
34. Chemical hazards
Mycotoxins
• Mycotoxins are secondary metabolites produced by
fungi of various genera when growing on
agricultural products before or after harvest or
during transportation or storage.
• Contamination by such fungi can occur at many
stages during feed production, e.g. during plant
growth, harvesting, storage and processing.
• Mycotoxins are found mostly on feed ingredients
such as maize, sorghum, wheat and groundnuts.
• Mycotoxins pose a risk to both animal and human
health, it is carcinogenic due to the activity of the
toxin.
35. • Fungal species of greatest concern in the dairy industry
are Aspergillus flavus it produces Aflatoxin B1 and B2
under optimum conditions of temperature, water
activity and nutrient availability.
• Following consumption of Aflatoxin B1 and B2
contaminated feeds,the metabolite, Aflatoxin M1 and
M2, is secreted in the milk.
• The aflatoxins have a very high toxigenicity, the
maximum Codex limit in milk for Aflatoxin M1 and M2 is
0.5 μg kg−1.
• Mycotoxins cannot be totally eliminated from feed
once the feed has been contaminated, and processing
the feed by means of heat treatment has little effect in
eliminating the mycotoxins.
• Continuous monitoring of levels needs to take place to
ensure that contamination does not exceed acceptable
tolerance levels.
36. • Preventing contamination at source is one of the most
effective methods of reducing the risk of mycotoxin
contamination.
• Suitable measures need to be applied during crop
production, handling, storage and processing.
• Practical steps that can be taken to reduce mycotoxin
contamination of grains and feed ingredients include
the pre-harvest selection of resistant seed varieties,
prevention of physical damage to crops by insects and
the use of appropriate crop rotation.
• At harvest, precautions to be taken include proper
handling to avoid physical damage and crop cleaning to
remove field soil.
• Storage practices include keeping crops dry and clean
and proper labelling of crops (dates, etc.) to ensure that
if problems do occur, traceability is ensured.
37. • Antimicrobials
• The most frequently and commonly used antimicrobials
associated with milk are antibiotics, employed to
combat mastitis-causing pathogens in the dairy cow.
• The occurrence of antibiotic residues in milk may have
economic, technological and even human health
implications.
• Residues can lead to partial or complete inhibition of
acid production by cheese starter cultures. This can
lead to inadequate ripening and maturation of the
cheese, resulting in flavour or texture defects and
substantial financial loss for the dairy industry.
• There has also been increasing public concern over the
possible links between veterinary drug residues in milk
and the transfer of antibiotic resistant organisms and
resistance genes to humans as a result of veterinary
use of antibiotics in food animals.
38. • The solution to the problem of drug residues in milk
lies in the application of the general principles of
‘Good Farming Practice’. These include the following
principles:
Good farm management should in the first place be
directed towards the prevention of infectious
diseases, such as (sub)clinical mastitis, in order to
limit the use of veterinary drugs.
In the process, farmers must keep their animals in
sound physical condition by ensuring hygiene and
good housekeeping practices and implementing
sound farm management.
39. Only registered pharmaceutical products with a known
depletion pattern should be used and correctly
administered in terms of prescribed dose and
frequency.
The keeping of reliable records of such drug use is also
essential. This remains the responsibility of the milk
producer to respect the prescribed withdrawal period.
In the process, the treated animals need to be marked
clearly to allow for correct identification (e.g. by taping
a hind leg).
Treated cows need to be milked last, and during the
withholding period the milk must be discarded in the
proper way. The milking equipment should also be
cleaned properly after contact with the contaminated
milk.
40. Industrial and environmental contaminants
Dioxins
• Dioxins is known as a human carcinogen, the
carcinogenic effect of dioxins does not occur at
levels below a certain threshold, the maximum level
set in the latter Regulations for dioxins in milk and
milk products is 3 pg World Health Organization
Toxic Equivalents (WHO-TEQ) per gram of fat.
