Weiber Stability Test Chambers/ are widely used for
confirmatory studies for direct comparison of drug
substance under controlled environmental conditions.
Weiber Stability Test Chambers/ are widely used for
confirmatory studies for direct comparison of drug
substance under controlled environmental conditions.
Weiber Stability Test Chambers/ are widely used for
confirmatory studies for direct comparison of drug
substance under controlled environmental conditions.
Weiber Stability Test Chambers/ are widely used for
confirmatory studies for direct comparison of drug
substance under controlled environmental conditions.
We are manufacturers of environmental chambers in India
since last two decades. Our environmental test
chambers/environmental control chambers are
conceptualized and designed to create test chambers to
study and contemplate the effects of different environmental
parameters such as humidity, temperature and light in
various applications tests involving micro-organisms,
plants, tissues, electronic components etc. apart from
various customized industrial and research applications.
Our environmental chambers have a variety of usage in R &
D laboratories, research studies and product testing
facilities across the globe.
We are manufacturers of Metabolic Shakers, Incubator shaker or orbital shakers in India since 1990. Our incubatorshakers are widely used for day to day bacteriological and varied laboratory applications requiring incubation aswell as shaking tests and procedures in variety of research and testing laboratories.For more information please log on http://cutt.us/3wtN
We are manufacturers of bacteriological incubators in India, bacteriological incubators suppliers, laboratory incubator exporters, bacteriological incubator India. We also supply BOD incubators, carbon di oxide incubator and other laboratory incubators For More Information Please Logon http://goo.gl/iQdqZJ
Temperature is controlled by two sensors located in the liquid-loaded monitor bottles,
Two thermistor sensors constantly monitor the temperature in both the upper and the lower part of chamber.
Microprocessor control ensures the most accurate temperature control available.
We are manufacturers of drying ovens, industrial drying ovens in India since 1990. Our heavy duty drying oven are
widely used for day to day heating and drying applications performed in various laboratories.
We are manufacturing Weiber BOD Incubators and Lab Ovens for varied usages in various research and R&D laboratories across India and abroad. We are committed to provide international standard Bacteriological Incubator at reasonable prices, working closely with the industry captains and leading scientists to continuously improve and enhance the quality, reliability and efficiency of our products by incorporating various inputs provided by them, from time to time. For More Information Please Logon http://goo.gl/66xIhr
Arduino based intelligent greenhouse ProjectAmit Saini
Final Year Project : - Arduino based ‘Intelligent Green House'
A complete greenhouse monitoring and controlling system ,that is automated, updating each and every detail on internet that can be accessed from anywhere. For sensors, it uses a light sensor, temperature sensor, moisture sensor, humidity sensor and all the updates will be available on internet through Ethernet shield through which the user can take care of the garden even when not at home.
With its unique ability to adapt to different research applications, the MTPGC400 offers an economical and flexible equipment platform.
• Single chamber uniquely adaptable to different applications
• Precisely designed airflow and lighting configurations for each application adjustable
• Castors for ease of mobility
• Product certifications/markings: CE
Temperature is controlled by two sensors located in the liquid-loaded monitor bottles,
Two thermistor sensors constantly monitor the temperature in both the upper and the lower part of chamber.
Microprocessor control ensures the most accurate temperature control available.
PID is short for "proportional plus integral and derivative", three algorithm components used by this type of controller in managing a control loop. Process loop controllers use one, two or all three of these to optimally control the process system. PID control is used in a wide variety of applications in industrial control and process system management.
Structura Curs SEO Personalizat TimisoaraFlavius Noja
Vrei sa inveti cum sa iti optimizezi site-ul pas cu pas pentru ca acesta sa fie mai bine plasat in motoarele de cautare si sa atraga mai multi vizitatori?
Echipa Star Marketing iti vine in ajutor cu Singurul Curs Personalizat de SEO din Romania!
Cursul dureaza 10 saptamani cu o sedinta de 2 ore / sapt.
