Walsh Construction rented two BAUER Drilling Rigs to replace a historic viaduct near Philadelphia. This story, published in Deep Foundations Magazine, details the many unique drilling challenges faced during this high-profile project.
Walsh Construction rented two BAUER Drilling Rigs from specialty foundation equipment supplier Equipment Corporation of America to overcome challenging subsurface conditions during the $89.9-million Crum Creek Viaduct Replacement project in Swarthmore, Pa. Story by Brian M. Fraley, Fraley AEC Solutions, LLC.
This cover story from the October 2000 edition of Constructioneer explains E.J. Breneman's cold in-place recycling process and how it was getting traction with local municipalities.
This cover story explains how heavy civil contractor Burke Construction conquered its first pile driving job using and RTG RG 19 T Piling Rig. This story also had one of Pile Buck Magazine's highest ever levels of engagement in the enewsletter.
This October 5, 1998 Constructioneer article by Brian Fraley explains how R.A.M. Construction executed a record-breaking pile driving project in Dover, Delaware.
The cover story for Rock Road Recycle tells the story of how Urban Foundation/Engineering used two BAUER BG Drilling Rigs from Equipment Corporation of America to conquer an underground boulder field in Brooklyn, N.Y. to make way for a high-profile tower.
This Piling Canada cover story reveals ECA's evolution from a World War I surplus equipment dealer to a global leader in specialty foundation equipment.
This 1921 brochure from Equipment Corporation of America (ECA) showcases the firm's manufacturing and rebuilding capabilities for construction and material handling equipment.
Featured in Vol. 33 No. 6 2017 of Pile Buck Magazine, this story focuses on the role of Deep Foundations Contractors' extensive fleet of BAUER Drilling Rigs on its Crosstown LRT project in downtown Toronto.
Walsh Construction rented two BAUER Drilling Rigs from specialty foundation equipment supplier Equipment Corporation of America to overcome challenging subsurface conditions during the $89.9-million Crum Creek Viaduct Replacement project in Swarthmore, Pa. Story by Brian M. Fraley, Fraley AEC Solutions, LLC.
This cover story from the October 2000 edition of Constructioneer explains E.J. Breneman's cold in-place recycling process and how it was getting traction with local municipalities.
This cover story explains how heavy civil contractor Burke Construction conquered its first pile driving job using and RTG RG 19 T Piling Rig. This story also had one of Pile Buck Magazine's highest ever levels of engagement in the enewsletter.
This October 5, 1998 Constructioneer article by Brian Fraley explains how R.A.M. Construction executed a record-breaking pile driving project in Dover, Delaware.
The cover story for Rock Road Recycle tells the story of how Urban Foundation/Engineering used two BAUER BG Drilling Rigs from Equipment Corporation of America to conquer an underground boulder field in Brooklyn, N.Y. to make way for a high-profile tower.
This Piling Canada cover story reveals ECA's evolution from a World War I surplus equipment dealer to a global leader in specialty foundation equipment.
This 1921 brochure from Equipment Corporation of America (ECA) showcases the firm's manufacturing and rebuilding capabilities for construction and material handling equipment.
Featured in Vol. 33 No. 6 2017 of Pile Buck Magazine, this story focuses on the role of Deep Foundations Contractors' extensive fleet of BAUER Drilling Rigs on its Crosstown LRT project in downtown Toronto.
ECA is one of the first equipment distributors to participate in AED's Technician Certification Program. This article in CED Magazine explains how the move will benefit its customers.
This article in the December 20, 1999 issue of Constructioneer Magazine, explains how lifting equipment helped to transport and erect the famous Rockefeller Center Christmas tree in 1999.
This construction job story, "Keep on Boring," ran in the November 2017 issue of Foundation Drilling Magazine. It also ran in several American, Canadian, and European construction magazines.
This construction job story, "Deep Foundations Drill to Keep TBMs Crawling on Canada's Largest Transit Expansion," ran on the cover of Foundation Drilling Magazine. It also ran in several American, Canadian, and European construction magazines.
This advertorial for Pile Buck Magazine explains the Second Chance Line Restraint, an innovative crane safety product that prevents the snapping of overloaded hoisting lines. It appeared in Volume 33 No. 4 2017 issue of Pile Buck.
This column by then-Editor Brian M. Fraley addresses the Pennsylvania Department of Transportation's (PennDOT) adoption of GPS-controlled surveying. It was featured in the Spring 2007 edition of Highway Builder, the official publication of the Associated Pennsylvania Constructors.
Cover story from the November 6, 2000 issue of Constructioneer on how Popple Construction used a fleet of 20 Cat earthmovers to move 2.6-million cubic yards of dirt in preparation for a Procter & Gamble warehouse in Northeastern Pennsylvania.
This cover story, featured in the May 2017 issue of Hard Hat News, explains how PKF-Mark IIII took a break from traditional pile driving methods to rent two RTG Pile Driving Rigs from Equipment Corporation of America for its PA Turnpike/I-95 Interchange Project in Bucks County, Pa. The switch paid off.
