This biannual publication, reSearch, is dedicated to the mission of informing and inspiring readers by highlighting scientific performance at The Research Institute at Nationwide Children's Hospital.
In this longitudinal study, researchers used standardized measures and multiple informants to examine differences in externalizing behavior and substance use among childhood cancer survivors and comparison peers during adolescence. The roles of peer acceptance, social behavior and medical factors were of focus.
In this longitudinal study, researchers used standardized measures and multiple informants to examine differences in externalizing behavior and substance use among childhood cancer survivors and comparison peers during adolescence. The roles of peer acceptance, social behavior and medical factors were of focus.
This biannual publication, reSearch, is dedicated to the mission of informing and inspiring readers by highlighting scientific performance at The Research Institute at Nationwide Children's Hospital.
How participatory research can inform practice and policy? The CanChild exper...Olaf Kraus de Camargo
Conférences scientifiques du Département de pédiatrie
CHU St. Justine, Montréal, Québec – 23 November 2022
Invited Rounds describing CanChild approach to participatory research.
Why aren’t we solving the greatest scientific problems of the world today? Innovation is critical to our nation’s scientific enterprise. However, creative thinking has been on the decline and is not generally taught in academic institutions. Renowned public health scientist and clinician, Dr. Roberta Ness, Dean of the University of Texas Health School of Public Health, believes that students, established scientists, researchers, and engineers can learn to be more innovative. Through her book Innovation Generation: How to Produce Creative and Useful Scientific Ideas, and graduate course on Innovative Thinking at the University of Texas, Dr. Ness provides the framework and tools to “think outside the box.” She shared these basic concepts in this one-hour lecture. Dr. Ness is a leading researcher in women’s health and widely known for her efforts to bridge from research to policy. She is a member of the Institute of Medicine.
Down Syndrome Cognition Research 101: An Introductionplus15campaign
An introduction to topics in Down syndrome cognition research, including current initiatives DSRTF supports and clinical trials now underway. Presenters: DSRTF board member Sarah Wernikoff; DSRTF Chief Scientific Officer Dr. Michael Harpold; and Roche Pharmaceuticals' Dr. Omar Khwaja.
This biannual publication, reSearch, is dedicated to the mission of informing and inspiring readers by highlighting scientific performance at The Research Institute at Nationwide Children's Hospital.
In this study, researchers examined the extent to which stress, coping, positive affect, negative affect and effortful control accounted for differences in the adjustment of children with cancer.
This biannual publication, reSearch, is dedicated to the mission of informing and inspiring readers by highlighting scientific performance at The Research Institute at Nationwide Children's Hospital.
How participatory research can inform practice and policy? The CanChild exper...Olaf Kraus de Camargo
Conférences scientifiques du Département de pédiatrie
CHU St. Justine, Montréal, Québec – 23 November 2022
Invited Rounds describing CanChild approach to participatory research.
Why aren’t we solving the greatest scientific problems of the world today? Innovation is critical to our nation’s scientific enterprise. However, creative thinking has been on the decline and is not generally taught in academic institutions. Renowned public health scientist and clinician, Dr. Roberta Ness, Dean of the University of Texas Health School of Public Health, believes that students, established scientists, researchers, and engineers can learn to be more innovative. Through her book Innovation Generation: How to Produce Creative and Useful Scientific Ideas, and graduate course on Innovative Thinking at the University of Texas, Dr. Ness provides the framework and tools to “think outside the box.” She shared these basic concepts in this one-hour lecture. Dr. Ness is a leading researcher in women’s health and widely known for her efforts to bridge from research to policy. She is a member of the Institute of Medicine.
Down Syndrome Cognition Research 101: An Introductionplus15campaign
An introduction to topics in Down syndrome cognition research, including current initiatives DSRTF supports and clinical trials now underway. Presenters: DSRTF board member Sarah Wernikoff; DSRTF Chief Scientific Officer Dr. Michael Harpold; and Roche Pharmaceuticals' Dr. Omar Khwaja.