Preturi de la 150 euro.
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We are manufacturers of environmental chambers in India
since last two decades. Our environmental test
chambers/environmental control chambers are
conceptualized and designed to create test chambers to
study and contemplate the effects of different environmental
parameters such as humidity, temperature and light in
various applications tests involving micro-organisms,
plants, tissues, electronic components etc. apart from
various customized industrial and research applications.
Our environmental chambers have a variety of usage in R &
D laboratories, research studies and product testing
facilities across the globe.
We are manufacturers of Metabolic Shakers, Incubator shaker or orbital shakers in India since 1990. Our incubatorshakers are widely used for day to day bacteriological and varied laboratory applications requiring incubation aswell as shaking tests and procedures in variety of research and testing laboratories.For more information please log on http://cutt.us/3wtN
We are manufacturers of bacteriological incubators in India, bacteriological incubators suppliers, laboratory incubator exporters, bacteriological incubator India. We also supply BOD incubators, carbon di oxide incubator and other laboratory incubators For More Information Please Logon http://goo.gl/iQdqZJ
Temperature is controlled by two sensors located in the liquid-loaded monitor bottles,
Two thermistor sensors constantly monitor the temperature in both the upper and the lower part of chamber.
Microprocessor control ensures the most accurate temperature control available.
We are manufacturers of drying ovens, industrial drying ovens in India since 1990. Our heavy duty drying oven are
widely used for day to day heating and drying applications performed in various laboratories.
We are manufacturing Weiber BOD Incubators and Lab Ovens for varied usages in various research and R&D laboratories across India and abroad. We are committed to provide international standard Bacteriological Incubator at reasonable prices, working closely with the industry captains and leading scientists to continuously improve and enhance the quality, reliability and efficiency of our products by incorporating various inputs provided by them, from time to time. For More Information Please Logon http://goo.gl/66xIhr
Arduino based intelligent greenhouse ProjectAmit Saini
Final Year Project : - Arduino based ‘Intelligent Green House'
A complete greenhouse monitoring and controlling system ,that is automated, updating each and every detail on internet that can be accessed from anywhere. For sensors, it uses a light sensor, temperature sensor, moisture sensor, humidity sensor and all the updates will be available on internet through Ethernet shield through which the user can take care of the garden even when not at home.
With its unique ability to adapt to different research applications, the MTPGC400 offers an economical and flexible equipment platform.
• Single chamber uniquely adaptable to different applications
• Precisely designed airflow and lighting configurations for each application adjustable
• Castors for ease of mobility
• Product certifications/markings: CE
Temperature is controlled by two sensors located in the liquid-loaded monitor bottles,
Two thermistor sensors constantly monitor the temperature in both the upper and the lower part of chamber.
Microprocessor control ensures the most accurate temperature control available.
PID is short for "proportional plus integral and derivative", three algorithm components used by this type of controller in managing a control loop. Process loop controllers use one, two or all three of these to optimally control the process system. PID control is used in a wide variety of applications in industrial control and process system management.
Structura Curs SEO Personalizat TimisoaraFlavius Noja
Vrei sa inveti cum sa iti optimizezi site-ul pas cu pas pentru ca acesta sa fie mai bine plasat in motoarele de cautare si sa atraga mai multi vizitatori?
Echipa Star Marketing iti vine in ajutor cu Singurul Curs Personalizat de SEO din Romania!
Cursul dureaza 10 saptamani cu o sedinta de 2 ore / sapt.
Preturi de la 150 euro.
Prima saptamana este gratuita din partea Star Marketing!
