Raynaud
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The document discusses micronutrient deficiency in elderly populations. It finds that 36-47% of community-dwelling elderly have low vitamin D levels, while nursing home residents have lower levels of several vitamins and minerals compared to independently living elderly. Hospitalized elderly also experience high rates of deficiencies like vitamin C deficiency. Supplementation with multiple micronutrients has not shown benefits for health outcomes in studies. Higher vitamin D intake and achieving serum levels over 30 ng/mL through supplementation is recommended due to benefits for muscle function, falls prevention, and fracture reduction in the elderly.
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1) The document discusses vitamin D deficiency and its link to various health issues. It reports that 61-82% of postmenopausal women and 98% of patients with osteoporotic fractures have inadequate vitamin D levels.
2) Several causes of vitamin D deficiency in the elderly are described, including lack of sun exposure and less effective vitamin D synthesis in the skin.
3) The text reviews results from studies that show vitamin D supplementation can reduce fracture risk by 33%, falling risk by 49%, and improve lower limb function. It is suggested that maintaining higher vitamin D levels may provide significant economic savings in healthcare costs.
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Vitamin D has important roles in bone health, immune function, cell growth and many other physiological processes. It is produced in the skin upon exposure to sunlight, but can also be obtained through dietary sources. Deficiency is associated with increased risk of various diseases such as cancer, cardiovascular disease, diabetes and autoimmune disorders. Maintaining sufficient vitamin D levels through sunlight exposure and/or supplementation may provide protective health benefits.
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Vitamin D plays an important role in regulating calcium levels and bone health. It is also involved in insulin regulation and may protect against cancer, cardiovascular disease, and infections. Vitamin D deficiency can lead to rickets in children and osteomalacia in adults as well as increased risk of falls in older adults. Supplementation is recommended for those with inadequate sunlight exposure or dietary intake, with dosage depending on age.
Eggs: Solutions to Vitamin D deficiency - Knowledge Day 2016
Dr. Linda Browning discusses vitamin D deficiency as a global health issue and proposes that eggs can be a solution. At the end of the 19th century, rickets afflicted 90% of dead children in cities due to lack of vitamin D. While vitamin D is important for calcium absorption and bone health, deficiency is also linked to increased risk of cancer, cardiovascular disease, and autoimmune disorders. The document outlines ways to increase vitamin D content in eggs through supplemental feeding of hens. Enriched eggs could help address widespread vitamin D inadequacy globally by providing a rich, affordable source through regular consumption.
Nutrient Risk Assessment and Upper Intake Levels - Korea_2015
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Vitamin D has effects on bone, muscles, and non-musculoskeletal conditions. It is very common for risk groups like children, older adults, pregnant women, and immigrants to be vitamin D deficient. While vitamin D supplements can help with bone health, the evidence for other benefits is less clear. Large ongoing clinical trials are investigating the effects of vitamin D supplements on conditions like fractures, cardiovascular disease, respiratory infections, diabetes, and cancer. Recommendations for vitamin D intake vary between health organizations.
vitdospi-091024063028-phpapp01.pptx
1) Vitamin D plays an important role in bone metabolism by facilitating calcium absorption in the gut and maintaining calcium and phosphate levels, which are needed for bone mineralization.
2) The recommended daily intake of vitamin D is 600-800 IU for those under age 50 and 800-1000 IU for those over 50, though some studies suggest a minimum of 2000 IU may be needed to achieve optimal vitamin D levels.
3) While sunlight exposure can produce significant amounts of vitamin D, individual factors like skin pigmentation, sunscreen use, and latitude can influence vitamin D production, so measuring vitamin D levels is recommended for those at risk of deficiency.
Higher Vitamin D Levels Associated With Improved Survival in Metastatic Color...
