This document discusses Papaverine Hydrochloride Injection BP 60mg/2ml, a drug made by Taj Pharma used to treat erectile dysfunction. It provides information on the drug's uses, dosage, administration through intracavernosal injection, contraindications like certain medical conditions and risks of priapism, and warnings regarding proper use and monitoring for side effects. The document also covers drug interactions, use in special populations, and adverse effects. It aims to educate medical professionals and patients on the appropriate and safe use of this treatment for erectile dysfunction.
Urokinase Powder For Injection (Dukinase) Taj Pharma SmPCTajPharmaQC
Urokinase Powder For Injection (Dukinase) Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Urokinase Powder For Injection (Dukinase) Taj Pharma Dosage & Rx Info | Urokinase Powder For Injection (Dukinase) Taj Pharma Uses, Side Effects, Urokinase Powder For Injection (Dukinase) Taj Pharma : Indications, Side Effects, Warnings, Urokinase Powder For Injection (Dukinase) Taj Pharma - Drug Information - Taj Pharma, Urokinase Powder For Injection (Dukinase) Taj Pharma dose Taj pharmaceuticals Urokinase Powder For Injection (Dukinase) Taj Pharma interactions, Taj Pharmaceutical Urokinase Powder For Injection (Dukinase) Taj Pharma contraindications, Urokinase Powder For Injection (Dukinase) Taj Pharma price, Urokinase Powder For Injection (Dukinase) Taj Pharma Taj Pharma Urokinase Powder For Injection (Dukinase) Taj Pharma PIL- Taj Pharma Stay connected to all updated on Urokinase Powder For Injection (Dukinase) Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, SmPC.
Epirubicin hydrochloride 2 mgml solution for injection or infusion smpc taj ...Taj Pharma
EPIRUBICIN HYDROCHLORIDE - Drug Information - Taj Pharma, EPIRUBICIN HYDROCHLORIDE dose Taj pharmaceuticals EPIRUBICIN HYDROCHLORIDE interactions, Taj Pharmaceutical EPIRUBICIN HYDROCHLORIDE contraindications, EPIRUBICIN HYDROCHLORIDE price, EPIRUBICIN HYDROCHLORIDE Taj Pharma Cancer, oncologyEpirubicin Hydrochloride 2mg/ml solution for injection or infusion SMPC- Taj Pharma . Stay connected to all updated on EPIRUBICIN HYDROCHLORIDE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Ciprofloxacin 3mg per ml and dexamethasone 1mg per ml eye drops smpc taj ph...Taj Pharma
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Doxorubin 10 mg, 50mg powder for solution for injection smpc taj pharmaceuti...Taj Pharma
Warnings, DOXORUBIN Dosage & Rx Info | DOXORUBIN Uses, Side Effects -: Indications, Side Effects, Warnings, DOXORUBIN - Drug Information - Taj Pharma, DOXORUBIN dose Taj pharmaceuticals DOXORUBIN interactions, Taj Pharmaceutical DOXORUBIN contraindications, DOXORUBIN price, DOXORUBIN Taj Pharma Cancer, oncologyDoxorubin 10 mg, 50mg powder for solution for Injection. SMPC- Taj Pharma . Stay connected to all updated on DOXORUBIN Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Dobutamine Injection USP Taj Pharma SmPCTajPharmaQC
Dobutamine Injection USP 250mg/5ml, 250mg/20ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Dobutamine Dosage & Rx Info | Dobutamine Uses, Side Effects Dobutamine: Indications, Side Effects, Warnings, Dobutamine -Drug Information –Taj Pharma, Dobutamine dose Taj pharmaceuticals Dobutamine interactions, Taj Pharmaceutical Dobutamine contraindications, Dobutamine price, Dobutamine Taj Pharma Dobutamine SmPC-Taj Pharma Stay connected to all updated on Dobutamine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Urokinase Powder For Injection (Dukinase) Taj Pharma SmPCTajPharmaQC
Urokinase Powder For Injection (Dukinase) Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Urokinase Powder For Injection (Dukinase) Taj Pharma Dosage & Rx Info | Urokinase Powder For Injection (Dukinase) Taj Pharma Uses, Side Effects, Urokinase Powder For Injection (Dukinase) Taj Pharma : Indications, Side Effects, Warnings, Urokinase Powder For Injection (Dukinase) Taj Pharma - Drug Information - Taj Pharma, Urokinase Powder For Injection (Dukinase) Taj Pharma dose Taj pharmaceuticals Urokinase Powder For Injection (Dukinase) Taj Pharma interactions, Taj Pharmaceutical Urokinase Powder For Injection (Dukinase) Taj Pharma contraindications, Urokinase Powder For Injection (Dukinase) Taj Pharma price, Urokinase Powder For Injection (Dukinase) Taj Pharma Taj Pharma Urokinase Powder For Injection (Dukinase) Taj Pharma PIL- Taj Pharma Stay connected to all updated on Urokinase Powder For Injection (Dukinase) Taj Pharma Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, SmPC.
