PhD THESIS TOPICS AND MATERIALS IN MEDICAL MICROBIOLOGY.docx

1. PhD THESIS TOPICS AND MATERIALS IN MEDICAL MICROBIOLOGY
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PhD THESIS TOPICS AND MATERIALS IN MEDICAL MICROBIOLOGY
1. Molecular epidemiology and mechanisms of colistin and carbapenem resistance
in Enterobacteriaceae from clinical isolates, the environment and porcine samples
in Pretoria, South Africa
2. Phenotypic and genotypic characterization of isoniazid resistance mutations in
Mycobacterium tuberculosis isolates from new and previously treated patients in
the Tshwane region
3. Evaluation of single nucleotide polymorphisms in virulence genes of
Mycobacterium tuberculosis as markers of lineages and sub-lineages in Tshwane
region
4. Genotypic and phenotypic diversity of Mycobacterium tuberculosis strains in
patients with concomitant pulmonary and extra-pulmonary tuberculosis
5. The association between genital mycoplasmas and bacterial vaginosis in
pregnant women with or without genital symptoms
6. Genetic diversity of methicillin resistant Staphylococcus aureus strains in the
Pretoria region in South Africa
7. Trichomonas vaginalis and bacterial co-infections identified in reproductive age
women

2. 8. Evaluation of Mycobacterium tuberculosis clinical isolates with discordant
rifampicin genotypic and phenotypic susceptibility testing results from Pretoria
South Africa
9. Association of Mycobacterium tuberculosis genotypes and treatment outcome in
pulmonary tuberculosis patients in Tshwane Metropolitan area
10. The antimicrobial effect of colistin methanesulfonate (polymyxin E) on
Mycobacterium tuberculosis in vitro
11. Innovative approaches to tuberculosis diagnosis with emphasis on nucleic acid
amplification tests in a resource constrained high burden tuberculosis setting
12. Phenotypic and genotypic susceptibility testing of Mycobacterium tuberculosis
cultures from Tshwane Metropolitan area
13. Characterisation and detection of Mycobacterium tuberculosis in pleural biopsies
using Proteomics and Molecular techniques
14. Phenotypic and molecular antifungal susceptibility testing of yeast isolates from
Pretoria
15. Genetic relatedness of Mycobacterium tuberculosis strains obtained from
Kalafong Hospital in Pretoria using Spoligotyping and MIRU-VNTR typing
16. Ausceptibility testing and resistance mechanisms to second-line agents against
Mycobacterium tuberculosis in Pretoria, South Africa
17. Detection and characterization of ESBL positive Klebsiella pneumoniae clinical
isolates
18. Detection and characterisation of Ureaplasma spp in men with and without
urogenital symptoms
19. Characterization and drug resistance of Trichomonas vaginalis clinical isolates
20. Genetic relatedness of methicillin resistant Staphylococcus aureus isolates from
Steve Biko hospital
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