Higher levels of vitamin D were associated with improved survival outcomes in patients with previously untreated metastatic colorectal cancer (mCRC) who were enrolled in a clinical trial. Patients in the highest quintile of vitamin D levels had a 35% lower risk of death and a 21% lower risk of disease progression compared to those in the lowest quintile. An exploratory analysis found that patients with a specific genotype may experience even greater survival benefits from higher vitamin D levels. Ongoing research is investigating whether vitamin D supplementation can improve outcomes for patients with mCRC receiving chemotherapy.
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1) Several studies show high rates of vitamin D deficiency and insufficiency among children with asthma. Low vitamin D levels are associated with worse asthma control, including increased exacerbations and hospitalizations.
2) Observational studies link higher maternal vitamin D intake during pregnancy to lower rates of wheezing and asthma in offspring. However, the evidence for a causal relationship is still insufficient.
3) Maintaining adequate vitamin D levels, especially during pregnancy and childhood, may help reduce asthma risk and severity by supporting lung development and function. Further research is still needed.
To D or not to D that is the question? Vitamin D deficiency in Australia
This document summarizes the results of a study investigating vitamin D status in over 24,000 individuals in New South Wales, Australia. The study found:
1) Over 40% of participants had insufficient or deficient vitamin D levels, with the highest rates in spring.
2) Younger women, inpatients, and those in major cities or of lower socioeconomic status were most at risk of deficiency.
3) Factors like being male, living rurally, and higher SES were protective against deficiency.
4) Season, gender, age, location, and SES explained over 30% of the variability in vitamin D levels.
Nephrotic syndrom and vitamins
losses of both vitamin D binding protein and 25(OH)D in the urine
The urinary losses of vitamin D binding protein may be secondary to proteinuria.
Deficiency in 25(OH)D may lead to hypocalcemia, hyperparathyroidism, and diminished bone mineral density/content.
Vitamin D deficiency has also been associated with multiple systemic effects including elevated blood pressure ,metabolic syndrome, cardiovascular disease ,anemia and impaired immune system regulation .
Papanikolaou
1. Exercise is essential for building and maintaining bone density throughout life. Weight-bearing and resistive exercises stimulate bone growth, especially in childhood and adolescence.
2. Therapeutic exercise programs for osteoporosis patients should be tailored based on factors like bone mineral density, fitness level, and fracture risk. Exercises should progressively build strength, balance, and flexibility to prevent falls and fractures.
3. Even gentle, non-strenuous exercises can benefit older osteoporosis patients and those with fractures by improving balance, cardiovascular health, and reducing falls. Programs combining exercise, nutrition, fall prevention and medical treatment can optimize bone health and quality of life.
Bollheimer
This document discusses methods for assessing fracture risk in patients with primary osteoporosis. It outlines that fracture risk is determined by bone mineral density as well as clinical risk factors related to bone quality. The document recommends using FRAX, a WHO fracture risk assessment tool, which calculates 10-year fracture probability based on clinical risk factors with or without a bone mineral density scan. FRAX is presented as the most important algorithm for assessing osteoporosis and determining treatment based on an individual's estimated fracture risk.
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Optimum Vitamin Nutrition (OVN) for Swine - Gilbert M. Weber
Recent research on vitamin requirement of modern swine breeds under current husbandry conditions is limited; tabular recommendations may underestimate the actual needs of growing pigs and breeding sows.
Clinical / subclinical vitamin deficiency can still occur within industrial swine production:
optimum vitamin supplementation prevents from deficiency and
exploits the genetic performance potential of swine.
Superior dietary supplementation levels of certain vitamins do provide additional value, such as improved stress and disease resistance, adequate welfare or better product quality.
Rajeev slides
Vitamin D deficiency in children can cause rickets, a softening and weakening of bones. Some key signs of rickets include bowed legs, delayed growth, muscle weakness, and fractures. Historically, rickets was common in industrialized cities due to lack of sun exposure. While sunlight is the primary natural source of vitamin D, many foods like milk are fortified and supplements can also provide it. Public health recommendations are for 400-1000 IU per day for children. Studies show vitamin D supplementation may help conditions like cerebral palsy and reduce influenza infections in kids. Ensuring adequate vitamin D intake is important for children's health.