This biannual publication, reSearch, is dedicated to the mission of informing and inspiring readers by highlighting scientific performance at The Research Institute at Nationwide Children's Hospital.
In this study, researchers examined the extent to which stress, coping, positive affect, negative affect and effortful control accounted for differences in the adjustment of children with cancer.
This research focuses on parents’ perceptions of pediatric antidepressant use—relative to psychotherapy—and is one of the first to measure parents’ perceptions of the risk and benefits of pediatric antidepressant use.
Study finds massage lowers depression, anxiety and pain in children with sickle cell disease. This is a Research Brief on the first study on topic that solely focused on children and used a conrol group.
This biannual publication, reSearch, is dedicated to the mission of informing and inspiring readers by highlighting scientific performance at The Research Institute at Nationwide Children's Hospital.
More from The Research Institute at Nationwide Children's Hospital (7)
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
1. research
A P u b L Ic AT I o n o f T he R e s ea Rc h I ns T I T u T e aT n aT I o nwI d e c hI l dRe n’s ho sp I Tal
A Day in the Life of
The ReseARch InsTITuTe
2. 7:30 a.M.
daYBReaK
A crescent moon appears
above Research Building II
as dawn breaks on a beautiful
Ohio Tuesday morning.
3. fALL / WI nTeR 2008
research is dedicated to the
mission of informing and inspiring
Twenty-four hours from now, Nationwide Children’s Hospital readers by highlighting scientific
will not be the same hospital it is at this moment. Knowledge performance at The Research Institute
will grow. Possibilities will emerge. Enthusiasm will escalate. at nationwide children’s hospital.
Lives will be changed through discovery. This publication is produced
biannually by the Marketing and
Public Relations Department at
As the research engine of Nationwide Children’s, The Research
nationwide children’s hospital.
Institute is a key contributor to this daily transformation. Each
day begins with a sense of excitement and mission. Innovative
experiments are conceived and carried out by our research teams,
data are collected and careful analyses are conducted. Data are
collaboratively shared among faculty, staff and students. We
strive for exciting conclusions, but sometimes more questions
arise than answers. We persevere, stubbornly emboldened by the
l e a d e Rs hI p
potential that scientific inquiry will lead to better health for The Research Institute at
nationwide children’s hospital
children and their families. The beat goes on.
John a. Barnard, Md
President
In this issue of reSearch, we provide you with snapshots of a
reSearch lauren o. Bakaletz, phd
Vice President, Basic Sciences Research
“typical Tuesday” in a day in the life of The Research Institute.
Kelly Kelleher, Md, Mph
Through this photographic timeline, we hope you will appreciate Vice President, Health Services Research
william e. smoyer, Md
the heart and soul of one of the top pediatric research centers in Vice President, Clinical and Translational Research
the United States. Grant Morrow III, Md
Medical Director
daniel R. Mann
Vice President, Research Administration
and Operations
Katherine s. Milem
Vice President, Research Business Services
research
John Barnard, MD Writer and editor
Melissa hamilton
President
The Research Institute at Nationwide Children’s Hospital Art Directors
John ordaz
Professor of Pediatrics Tanya Burgess Bender
The Ohio State University College of Medicine
Photographers
Brad smith
dan smith
Manager, Research communications
Jan arthur
contact us at
ResearchMagazine@nationwidechildrens.org
The ReseaRch InsTITuTe at nationwide children’s hospital | 1
4. 8:03 a.M.
FocusInG on FIRsT-RaTe FacIlITIes
Phil Bowers helps Mary Connell from
Children’s Hospital of Philadelphia pour
off excess liquid nitrogen from shipping
containers holding tissue samples that are
being sent to Boston.
As facilities manager at The Research
Institute, Bowers begins his work day
at 6 a.m. and spends his early hours
walking through and “waking up” the
research buildings. Bowers checks for alarms,
notes equipment problems and performs
safety checks. By the time he completes his
rounds he will have covered every floor in
the 300,000 square feet of research space,
trekking through more than 90 labs.