-تقوم الشركة المتحده
بتوريد وتركيب ومعالجه جميع الشبكات من (كبلات-دكدات-فسبليت- باتش بانيل-راكات- سوتشات-الخ
- بواسطة فريق فنى يعمل على اعلى مستوى مراعى ادق التفاصيل مستخدم احدث الاجهزة لاجراء الاختبارات عند التسليم
-تقوم الشركة بخدمة الربط بين مقرالشركات بعضها البعض سواء كابلات فايبر و وكابلات نحاسية والربط كذلك بين الشركات والسنترالات
للاستعلام
منال زين
01118455507 - 01206001014
صفحتنا على الفيس بوك :
https://www.facebook.com/United.Communication.Systems
Email : Unitedtch@gmail.com
أحدث تقنية لبوابات إنذار السرقة لتأمين الملابس والأكسسورات و بوابات ملابس لحماية المحلات من السرقة
من ماركات عالمية مجربة ومثبت فاعليتها في السوق المصري وفي المولات الكبيرة
بوابة لمنع سرقة الملابس ،، تصدر أنذار عند مرور السلعة خلالها دون خلع التاج المثبت.
لدينا موديلات متعدده تغطى جميع المساحات ضمان سنه والتركيب
أتصل الااان أسعاار خااااصة جدااا لعملائنا الكرام
للاستعلام
منال زين
01118455507 – 01206001014
صفحتنا على الفيس بوك :
https://www.facebook.com/United.Communication.Systems
Email : Unitedtch@gmail.com
A 13ª Edição da Humangext Magazine foi publicada em janeiro de 2016 e aborda os seguintes temas: Desafio actual: gerir a carreira pois não há empregos para toda a vida; Âncoras de carreira - Alinhamento entre individuo e empresa; Progressão na carreira e mobilidade funcional; carreiras e remunerações. Conta ainda com a participação do Sr. Dr. Nuno Serra e Silva da Schaeffler Portugal; Prof. Dr. Paulo Cardoso Da Sociedade Portuguesa de Psicologia; Sr. Dr. António Gonçalves da Ag Consultores; Sr. Dr. José Manuel Inácio da Financertus
Una breve descripción ilustrada que muestra dentro de los 4 niveles de desarrollo social (revolucionario "yo lo tomo"; asistencial "yo te lo doy"; transferencia de conocimiento "te enseño a hacerlo"; y transformacional "lo hacemos juntos"), para conseguir la participación deseada, recordando que la teoría de convergencia social dicta que la gente lleva su estado de ánimo a los grupos en los cuales participa.
Hey YOU! In this Video I am live streaming via the periscope app where people can give you comments live. This is a replay of me showing a foreclosure.
This house is a foreclosure and is a homepath property. HomePath is a brand name and refers to foreclosed homes sold by Fannie Mae directly. For first time homebuyer you need to have a Rehab loan or pay for cash if you are looking for fixer upper. In this periscope I am giving you an example of a home that would need rehab and wouldn't qualify for your traditional conventional and FHA loans. The price of this house is $185,000.
We are manufacturers of <b>humidity control cabinets, temperature control cabinets</b> in India since last two decades. Our <b>temperature and humidity control cabinets</b> are conceptualized and designed to create test chambers to study and contemplate the effects of different environmental parameters such as humidity, temperature applications tests involving micro-organisms, plants, tissues, electronic components etc. apart from various customized industrial and research applications. Our <b>temperature control cabinets</b> and <b>humidity control cabinets</b> have a variety of usage in R and D laboratories, research studies and product testing facilities across the globe. Apart from that, these temperature and humidity control cabinets have a variety of usages in tissue culture applications, enzyme reaction studies, growth For more information please logon http://cutt.us/EhCD
We are manufacturers of Hot air oven or laboratory oven in India since 1990. Our laboratory oven are widely used
for day to day heating and drying applications performed in various laboratories.
Humidity & Temperature Control Cabinet are well designed for conducting different laboratory and research experiments for different quality control tests to be carried out on different materials For more information please log on http://cutt.us/EhCD
Compact design, Energy Efficient with large storage capacity – Upright Vertical Model
Ÿ Outer casing is Stainless Steel SS 304
Ÿ Inner Chamber And Shelves are of Stainless Steel SS 304
Ÿ Robust construction and elegant looks with Three
Compartments
Ÿ Mi c roproces sor based programmable
temperature Controller cum Indicator
Ÿ Higher Capacity System for fast pulls down.
