This document summarizes two high-profile murder trials in the United States - the OJ Simpson trial and the Casey Anthony trial. Both trials resulted in controversial acquittals that highlighted the power of juries to nullify charges despite evidence. The OJ Simpson jury acquitted him of murder charges related to the deaths of Nicole Brown Simpson and Ron Goldman despite DNA evidence. Similarly, the Casey Anthony jury acquitted her of murdering her daughter Caylee, though she was found guilty of lying to police. Both verdicts emphasized the juries' ability to disregard instructions and evidence to reach their own conclusions.