This document lists 18 pediatric oncology phase I and II clinical studies being conducted at Doernbecher Children's Hospital as of December 7, 2010. It provides the study name and description, amendment number, institutional review board number, study phase, and eligibility criteria for each study. The studies cover a range of cancer types including brain tumors, leukemia, and other solid tumors. Many of the studies involve testing novel targeted therapies or drug combinations.
Leadership involves leading an organization or group to a new destination of excellence. To be a strong leader, one must be self-aware of their strengths and weaknesses. This involves acknowledging weaknesses and then either building, buying, or leasing capabilities to supplement areas of weakness. A leader must then continuously evaluate and work to minimize weaknesses through relentless improvements in cycles over time.
Slideshare es una aplicación web para almacenar y compartir presentaciones de diapositivas creadas en programas como PowerPoint u OpenOffice. Los usuarios pueden subir sus presentaciones a su cuenta de Slideshare y clasificarlas con tags o palabras clave para que sean encontradas fácilmente por los buscadores. Las presentaciones también se pueden incrustar en páginas web como blogs.
La hipérbola es una curva cónica definida como el lugar geométrico de los puntos cuyas distancias a dos puntos fijos llamados focos difieren en una cantidad constante. El documento describe los elementos de una hipérbola, sus características y cómo construirla paso a paso tomando puntos en los ejes y trazando arcos con radios entre los focos.
La Escuela Normal Superior de Hermosillo Subsede Obregón presenta un documento sobre los niveles de comprensión escrita por parte de siete estudiantes: José Alberto Félix Torres, Claudia Danaily Galaviz López, Blanca Yaneth García Corral, Gabriela Marysol García Zamorano, Gustavo Alfredo Gómez Valenzuela y Alejandra Huidobro García.
Leadership involves leading an organization or group to a new destination of excellence. To be a strong leader, one must be self-aware of their strengths and weaknesses. This involves acknowledging weaknesses and then either building, buying, or leasing capabilities to supplement areas of weakness. A leader must then continuously evaluate and work to minimize weaknesses through relentless improvements in cycles over time.
Slideshare es una aplicación web para almacenar y compartir presentaciones de diapositivas creadas en programas como PowerPoint u OpenOffice. Los usuarios pueden subir sus presentaciones a su cuenta de Slideshare y clasificarlas con tags o palabras clave para que sean encontradas fácilmente por los buscadores. Las presentaciones también se pueden incrustar en páginas web como blogs.
La hipérbola es una curva cónica definida como el lugar geométrico de los puntos cuyas distancias a dos puntos fijos llamados focos difieren en una cantidad constante. El documento describe los elementos de una hipérbola, sus características y cómo construirla paso a paso tomando puntos en los ejes y trazando arcos con radios entre los focos.
La Escuela Normal Superior de Hermosillo Subsede Obregón presenta un documento sobre los niveles de comprensión escrita por parte de siete estudiantes: José Alberto Félix Torres, Claudia Danaily Galaviz López, Blanca Yaneth García Corral, Gabriela Marysol García Zamorano, Gustavo Alfredo Gómez Valenzuela y Alejandra Huidobro García.
Funciones de vladimir propp encontradas en el cuento de hansel y gretelanabellalopez
El documento resume las funciones narrativas encontradas en el cuento de Hansel y Gretel según la teoría de Vladimir Propp. Describe cómo Hansel y Gretel son alejados de su hogar, engañados por la bruja quien los mantiene prisioneros, pero logran escapar después de que Gretel derrota a la bruja usando humo de tilo. Luego regresan a casa donde son reconocidos y su familia se reúne.
El documento describe el plan de estudios de Educación Física, el cual incluye los deportes de básquetbol, handball y voleibol. Se enfocará en la técnica, forma de juego y reglamento de cada deporte, y evaluará los conocimientos teóricos y progreso práctico de los estudiantes a través de presentaciones en Power Point y un edublog para interactuar fuera de clase.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against developing mental illness and improve symptoms for those who already have a condition.
