This document discusses using custom polymer particles for targeted drug delivery. Specifically, it mentions using polymer design parameters like brush thickness and particle size to control repulsion between particles and proteins or cells to achieve targeted uptake. It also references several papers on using polyethylene glycol and random copolymer brushes to create neutral surfaces and a two-phase separation for drug delivery applications.

1. Custom particles www.nlm.nih.gov Preventing immune-response induced thrombosis* *Lee, et. al. Prog Polym Sci, 1995 **Storm, et. al. Adv. Drug. Del. Revs, 1995 ***Jonas, et. al. Nano Letters, 2008, van Vlerken, et. al. Pharm Rsch, 2007 Targeted uptake of genes, drugs by specific cells, stimuli-responsive materials*** Polymer design parameters for drug delivery R drug H brush R protein σ σ R g 2 Goal: find the polymer-induced repulsion as a function of: R protein R drug H brush R drug

2. Trombly and Ganesan, JPS(B), 2009 Drug-protein project

3. Extensions Trombly and Ganesan, JCP, 2010 (accepted) Polyethylene glycol hydrogen bonding Result: two phases

4. Design of neutral surfaces Random copolymer brush Mansky, et al, Science, 1997 f A B

5. Model-SCFT w( r ) q( r ,s) q c ( r ,s) w( r ) = v ρ ( r ) Energetic Entropic Blood protein Polymer-coated drug ρ ( r ) Bispherical coordinates Fredrickson, “The Equilibrium Theory of Inhomogeneous Polymers,” 2005