Epirubicin hydrochloride 2 mgml solution for injection or infusion smpc taj ...Taj Pharma
EPIRUBICIN HYDROCHLORIDE - Drug Information - Taj Pharma, EPIRUBICIN HYDROCHLORIDE dose Taj pharmaceuticals EPIRUBICIN HYDROCHLORIDE interactions, Taj Pharmaceutical EPIRUBICIN HYDROCHLORIDE contraindications, EPIRUBICIN HYDROCHLORIDE price, EPIRUBICIN HYDROCHLORIDE Taj Pharma Cancer, oncologyEpirubicin Hydrochloride 2mg/ml solution for injection or infusion SMPC- Taj Pharma . Stay connected to all updated on EPIRUBICIN HYDROCHLORIDE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Ciprofloxacin 3mg per ml and dexamethasone 1mg per ml eye drops smpc taj ph...Taj Pharma
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Doxorubin 10 mg, 50mg powder for solution for injection smpc taj pharmaceuti...Taj Pharma
Warnings, DOXORUBIN Dosage & Rx Info | DOXORUBIN Uses, Side Effects -: Indications, Side Effects, Warnings, DOXORUBIN - Drug Information - Taj Pharma, DOXORUBIN dose Taj pharmaceuticals DOXORUBIN interactions, Taj Pharmaceutical DOXORUBIN contraindications, DOXORUBIN price, DOXORUBIN Taj Pharma Cancer, oncologyDoxorubin 10 mg, 50mg powder for solution for Injection. SMPC- Taj Pharma . Stay connected to all updated on DOXORUBIN Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Dobutamine Injection USP Taj Pharma SmPCTajPharmaQC
Dobutamine Injection USP 250mg/5ml, 250mg/20ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Dobutamine Dosage & Rx Info | Dobutamine Uses, Side Effects Dobutamine: Indications, Side Effects, Warnings, Dobutamine -Drug Information –Taj Pharma, Dobutamine dose Taj pharmaceuticals Dobutamine interactions, Taj Pharmaceutical Dobutamine contraindications, Dobutamine price, Dobutamine Taj Pharma Dobutamine SmPC-Taj Pharma Stay connected to all updated on Dobutamine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Pantoprazole Sodium for Injection Taj Pharma SmPCTajPharmaQC
Pantoprazole Sodium for Injection 40mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Pantoprazole Sodium Dosage & Rx Info | Pantoprazole Sodium Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Pantoprazole Sodium-Drug Information –Taj Pharma, Pantoprazole Sodium dose Taj pharmaceuticals Pantoprazole Sodium interactions, Taj Pharmaceutical Pantoprazole Sodium contraindications, Pantoprazole Sodium price, Pantoprazole Sodium Taj Pharma Pantoprazole Sodium SmPC-Taj Pharma Stay connected to all updated on Pantoprazole Sodium Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Paracetamol 10 mg per ml solution for infusion smpc taj pharmaceuticalsTaj Pharma
Paracetamol - Drug Information - Taj Pharma, Paracetamol dose Taj pharmaceuticals Paracetamol interactions, Taj Pharmaceutical Paracetamol contraindications, Paracetamol price, Paracetamol Taj Pharma Paracetamol 10 mg/ml Solution for Infusion SMPC- Taj Pharma . Stay connected to all updated on Paracetamol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Vecuronium bromide 4mg, and 10mg powder for solution for injection SmPCTajPharmaQC
Vecuronium bromide 4mg, and 10mg powder for solution for injection (Brufage) Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Vecuronium bromide 4mg, and 10mg powder for solution for injection (Brufage) Taj Pharma Dosage & Rx Info | Vecuronium bromide 4mg, and 10mg powder for solution for injection (Brufage) Taj Pharma Uses, Side Effects, Vecuronium bromide 4mg, and 10mg powder for solution for injection (Brufage) Taj Pharma : Indications, Side Effects, Warnings SmPC
