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M.A. Sikma, intensivist
Nationaal Vergiftigingen Informatie
Centrum en Intensive Care Centrum
UMCU
“Gezonde” voeding
is niet altijd gezond!
Vrouw 34 jaar

Voorgeschiedenis:
•Infantiele spieratrofie type1 (Werdnig-Hoffman), waarbij
thoraxdeformatie met chronische beademing
•‘05 asystolie obv laag kalium, magnesium en fosfaat
•‘06 PEG-sonde ivm ondervoeding
•‘08 aspiratie pneumonie
•‘09 dehydratie en electrolytstoornissen obv braken en
pneumonie
Reden van opname

• Recidief pneumonie
Tijdens opname
• Weigering antibiotica
• Patiënte wil door eigen verzorgers
  verpleegd worden
• Eigen gemalen voeding: weigert
  sondevoeding wegens angst voor
  misselijkheid en braken
Tijdens opname

• Comateus na 10 mg oxazepam
• Flumazenil; kort effect

• Bloedgas: pH 6.99, pCO2 43,
   pO2 65, HCO3- 10.3, BE -20.8,   SO2
93%
• C/ metabole acidose
Tijdens opname

• Comateus na 10 mg oxazepam
• Flumazenil; kort effect

• Bloedgas: pH 6.99, pCO2 43,
   pO2 65, HCO3- 10.3, BE -20.8,   SO2
93%
• C/ metabole acidose
   met respiratoire acidose!
Metabole acidose
• Aniongap:
   • Na + K – (CL + HCO3-) =
  155 + 2,8 – (117 + 10,3) =
  30,5
  Dus een verhoogde aniongap

• Osmolgap:
   • 2X Na + glc + ureum= 310 + 9,6 +
     6,2= 325,8
   • gemeten osmol = 326
   • dus geen verhoogde osmolgap
Differentiaal Diagnose
Endogene zuurproductie:
•Lactaat 0,9 mmol/l
•Ketonen: geen ketonurie
•Geen rhabdomyolyse: fosfaat 1,45 mmol/L
•5-Oxoproline (glutathionsynthetase deficiëntie)

Andere toegediende zuren?
•Alcoholen: geen osmolgap
•Aspirine en tolueen niet waarschijnlijk

Verminderde renale uitscheiding:
•Kreat 70
Deze pot stond naast het
           bed?




Maar ze was geen bodybuilder!
  Oorzaak van de acidose?
Ze kreeg ook Vitamine C
           toediening!
• Vitamine C = ascorbinezuur
• Eliminatie via nieren
• Bij doseringen hoger dan 2 gram per dag kunnen
  diarree en darmklachten ontstaan
Oorzaak metabole acidose?

Mogelijk de Vitamine C
toediening in combinatie met
nierfunctiestoornissen
“Gezonde” voeding
is niet altijd gezond!

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Presentatie umcu

  • 1. M.A. Sikma, intensivist Nationaal Vergiftigingen Informatie Centrum en Intensive Care Centrum UMCU
  • 3. Vrouw 34 jaar Voorgeschiedenis: •Infantiele spieratrofie type1 (Werdnig-Hoffman), waarbij thoraxdeformatie met chronische beademing •‘05 asystolie obv laag kalium, magnesium en fosfaat •‘06 PEG-sonde ivm ondervoeding •‘08 aspiratie pneumonie •‘09 dehydratie en electrolytstoornissen obv braken en pneumonie
  • 4. Reden van opname • Recidief pneumonie
  • 5. Tijdens opname • Weigering antibiotica • Patiënte wil door eigen verzorgers verpleegd worden • Eigen gemalen voeding: weigert sondevoeding wegens angst voor misselijkheid en braken
  • 6. Tijdens opname • Comateus na 10 mg oxazepam • Flumazenil; kort effect • Bloedgas: pH 6.99, pCO2 43, pO2 65, HCO3- 10.3, BE -20.8, SO2 93% • C/ metabole acidose
  • 7. Tijdens opname • Comateus na 10 mg oxazepam • Flumazenil; kort effect • Bloedgas: pH 6.99, pCO2 43, pO2 65, HCO3- 10.3, BE -20.8, SO2 93% • C/ metabole acidose met respiratoire acidose!
  • 8. Metabole acidose • Aniongap: • Na + K – (CL + HCO3-) = 155 + 2,8 – (117 + 10,3) = 30,5 Dus een verhoogde aniongap • Osmolgap: • 2X Na + glc + ureum= 310 + 9,6 + 6,2= 325,8 • gemeten osmol = 326 • dus geen verhoogde osmolgap
  • 9. Differentiaal Diagnose Endogene zuurproductie: •Lactaat 0,9 mmol/l •Ketonen: geen ketonurie •Geen rhabdomyolyse: fosfaat 1,45 mmol/L •5-Oxoproline (glutathionsynthetase deficiëntie) Andere toegediende zuren? •Alcoholen: geen osmolgap •Aspirine en tolueen niet waarschijnlijk Verminderde renale uitscheiding: •Kreat 70
  • 10. Deze pot stond naast het bed? Maar ze was geen bodybuilder! Oorzaak van de acidose?
  • 11. Ze kreeg ook Vitamine C toediening! • Vitamine C = ascorbinezuur • Eliminatie via nieren • Bij doseringen hoger dan 2 gram per dag kunnen diarree en darmklachten ontstaan
  • 12. Oorzaak metabole acidose? Mogelijk de Vitamine C toediening in combinatie met nierfunctiestoornissen