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Unit-6(a) Pharm D
(4th year)
Sterile Formulations:
Parenterals
Presented By:
Mr. Rajat Goyal
(Assistant Professor)
MM School of Pharmacy,
Maharishi Markandeshwar (Deemed to be University,
Mullana-Ambala (Haryana)
Introduction
The term ‘Parenteral’ derived from the Greek work ‘Para’
outside and ‘Enterone’ intestine.
These are sterile solutions or suspensions of drug(s) in
aqueous or oily vehicle.
They are administered directly into veins, muscles or
under the skin, or more specialized tissues such as spinal
cord.
Routes of Administration
Parenterals routes of administration usually have a more
rapid onset of action than other routes of administration.
Various parenterals routes are as follow:
1. Subcutaneous
2. Intravenous
3. Intramuscular
4. Intradermal
5. Intracardiac
6. Peridural
7. Intra-arterial
8. Intrathecal
9. Intra-articular
10. Intracerebral
General Requirements for
Parenteral dosage forms
 Isotonicity
 Sterility
 Stability
 Free from pyrogens & toxins
 Free from foreign particles
 Chemical Purity
Advantages
 Rapid onset of action.
 Avoid first pass metabolism.
 Complete bioavailability.
 Useful for patients who cannot take drugs orally.
 Useful for emergency situations.
 Useful for delivering fluids, electrolytes,
nutrients etc.
Disadvantages
 Pain on injection.
 Trained staff required.
 More expensive.
 Requires strict control of sterility.
 Require specialized equipments, devices and
techniques to prepare and administer drugs.
Thanks

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Parenterals.pptx

  • 1. Unit-6(a) Pharm D (4th year) Sterile Formulations: Parenterals Presented By: Mr. Rajat Goyal (Assistant Professor) MM School of Pharmacy, Maharishi Markandeshwar (Deemed to be University, Mullana-Ambala (Haryana)
  • 2. Introduction The term ‘Parenteral’ derived from the Greek work ‘Para’ outside and ‘Enterone’ intestine. These are sterile solutions or suspensions of drug(s) in aqueous or oily vehicle. They are administered directly into veins, muscles or under the skin, or more specialized tissues such as spinal cord.
  • 3. Routes of Administration Parenterals routes of administration usually have a more rapid onset of action than other routes of administration. Various parenterals routes are as follow: 1. Subcutaneous 2. Intravenous 3. Intramuscular 4. Intradermal 5. Intracardiac 6. Peridural 7. Intra-arterial 8. Intrathecal 9. Intra-articular 10. Intracerebral
  • 4. General Requirements for Parenteral dosage forms  Isotonicity  Sterility  Stability  Free from pyrogens & toxins  Free from foreign particles  Chemical Purity
  • 5. Advantages  Rapid onset of action.  Avoid first pass metabolism.  Complete bioavailability.  Useful for patients who cannot take drugs orally.  Useful for emergency situations.  Useful for delivering fluids, electrolytes, nutrients etc.
  • 6. Disadvantages  Pain on injection.  Trained staff required.  More expensive.  Requires strict control of sterility.  Require specialized equipments, devices and techniques to prepare and administer drugs.