Cyclophosphamide for Injection USP 500mg, 1000mg, 2000mg Taj Pharma PILTajPharmaQC
Cyclophosphamide for Injection USP 500mg/1000mg/2000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Clindamycin Injection USP Taj Pharma SmPCTajPharmaQC
Clindamycin Injection USP 300mg/2ml, 600mg/4ml, 900mg/6ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Clindamycin Dosage & Rx Info | Clindamycin Uses, Side Effects Clindamycin: Indications, Side Effects, Warnings, Clindamycin -Drug Information –Taj Pharma, Clindamycin dose Taj pharmaceuticals Clindamycin interactions, Taj Pharmaceutical Clindamycin contraindications, Clindamycin price, Clindamycin Taj Pharma Clindamycin SmPC-Taj Pharma Stay connected to all updated on Clindamycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Fluorouracil 50mgml injection smpc taj pharmaceuticalsTaj Pharma
FLUOROURACIL Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, FLUOROURACIL Dosage & Rx Info | FLUOROURACIL Uses, Side Effects -: Indications, Side Effects, Warnings, FLUOROURACIL - Drug Information - Taj Pharma, FLUOROURACIL dose Taj pharmaceuticals FLUOROURACIL interactions, Taj Pharmaceutical FLUOROURACIL contraindications, FLUOROURACIL price, FLUOROURACIL Taj Pharma Cancer, oncologyFluorouracil 50mg/ml Injection. SMPC- Taj Pharma
Bivalirudin for Injection Taj Pharma SmPCTajPharmaQC
Bivalirudin for Injection 250mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Bivalirudin Dosage & Rx Info | Bivalirudin Uses, Side Effects Bivalirudin: Indications, Side Effects, Warnings, Bivalirudin -Drug Information –Taj Pharma, Bivalirudin dose Taj pharmaceuticals Bivalirudin interactions, Taj Pharmaceutical Bivalirudin contraindications, Bivalirudin price, Bivalirudin Taj Pharma Bivalirudin SmPC-Taj Pharma Stay connected to all updated on Bivalirudin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Levofloxacin Injection 5mg/ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Levofloxacin Dosage & Rx Info | Levofloxacin Uses, Side Effects Levofloxacin: Indications, Side Effects, Warnings, Levofloxacin -Drug Information –Taj Pharma, Levofloxacin dose Taj pharmaceuticals Levofloxacin interactions, Taj Pharmaceutical Levofloxacin contraindications, Levofloxacin price, Levofloxacin Taj Pharma Levofloxacin SmPC-Taj Pharma Stay connected to all updated on Levofloxacin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Ondansetron Injection USP Taj Pharma SmPCTajPharmaQC
Ondansetron Injection USP 4mg/2ml, 8mg/4ml, 40mg/20ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Ondansetron Dosage & Rx Info | Ondansetron Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Ondansetron-Drug Information –Taj Pharma, Ondansetron dose Taj pharmaceuticals Ondansetron interactions, Taj Pharmaceutical Ondansetron contraindications, Ondansetron price, Ondansetron Taj Pharma Ondansetron SmPC-Taj Pharma Stay connected to all updated on Ondansetron Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Pantoprazole Sodium for Injection Taj Pharma SmPCTajPharmaQC
Pantoprazole Sodium for Injection 40mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Pantoprazole Sodium Dosage & Rx Info | Pantoprazole Sodium Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Pantoprazole Sodium-Drug Information –Taj Pharma, Pantoprazole Sodium dose Taj pharmaceuticals Pantoprazole Sodium interactions, Taj Pharmaceutical Pantoprazole Sodium contraindications, Pantoprazole Sodium price, Pantoprazole Sodium Taj Pharma Pantoprazole Sodium SmPC-Taj Pharma Stay connected to all updated on Pantoprazole Sodium Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Paracetamol 10 mg per ml solution for infusion smpc taj pharmaceuticalsTaj Pharma