Tanda tangan digital memberikan otentikasi untuk dokumen digital dengan cara yang serupa dengan tanda tangan konvensional pada dokumen fisik. Tanda tangan digital dibuat dengan mengenkripsi nilai hash dari pesan menggunakan kunci pribadi, sehingga hanya pengirim yang dapat membuat tanda tangan tersebut untuk memberikan otentikasi pesan. Tanda tangan digital dapat diverifikasi dengan dekripsi menggunakan kunci publik pengirim untuk memastikan
La autoevaluación implica que un individuo evalúe sus propias actuaciones de forma permanente a lo largo de su vida. Mediante la autoevaluación, los estudiantes pueden reflexionar sobre sus aprendizajes, avances y dificultades para mejorar. La coevaluación implica que pares evalúen trabajos o actividades del otro. La heteroevaluación es el proceso por el cual una persona evalúa las actuaciones de otros.
El CEIP Ciudad de Merida es una escuela pública en Mérida, España. Ofrece educación primaria para niños de 6 a 12 años de edad. El centro sigue el currículo educativo establecido por el gobierno regional y busca desarrollar las habilidades académicas y personales de sus estudiantes a través de una variedad de actividades dentro y fuera del aula.
This document discusses different types of questions, including indirect questions, direct questions, questions within statements, and questions within questions. Indirect questions are formed by putting the question into a subordinate clause beginning with a WH word or with if or whether. Direct questions have the normal question word order of verb + subject + object and can be either information questions or yes/no questions. Questions within statements and questions within other questions are also discussed through examples.
El documento analiza dos discursos influyentes de Adolfo Suárez durante la transición de España a la democracia. Explica que Suárez usó hábilmente las técnicas de persuasión de Aristóteles como ethos, pathos y logos para convencer al público español de los beneficios de la democracia. El documento también proporciona contexto sobre la dictadura de Franco y el estado de España antes y durante la transición para demostrar el papel crucial que desempeñó Suárez a través de sus discursos persuasivos.
Este documento discute la importancia de recurrir a fuentes científicas confiables sobre nutrición y dietas en lugar de rumores o mitos. Señala que mucha de la información sobre alimentación que circula carece de base científica. También enfatiza la necesidad de que los planes de alimentación sean diseñados por profesionales para cada individuo en lugar de dietas generalizadas que se ofrecen a través de varios medios.
WED 2.0 es una agrupación de servicios web que permite elaborar, modificar, almacenar, introducir y compartir información desde cualquier lugar del mundo a través de un navegador web, permitiendo que varias personas trabajen en los mismos documentos de forma simultánea.
El documento define el trabajo como un esfuerzo personal para producir bienes o servicios a cambio de una remuneración. En 1884, la Federación Estadounidense del Trabajo propuso una jornada laboral de 8 horas y en 1886 hubo más de 5,000 huelgas para exigir este derecho. La represión a las protestas en Chicago llevó a la ejecución injusta de 4 líderes sindicales conocidos como los "Mártires de Chicago". En 1889, el 1 de mayo fue establecido como el Día Internacional de los Trabaj
Los problema de la libertady la realidad jesus erazo 11º2chuchitojr
La película Matrix y la teoría de la duda de Descartes exploran temas similares. Ambos cuestionan la naturaleza de la realidad y cómo los sentidos pueden engañar. Neo, al igual que Descartes, comienza a dudar de lo que consideraba real cuando se da cuenta que el mundo que conoce podría ser una simulación creada por las máquinas, similar a cómo Descartes planteaba que un genio maligno podría engañar nuestros sentidos. Tanto Neo como Descartes concluyen que la única certeza es el pensamiento
Dasatinib is an effective first-line treatment for chronic myeloid leukemia (CML) based on results from the DASISION trial. The trial showed that dasatinib induced higher and faster rates of complete cytogenetic response and major molecular response compared to imatinib. At 5 years of follow-up, dasatinib maintained superior rates of molecular responses including deeper responses below 0.1% BCR-ABL1. Dasatinib therefore provides improved long-term outcomes for patients with newly diagnosed CML compared to standard imatinib treatment.
