More Related Content
Similar to Presentasi Biosel 2.pptx
Similar to Presentasi Biosel 2.pptx (20)
Recently uploaded
Recently uploaded (20)
Presentasi Biosel 2.pptx
- 1. Metabolic Disease dan Brain Disfunction akibat Disregulasi Insulin Signaling Pathway pada Penderita Down Syndrome Kelompok 5 21120302 - Silmi Rahmani 21120310 - Nilamsari Kurniasih I.
- 2. Outline Pembahasan Down Syndrome Disease Metabolic Disease pada Down Syndrome Insulin Resistence Signalling in Down Syndrome Side Effect in Down Syndrome Treatment You could describe the topic of the section here Conclusions You could describe the topic of the section here 01 02 03 04 05 06
- 4. Enter a subtitle here if you need it Down Syndrome Disease 01
- 5. Down Syndrome Down Syndrome: merupakan kelainan pada seseorang yang diakibatkan oleh penambahan jumlah kromosom 21 https://www.cdc.gov/ncbddd/birthde fects/downsyndrome.html CIri Morfologi: 1. Brachychepalia (Kepala rata) 2. Mata kecil (epicantus) 3. Bentuk Gigi Abnormal 4. Lengan pendek 5. Tangan dan jari kecil 6. Leher Pendek
- 6. Disregulasi Gen Down Syndrome • Down Syndrome Critical Region (DSCR) memiliki regulasi berlangsungnya penurunan serta peningkatan ekspresi suatu gen (Dierssen et al., 2020). • Gen The -Dual Specificity Tyrosine (Y)-Phosphorylation regulated Kinase 1 A (DYRK1A) proses perkembangan otak, proses belajar dan memori • The regulator of Calcineurin 1 (RCAN1) signaling sel transpor kalsium menjaga homeostasis, pertmubuhan sel dan imun respon • Gen pengkode enzim cystathionine beta synthase (CBS) pada jalur homocysteine/folate/ transsulfuration. Sumber: https://www.aboutkidshealth.ca/Article?contentid=9&language=English
- 7. 1. Peningkatan kadar fenilalanin dan tirosin 2. penurunan kadar histidin, lisin, tirosin, fenilalanin, leusin, isoleusin, dan triptofan 3. kadar leusin, isoleusin, sistein, dan fenilalanin yang lebih tinggi pada usia yang rentan terhadap perubahan Alzheimer 4. penurunan konsentrasi serine pada usia berapapun 5. peningkatan konsentrasi lisin pada pasien berusia di atas 10 tahun (Caracausi et al., 2018). Hipotesis “Leujeune Machine” Hipotesis Leujeune Machine menggambarkan bahwa metabolisme menjadi mesin mekanik yang berperan sebagai poros pusat kinerja tubuh
- 8. Komplikasi Down Syndrome Gagal Jantung Bawaan Diabetes Melitus Diabetes tipe 1 dan tipe 2 Obesitas Abnormal Fungsi dan Struktur Otak Alzheimer, Demensia, Craniofacial
- 9. Komplikasi Down Syndrome Gagal Jantung Bawaan Diabetes Melitus Diabetes tipe 1 dan tipe 2 Obesitas Abnormal Fungsi dan Struktur Otak Alzheimer, Demensia, Craniofacial • Bahwa protein prekursor amiloid (APP) pada membran integral di sinapsis sel neuron menyebabkan peningkatan ekspresi gen pengkode protein amiloid beta (AB)-peptida menjadi toksik • Protein AB dan menyebabkan peningkatan reactive oxygen species (ROS), peningkatan oxidative stress dan menyebabkan excitotoxicity yang mengganggu respirasi seluler dan fungsi sinapsis
- 10. Metabolic Disease pada Down Syndrome 02
- 11. • RNAC1 meningkat ketidak seimbangan Kalsium • Defisit mitokondria pada sel Down Syndrome • Phosphofructokinase (PFK) mengatur katalisis perubahan salah satu substrat fosforilasi fruktosa-6- fosfat menjadi fruktosa-1,6-bifosfat • Disregulasi Mitokondria mengarahkan pada kematian sel Metabolic Disease • Metabolic Disease adalah kelainan yang terjadi dysfunction metabolisme yang disebabkan oleh berbagai macam faktor sehingga mempengaruhi pembentukan ATP yang akan digunakan sebagai sumber energi bagi sel
- 12. ● Kadar Lemak meningkat ● Kadar Leptin meningkat insulin menurun ● HSPA72 dan Galectine-3 menyebabkan tingkat inflamasi merusak sel Pankreas ● Keadaan DS terjadi penurunan ukuran sel B pancreas