2 | The ReseaRch InsTITuTe at nationwide children’s hospital
5. 9:18 a.M.
Fedex FRenzY
This Tuesday is like every other weekday in the Biopathology
Center. Staff members receive between 20 and 40 FedEx
packages containing pediatric and adult cancer samples
from hospitals all across North America. After the samples
are unpacked, they are entered into a detailed, secure
database. Tissue samples are prepared for digital microscopy
and shared with other national experts using a virtual
microscope. Some samples are carefully catalogued for storage
in a liquid nitrogen freezer, while others undergo clinical
testing to help make vital cancer treatment decisions.
The Biopathology Center is funded by the National Cancer
Institute and serves as the data repository for cancer samples
from more than 500 hospitals. Specimens from this Center are
used for cancer research in institutions worldwide. Because of
the Biopathology Center, The Research Institute at Nationwide
Children’s Hospital receives more grant funds from the
Children’s Oncology Group than any other national program.
The ReseaRch InsTITuTe at nationwide children’s hospital | 3
6. 9:24 a.M.
FRoM BedsIde To Bench and BacK aGaIn
Dr. W. Joshua Frazier is both a researcher in the Center for Perinatal Research and a critical care clinician at Nationwide
Children’s. Shown here in the Pediatric Intensive Care Unit, (top), Dr. Frazier facilitates patient rounds and discusses clinical
cases with colleagues.
Under the mentorship of Dr. Yusen Liu, Dr. Frazier is studying septic shock, a condition he has seen affect many of his critical
care patients. Using mouse models of sepsis and septic shock, Dr. Frazier measures markers and pathways of inflammation with
hopes of identifying key molecular interactions that will lead to improved treatment of critically ill children.
4 | The ReseaRch InsTITuTe at nationwide children’s hospital
7. 10:00 a.M.
MIndInG The MedIa
Dr. Lara McKenzie, a faculty member in the Center for Injury Research and Policy, prepares for an interview with ABC’s Good
Morning America regarding her diving injury research. Later this same week, Dr. McKenzie would provide interviews to additional
media outlets including USA Today and U.S.News & World Report.
Collectively, the Center for Injury Research and Policy at Nationwide Children’s garners millions of media impressions annually.
10:16 a.M. 10:35 a.M.
execuTIve exchanGe calIBRaTInG a cRITIcal coRe ResouRce
President of The Research Institute Dr. John Barnard, Dave Dunaway calibrates a flow cytometer, a highly sophisti-
(right), meets with Nationwide Children’s Chief Operating cated instrument used for identifying and sorting cells. Dave
Officer Rick Miller and other hospital administrators during places colored beads in the flow cytometer to mimic cells and
a facilities meeting. Dr. Barnard regularly meets with evaluates the accuracy of the machine’s four lasers by studying
hospital administration to discuss activities at The Research color graphs produced on his computer monitor.
Institute, including details regarding Research Building III,
The Flow Cytometry Core is one of 13 Shared Research Services
soon to break ground.
at The Research Institute. Scientists are charged a users fee,
creating a cost efficient way to keep state-of-the-art technology
available to all the scientists at The Research Institute.
The ReseaRch InsTITuTe at nationwide children’s hospital | 5
8. 10:45 a.M. 11:00 a.M.
FacIlITaTInG FInance and FundInG assIsTInG The assIsTanTs
Director of Sponsored Projects, Aaron Ufferman, Roy Goudy of Research Information Services helps Administrative
works at his desk. Behind him appears a monthly list Assistant Char Cameron sign onto a training program used to
of upcoming grant applications for faculty under his update faculty biographical sketches on The Research Institute’s
purview. The Finance and Sponsored Projects Internet site. The Research Institute’s overhead provides
Department supports grant and contract funding outstanding administrative and information technology
from the start of a search for funding through the support for its scientists.
closeout of a project.