This is a presentation given at the teaching programme for Ophthalmologists in training at the Royal Victoria Eye and Ear Hospital, March 2011. It covers new developments in the treatment of Retinopathy of Prematurity.
This document summarizes systemic treatment options for uveal melanoma including FDA-approved drugs and clinical trials. It discusses interferon alpha and pegylated interferon alpha as adjuvant therapies approved in the 1990s. It also discusses targeted therapies like vemurafenib approved in 2011 for BRAF V600E mutant melanomas, and immunotherapies like ipilimumab approved in 2011. Ongoing clinical trials exploring therapies targeting GNAQ/GNA11 mutations in uveal melanoma are summarized.
This document summarizes key findings from the 2016 ASCO conference regarding neuro-oncology updates. It discusses several studies on treatments for glioblastoma, anaplastic gliomas, low-grade gliomas, and brain metastases. For newly diagnosed glioblastoma in elderly patients, short-course radiation alone was found inferior to temozolomide and short-course radiation. For recurrent glioblastoma, adding lomustine to bevacizumab did not provide a survival advantage. The document also reviews findings on adjuvant temozolomide for anaplastic gliomas without 1p/19q co-deletion and a study comparing surgery with stereotactic radiosurgery versus surgery with whole brain radiation for
Neuroblastoma is the third most common childhood cancer and arises from sympathetic nervous system. Staging involves evaluating tumor size, spread and biomarkers. Treatment ranges from observation to intensive chemotherapy and stem cell transplant depending on risk factors like age, stage, genetics and response to initial treatment. Targeted therapies are being studied in recurrent and high risk disease.
Funciones de vladimir propp encontradas en el cuento de hansel y gretelanabellalopez
El documento resume las funciones narrativas encontradas en el cuento de Hansel y Gretel según la teoría de Vladimir Propp. Describe cómo Hansel y Gretel son alejados de su hogar, engañados por la bruja quien los mantiene prisioneros, pero logran escapar después de que Gretel derrota a la bruja usando humo de tilo. Luego regresan a casa donde son reconocidos y su familia se reúne.
El documento describe el plan de estudios de Educación Física, el cual incluye los deportes de básquetbol, handball y voleibol. Se enfocará en la técnica, forma de juego y reglamento de cada deporte, y evaluará los conocimientos teóricos y progreso práctico de los estudiantes a través de presentaciones en Power Point y un edublog para interactuar fuera de clase.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against developing mental illness and improve symptoms for those who already have a condition.
Tanda tangan digital memberikan otentikasi untuk dokumen digital dengan cara yang serupa dengan tanda tangan konvensional pada dokumen fisik. Tanda tangan digital dibuat dengan mengenkripsi nilai hash dari pesan menggunakan kunci pribadi, sehingga hanya pengirim yang dapat membuat tanda tangan tersebut untuk memberikan otentikasi pesan. Tanda tangan digital dapat diverifikasi dengan dekripsi menggunakan kunci publik pengirim untuk memastikan
La autoevaluación implica que un individuo evalúe sus propias actuaciones de forma permanente a lo largo de su vida. Mediante la autoevaluación, los estudiantes pueden reflexionar sobre sus aprendizajes, avances y dificultades para mejorar. La coevaluación implica que pares evalúen trabajos o actividades del otro. La heteroevaluación es el proceso por el cual una persona evalúa las actuaciones de otros.
El CEIP Ciudad de Merida es una escuela pública en Mérida, España. Ofrece educación primaria para niños de 6 a 12 años de edad. El centro sigue el currículo educativo establecido por el gobierno regional y busca desarrollar las habilidades académicas y personales de sus estudiantes a través de una variedad de actividades dentro y fuera del aula.
This document discusses different types of questions, including indirect questions, direct questions, questions within statements, and questions within questions. Indirect questions are formed by putting the question into a subordinate clause beginning with a WH word or with if or whether. Direct questions have the normal question word order of verb + subject + object and can be either information questions or yes/no questions. Questions within statements and questions within other questions are also discussed through examples.