• Dioxins are extremely resistant to chemical and
biological degradation and therefore persist in the
environment and accumulate in the feed and food
chain.
41. • Dioxins arise during the production of chloro-organics
and in emissions of industrial and municipal
incineration processes.
• Contamination of animal feed occurs via particle-bound
distribution on grass and other fodder plants.
• The accumulation of dioxins in animals is mainly from
these contaminated feeding stuffs.
• Human foods of animal origin in turn contribute to
approximately 80% of the overall human exposure to
dioxins.
• For these reasons, feeding stuffs and, in some cases
soil, raise concerns as potential sources of dioxins. Like
the organochlorine pesticides, the dioxins are
fatsoluble.
42. Heavy metals
• The term ‘heavy metals’ is a general term that applies
to a group of metals, it is widely recognized and usually
applied to elements such as Cr, Ni, Cu, Zn, Hg and Pb
that are commonly associated with pollution and
toxicity problems.
• The widespread distribution, contamination and
multiple effects of heavy metals in the environment has
become a global problem.
• Pb is among the most common metal pollutants. Major
sources of lead exposure include lead in paint, gasoline,
water distribution systems, food, industrial emissions
and lead used in hobby activities. Lead exposure
attributable to automobile air emissions.
43. • The adverse effects of Pb are now well recognized,
and these include effects on the development of
cognitive brain function in children, as well as on
the kidney and haematopoietic system.
• In a study the highest metal concentrations in dairy
cattle feeds were for Zn and Cu.
• Mineral supplements contained higher
concentrations of Ni, Pb, Cd, As and Cr than did
other feed components.
44. Procedures to minimize risk of feed and milk
contamination
(1) The production, processing, storage, transport and
distribution of safe, suitable feed and feed ingredients
is the responsibility of all participants in the food
chain. These participants include farmers, feed
ingredient manufacturers, feed compounders,
transport contractors, etc. Each participant is
responsible for all the activities under their direct
control. The Dutch Animal feed sector has opted for a
quality-assurance system based on the HACCP
approach applied by the European food industry. This
emphasizes that the animal feed industry and the
preceding ingredient suppliers are part of the food
chain. Hence, their slogan of ‘Feed for Food’.
45. (2) Production of feed and feed ingredients on the farm:
Adherence to good agricultural practices (GAP) is encouraged
in the production of natural, improved and cultivated
pastures, and forage and cereal grain crops used as feed or
feed ingredients for food-producing animals. Following GAP,
prescriptions will minimize the risk of biological, chemical or
physical contaminants entering the feed chain. Crop residuals
and stubbles used for grazing after harvest should also be
considered as livestock feed. The same applies to livestock
bedding, since most livestock will consume a portion of their
bedding. Straw or wood shavings should therefore be
managed in the same manner as animal feed ingredients.
Rational grazing and dispersion of manure droppings should
be applied to reduce cross-contamination between animals.
Other factors should also be taken into consideration such as
the proximity of the agricultural land to industrial operations
where effluent or gas emissions can lead to feed
contamination. Similarly, chemical fertilizers, manure,
pesticides and other agricultural chemicals should be stored,
managed and disposed of correctly.
46. (3) Monitoring and identification of health hazards:
When purchasing feed ingredients from suppliers, such
suppliers should be able to demonstrably guarantee
product safety. Audit procedures can include
inspection, sampling and analysis for undesirable
substances. Feed ingredients should meet acceptable
and, if applicable, statutory standards for levels of
pathogens, mycotoxins, pesticides and other
undesirable substances that may constitute a health
hazard for the consumer. Any contaminated feed or
feed ingredient is unsuitable for animal feed and should
be discarded. Traceability of feed and feed ingredients,
including additives, should be enabled by proper
labelling and record keeping at all stages of production
and distribution.
47. (4) Processing, storage and distribution of feeds and feed
ingredients. The effective implementation of GMPs and,
where applicable, HACCP-based approaches should ensure
that the following areas are addressed:
Premises – Buildings and equipment must be constructed
to permit ease of operation, maintenance and cleaning.