11:15 a.M. noon
cRoss-caMpus collaBoRaTIon shuTTlInG BeTween sITes
Ohio State University residents, Drs. John Novak and W. In 2007, Nationwide Children’s began a shuttle
David Arnold, prepare to meet with Dr. Zarife Sahenk in service to The Ohio State University Medical Center.
the Center for Gene Therapy, to review muscle biopsies. An average of 80 students, faculty and staff members
Like most research faculty members, Dr. Sahenk works ride the shuttle each day. The shuttle service is one of
closely with colleagues at The Ohio State University many services and programs designed to enhance
Medical Center and serves as a professor in the OSU interaction between the campuses.
College of Medicine.
6 | The ReseaRch InsTITuTe at nationwide children’s hospital
9. 12:14 p.M.
seMInaR seRIes
Dr. Kurt Albertine of the University of Utah Health Sciences Center, presents his research on bronchopulmonary dysplasia at a
seminar in the Research Building II amphitheater. The Research Institute holds such seminars twice a week, featuring visiting
scientists from all over the world.
12:40 p.M.
couch-sIde collaBoRaTIve
Research associates Adam Nation and Michele
Patak discuss plans for a research project exploring
the relationship between safety practices and
impulsivity, a collaborative effort between the Center
for Biobehavioral Health and the Center for Injury
Research and Policy. Adam and Michele work under
the supervision of Dr. Lara McKenzie, a safety expert,
and Dr. Brady Reynolds, a psychologist with expertise
in impulsive behavior. The project is funded by the
Centers for Disease Control and Prevention. At The
Research Institute, collaboration between research
centers is commonplace.
The ReseaRch InsTITuTe at nationwide children’s hospital | 7
10. 1:10 p.M.
a sTudenT’s schedule
Chelsea Bolyard injects a drug into cultured cancer cells to test an alternative gene therapy treatment for ovarian cancer. As a
third-year graduate student at The Ohio State University and a member of the Center for Gene Therapy, Chelsea divides her time
between Dr. Jeff Bartlett’s lab at Nationwide Children’s and classes on the main OSU campus. Annually, more than fifty graduate
students from OSU receive training at The Research Institute.
8 | The ReseaRch InsTITuTe at nationwide children’s hospital
11. 2:06 p.M.
coMMuTInG FoR
clInIcal ReseaRch
12-year-old Caroline Brendsel begins
a study visit with Clinical Research
Coordinator Kassi Speakman in the
Clinical Studies Center. Caroline has
been participating in a research
trial for hereditary angiodema, a
rare genetic disorder that causes
intermittent severe tissue swelling,
sometimes in vital areas of the body.
As part of the trial, the test medication
is delivered via a central venous line.
Although the initial portion of
the phase III clinical trial is complete,
Caroline receives the medication under
an open label protocol. Caroline and
her mother faithfully make the
100-mile round trip from south of
Lancaster, Ohio to Nationwide
Children’s two to three times a week
as they have done for three years.
Hundreds of other children visit the
Clinical Studies Center annually as
participants in dozens of local and
national clinical research trials.
The ReseaRch InsTITuTe at nationwide children’s hospital | 9
12. 3:00 p.M.
scRuTInIzInG huMan ReseaRch sTudIes
Members of the Institutional Review Board (IRB) at Nationwide Children’s meet twice a month on Tuesday afternoon. This 19-member
board provides critical oversight of all research involving human subjects at Nationwide Children’s and its affiliated institutions. The IRB
has the authority to approve, require modifications in, or disapprove all research activities that fall within its jurisdiction. This function is
federally-mandated and regulated by the Department of Health and Human Services and the Food and Drug Administration. The
Nationwide Children’s IRB was among the first of such committees in the United States to be fully electronic.