El documento analiza dos discursos influyentes de Adolfo Suárez durante la transición de España a la democracia. Explica que Suárez usó hábilmente las técnicas de persuasión de Aristóteles como ethos, pathos y logos para convencer al público español de los beneficios de la democracia. El documento también proporciona contexto sobre la dictadura de Franco y el estado de España antes y durante la transición para demostrar el papel crucial que desempeñó Suárez a través de sus discursos persuasivos.
Este documento discute la importancia de recurrir a fuentes científicas confiables sobre nutrición y dietas en lugar de rumores o mitos. Señala que mucha de la información sobre alimentación que circula carece de base científica. También enfatiza la necesidad de que los planes de alimentación sean diseñados por profesionales para cada individuo en lugar de dietas generalizadas que se ofrecen a través de varios medios.
WED 2.0 es una agrupación de servicios web que permite elaborar, modificar, almacenar, introducir y compartir información desde cualquier lugar del mundo a través de un navegador web, permitiendo que varias personas trabajen en los mismos documentos de forma simultánea.
El documento define el trabajo como un esfuerzo personal para producir bienes o servicios a cambio de una remuneración. En 1884, la Federación Estadounidense del Trabajo propuso una jornada laboral de 8 horas y en 1886 hubo más de 5,000 huelgas para exigir este derecho. La represión a las protestas en Chicago llevó a la ejecución injusta de 4 líderes sindicales conocidos como los "Mártires de Chicago". En 1889, el 1 de mayo fue establecido como el Día Internacional de los Trabaj
Los problema de la libertady la realidad jesus erazo 11º2chuchitojr
La película Matrix y la teoría de la duda de Descartes exploran temas similares. Ambos cuestionan la naturaleza de la realidad y cómo los sentidos pueden engañar. Neo, al igual que Descartes, comienza a dudar de lo que consideraba real cuando se da cuenta que el mundo que conoce podría ser una simulación creada por las máquinas, similar a cómo Descartes planteaba que un genio maligno podría engañar nuestros sentidos. Tanto Neo como Descartes concluyen que la única certeza es el pensamiento
Dasatinib is an effective first-line treatment for chronic myeloid leukemia (CML) based on results from the DASISION trial. The trial showed that dasatinib induced higher and faster rates of complete cytogenetic response and major molecular response compared to imatinib. At 5 years of follow-up, dasatinib maintained superior rates of molecular responses including deeper responses below 0.1% BCR-ABL1. Dasatinib therefore provides improved long-term outcomes for patients with newly diagnosed CML compared to standard imatinib treatment.
This is a presentation given at the teaching programme for Ophthalmologists in training at the Royal Victoria Eye and Ear Hospital, March 2011. It covers new developments in the treatment of Retinopathy of Prematurity.
This document summarizes systemic treatment options for uveal melanoma including FDA-approved drugs and clinical trials. It discusses interferon alpha and pegylated interferon alpha as adjuvant therapies approved in the 1990s. It also discusses targeted therapies like vemurafenib approved in 2011 for BRAF V600E mutant melanomas, and immunotherapies like ipilimumab approved in 2011. Ongoing clinical trials exploring therapies targeting GNAQ/GNA11 mutations in uveal melanoma are summarized.
This document summarizes key findings from the 2016 ASCO conference regarding neuro-oncology updates. It discusses several studies on treatments for glioblastoma, anaplastic gliomas, low-grade gliomas, and brain metastases. For newly diagnosed glioblastoma in elderly patients, short-course radiation alone was found inferior to temozolomide and short-course radiation. For recurrent glioblastoma, adding lomustine to bevacizumab did not provide a survival advantage. The document also reviews findings on adjuvant temozolomide for anaplastic gliomas without 1p/19q co-deletion and a study comparing surgery with stereotactic radiosurgery versus surgery with whole brain radiation for
Neuroblastoma is the third most common childhood cancer and arises from sympathetic nervous system. Staging involves evaluating tumor size, spread and biomarkers. Treatment ranges from observation to intensive chemotherapy and stem cell transplant depending on risk factors like age, stage, genetics and response to initial treatment. Targeted therapies are being studied in recurrent and high risk disease.
