Pure Barre
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Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
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Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre 8792 19th street-
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
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Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre 8792 19th street-
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
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Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure Barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
Pure barre
Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles.
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
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Identification and nursing management of congenital malformations Physiology of Chemical Sensation of smell.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
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Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
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Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
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- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
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Pure Barre
- 1. Business Name: Pure Barre Address: 12151 Seal Beach Boulevard, Suite A, Seal Beach, CA 90740 Phone: (562) 252-3766 Email: rossmoor@purebarre.com Website: http://purebarre.com/ca-rossmoor Description: Pure Barre is a barre fitness studio with a focus on empowering women through group classes. They practice a total body workout that uses ballet barre to perform small, isometric movements with the goal of burning fat and sculpting muscles. Keywords: barre cardio, barre fitness class, group fitness class for women. Hour: Mon - Fri: 6am-9pm. Classes as scheduled. Saturday: 8am-1pm. Classes as scheduled. Sunday: 9am-5pm. Classes as scheduled.