3:32 p.M.
a pReMIeR pRoGRaM
FoR oTITIs MedIa
pRevenTIon
Laura Novotny, senior
research associate in the
laboratory of Dr. Lauren
Bakaletz, checks a bacterial
culture to make sure it is
sufficient for her experi-
ment, which will test how
well vaccine candidates
block bacterial adherence.
As part of the Center for
Microbial Pathogenesis,
the team led by Dr.
Bakaletz is an international
leader in understanding
immune mechanisms in
the middle ear. The group
is working on a promis-
ing vaccine to prevent
ear infections in children,
one of the most common
childhood illnesses.
10 | The ReseaRch InsTITuTe at nationwide children’s hospital
13. 4:07 p.M.
InTeRnaTIonal InvesTIGaToR
Postdoctoral fellow Mandar Joshi in
the Center for Cardiovascular and
Pulmonary Research processes human
and animal cardiac tissue samples by
“sealing” them in paraffin wax and
placing them in cassettes for use in later
research. Clinical cardiac tissue samples
are obtained through partnerships with
The Heart Center at Nationwide Children’s
and The Ohio State University.
As an international employee, Dr. Joshi
is on a visa from India. International
employees on visas account for about 10
percent of The Research Institute’s total
employees and come from 24 countries.
The ReseaRch InsTITuTe at nationwide children’s hospital | 11
14. 4:28 p.M.
leadInG MusculaR dYsTRophY ReseaRch
Research Assistant Danielle Tucker prepares a muscle biopsy extracted from the left deltoid of a patient with limb-girdle muscular
dystrophy being evaluated at the Nationwide Children’s Hospital Close To HomeSM Center in Westerville, Ohio.
After the sample is frozen and stained, researchers will examine it to determine whether or not the patient could be a candidate
for gene therapy trials to treat limb girdle muscular dystrophy type 2D.
The Mendell Lab is part of the Center for Gene Therapy and is an international leader in muscular dystrophy research. Dr. Jerry
Mendell’s group initiated the first U.S. human gene therapy trial directed at Duchenne muscular dystrophy in children and the
first national muscular newborn screening study.
4:44 p.M.
unITInG scIence and TechnoloGY
Dr. Richard Ransom, principal investigator in the Center
for Clinical and Translational Research, inspects an image
of a specialized kidney cell known as a podocyte.
Using the graphics editing program Adobe® Photoshop®,
Dr. Ransom is able to stack images of the same cell using
different fluorescence filters. This allows him to superim-
pose images for comparison, in this case, images labeling
the actin filaments that make up the cell’s “skeleton”
(shown in green), and the heat shock proteins (shown in
red) that are expressed when cells are exposed to stress.
Dr. Ransom uses this method to determine whether actin
filaments and heat shock proteins are found in the same
structures in the cell, since the areas where they co-localize
are yellow in the superimposed image. This examination is
a first step in studies aimed at treating nephrotic syndrome,
one of the leading reasons for kidney disease in children.
12 | The ReseaRch InsTITuTe at nationwide children’s hospital
15. 8:54 p.M.
ReseaRch aFTeR daRK
As darkness falls, Postdoctoral Fellow Benoit Callendret continues his work. At The Research Institute, scientific discovery often
continues late into the evening.
This evening, Dr. Callendret uses the flow cytometer to evaluate a liver biopsy that arrived at 8:30 a.m. He is quantifying the
frequency of hepatitis C virus-specific T cells in order to develop a baseline for an upcoming study. The study aims to assess
whether or not identified hepatitis C virus-specific T cells are functional in the context of chronic infection. This research will
be the first of its kind to be performed directly in vivo.
Dr. Callendret is part of Dr. Chris Walker’s team in the Center for Vaccines and Immunity. Dr. Walker is an international leader
in hepatitis C virus research.
The ReseaRch InsTITuTe at nationwide children’s hospital | 13
16. 2221
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pa I d
coLuMbus, oh
700 children’s Drive PeRMIT no. 777
columbus, ohio 43205-2696