Ÿ NANOGEL Panel & Tollesbury Technology
system to reduce temperature recovery time after
door opening
Ÿ High density, environment friendly, polyurethane
foam for better insulation.
Ÿ High-pressure injection machine used for efficient
insulation.
Ÿ R-134 a refrigerant, chlorine free, environment
friendly. CFC-FREE, HCFC-FREE non flammable
refrigerants
Ÿ Carrier/Kirloskar/Tecumseh compressor.
Ÿ Battery Back up for Two Hours
Ÿ Audible and visible alarms for temperature, power
failure, system failure, battery low
We are manufacturers of rectangular vacuum oven, vacuum ovens India, vacuum oven suppliers Delhi, vacuum oven manufacturers Delhi, vacuum ovens exporter, rectangular vacuum oven exporters, vacuum oven supplier India, vacuum ovens India. For More Information Please Logon http://cutt.us/6ReQm
Catalog Frenic-HVAC (Fuji Electric): Biến tần Frenic-HVAC
Beeteco.com là trang mua sắm trực tuyến thiết bị điện - Tự động hóa uy tín tại Việt Nam.
Chuyên cung cấp các thiết bị: Đèn báo nút nhấn, Relay, Timer, Contactor, MCCB ELCB, Biến tần, Van, Thiết bị cảm biến, phụ kiện tủ điện, .... Từ các thương hiệu hàng đầu trên thế giới.
www.beeteco.com @ Công ty TNHH TM KT ASTER
Số 7 Đại Lộ Độc Lập, KCN Sóng Thần 1, P. Dĩ An, Tx. Dĩ An, Bình Dương
www.facebook.com/beeteco
Tel: 0650 3617 012
DĐ: 0904 676 925
We are manufacturers of plant growth chambers in India
since last two decades. Our plant growth chamber rare
conceptualized and designed to create test chambers to
study and contemplate the effects of different environmental
parameters such as humidity, temperature and light in
various applications tests involving micro-organisms,
plants, tissues, and animals etc apart from various
customized industrial and research applications.
Our plant growth chambers have a variety of usage in R & D
laboratories and research studies across the globe. Apart
from that, these plant growth chamber have a variety of
usages in tissue culture applications, enzyme reaction
studies, growth observation studies, fermentation analysis
and Various other general and specialized applications in
various laboratories.
Prominent trader of a high quality range of Gas Chromatography, Spectrophotometer, Viscometer, Micro - Ultra Micro Balances, Semi Micro Balance, Analytical Balance, High Precision Balance, Precision Balances, Industrial Balance & Scales, Moisture Analyzer, etc.
Incorporated in the year 2013, at Mumbai(Maharashtra, India), we “K Tek Analytics” are known as the prominent trader of a high quality range of Gas Chromatography, Spectrophotometer, Viscometer, Micro - Ultra Micro Balances, Semi Micro Balance, Analytical Balance, High Precision Balance, Precision Balances, Industrial Balance & Scales, Moisture Analyzer, etc.These products are manufactured by our reliable vendors’ in their state-of-the-art manufacturing unit using optimum quality components and cutting-edge technology in adherence to international quality standards. Owning to features such as high accuracy, robust design, easy installation, optimum functionality and longer working life, these products are widely demanded. Furthermore, the offered range of products can be availed in various technical specifications at reasonable prices.
Weiber Stability Test Chambers are widely used for confirmatory studies for direct comparison of drug substance under controlled environmental conditions.
We are manufacturers of Incubator shaker or orbital shakers in India since 1990. Our incubator shakers are widely
used for day to day bacteriological and varied laboratory applications requiring incubation as well as shaking tests
and procedures in variety of research and testing laboratories.