This story, featured on the cover of PileDriver Magazine's Issue 2, tells the story of a forward-thinking contractor that abandoned its traditional pile driving approach and took a gamble on two RTG Pile Driving Rigs from Equipment Corporation of America. The results were positive and drastically improved the firm's performance on a $142.9-million infrastructure project in Pennsylvania.
This story, featured in GeoDrilling International, explains how a forward-thinking contractor broke with tradition to install bridge foundations on the PA Turnpike/I-95 Connector Project in Pennsylvania. PKF Mark III historically relied on a crane-suspended pile hammer. Its decision to rent RTG pile driving rigs from Equipment Corporation of America (ECA) is paying off with doubled productivity, reduced labor, increased safety, and cost-savings.
This story, featured in Pile Buck Magazine, explains how a forward-thinking contractor broke with tradition to install bridge foundations on the PA Turnpike/I-95 Connector Project in Pennsylvania. PKF Mark III historically relied on a crane-suspended pile hammer. Its decision to rent RTG pile driving rigs from Equipment Corporation of America (ECA) is paying off with doubled productivity, reduced labor, increased safety, and cost-savings.
Fraley AEC Solutions Owner Brian Fraley and Pile Buck Magazine Editor Alex Smoot have a discussion in a Q&A format on the importance of marketing in the construction industry.
This in-depth feature story, feared in the January 2015 issue of Foundation Drilling Magazine, tells the story of three generations of the Kern family that have guided Specialty Foundation Equipment supplier Equipment Corporation of America toward a century in business.
This article by Brian M. Fraley, featured in the February 23, 2015 edition of The Zweig Letter, delves into the branding lessons to be learned from the famed WWII Battle of Iwo Jima.
ECA is one of the first equipment distributors to participate in AED's Technician Certification Program. This article in CED Magazine explains how the move will benefit its customers.
This article in the December 20, 1999 issue of Constructioneer Magazine, explains how lifting equipment helped to transport and erect the famous Rockefeller Center Christmas tree in 1999.
This construction job story, "Keep on Boring," ran in the November 2017 issue of Foundation Drilling Magazine. It also ran in several American, Canadian, and European construction magazines.
This construction job story, "Deep Foundations Drill to Keep TBMs Crawling on Canada's Largest Transit Expansion," ran on the cover of Foundation Drilling Magazine. It also ran in several American, Canadian, and European construction magazines.
This advertorial for Pile Buck Magazine explains the Second Chance Line Restraint, an innovative crane safety product that prevents the snapping of overloaded hoisting lines. It appeared in Volume 33 No. 4 2017 issue of Pile Buck.
This column by then-Editor Brian M. Fraley addresses the Pennsylvania Department of Transportation's (PennDOT) adoption of GPS-controlled surveying. It was featured in the Spring 2007 edition of Highway Builder, the official publication of the Associated Pennsylvania Constructors.
Cover story from the November 6, 2000 issue of Constructioneer on how Popple Construction used a fleet of 20 Cat earthmovers to move 2.6-million cubic yards of dirt in preparation for a Procter & Gamble warehouse in Northeastern Pennsylvania.
This cover story, featured in the May 2017 issue of Hard Hat News, explains how PKF-Mark IIII took a break from traditional pile driving methods to rent two RTG Pile Driving Rigs from Equipment Corporation of America for its PA Turnpike/I-95 Interchange Project in Bucks County, Pa. The switch paid off.
This story, featured on the cover of PileDriver Magazine's Issue 2, tells the story of a forward-thinking contractor that abandoned its traditional pile driving approach and took a gamble on two RTG Pile Driving Rigs from Equipment Corporation of America. The results were positive and drastically improved the firm's performance on a $142.9-million infrastructure project in Pennsylvania.
This story, featured in GeoDrilling International, explains how a forward-thinking contractor broke with tradition to install bridge foundations on the PA Turnpike/I-95 Connector Project in Pennsylvania. PKF Mark III historically relied on a crane-suspended pile hammer. Its decision to rent RTG pile driving rigs from Equipment Corporation of America (ECA) is paying off with doubled productivity, reduced labor, increased safety, and cost-savings.
This story, featured in Pile Buck Magazine, explains how a forward-thinking contractor broke with tradition to install bridge foundations on the PA Turnpike/I-95 Connector Project in Pennsylvania. PKF Mark III historically relied on a crane-suspended pile hammer. Its decision to rent RTG pile driving rigs from Equipment Corporation of America (ECA) is paying off with doubled productivity, reduced labor, increased safety, and cost-savings.
Fraley AEC Solutions Owner Brian Fraley and Pile Buck Magazine Editor Alex Smoot have a discussion in a Q&A format on the importance of marketing in the construction industry.
This in-depth feature story, feared in the January 2015 issue of Foundation Drilling Magazine, tells the story of three generations of the Kern family that have guided Specialty Foundation Equipment supplier Equipment Corporation of America toward a century in business.
This article by Brian M. Fraley, featured in the February 23, 2015 edition of The Zweig Letter, delves into the branding lessons to be learned from the famed WWII Battle of Iwo Jima.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.