The document discusses the development of a glucose nanosensor tattoo that aims to provide continuous glucose monitoring for diabetes patients, addressing the limitations of conventional electrochemical sensors. Key components of the nanosensor include hydrophobic polymers with glucose recognition elements and fluorescent reporters. The technology has potential advantages, such as reduced patient discomfort and the ability to measure glucose levels during sleep, although it also presents challenges and costs compared to existing solutions.

1. PRESENT BY
ROZANA ABOALKHAIR
GLUCOSE NANOSENSOR
TATTOO

2. OVERVIEW
• INTRODUCTION
• GLUCOSE NANOSENSOR TOOLS
i- INJECTOR
ii-NANOSENSOR TATTO
iii- IMAGING DEVICE
• CONCLUSION

3. Diabetes Has Become Epidemic
• Every day,
 3,600 new cases of diabetes are diagnosed.
 580 people die of diabetes-related complications.
 225 people have a diabetes-related amputation.
 120 people with diabetes progress to end-stage renal disease.
 55 people with diabetes become blind.
American diabetes association, May,2012.

4. GLUCOSE NANOSENSOR TOOLS
• Injector
• Nanosensor tattoo
• Imaging device
Trends in Molecular Medicine, Volume 16, Issue 12,
584-593, 23 September 2010

5. PLACEMENT IN SKIN
Skin Pharmacol Physiol,2009

6. PLACEMENT IN SKIN
Skin Pharmacol Physiol,2009

7.  Nanosensors composed of a
hydrophobic polymer containing:
• Lipophilic glucose recognition
elements
(boronic acid derivatives, PhB(OH)2 )
• Fluorescent reporters.
(alizarin, C14H8O4 )
Trends in Molecular Medicine, Volume 16, Issue 12, 584-593, 23 September
2010
NANOSENSOR TATTOO COMPONENTS

8. Imaging Device
Trends in Molecular Medicine, Volume 16, Issue 12, 584-593, 23 September
2010

9. CONCLUSION
• minimize the need for the implantation of electrochemical sensors , which minimizes
patient inconvenience and pain.
• Can performed when the patient is sleeping.
• Provide a means to measure the glucose levels continuously instead of only specific time.
• It would be an additional cost of producing this smart tattoo, by thoroughly comparing the
smart tattoo with other commercially available nanosensors.
• The tattoo, like most cutting-edge technologies have drawbacks, but can be turned
around to full efficiency.

10. Reference
• American Diabetes Association. (2012). "Diabetes Basics.”
• Cash, Kevin J., and Heather A. Clark. "Nanosensors and nanomaterials for monitoring
glucose in diabetes." Trends in molecular medicine 16.12 (2010): 584-593.
• Card, Jeffrey W., and Bernadene A. Magnuson. "A review of the efficacy and safety of
nanoparticle-based oral insulin delivery systems." American Journal of Physiology-
Gastrointestinal and Liver Physiology 301.6 (2011): G956-G967.

11. THANK YOU…