This document discusses respiration and the pleura. It defines respiration and lists normal respiratory rates by age group. Respiration involves external respiration between the lungs and blood and internal respiration between blood and tissues. The pleura is a bi-layered membrane enclosing each lung. The intra-pleural space between the layers contains a thin film of fluid that lubricates the layers and creates negative pressure within the pleural cavity. Potential issues involving the pleural space include pneumothorax, hydrothorax, hemothorax, and pyothorax.