This study investigated the expression of RRBP1 in central and peripheral astrocytoma tissue samples. The results found that RRBP1 expression was higher, though not statistically significantly, in peripheral astrocytoma tissues compared to central tissues. RRBP1 expression was significantly correlated with proliferation marker Ki-67 and invasion marker MMP9 expression. This suggests that high RRBP1 expression may regulate astrocytoma proliferation and invasion. Further research is needed to understand the underlying mechanisms.