Use of vitamin d in non bone diseases
This document discusses the use of vitamin D in preventing and treating non-bone diseases. It begins with an introduction and covers topics like immunomodulation related to allergy, fetal development, and the prevention and modification of diseases like asthma, COPD, allergic rhinitis, atopic dermatitis, and food allergy. It also briefly mentions autoimmunity and other diseases. The document provides information on vitamin D synthesis and metabolism and cites several studies on vitamin D levels in different populations and its effects. It concludes with a discussion of vitamin D's immunomodulatory effects in relation to allergy.
Vitamin d up to date
This document provides recommendations and guidelines regarding vitamin D. It discusses the forms and dietary sources of vitamin D, causes and epidemiology of vitamin D deficiency worldwide and in Saudi Arabia. It covers approaches to evaluating and diagnosing vitamin D deficiency, including which patient populations to screen. Treatment guidelines are presented for vitamin D supplementation based on age. Research associations between vitamin D and cancer, cardiovascular outcomes, and osteoporosis are summarized. Recommendations are also provided regarding vitamin D in pediatrics, pregnancy, older adults, and sun exposure.
Lunch session p lakatos
1) The document discusses vitamin D deficiency and its link to various health issues. It reports that 61-82% of postmenopausal women and 98% of patients with osteoporotic fractures have inadequate vitamin D levels.
2) Several causes of vitamin D deficiency in the elderly are described, including lack of sun exposure and less effective vitamin D synthesis in the skin.
3) The text reviews results from studies that show vitamin D supplementation can reduce fracture risk by 33%, falling risk by 49%, and improve lower limb function. It is suggested that maintaining higher vitamin D levels may provide significant economic savings in healthcare costs.
Shafei vit.d
Vitamin D has important roles in bone health, immune function, cell growth and many other physiological processes. It is produced in the skin upon exposure to sunlight, but can also be obtained through dietary sources. Deficiency is associated with increased risk of various diseases such as cancer, cardiovascular disease, diabetes and autoimmune disorders. Maintaining sufficient vitamin D levels through sunlight exposure and/or supplementation may provide protective health benefits.
Seminar 26-11-10 - Vitamine d
Vitamin D supplementation, especially at doses of 700-800 IU/day of cholecalciferol, has been shown to reduce the risk of hip fractures and nonvertebral fractures when combined with calcium intake of at least 500 mg/day. Several meta-analyses found the greatest benefits in individuals with vitamin D levels <50 nmol/L or calcium intake <700 mg/day. While vitamin D alone showed no significant fracture reduction, supplementation that achieved 25(OH)D levels >75 nmol/L or included additional calcium intake was more effective in preventing fractures.
Vitamin D and Pain
This document discusses vitamin D and pain. It provides information on vitamin D metabolism and transformation to its active form. It discusses vitamin D's mechanism of actions, roles in epigenetics, immunomodulation, and relationship to conditions like pain, cardiovascular risk factors, depression, asthma control, testosterone levels, and mortality in the elderly. The document also addresses vitamin D deficiency, testing and interpretation of vitamin D levels, recommended intake, risk factors for deficiency, and treatment of deficiencies. Safety of vitamin D supplementation is discussed. The summary concludes by noting some natural substances like curcumin that have synergistic anti-inflammatory activity with vitamin D.
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Vitamin D And Chronic Periodontitis – A Randomised Double Blinded Placebo Con...
Background: Vitamin D is crucial for a wide variety of organ systems; nevertheless, evidence has demonstrated that vitamin D deficiency may place subjects at risk for not only low mineral bone density /osteoporosis and osteopenia but also infectious and chronic inflammatory diseases Vitamin D also has anti-inflammatory effects by suppressing pro-inflammatory cytokines through its effect on bone and mineral metabolism, innate immunity and several VDR gene polymorphisms, vitamin D has been reported to be associated with periodontal disease. Objectives: To assess anti-inflammatory effect of vitamin D3, when administered as monotherapy in generalised chronic periodontitis. Methods: This study comprises of 56 patients of generalised chronic periodontitis who were screened for their serum vitamin D3 levels. Out of which 30 patients who were vitamin D3 deficient (<20ng /><0.002)><0.000). Conclusion: Vitamin D deficiency may place subjects at risk for not only low bone mineral density/osteoporosis and osteopenia, but also infectious and chronic inflammatory diseases like periodontitis.
