45-year-old male presented with 6 months of progressive right nasal obstruction and blood-stained nasal discharge. He developed right-sided hearing loss and tinnitus 5 months ago. One month ago, he noticed hoarseness of voice, difficulty swallowing, and a painful right neck mass. Examination found restricted movement of the soft palate and right vocal cord with an enlarged right neck lymph node. Differential diagnoses included nasopharyngeal carcinoma and sinus malignancy. CT scan and biopsy were requested to investigate.
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
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The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
5. History of presenting illness:
The condition started 6 months ago
with right side nasal obstruction,
insidious onset , start on and off
progressively become constant before
1 month. No aggravating or relieving
factors, associated with ipsilateral
blood stained nasal discharge. There is
nasal regurgitation, snoring and post
nasal dripping, no mouth breathing,
SOB or obstructive sleep apnoea.
6. 1 months latter he developed right side
epistaxis ,2-3 times, small amount , start
and stopped spontaneously ,Last attack
before week. There is right side facial pain
and numbness.
No smell disturbance, no itching or
sneezing.
No dental pain, no loose or lost teeth
7. 5months ago, he developed progressive
decrease hearing, associated with severe
tinnitus(all over the day) which is roaring
in nature, and aural fullness. No vertigo,
no ear pain or discharge, no mouth
deviation.
1 month latter he developed severe
headache, dull aching, at temporal area
,no specific time of day, no aggravating
factors relieved by analgesia. No projectile
vomiting, no convulsions ,no loss of
consciousness or change in behavior.
8. There is blurring of vision and ,double
vision, no epiphora or eye protrusion
9. 1 month latter he noticed right side neck
mass, painless, gradually increase in size,
no other masses. Also he developed
,change of voice in form of hoarseness,
and chocking.
No sore throat ,odynophagia or dysphagia.
No loss of weight or appetite, no chronic
cough, no fever or sweating.
13. Drug history:
Not known to be allergic to aspirin or
any drug known by him.
Not on long term medication.
14. Social history:
Not known to be smoker or
alcoholic consumer
low socioeconomic status, no
health insurance.
15. summary
45 years old male presented with RT side
progressive nasal obstruction/6 months, associated
with blood stained nasal discharge. Epistaxis and
facial pain. 1 months latter he developed RT side
progressive decrease hearing and aural fullness
associated with severe roaring tinnitus.
1 months ago he developed hoarseness of voice
,nasal regurgitation for water and chocking.
There is RT side painless progressive neck mass
for1 month .no other masss.
18. Nose normal in shape ad contour.
No area of tenderness.
Cold spatula test:
Decrease fogging in RT side
present in Left side
Nasal
examination
19. Anterior rhinoscopy: Normal vestibule
and columella bilaterally. There is blood
stained purulent nasal discharge at RT
side.
Normal mucosa covering septum ,middle
and inferior turbinate, bilaterally.
Posterior rhinoscopy: difficult
21. Oral examination :
Normal lips, normal teeth, gums
and buccal mucosa. Tongue
deviated to right.
Normal hard palate
Soft palate mobility restricted at
right.
Uvula deviated to left.
22. Ear examination :
Both auricles were normal . No pre or post
auricular swelling or scar , normal external
auditory canals bilaterally. No area of
tenderness
TM bilaterally dull and immobile.
-Rhine's test : -ve in RT .
Weber test is Lateralized TO RT .
23. Neck examination :
There is right side lymph nodes at level 2
and 5.largest one about 6*4 cm ,rounded,
skin over it is normal. Rounded6*4 cm, firm
in consistency,not attached to skin or deep
structures.
No limitation in neck movement .
Laryngeal crepitus is present .
Trachea central.
24. Normal base of tongue , vallecullae,
RT vocal cord restricted in mobility, LT
normal , pyriform fossae free