S&A CWFL-1000 dual temperature water chillers with 4200W cooling capacity, specially designed for cooling 1000W fiber lasers, are characterized by dual circulating refrigeration system and dual temperature control system.
Window Ventilation brochure »
An introduction to this ventilation technology, closely associated to, and complementing our Natural Ventilation products. Includes data and information about dampers, actuators, controls sytems, building modelling and installation.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
3. TECHNOLOGIES PVT. LTD.
R
Weiber Photostability Test Chambers are widely used for
confirmatory studies as per ICH GUIDELINES (ICH Q1B)
for direct comparison of drug substance under controlled
environmental conditions, where samples are exposed to
light illumination level of 1.2 million lux ,which is effectively
controlled through a programmable illumination controller
and ulta violet light module incorporated in the same diffuser
module with protection coating, designed to provide a UV
light energy which can also be controlled from 200 watt hour
per sq m.to allow direct comparisons to be made between
the drug substance and drug product.
40% to 95% RH (Accuracy: + 2%)
The temperature inside the photo stability test chamber is
controlled by intelligent programmable temperature
controller and indicator. This controller is based on the
microcontroller nano watt technology and its ergonomic
design suits for any specific requirement of the
photostability test chambers like Data logger facility,
Thermal and DOT Matrix interface, direct data load facility in
computer office automation software like MS-Word and
Excel and many other features listed in the specification
below.
HUMIDITY RANGE
TEMPERATURE CONTROL
Castor wheel mounted cabinet is double walled with inner
chamber of Stainless steel sheet of grade SS 304 and outer
wall of heavy gauge PCRC steel. sheet duly degreased and
pre treated with primers for rust proofing duly painted with
attractive stove enamel or powder coated.
MATERIAL OF CONSTRUCTION
10 Degree C to 60 degree C (Accuracy: + 0.5o C)
TEMPERATURE RANGE
HUMIDITY CONTROL SYSTEM
The WEIBER” Photo Stabiliy Chamber uses a
microprocessor based, electronic humidity sensor detector
is an exact logarithmic function of the humidity
concentration in the environment of the chamber between
source and detector. Advanced design provides a very
stable drift-free output requiring less frequent calibration.
4. TECHNOLOGIES PVT. LTD.
R
Our photostability test chamber/pharmaceutical
photostability test chamber conforms to the illumination
requirement as per the International Conference on
Harmonisation of Technical Requirements for Registration
of Pharmaceuticals for Human Use (ICH) ICH GUIDELINES
(ICH Q1B). The unit is provided with four fluorescent light
mounted in a diffuser enclosure at the top of the chamber
providing minimum illumination level of 1.2 million lux,
Which iseffectively controlled through a programmable
illumination controller. This unit is combined with a ulta violet
light module incorporated in the same diffuser module with
protection coating, designed to provide a UV light energy
which can also be controlled from 200 watt hour per sq.
ILLUMINATION
This LED indicates the heating system on condition and it
light up when the set temperature is higher than the ambient
temperature.
light up when the set temperature is lower than the ambient
temperature.
This LED indicates the cooling system on condition and it
1) Heater Mode
2) Cooling Mode
This LED indicated the extreme Ambient condition and the
temperature failure condition.
This Alarm indicates the visual alarm and indiactes any
failure and Temperature overshoot conditions.
3) Temperature Alarm
4) Audio Alarm
Visual indication with door open conditions.
This LED indicates the battery backup status, This LED
indicates when the battery charge capacity available at 25%
of the total charge.
This visual indicator light up when the mains power fail and
the system working in the battery mode.
5) Door Open
7) Low battery indicator
6) A.C Power failure
5. R
TECHNOLOGIES PVT. LTD.
Ÿ Temperature set point controls relays for refrigeration
compressor and evaporator fan.
Ÿ Relays rated min. 200VAC: (a) Compressor: min. 8 A,
min. 60 LRA, (b) Fan: min. 4 A, (c) High/low temp
alarm.
SYSTEM SETTING
Count up key.