This document discusses the management of germ cell tumors in pediatric patients. It covers the embryology, epidemiology, classification, staging, risk groups, and treatment approaches for various germ cell tumors including medical therapy using chemotherapy regimens like PEB or JEB as well as surgical management principles and approaches for tumors in different locations like the ovaries. For ovarian germ cell tumors specifically, it describes the different subtypes including mature and immature teratomas, dysgerminomas, yolk sac tumors and others; and the optimal surgical approach of complete resection without rupture along with peritoneal staging.
This document recognizes and honors individuals from the OHSU Knight Cancer Institute for their contributions in areas like clinical care, research, outreach, diagnostics, and informed consent. It provides photos and names of researchers, doctors, nurses, and staff being recognized for their work in areas such as breast cancer research and care, clinical scholars, phase I clinical trials, community outreach, prostate cancer research, diagnostic testing, and developing an informed consent model.
The document provides an agenda for OHSU PAIN Day 2012, an event taking place on February 28th from 12pm to 6pm at the Vey Conference Center at Doernbecher Children's Hospital. The agenda includes introductions, workshops on managing pain in different populations and facial pain, presentations on drug development and opioids for chronic pain, poster sessions, and a networking social hour. Registration is free online and continuing education credits will be provided.
This grant supports research using quantitative dual-energy CT (DECT) iodine measurements to evaluate treatment response in patients with liver metastases from colon cancer undergoing chemotherapy. DECT may allow earlier detection of treatment response compared to current size-based methods. The goal is to validate intralesional iodine concentration as a biomarker for predicting and monitoring response to anti-angiogenic chemotherapy. If successful, DECT iodine quantification could help personalize chemotherapy regimens and lead to improved outcomes for these patients.
A benefit event will be held on December 8th from 6:30-8:30pm at AVA Roasteria in Beaverton, Oregon to support patient services at the OHSU Knight Cancer Institute. Attendees can enjoy wine, hors d'oeuvres and music while learning how donations make a difference for cancer patients. A "snowball effect" fundraiser will also be held where purchasing gifts between $50-$1000 will help support wellness programs, art therapy, and patient assistance.
The Knight Cancer Institute Seminar Series will host Dr. Bradley Olwin from the University of Colorado, Boulder on December 13, 2011. Dr. Olwin will present on "The Role of the Niche in Self-Renewal & Transplantation of Muscle Stem Cells". The seminar will take place from 4:00-5:00pm in the OHSU Main Hospital 8th Floor Conference Room 8B60. The presentation will discuss the potential of muscle stem cell therapies and the mechanisms governing muscle stem cell self-renewal. The seminar is open to the public and provides continuing education credits for physicians.
Carolyn Blasdel is a research nurse at The Knight Cancer Institute. A patient submitted a letter praising Carolyn for her outstanding care and dedication. When the patient developed severe abdominal pain on a trip to Portland for a clinical trial, Carolyn dropped everything to meet and help the patient, correctly diagnosing acute pancreatitis. She stayed with the patient until evening and worked late into the night to prepare for the next day, showing continued support over following days. The patient said Carolyn is a huge asset to her care team and deserves recognition for her dedication to patients.
Sierra Romesburg from the Breast Center went above and beyond her normal duties to fill a gap when the center was without a nurse for six months. She teamed up with a registered nurse to take on nurse duties like calling patients to provide reassurance about their cancer diagnosis. Sierra is very knowledgeable about breast cancer treatments from independently researching the topic. She strives to educate patients on all treatment options available and never refuses patient requests, going to great lengths to fulfill them. Her dedication and willingness to take on extra work impress her colleagues.
