This document discusses how quant trading and dark pools have come to dominate the markets in Europe and beyond. It outlines how regulatory changes like MiFID led to growth in multi-lateral trading facilities and off-exchange trading between major banks and institutions. Now, over-the-counter markets with little transparency have much larger trading volumes than public exchanges. Traditional investors and day traders have little chance of success against high-frequency quant strategies that access non-public order flows and data. The landscape has changed dramatically and any trader ignoring these new realities does so at their own peril.