This is a set button to set any parameter on the screen, by
pressing of this key a cursor blink on the corresponding
parameter, So you can select any desired parameter and
use UP and Down key to set specific value/setting.
This seven segment display indicates the read temperature
value inside the chamber.
DATE and TIME : From normal operational mode, press
SET key ones, The cursor blinks at DATE (20), and for
second press of KEY SET the cursor blinks at MONTH ( 12 ),
and similary on Third press of key SET cursor blinks at
YEAR and repeat the steps to move to any parameter.
Similary you move cursor on any parameter and set desired
value for system operation. To increase any parameter use
UP key and to decrease any parameter use DOWN key.
After completion of all correct setting press ESC key to
return back to the main menu.
8) UP
9) SET
OPTIONAL FEATURES (Can Be incorpora-
ted At Extra Cost If Desired)
10) TEMPERATURE DISPLAY
Ÿ Audio and Visual Alarm. Programmable.
Ÿ Alarm mute w/ ring back in 5 minutes.
Ÿ Touch Button Control for Alarm Mute/Ring Back.
Ÿ Keyed alarm silence switch.
Ÿ External Keyed Alarm Mute. Alternate: Supervisor
programmable code.
Ÿ Door Buzzer alarm.
Ÿ IR Sensor/ Micro Switch Based Door open Alarm.
Adjustable or fixed 30s delay before alarm.
Ÿ Power failure alarm: Automatic Power detection and
Audio Visual Alarm. Adjustable or fixed 15 min delay
before alarm.
6. R
TECHNOLOGIES PVT. LTD.
Triple walled back of unit is fitted with two air circulation fans
for maintaining temperature uniformly throughout the
chamber.
Ÿ Vacuum impregnated stator winding with dr. back
varnish under red baktol.
Ÿ Non-Hygroscopic
Glass mineral wool is one of the most environmentally
friendly, stable and sustainable insulants available. Glass
wool is incombustible by nature. Euro class classification is
A. It does not propagate flames and toxic smokes. Thanks to
a dense entanglement of materials with a low conduction
and trapping a great amount of air, glass wool is a an
excellent thermal insulant. The thickest it is the best thermal
resistance it has, thus reducing heat losses in our
equipments for better sensitivity and economical
operations. And its impact on the environment in
manufacture, use and disposal is minimal.
AIR CIRCULATION
FEATURES OF COAXIAL CIRCULATION FAN
Ÿ Programmable temp range: Touch Button Control to
Program Temperature. User Settable.
Ÿ Battery backup: Automatic Battery Charging Facility
inbuilt in circuit. Provides up to 24 hr of display power.
Ÿ Mounted temp probe.
Ÿ R.F based Remote Alarm System.
Ÿ Built-in chart recorder/Thermal Printer standard for
blood bank units or data acquisition in the controller
memory which can be down loaded on a computer
through a suitable world standard interface like RS232
and/or RS485.
Ÿ RS-232 I/O Port Provided.
Ÿ Serial Thermal Printing facility.
Ÿ 24 hr non-volatile temperature Record Storage
Capacity, and Record Download facility in MS-
WORD/Hyper terminal / MS-Excel.
Ÿ Up to 1 MB data storage Facility.
Ÿ Seven Day Profile Timer with Real Time Clock.
The gap of 75 mm between the outer and the inner wall is
filled with special grade glass wool to prevent thermal
losses.
INSULATION
MINERAL GLASS WOOL INSULATION
7. R
TECHNOLOGIES PVT. LTD.
Ÿ Best IR value
Ÿ Bright bar (EN - 8 class) shaft.
Ÿ Bush bearing of branded companies.
Ÿ Surge comparison testing in fans and pumps eliminates
into turn short circulating of the stator.
Ÿ Pressure die-casted-rotor manufactured with zero
error.
Ÿ Boats of high accuracy.
Full view inner glass/perspex door permits inspection of
specimens, without disturbing the chamber temperature.