Paracetamol - Drug Information - Taj Pharma, Paracetamol dose Taj pharmaceuticals Paracetamol interactions, Taj Pharmaceutical Paracetamol contraindications, Paracetamol price, Paracetamol Taj Pharma Paracetamol 10 mg/ml Solution for Infusion SMPC- Taj Pharma . Stay connected to all updated on Paracetamol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Vecuronium bromide 4mg, and 10mg powder for solution for injection SmPCTajPharmaQC
Vecuronium bromide 4mg, and 10mg powder for solution for injection (Brufage) Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Vecuronium bromide 4mg, and 10mg powder for solution for injection (Brufage) Taj Pharma Dosage & Rx Info | Vecuronium bromide 4mg, and 10mg powder for solution for injection (Brufage) Taj Pharma Uses, Side Effects, Vecuronium bromide 4mg, and 10mg powder for solution for injection (Brufage) Taj Pharma : Indications, Side Effects, Warnings SmPC
Cyclophosphamide for Injection USP 500mg, 1000mg, 2000mg Taj Pharma PILTajPharmaQC
Cyclophosphamide for Injection USP 500mg/1000mg/2000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Clindamycin Injection USP Taj Pharma SmPCTajPharmaQC
Clindamycin Injection USP 300mg/2ml, 600mg/4ml, 900mg/6ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Clindamycin Dosage & Rx Info | Clindamycin Uses, Side Effects Clindamycin: Indications, Side Effects, Warnings, Clindamycin -Drug Information –Taj Pharma, Clindamycin dose Taj pharmaceuticals Clindamycin interactions, Taj Pharmaceutical Clindamycin contraindications, Clindamycin price, Clindamycin Taj Pharma Clindamycin SmPC-Taj Pharma Stay connected to all updated on Clindamycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Fluorouracil 50mgml injection smpc taj pharmaceuticalsTaj Pharma
FLUOROURACIL Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, FLUOROURACIL Dosage & Rx Info | FLUOROURACIL Uses, Side Effects -: Indications, Side Effects, Warnings, FLUOROURACIL - Drug Information - Taj Pharma, FLUOROURACIL dose Taj pharmaceuticals FLUOROURACIL interactions, Taj Pharmaceutical FLUOROURACIL contraindications, FLUOROURACIL price, FLUOROURACIL Taj Pharma Cancer, oncologyFluorouracil 50mg/ml Injection. SMPC- Taj Pharma
Bivalirudin for Injection Taj Pharma SmPCTajPharmaQC
Bivalirudin for Injection 250mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Bivalirudin Dosage & Rx Info | Bivalirudin Uses, Side Effects Bivalirudin: Indications, Side Effects, Warnings, Bivalirudin -Drug Information –Taj Pharma, Bivalirudin dose Taj pharmaceuticals Bivalirudin interactions, Taj Pharmaceutical Bivalirudin contraindications, Bivalirudin price, Bivalirudin Taj Pharma Bivalirudin SmPC-Taj Pharma Stay connected to all updated on Bivalirudin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Levofloxacin Injection 5mg/ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Levofloxacin Dosage & Rx Info | Levofloxacin Uses, Side Effects Levofloxacin: Indications, Side Effects, Warnings, Levofloxacin -Drug Information –Taj Pharma, Levofloxacin dose Taj pharmaceuticals Levofloxacin interactions, Taj Pharmaceutical Levofloxacin contraindications, Levofloxacin price, Levofloxacin Taj Pharma Levofloxacin SmPC-Taj Pharma Stay connected to all updated on Levofloxacin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Ondansetron Injection USP Taj Pharma SmPCTajPharmaQC