- 13. Skema Metabolic Disease • Disfunction Hormonal mempengaruhi metabolism sel • Peningkatan RCAN1 menyebabkan peningkatan inflamasi dan reaktif sistem imun merusak sel B pancreas insulin menurun • Menurunkan jumlah sel B Pankreas
- 14. About the Disease Venus has a beautiful name Mercury is the smallest planet Mars is actually a cold place Neptune is the farthest planet 10% 30% 25% 50% Mercury Venus Mars Neptune
- 15. A PICTURE IS WORTH A THOUSAND WORDS
- 16. Risk Factors To modify this graph, click on it, follow the link, change the data and paste the resulting graph here 50% 58% 40% 36% 52% 58% Saturn Mars Neptune Jupiter
- 17. Disfungsi Insulin Signaling Pathway pada Down Syndrom 03
- 18. INSULIN Insulin merupakan hormon yang diproduksi pankreas, tepatnya oleh sel B di pulau Langerhans. 1 Insulin dan atau IGF1 mengikat reseptor insulin dan dan mengaktifkan kaskade sinyal pada persinyalan insulin 2 Jalur pensinyalan insulin mengatur homeostasis glukosa darah dalam tubuh dan mempengaruhi banyak regulasi seluler pada berbagai jenis sel 3
- 19. Jalur Persinyalan Insulin Nat Rev Neurol. 2018 Mar; 14 (3): 168–181. Nat Rev Mol Cell Biol. 2018 Jan; 19(1): 31–44. & beragam aksi seluler
- 20. Disregulasi sejumlah protein pada jalur persinyalan insulin yang menyebabkan resistensi insulin otak Disregulasi jalur persinyalan insulin yang menyebabkan resistensi insulin otak pada penderita Down Sindrom dan Alzheimer
- 23. Pathology Jupiter Jupiter is a gas giant and the biggest planet in the Solar System Saturn Saturn is the ringed one. It’s composed of hydrogen and helium Mercury is the closest planet to the Sun, but does its name have anything to do with the liquid metal? Venus Despite its beautiful name, its atmosphere is poisonous
- 24. Diagnosis Mercury Mercury is the smallest Venus Venus is the second planet Mars Mars is a cold place Jupiter It’s the biggest planet Saturn Saturn has several rings Neptune Neptune is the farthest
- 25. Treatment Mars Despite being red, Mars is actually a cold place Venus Venus has a beautiful name, but it’s very hot 30% 58%
- 26. Enter a subtitle here if you need it About the Disease 03
- 27. Prevention Venus Despite being red, Mars is actually a cold place Saturn Jupiter Jupiter is a gas giant and the biggest planet Mars Venus is the second planet from the Sun
- 28. Results Treatment Test 1 Test 2 Test 3 Group 1 254 458 213 Group 2 454 552 128 Group 3 454 457 445 Experiment A Treatment Test 1 Test 2 Test 3 Group 1 180 154 320 Group 2 127 162 123 Group 3 635 130 110 Experiment B
- 29. Diagnosis 04 Enter a subtitle here if you need it
- 31. Mercury Jupiter Mercury is the smallest planet Jupiter is the biggest planet Prevalence
- 32. References ● AUTHOR (YEAR). Title of the publication. Publisher ● AUTHOR (YEAR). Title of the publication. Publisher ● AUTHOR (YEAR). Title of the publication. Publisher ● AUTHOR (YEAR). Title of the publication. Publisher ● AUTHOR (YEAR). Title of the publication. Publisher ● AUTHOR (YEAR). Title of the publication. Publisher
- 33. Our Team Dr. Jenna James You can replace the image on the screen Dr. James John You can replace the image on the screen Dr. John Smith You can replace the image on the screen
- 34. 1. You can describe what the patient shouldn’t do here 1. You can describe what the patient shouldn’t do here 1. You can describe what the patient shouldn’t do here 1. You can describe what the patient should do here 2. You can describe what the patient should do here 3. You can describe what the patient should do here Recommendations What to Do What to Avoid
- 35. Research Conclusions Mercury is the closest planet to the Sun and the smallest one in the Solar System—it’s only a bit larger than the Moon Conclusions