Survival rates for adolescents and young adults (ages 15-39) with cancer have lagged behind progress made in children and older adults over the past 20 years. While significant strides have been made recently, more work is still needed. Key challenges contributing to lower survival in this age group include differences in cancer biology, lack of clinical trial participation, health insurance barriers, and lack of psychosocial support systems tailored for their unique needs and life stages. The oncology community has started to address these issues through greater research focus on this population, improved guidelines, and programs dedicated to their care. However, broad changes are still required to improve outcomes for adolescents and young adults with cancer.
Imjai Chitapanarux is a radiation oncologist and chair of the Division of Therapeutic Radiology and Oncology at Chiang Mai University's Faculty of Medicine in Thailand. He holds an MD and leads the division of radiation oncology and oncology at one of Thailand's top medical schools.
This project describes methods for recruiting and retaining adolescent and young adult (AYA) oncology patients in psychosocial research studies at a single institution. Key methods included:
1) Monitoring clinic schedules and patient wards daily to identify eligible patients and approach them during appointments to minimize interference.
2) Using a dedicated research assistant to have greater coverage of clinics and flexibility in approaching patients.
3) Collecting multiple contact methods and an alternate contact to facilitate retention through regular reminders via phone, email, and in-person.
4) Carefully tracking patients in databases helped with retention rates averaging over 80% at follow-up timepoints up to a year later despite the challenges of this patient group.
This editorial discusses a study that uses survival modeling to predict the benefits of adjuvant chemoradiotherapy for patients with resected gallbladder cancer. The editorial makes three key points:
1) Computer modeling can help address gaps in clinical cancer research when randomized controlled trial data is limited, by using existing data to generate individualized survival predictions and treatment benefit estimates.
2) The gallbladder cancer study demonstrates how modeling can provide guidance for clinical decisions and research directions when high-quality evidence is lacking.
3) Models must be rigorously developed and validated, but can complement clinical trials by extending findings to new populations and longer time horizons not feasible in trials.
This document describes a study that aimed to create a predictive nomogram to help clinicians determine which patients with resected gallbladder cancer would benefit from adjuvant chemoradiotherapy (CRT). The study used a database of 1,137 patients from the SEER-Medicare database to develop several multivariate survival models. A lognormal survival model showed the best performance. From this model, researchers built a nomogram available online to provide individualized estimates of survival benefit from adjuvant CRT. The nomogram can predict that certain high-risk patients with T2 or N1 disease would gain a survival benefit from adjuvant CRT.
This case study describes the treatment of a 29-year-old man diagnosed with medulloblastoma, a rare pediatric brain tumor. He faced challenges due to being in the adolescent and young adult (AYA) population with limited access to insurance and care. Through multidisciplinary coordination between pediatric and adult specialists, he received aggressive treatment including surgery, radiation, and chemotherapy according to a pediatric protocol. While treatment caused morbidity, he remains disease-free one year later, demonstrating how comprehensive care can benefit AYAs despite the unique barriers they face.
This document describes the implementation of an Adolescent and Young Adult Oncology (AYAO) training program at Oregon Health & Science University (OHSU). The program includes two training pathways - a primary 4-year pathway following a combined Med-Peds residency, and an alternate supplemental 1-year pathway following a 3-year pediatric or medical hematology/oncology fellowship. The goal is to train oncologists in both pediatric and adult oncology to improve care, models, and outcomes for patients aged 15-39 with cancer. OHSU currently has two AYAO fellows, one in each pathway, gaining experience in both pediatric and adult oncology clinics and conducting AYA-focused clinical research. The training models
Knight Cancer Institute will host a seminar on November 15, 2011 titled "Autosomal Analog of X-Inactivation" presented by Dr. Alexander Gimelbrant from Dana-Farber Cancer Institute and Harvard Medical School. The seminar will discuss random monoallelic expression on autosomes, similar to X-inactivation, for genes coding cytokines, immunoglobulins, and olfactory receptors. The event will be held in the OHSU Main Hospital 8th Floor Conference Room B860 and is open to the public and provides continuing medical education credits.