Ondansetron Injection USP 4mg/2ml, 8mg/4ml, 40mg/20ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Ondansetron Dosage & Rx Info | Ondansetron Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Ondansetron-Drug Information –Taj Pharma, Ondansetron dose Taj pharmaceuticals Ondansetron interactions, Taj Pharmaceutical Ondansetron contraindications, Ondansetron price, Ondansetron Taj Pharma Ondansetron SmPC-Taj Pharma Stay connected to all updated on Ondansetron Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Adenosine Injection USP Taj Pharma SmPCTajPharmaQC
Adenosine Injection USP 6mg/2ml, 12mg/4ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Adenosine Dosage & Rx Info | Adenosine Uses, Side Effects Adenosine: Indications, Side Effects, Warnings, Adenosine -Drug Information –Taj Pharma, Adenosine dose Taj pharmaceuticals Adenosine interactions, Taj Pharmaceutical Adenosine contraindications, Adenosine price, Adenosine Taj Pharma Adenosine SmPC-Taj Pharma Stay connected to all updated on Adenosine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Diazepam Injection USP 10mg/2ml, 50mg/10ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Diazepam Dosage & Rx Info | Diazepam Uses, Side Effects Diazepam: Indications, Side Effects, Warnings, Diazepam -Drug Information –Taj Pharma, Diazepam dose Taj pharmaceuticals Diazepam interactions, Taj Pharmaceutical Diazepam contraindications, Diazepam price, Diazepam Taj Pharma Diazepam SmPC-Taj Pharma Stay connected to all updated on Diazepam Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Beprin 5,000 i.u.ml solution for injection smpc taj pharmaceuticalsTaj Pharma
Beprin (Heparin) Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Beprin (Heparin) Dosage & Rx Info | Beprin (Heparin) Uses, Side Effects -: Indications, Side Effects, Warnings, Beprin (Heparin) - Drug Information - Taj Pharma, Beprin (Heparin) dose Taj pharmaceuticals Beprin (Heparin) interactions, Taj Pharmaceutical Beprin (Heparin) contraindications, Beprin (Heparin) price, Beprin (Heparin) Taj Pharma Beprin (Heparin) Solution for Injection 5000IU/ml 1000IU/ml SMPC- Taj Pharma . Stay connected to all updated on Beprin (Heparin) Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Chlordiazepoxide 10mg capsules smpc taj pharmaceuticalsTaj Pharma
Chlordiazepoxide Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Chlordiazepoxide Dosage & Rx Info | Chlordiazepoxide Uses, Side Effects -: Indications, Side Effects, Warnings, Chlordiazepoxide - Drug Information - Taj Pharma, Chlordiazepoxide dose Taj pharmaceuticals Chlordiazepoxide interactions, Taj Pharmaceutical Chlordiazepoxide contraindications, Chlordiazepoxide price, Chlordiazepoxide Taj Pharma Chlordiazepoxide 10mg Capsules SMPC- Taj Pharma . Stay connected to all updated on Chlordiazepoxide Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Voriconazole for Injection Taj Pharma SmPCTajPharmaQC
Voriconazole for Injection 200mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Voriconazole Dosage & Rx Info | Voriconazole Uses, Side Effects Voriconazole: Indications, Side Effects, Warnings, Voriconazole -Drug Information –Taj Pharma, Voriconazole dose Taj pharmaceuticals Voriconazole interactions, Taj Pharmaceutical Voriconazole contraindications, Voriconazole price, Voriconazole Taj Pharma Voriconazole SmPC-Taj Pharma Stay connected to all updated on Voriconazole Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Urokinase for Injection Taj Pharma SmPCTajPharmaQC