Water should be of a suitable quality, and effluent should
be adequately disposed of.
Receiving, storage and transportation – Feed and feed
ingredients should be stored separately from fertilizers,
pesticides, etc. Processed material should also be stored
separately from unprocessed ingredients. The presence of
undesirable substances should be monitored for and
controlled. The finished products should be delivered and
used as quickly as possible. During storage, special
precautions should be taken to restrict microbial growth in
feedstuffs and ingredients.
Personnel training – Personnel should be adequately trained and
aware of their role and responsibility in protecting food safety.
48. Physical hazards
• Physical hazards, like microbiological and chemical
hazards, can enter a food product at any stage in its
production. There is a huge variety of physical items
that can enter food as foreign material, and some of
these are hazards to food safety.
• The main physical food safety hazards include items
such as glass, metal (including broken needles), stones,
wood, plastic, dust and hair. The main risk area for
physical contamination of milk at the farm level is the
stored milk in the bulk tank. Producers should,
therefore, assess potential physical hazard risks in
storage areas (e.g. breakable glass, loose material, etc.).
Corrective action to be taken in the area housing the
bulk milk storage tank is, for example, to use
shatterproof light-covers to prevent glass
contamination from taking place.
49. • During the processing of milk, it is invariably subjected
to procedures that will remove any physical
contaminant. Examples of such procedures may include
filtration, while centrifugal clarifiers are standard
equipment in any commercial milk-processing
operation. However, similar to food beverages such as
fruit juice, consideration of potential hazards
associated with glass breakage should be part of an
HACCP plan in any processing plant that may be
packaging liquid milk products in glass. Glass fragments
caused by glass bottle breakage may result in serious
injury and can be caused in a number of ways, including
damage to the bottles in transit to the processing plant,
or damage to bottles during mechanized handling
(cleaning, filling or capping) of the bottles.
50. • If control measures for glass fragments in the product
are deemed necessary, one way is the use of online
glass detection equipment such as X-ray detection. In
this method, the product itself is continuously
monitored after the last step at which glass inclusion is
reasonably likely to occur (e.g. after bottling and
sealing of the product. The HACCP critical limit may
then be designated as ‘no glass in the finished product’.
• Another way to control glass fragments, applicable in
operations where the containers are manually (not
mechanically) handled and sealed, involves inspecting
glass containers visually before they are filled to ensure
that glass fragments are not present in the containers.
An appropriately trained individual at a container
inspection step in the process may do this.
51. • A third way to control glass fragments is visual
inspection at steps in the process where glass breakage
can result in glass entering the product, this can take
place upon reception of the glass containers, during
glass container storage, mechanical conveying,
mechanical filling and mechanical capping. The
inspection looks for any evidence of glass breakage in
those areas.
• The consideration of potential hazards associated with
metal fragments may be less relevant in dairy products
such as milk. In dairy products containing fruit pulp or
in the processing of fruit juice, metal fragments may
become a part of the hazard analysis if operations such
as the grinding of fruit or cutting operations are
involved. If hazard analysis shows that it is reasonably
likely that metal fragments can be a problem, controls
for metal fragments should be established in the
HACCP plan of the operation.
52. • The following ways to establish control measures for metal
fragments in the product:
Use of online metaldetection equipment. With this method,
the equipment continuously monitors the product after the
last step at which metal inclusion is reasonably likely to occur
(e.g. after bottling and sealing of the product) at a process
step designated for metal detection.
Use of a separation device such as a screen after the last step
at which metal inclusion is reasonably likely to occur, at a
process step designated for screening.
Visually inspecting equipment for damage or missing parts at
process steps such as extracting and grinding, where such
damage or loss of parts could lead to metal fragments in the
fruit pulp or juice. This approach may only be feasible for
relatively simple equipment that can be fully inspected
visually in a reasonable time period.