Vitamin D And Chronic Periodontitis – A Randomised Double Blinded Placebo Con...
Background: Vitamin D is crucial for a wide variety of organ systems; nevertheless, evidence has demonstrated that vitamin D deficiency may place subjects at risk for not only low mineral bone density /osteoporosis and osteopenia but also infectious and chronic inflammatory diseases Vitamin D also has anti-inflammatory effects by suppressing pro-inflammatory cytokines through its effect on bone and mineral metabolism, innate immunity and several VDR gene polymorphisms, vitamin D has been reported to be associated with periodontal disease. Objectives: To assess anti-inflammatory effect of vitamin D3, when administered as monotherapy in generalised chronic periodontitis. Methods: This study comprises of 56 patients of generalised chronic periodontitis who were screened for their serum vitamin D3 levels. Out of which 30 patients who were vitamin D3 deficient (<20ng /><0.002)><0.000). Conclusion: Vitamin D deficiency may place subjects at risk for not only low bone mineral density/osteoporosis and osteopenia, but also infectious and chronic inflammatory diseases like periodontitis.
Vit d
Vitamin D plays an important role in regulating calcium levels and bone health. It is also involved in insulin regulation and may protect against cancer, cardiovascular disease, and infections. Vitamin D deficiency can lead to rickets in children and osteomalacia in adults as well as increased risk of falls in older adults. Supplementation is recommended for those with inadequate sunlight exposure or dietary intake, with dosage depending on age.
Eggs: Solutions to Vitamin D deficiency - Knowledge Day 2016
Dr. Linda Browning discusses vitamin D deficiency as a global health issue and proposes that eggs can be a solution. At the end of the 19th century, rickets afflicted 90% of dead children in cities due to lack of vitamin D. While vitamin D is important for calcium absorption and bone health, deficiency is also linked to increased risk of cancer, cardiovascular disease, and autoimmune disorders. The document outlines ways to increase vitamin D content in eggs through supplemental feeding of hens. Enriched eggs could help address widespread vitamin D inadequacy globally by providing a rich, affordable source through regular consumption.
Nutrient Risk Assessment and Upper Intake Levels - Korea_2015
Nutrient Risk Assessment and Upper Intake Levels - Korea_2015Asian Food Regulation Information Service
Expert Consultation on Nutrient Risk Assessment for Determination of Safe Upper Levels for Nutrients held on 4th December, 2015 by International Life Sciences Institute, India Seminair 09-09-2015 Prof. Lips
Vitamin D has effects on bone, muscles, and non-musculoskeletal conditions. It is very common for risk groups like children, older adults, pregnant women, and immigrants to be vitamin D deficient. While vitamin D supplements can help with bone health, the evidence for other benefits is less clear. Large ongoing clinical trials are investigating the effects of vitamin D supplements on conditions like fractures, cardiovascular disease, respiratory infections, diabetes, and cancer. Recommendations for vitamin D intake vary between health organizations.
vitdospi-091024063028-phpapp01.pptx
1) Vitamin D plays an important role in bone metabolism by facilitating calcium absorption in the gut and maintaining calcium and phosphate levels, which are needed for bone mineralization.
2) The recommended daily intake of vitamin D is 600-800 IU for those under age 50 and 800-1000 IU for those over 50, though some studies suggest a minimum of 2000 IU may be needed to achieve optimal vitamin D levels.
3) While sunlight exposure can produce significant amounts of vitamin D, individual factors like skin pigmentation, sunscreen use, and latitude can influence vitamin D production, so measuring vitamin D levels is recommended for those at risk of deficiency.
