This document discusses the use of personal digital assistants (PDAs) in evidence-based medicine (EBM). It notes that PDAs have the potential to save time and money while reducing medical errors. It examines different PDA operating systems, devices, and applications that can be used for clinical drug references, electronic prescriptions, medical calculations, and accessing evidence-based resources like PubMed and clinical practice guidelines. Specific PDA tools are highlighted, including ePocratesRx for drug information, MD on Tap for accessing PubMed, and calculators for diagnostic test statistics and numbers needed to treat. The document encourages readers to try out different PDA applications and resources.