The document announces a lecture titled "Childhood Cancer Research: 21st Century Science, 20th Century Clinical Trials" to be presented by Peter C. Adamson, MD on November 3, 2011 from 8:00-9:00am in the Marion Miller Auditorium on the 11th floor of Doernbecher Children's Hospital.
This document summarizes an upcoming seminar hosted by the Knight Cancer Institute at OHSU. The seminar will feature Dr. Ranadip Pal who will present on "Modeling Cancer Pathways: How Mathematical Modeling can Assist in Selecting & Predicting the Effectiveness of Targeted Drug Combinations." The seminar will take place on October 18, 2011 from 4:00-5:00pm in the OHSU Main Hospital 8th Floor Conference Room 8B60. The seminar series is designed to assist healthcare professionals and promote the integration of engineering and medicine in cancer treatment.
The 19th annual Harvey Baker Memorial Lecture will be held on Wednesday, October 19, 2011 at OHSU's Old Library auditorium. Dr. Scott Howard, director of clinical trials in international pediatric oncology at St. Jude Children's Hospital, will give a lecture titled "Childhood Cancer Care in Low Income Countries" from 7:00-8:30 PM. The lectureship honors Dr. Harvey Baker, the first formally trained surgical oncologist in Oregon who had a keen interest in cancer education.
The Knight Cancer Institute seminar series provides presentations by leading scientists on topics of fundamental science and translational research related to cancer. The seminars take place on Tuesdays from 4-5pm in the OHSU Main Hospital 8th floor conference room. The schedule lists seminar speakers from October 2011 through May 2012, including their institutional affiliations and topics. The seminars are open to physicians, nurses, researchers, and other healthcare professionals and offer continuing education credits.
1. Doernbecher Pediatric Oncology Phase I & II Study list
December 7, 2010
Study Name & description Amend# eIRB# Phase Eligibility
RAD001 A Phase II Study of RAD001 (Everolimus) for Children 2 v.3 6555 II Reservation required prior to consent.
with Chemotherapy and/or Radiation Refractory Astrocytoma, Pilocytic Astrocytoma,
Progressive or Recurrent Low-Grade Gliomas CNS High grade glioma,
Oligodendroglioma, Infantile
Age > 3 years < 21 years desmoplastic astrocytoma, mixed
glioma, pleomorphic
xanthoastrocytoma, ganglioglioma
ACNS0221 A Phase II Study of Conformal Radiotherapy in 11/15/05 3781 II CNS High Grade Glioma
Patients with Low-Grade Gliomas
< 21 years of age
ACNS0621 Cilengitide (EMD 121974) (IND# 59073) in Recurrent 3 4841 II Reservation required. **Temporarily
or Progressive and Refractory Childhood High-Grade Closed as of 8/30/2010**
Glioma CNS High Grade Glioma
< 21 years of age
ADVL04P2 A Phase I/II Pilot Study of Chemoimmunotherapy 6 1211 I/II Part A closed permanently. Part B
with Epratuzumab for Children with Relapsed CD- (Group-wide Phase 2 Pilot) now open.
22-Positive ALL
be ≥ 2 years and ≤ 31 years of age
ADVL0413 A Phase I Study of the Raf Kinase and Receptor 7A 3023 I Part C open to AML and FLT3-ITD
Tyrosine Kinase Inhibitor Sorafenib in Children with mutation. PK mandatory. Part A & B
Refractory Solid Tumors or Refractory Leukemias completed.
≥ 24 months and < 21 years of age
ADVL0612 A Phase I Study of Sunitinib (SU11248), and Oral 4 3361 I Check with Rae or Amanda to see if
Multi-Targeted Tyrosine Kinase Inhibitor, in children there are any open reservations
with Refractory Solid Tumors Solid tumors including CNS Tumors
≥ 2 years of age and < 21 years of age
ADVL0813 A Phase I study of IMC-A12 (Anti-Insulin-Like 3 5341 I Check with Rae or Amanda to see if
Growth Factor-1 Receptor Monoclonal Antibody) in there are any open reservations
Combination with CCI-779 (Temsirolimus) in Solid tumors including CNS tumors
Pediatric Patients with Recurrent or Refractory Solid
Tumors
> than 12 months and < 21 years of age
ADVL0815 A Phase 1 Study of Pazopanib as a Single Agent 1A 5544 I Per COG, as of 5/7/2010; Part 1 not
for Children with Refractory Solid Tumors scheduled to re-open unless
replacement is needed. Part 2 will
> than 12 months and < 21 years of age open when Part 1 is completed.