Lock and Key arrangement is provided in the double walled
outer door.
Ÿ High Energy Efficiency
Ÿ Compact
Ÿ Ozone-friendly refrigerants
Ÿ Proven Technology
Ÿ Wide Voltage Range
Unit is fitted with door operated illumination lamp inside the
chamber. 40 watt/120 volt replacement light bulb fits inside
the illumination cavity of the chamber.
DOORS
Refrigeration unit is formed by ISI marked
compressor/cooling kit. Of Kioloskar Copeland or
Tecumseh.
REFRIGERATION UNIT
The unit is supplied with three shelves of stainless steel
sheet.
To work on 220/230V A.C. supply.
SHELVES
VOLTAGE
FEATURES STABILITY CHAMBER
ILLUMINATION
8. R
TECHNOLOGIES PVT. LTD.
TECHNICAL SPECIFICATION
Accessories
Automatic De-icing
system
Timer (1-999 minutes of
hours)
Real Time Program
Printer Report Program
Serial Port (Printer)
Inspection window in
door
-
-
-
Optional
- Optional
-
-
Rs 232
-
Inbuilt
Inbuilt
Inbuilt
Inbuilt
Shelves
Standard /max
Dimension w,d
Max load per shelf
Permitted total load
Power Consumption
Nominal Power
Nominal Voltage
Frequency
-
-
mm
kg
kg
-
W
V
Hz 50/60
-
-
-
-
-
-
950-2250W
230, 1~
Temperature Control
Temperature Variation (time)
Temperature Deviation
(Spatial)
Readability
Temperature range
Sensor Thermocouple
Controller
Display
Adjustable alarm limits
-
± °C
±°C
°C
ºC
-
-
-
-
-
0.5
0.5
Safety thermostats
Temperature variation
(time)
Sensors Thermocouple
Automatic temperature
setting
Adjustable limits Y e s ( W i t h P I D
Controllers only)
-
-
-
-
-
-
3 (With PID Controllers
only)
Type K
Yes (With PID
Controllers only)
Light control
Readability or Set ability
Light intensity (Middle chamber)
-
%
Lux
-
5%
1.2 million lux
Light intensity (UV) Min 200 Watt hour/square
meter
0.5l
10°C to 60°C
Type K
Solid State digital
Controller/PID optional
LED/LCD
Optional
9. R
TECHNOLOGIES PVT. LTD.
(W x D x H)
505X830X415 mm
570x875x550 mm
650x900x550 mm
700x900x650 mm
775x900x775 mm
825x1200x825 mm
900x1720x800 mm
CAPACITY
6 Cu.ft
10 Cu.ft
12 Cu.ft
15 Cu.ft
20 Cu.ft
30 Cu.ft
45 Cu.ft
INTERNAL DIMENSIONS (STANDARD)
10. www.acmasindia.com | www.test-chambers.comwww.acmasglobal.com |
SALES OFFICE (HONG KONG)
SALES OFFICE (RUSSIA)
Unit D 28 11/F Wing Tat Comm,Bidg 97, Bonham Strand East,
Sheung Wan, Hong Kong (PRC)
Tel.: 0086-13929598046 | 0086- 18922303099
E-mail.: hk@acmasindia.com
Inmed Trade Street Ozerkovsky Embankment,
Unit No 50, Straine- 1, Off- 502, Moscow, Russia
E-mail.: info@acmasindia.com
Tel.: 0049- 79592345 | Email: russia@acmasindia.com
TECHNOLOGIES PVT. LTD.
An ISO 9001 : 2208 | ISO 14001 : 2008 | ISO 13485
WHO: GMP Products | GLP Compliant Products
CORPORATE OFFICE/ (INDIA)SHOWROOM
Plot No. 352-353, Sector – 57
Phase- IV Kundli, Sonepat, HR 131028
Land Line No.: +91 - 11- 47619688,
Fax: +91-11-47619788
E-mail.: info@acmasindia.com
