Pine Lake Laboratories features a variety of instruments that excel clients projects and attract potential clients. All scientist are trained and have many years experience using all instrumentation.

1. Instrumentation
Pine Lake Laboratories

2. GC and GC-MS
Pine Lake Laboratories features Agilent
GC with FID, MS and NCD detectors.
These instruments are used to perform
residual solvents (USP <467>), volatile
Extractables and Leachables analyses,
and product specific volatile impurity
methods.

3. High Resolution Mass
Spectrometry
Pine Lake Laboratories features a
Bruker Aurora Impact HD Time-of-
Flight Mass Spectrometer (LC-QTOF).
This is a powerful tool we use to identify
non-volatile organic Extractables,
unknown degradation products and
metabolites. This instrument can also
be used to determine the molecular
weight of oligonucleotides.

4. ICP-MS
Pine Lake Laboratories features a
Thermo Scientific iCAP Q ICP-MS. This
ICP-MS is used for the identification
and quantitation of inorganic
Extractables and Leachables . The
instrument is also used to perform
elemental impurities following USP
<232> and <233>.

5. UPLC-MS/MS
Pine Lake Laboratories features Waters
AcQuity UPLC with Xevo TQ-S tandem
quadrupole mass spectrometers. There
powerful tools are used to quantitate
drugs in plasma and other biological
tissues. In addition, these instruments
can be used to identify metabolites.

6. UPLC-MS
Pine Lake Laboratories features a
Waters AcQuity UPLC with a SQ
Detector 2 single quadrupole mass
spectrometer. This instrument is used
for the analysis of Leachables and other
low level impurities in drug products.

7. HPLC
Pine Lake Laboratories has 13 HPLCs.
All of the HPLCs have UV detectors plus
some systems have CAD and
fluorescence detectors. These systems
routinely run reverse phase, HILIC, ion
pairing and normal phase methods.

8. Charged Aerosol Detector
Pine Lake Laboratories features Corona
Veo charged aerosol detectors (CADs)
on two of it’s HPLC systems. This
detector is used for the analysis of lipids
plus Leachables and poor UV absorbing
impurities in drug products.

9. FTIR
Pine Lake Laboratories features an
Agilent Cary 600 series FTIR. This
instrument is used to confirm the
identity of drug substances and to aid in
the identification of unknowns.

10. Total Organic Carbon
Pine Lake Laboratories features an
Sievers M9 TOC analyzer. This
instrument is used to determine when
an extraction is exhaustive for an
aqueous solvent and as a non-specific
test for the verification of the cleaning of
medical devices.