Higher Vitamin D Levels Associated With Improved Survival in Metastatic Color...
Higher levels of vitamin D were associated with improved survival outcomes in patients with previously untreated metastatic colorectal cancer (mCRC) who were enrolled in a clinical trial. Patients in the highest quintile of vitamin D levels had a 35% lower risk of death and a 21% lower risk of disease progression compared to those in the lowest quintile. An exploratory analysis found that patients with a specific genotype may experience even greater survival benefits from higher vitamin D levels. Ongoing research is investigating whether vitamin D supplementation can improve outcomes for patients with mCRC receiving chemotherapy.
Vitamina D ed Asma - Prof. Boner Attilio Università di Verona
1) Several studies show high rates of vitamin D deficiency and insufficiency among children with asthma. Low vitamin D levels are associated with worse asthma control, including increased exacerbations and hospitalizations.
2) Observational studies link higher maternal vitamin D intake during pregnancy to lower rates of wheezing and asthma in offspring. However, the evidence for a causal relationship is still insufficient.
3) Maintaining adequate vitamin D levels, especially during pregnancy and childhood, may help reduce asthma risk and severity by supporting lung development and function. Further research is still needed.
To D or not to D that is the question? Vitamin D deficiency in Australia
This document summarizes the results of a study investigating vitamin D status in over 24,000 individuals in New South Wales, Australia. The study found:
1) Over 40% of participants had insufficient or deficient vitamin D levels, with the highest rates in spring.
2) Younger women, inpatients, and those in major cities or of lower socioeconomic status were most at risk of deficiency.
3) Factors like being male, living rurally, and higher SES were protective against deficiency.
4) Season, gender, age, location, and SES explained over 30% of the variability in vitamin D levels.
Nephrotic syndrom and vitamins
losses of both vitamin D binding protein and 25(OH)D in the urine
The urinary losses of vitamin D binding protein may be secondary to proteinuria.
Deficiency in 25(OH)D may lead to hypocalcemia, hyperparathyroidism, and diminished bone mineral density/content.
Vitamin D deficiency has also been associated with multiple systemic effects including elevated blood pressure ,metabolic syndrome, cardiovascular disease ,anemia and impaired immune system regulation .
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1. Exercise is essential for building and maintaining bone density throughout life. Weight-bearing and resistive exercises stimulate bone growth, especially in childhood and adolescence.
2. Therapeutic exercise programs for osteoporosis patients should be tailored based on factors like bone mineral density, fitness level, and fracture risk. Exercises should progressively build strength, balance, and flexibility to prevent falls and fractures.
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Physical exercise, especially resistance training, and nutritional supplementation can help prevent sarcopenia, the age-related loss of muscle mass and strength. Resistance training is most effective when performed 2-3 times per week for 8-12 repetitions at moderate to high intensity. Protein intake above the recommended daily amount, especially around exercise, may further boost the benefits. Hormonal therapies and drugs also show promise but require more research due to potential safety concerns. Lifestyle changes alone may not be sufficient, so alternative preventive strategies are still needed.
Spatharakis
This document discusses the relationship between nutritional status and pressure ulcers. It provides epidemiological data showing that malnutrition is associated with increased risk of developing pressure ulcers. Experimental studies in animals also demonstrate impaired wound healing in malnourished subjects. However, clinical studies on the effect of nutritional supplementation on pressure ulcer prevention and treatment have shown mixed results, with some finding no effect of supplementation on ulcer outcomes. Overall, while malnutrition and pressure ulcers often coexist, the relationship is complex and a causal link has not been firmly established.
Queneau
This document summarizes key points about iatrogenesis and drug-related risks in the elderly. It discusses age-related changes that increase risks, such as changes in body composition and drug distribution. Examples of high-risk drug classes are provided, like anticoagulants, psychotropic drugs, and antineoplastic agents. Specific situations that increase risks, such as polypharmacy and malnutrition, are also described.