Part 2 is for Solid tumors expanded
Imaging cohort with at least 2 cm
tumor
ADVL0816 A Phase 1 Study of Obatoclax (Pan Anti-Apoptotic 3 5553 I Amendment #3 Approved
BCL-2 Family Small Molecule Inhibitor), in Excluding Primary CNS or pts with
Combination with known CNS metastases
Vincristine/Doxorubicin/Dexrazoxane, in Children
with Relapsed/Refractory Solid Tumors or Leukemia Temporarily Closed
> than 6 months and < 21 years of age
2. Doernbecher Pediatric Oncology Phase I & II Study list
ADVL0819 A Phase 1 Study of SAHA and Temozolomide in 1B 6287 I Check with Rae or Amanda to see if
Children with Relapsed or Refractory Primary Brain there are any open reservations
or Spinal Cord Tumors
Temporarily Closed
> than 12 months and < 21 years of age
ADVL0821 A Phase II study of IMC-A12 in Children with 5 5095 II Check with Rae or Amanda to see if
Relapsed/Refractory Solid Tumors there are any open reservations
Only cohorts for Retinoblastoma,
> 6 month and < 30 years of age neuroblastoma, and adrenocortical
carcinoma are open.
ADVL0912 PF-02341066 for ALK and C-Met for patients with 2 5871 I/2 Check with Rae or Amanda to see if
there are any open reservations
Relapsed/Refractory Solid Tumors and ALCL
Only the cohort with confirmed ALK
> than 12 months and < 21 years of age
fusion proteins is open.
ADVL0916 A Phase I Study of Vorinostat and Bortezomib in 2 5848 I Check with Rae or Amanda to see if
Children with Recurrent or Refractory Solid Tumors, there are any open reservations
including CNS Tumors and Lymphomas
> than 12 months and < 21 years of age Temporarily Closed
ADVL0918 A Phase 1 Study of Temsirolimus in Combination Orig 6519 I Check with Rae or Amanda to see if
with Irinotecan and Temozolomide in Children, there are any open reservations
Adolescents, and Young Adults with Relapsed or Including CNS tumors
Refractory Solid Tumors
> than 12 months and < 21 years of age
ADVL0919 A PHASE 1 STUDY OF RO4929097, AN ORAL 1B 5848 I Check with Rae or Amanda to see if
SMALL MOLECULE INHIBITOR OF there are any open reservations
GAMMA-SECRETASE, IN CHILDREN WITH
RELAPSED/REFRACTORY SOLID OR CNS
TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA
> than 12 months and < 21 years of age
AMG954 20050252, A Phase I Study to Evaluate th Safety Orig 5456 I Check with Rae or Amanda to see if
and PKs of Panitumumab in Children with Solid there are any open reservations
Tumors
1 to < 18 years of age
BMS A Phase II Study of Dasatinib Therapy in Children and 3 4971 II Check with Rae or Amanda to see if there ar
CA180226 Adolescents with Ph+ Leukemia with Resistance or reservations
Intolerance to Imatinib
>1 to < 21
AALL0622 Intensified Tyrosine Kinase Inhibitor Therapy 5 4876 III Open group wide
(Dasatinib: IND# 73969, NSC# 732517) in
Philadelphia Chromosome Positive ALL
> 1 year and ≤ 30 years
ADVL1011 JAK Inhibition (INCB018424) in Children with Relapsed or Orig 6814 I Check with Rae or Amanda to see if there ar
Refractory Solid Tumors, Leukemias, and reservations
Myeloproliferative Neoplasms
> than 12 months and < 21 years of age