- 36. Mockup You can replace the image on the screen with your own work. Just delete this one, add yours and center it properly
- 37. CREDITS: This presentation template was created by Slidesgo, including icons by Flaticon, and infographics & images by Freepik and illustrations by Stories THANKS! Do you have any questions? youremail@freepik.com +91 620 421 838 yourcompany.com Please keep this slide for attribution
- 38. Alternative Resources PHOTOS ● Cheerful team of medics ● Cheerful man and woman medics ● Young medics talking at door ● Doctors with tablet and smartphone VECTORS ● Geometric shapes background ● Geometric background concept ● Geometric models flat background ● Healthy Lifestyle Icon Pack Did you like the resources on this template? Get them for free at our other websites
- 39. Resources PHOTOS ● Young woman having stomach ache ● Portrait of a unhappy woman ● Woman suffering from head pain ● Confident doctors in office ● Doctors looking at camera ● Young woman sitting on sofa ● Woman with back pain from work ● Young woman having headache ● Female with strong stomach pain ● Cheerful young doctors at hospital ● Cheerful female doctor in clinic Did you like the resources on this template? Get them for free at our other websites
- 40. Resources Did you like the resources on this template? Get them for free at our other websites VECTOR ● Pollution on human body infographic ICONS ● Healthcare and medical Pack ● Medical services Pack ● Human Uterus
- 41. Instructions for use In order to use this template, you must credit Slidesgo by keeping the Thanks slide. You are allowed to: - Modify this template. - Use it for both personal and commercial projects. You are not allowed to: - Sublicense, sell or rent any of Slidesgo Content (or a modified version of Slidesgo Content). - Distribute Slidesgo Content unless it has been expressly authorized by Slidesgo. - Include Slidesgo Content in an online or offline database or file. - Offer Slidesgo templates (or modified versions of Slidesgo templates) for download. - Acquire the copyright of Slidesgo Content. For more information about editing slides, please read our FAQs or visit Slidesgo School: https://slidesgo.com/faqs and https://slidesgo.com/slidesgo-school
- 42. Fonts & colors used This presentation has been made using the following fonts: Red Had Text (https://fonts.google.com/specimen/Red+Hat+Text) Lato (https://fonts.google.com/specimen/Lato) #e06666 #ace4ed #fff2cc #323c50 #356fa5
- 43. Stories by Freepik Create your Story with our illustrated concepts. Choose the style you like the most, edit its colors, pick the background and layers you want to show and bring them to life with the animator panel! It will boost your presentation. Check out How it Works. Pana Amico Bro Rafiki Cuate
- 44. Use our editable graphic resources... You can easily resize these resources without losing quality. To change the color, just ungroup the resource and click on the object you want to change. Then, click on the paint bucket and select the color you want. Group the resource again when you’re done.
- 47. JANUARY FEBRUARY MARCH APRIL PHASE 1 Task 1 Task 2 JANUARY FEBRUARY MARCH APRIL MAY JUNE PHASE 1 PHASE 2 Task 1 Task 2 Task 1 Task 2
- 53. ...and our sets of editable icons You can resize these icons without losing quality. You can change the stroke and fill color; just select the icon and click on the paint bucket/pen. In Google Slides, you can also use Flaticon’s extension, allowing you to customize and add even more icons.
- 54. Educational Icons Medical Icons
- 55. Business Icons Teamwork Icons
- 56. Help & Support Icons Avatar Icons
- 57. Creative Process Icons Performing Arts Icons
- 58. Nature Icons
- 59. SEO & Marketing Icons