Rolland
The document discusses the need for a consensus definition of sarcopenia and summarizes different approaches to defining and assessing sarcopenia. It notes that while muscle mass is important, muscle strength is also a key parameter. Different clinical methods to measure muscle mass such as DXA, BIA and anthropometry are described, but each method has limitations. The document advocates that an operational definition is needed that can be used for both research and clinical practice.
Zamboni
1. Sarcopenic obesity is defined as the concurrent presence of both sarcopenia and obesity, which is an increasing health problem in the elderly population.
2. Sarcopenia is the loss of skeletal muscle mass and strength associated with aging, while obesity is defined as a body mass index over 30 or body fat percentage over 27% for men and 38% for women.
3. The prevalence of sarcopenic obesity increases with age and combines the negative health effects of both conditions, increasing risks for falls, fractures, physical disability, and other health issues in older adults.
Raynaud
The document discusses malnutrition in elderly patients and its risk factors and assessment. It reports on studies finding that weight loss over 5kg increases mortality risk over 5 years. Risk factors for malnutrition include medical conditions, disabilities, social factors, and medications. Assessment of malnutrition involves evaluating weight loss, body mass index, albumin levels, nutritional screening tools, and food intake. Nutritional parameters like low BMI, albumin, and muscle mass are associated with higher complication rates.
Tsolaki
The document discusses the benefits of physical exercise on cognitive function in older adults and patients with Alzheimer's disease or mild cognitive impairment. It provides evidence from multiple reviews and studies that both aerobic and resistance training can improve executive function and delay cognitive decline. The document also describes results from trials conducted by the author showing that regular physical exercise interventions led to sustained or improved cognitive performance and functional abilities in MCI patients and helped maintain cognitive skills longer in Alzheimer's patients compared to control groups without exercise.
Onder
This document discusses the role of physical activity and exercise in aging populations. It covers factors for successful aging, characteristics of study populations according to physical activity levels, and the health benefits and goals of exercise for both younger-old and older-old age groups. The document also summarizes studies on the relationship between physical activity and reduced risks of mortality, cardiovascular disease, and other health outcomes. It provides guidelines for endurance and resistance training programs as well as screening recommendations for exercise in older adults.
1 rolland
The document discusses physical activity and prevention of falls in older adults. It finds that sarcopenia, or loss of muscle mass and strength, is a risk factor for falls. Inactivity leads to further loss of muscle mass and strength and can create a fear of falling. Resistance training is identified as the most effective intervention for increasing muscle mass and strength, even in frail elderly populations. A multidimensional intervention that includes resistance training is recommended for fall prevention in older adults.
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- 1. Do elderly subjects need vitamin supplementation? Agathe Raynaud-Simon Service de Gériatrie, Hôpital Bichat APHP, Paris Faculté de Médecine Denis Diderot, Paris 7 Laboratoire de Biologie de la Nutrition, EA4466, Faculté de Pharmacie, Paris 5
- 2. Questions Prevalence of micronutrient deficiency in the elderly? What micronutrients? Vitamin D ? Others ? In what population? living at home in nursing homes In the hospital? Clinical effect of supplementation? Treatment? Correction in deficiency? Supra physiological supplementation? Possibility of toxicity with nutritional supplementation? Safety limits ?
