This document summarizes a clinical skills workshop on overdose prevention and response through administering naloxone. It provides statistics showing the rise in overdose deaths from prescription drugs and heroin in the US. It describes who is at risk of overdose and when naloxone should be prescribed. The workshop reviews videos demonstrating naloxone administration and discusses how distributing naloxone saves lives without enabling drug use. Over 150,000 laypeople have been trained to reverse over 26,000 overdoses. The workshop encourages participants to educate others on naloxone and reducing overdose risk.