- 3. Micronutrient deficiency in community dwelling elderly Euronut-SENECA study Blood status Low vitamin B12 2.7 - 7.3 % Low folic acid 0 - 0.3 % Low vitamin B6 5.7 - 23.3 % Low vitamin E 0.6 - 1.1 % Low vitamin D 36 - 47 % Dietary intake 23.9 % (men) - 46.8 % (women) had low dietary intakes for at least one of the following micronutrients: calcium, iron, retinol, ß-caroten, B1, B6 or vitamin C POLANUT study( Carrière, Int J Vitam Nutr Res 2007) 832 subjects aged >70, semi-quantitative food frequency questionnaire Median intakes <RDA for vitamins B6, B9, D, calcium and magnesium
- 4. Micronutrient deficiency in community dwelling elderly INCA Study (ANSES, march 2011) Intakes < thanmean nutritional needs in elderly subjects (> 75 yrs) Vitamin B6, C and E (67 - 82 %) Calcium, magnesium and selenium (65 - 84 %) 456 of 1863 adults took nutritional supplements (25 %) In > 75 population, nutritional supplementation only lowered inadequacy in calcium intake (65 to 56 %) Risk of reaching the safety limit with nutritional supplements: very low
- 5. Micronutrient deficiency in the institutionalized elderly Nursing Home 552 ± 1009 7.1 ± 3.5 31 ± 39 28 ± 16 28.0 ± 9.5 35.0 ± 20.1 69 ± 14 Indicator Vit B12 (pmol/L) Vit B9 (nmol/L) Vit B6 (nmol/L) Vit D (nmol/L) Vit E (μmol/L) Vit C (µmol/L) Selenium (ng/g) Independently living 294 ± 153 9.5 ± 3.5 54 ± 32 38 ± 15 32.6 ± 9.9 67.3 ± 16.6 90 ± 13 p NS < 0.001 < 0.01 < 0.01 < 0.05 < 0.001 < 0.001 Lowik 1992
- 6. Micronutrient deficiency in the hospitalized elderly Vitamin C 145 consecutive patients admitted to a geriatric acute care ward 18 (12%) patients with clinical symptoms of scurvy perifollicular hyperkeratosis, petechiae or bruises, haemorrhagic features caused by venous puncture, severe gingivitis plasma vitamin C (1.09 +/- 1.06 vs 4.87 +/- 4.2 mg/L, p < .001 ) need for assistance for feeding (56 vs 13 %, p=.006) in-hospital deaths (44 vs 9 %, p=.012) Raynaud-Simon 2010
- 7. Multi micronutrient supplementation Clinical efficacy ???
- 8. Micronutriments supplementation SUVIMAX study 7876 women (35-60 yrs) and 5141 men(45-60 yrs) Supplementation:120 mg vitamin C, 30 mg vitamin E, 6 mg beta-carotene, 100 g selenium, and 20 mg zinc or placebo Mean follow-up : 7.5 ans No difference in Cancer incidence 267 [4.1%] vs 295 [4.5%] Ischemic cardiovascular disease 134 [2.1%] vs 137 [2.1%] All-cause mortality 76 [1.2%] vs 98 [1.5%] Hercberg, S. et al. Arch Intern Med 2004;164:2335-2342.
- 9. Number and rate (per 100 000 person-years) of specific cancers in the intervention and placebo groups Men Women Hercberg, S. et al. Arch Intern Med 2004;164:2335-2342. Copyright restrictions may apply.
- 10. Micronutrient supplementationin nursing homes N = 725 elderly institutionalised subjects Supplementation (2 years) vitamins (vit C 120 mg, E 15 mg, ß-caroten 6 mg) trace elements (selenium 100 µg, zinc 20 mg) Both, or Placebo Results: no effect Incidence of respiratory tract infections Incidence of urogenital infections Mortality Girodon 1999
- 11. Vitamin D 25OH D (ng/mL) 0-24 24-30 30-50 > 50
- 12. Vitamin D supplementation: nonvertebral and hip fracture reduction RR = 0.80 [0.72 – 0.89] RR = 0.82 [0.69 – 0.97] Bischoff-Ferrari, H. A. et al. Arch Intern Med 2009;169:551-561.
- 13. Vitamin D and muscle function Institutionalized elderly Vitamin D : 150 000 IU once/month for 2 months and 90 000 IU once/month for 4 months Moreira-Pfrimer, Ann Nutr Metab 2009
- 17. JC Souberbielle:
- 18. Vit D < 10 ng/mL --> 4 x 100 000 IU in 2 months
- 19. 10 < Vit D < 20 --> 3 «
- 20. 20 < Vit D < 30 --> 2 «
- 21. Continue with
- 22. 800-1000 UI/day