Urokinase for Injection 500,000 IU Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Urokinase Dosage & Rx Info | Urokinase Uses, Side Effects Urokinase: Indications, Side Effects, Warnings, Urokinase -Drug Information –Taj Pharma, Urokinase dose Taj pharmaceuticals Urokinase interactions, Taj Pharmaceutical Urokinase contraindications, Urokinase price, Urokinase Taj Pharma Urokinase SmPC-Taj Pharma Stay connected to all updated on Urokinase Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Dobutamine Injection 5mg/ml, 12.5mg/ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Dobutamine Dosage & Rx Info | Dobutamine Uses, Side Effects Dobutamine: Indications, Side Effects, Warnings, Dobutamine -Drug Information –Taj Pharma, Dobutamine dose Taj pharmaceuticals Dobutamine interactions, Taj Pharmaceutical Dobutamine contraindications, Dobutamine price, Dobutamine Taj Pharma Dobutamine SmPC-Taj Pharma Stay connected to all updated on Dobutamine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Phytomenadione Injection BP 1mg/0.5ml Taj Pharma SmPC (Adult)TajPharmaQC
Phytomenadione Injection BP 1mg/0.5ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Phytomenadione Dosage & Rx Info | Phytomenadione Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Phytomenadione-Drug Information –Taj Pharma, Phytomenadione dose Taj pharmaceuticals Phytomenadione interactions, Taj Pharmaceutical Phytomenadione contraindications, Phytomenadione price, Phytomenadione Taj Pharma Phytomenadione SmPC-Taj Pharma Stay connected to all updated on Phytomenadione Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Fulvestrant 250 mg solution for injection smpc taj pharmaceuticalsTaj Pharma
FULVESTRANT Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, FULVESTRANT Dosage & Rx Info | FULVESTRANT Uses, Side Effects -: Indications, Side Effects, Warnings, FULVESTRANT - Drug Information - Taj Pharma, FULVESTRANT dose Taj pharmaceuticals FULVESTRANT interactions, Taj Pharmaceutical FULVESTRANT contraindications, FULVESTRANT price, FULVESTRANT Taj Pharma Cancer, oncologyFulvestrant 250 mg solution for injection.. SMPC- Taj Pharma
Telbivudine Tablet 600mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Telbivudine Dosage & Rx Info | Telbivudine Uses, Side Effects Telbivudine: Indications, Side Effects, Warnings, Telbivudine -Drug Information –Taj Pharma, Telbivudine dose Taj pharmaceuticals Telbivudine interactions, Taj Pharmaceutical Telbivudine contraindications, Telbivudine price, Telbivudine Taj Pharma Telbivudine SmPC-Taj Pharma Stay connected to all updated on Telbivudine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Raltegravir Tablets USP Taj Pharma SmPCTajPharmaQC
Raltegravir Tablet USP 25mg/100mg/400mg/600mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Raltegravir Dosage & Rx Info | Raltegravir Uses, Side Effects Raltegravir: Indications, Side Effects, Warnings, Raltegravir -Drug Information –Taj Pharma, Raltegravir dose Taj pharmaceuticals Raltegravir interactions, Taj Pharmaceutical Raltegravir contraindications, Raltegravir price, Raltegravir Taj Pharma Raltegravir SmPC-Taj Pharma Stay connected to all updated on Raltegravir Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Linezolid Tablets USP 600mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Linezolid Dosage & Rx Info | Linezolid Uses, Side Effects Linezolid: Indications, Side Effects, Warnings, Linezolid -Drug Information –Taj Pharma, Linezolid dose Taj pharmaceuticals Linezolid interactions, Taj Pharmaceutical Linezolid contraindications, Linezolid price, Linezolid Taj Pharma Linezolid SmPC-Taj Pharma Stay connected to all updated on Linezolid Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Lacosamide Tablets 50mg/100mg/150mg/200mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lacosamide Dosage & Rx Info | Lacosamide Uses, Side Effects Lacosamide : Indications, Side Effects, Warnings, Lacosamide-Drug Information –Taj Pharma, Lacosamide dose Taj pharmaceuticals Lacosamide interactions, Taj Pharmaceutical Lacosamide contraindications, Lacosamide price, Lacosamide Taj Pharma Lacosamide SmPC-Taj Pharma Stay connected to all updated on Lacosamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Digoxin Tablets USP 62.5mcg/125mcg/250mcg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Digoxin Dosage & Rx Info | Digoxin Uses, Side Effects Digoxin : Indications, Side Effects, Warnings, Digoxin -Drug Information –Taj Pharma, Digoxin dose Taj pharmaceuticals Digoxin interactions, Taj Pharmaceutical Digoxin contraindications, Digoxin price, Digoxin Taj Pharma Digoxin SmPC-Taj Pharma Stay connected to all updated on Digoxin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Digoxin Tablets USP 62.5mcg/125mcg/250mcg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Digoxin Dosage & Rx Info | Digoxin Uses, Side Effects Digoxin : Indications, Side Effects, Warnings, Digoxin -Drug Information –Taj Pharma, Digoxin dose Taj pharmaceuticals Digoxin interactions, Taj Pharmaceutical Digoxin contraindications, Digoxin price, Digoxin Taj Pharma Digoxin SmPC-Taj Pharma Stay connected to all updated on Digoxin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Ciprofloxacin Tablets USP 250mg/500mg/750mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Ciprofloxacin Dosage & Rx Info | Ciprofloxacin Uses, Side Effects Ciprofloxacin : Indications, Side Effects, Warnings, Ciprofloxacin -Drug Information –Taj Pharma, Ciprofloxacin dose Taj pharmaceuticals Ciprofloxacin interactions, Taj Pharmaceutical Ciprofloxacin contraindications, Ciprofloxacin price, Ciprofloxacin Taj Pharma Ciprofloxacin SmPC-Taj Pharma Stay connected to all updated on Ciprofloxacin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Azithromycin Tablets USP 250mg/500mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Azithromycin Dosage & Rx Info | Azithromycin Uses, Side Effects Azithromycin: Indications, Side Effects, Warnings, Azithromycin -Drug Information –Taj Pharma, Azithromycin dose Taj pharmaceuticals Azithromycin interactions, Taj Pharmaceutical Azithromycin contraindications, Azithromycin price, Azithromycin Taj Pharma Azithromycin SmPC-Taj Pharma Stay connected to all updated on Azithromycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Atomoxetine Capsules USP Taj Pharma SmPCTajPharmaQC
Atomoxetine Capsules USP 10mg/18mg/25mg/40mg/60mg/80mg/100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Atomoxetine Dosage & Rx Info | Atomoxetine Uses, Side Effects Atomoxetine: Indications, Side Effects, Warnings, Atomoxetine -Drug Information –Taj Pharma, Atomoxetine dose Taj pharmaceuticals Atomoxetine interactions, Taj Pharmaceutical Atomoxetine contraindications, Atomoxetine price, Atomoxetine Taj Pharma Atomoxetine SmPC-Taj Pharma Stay connected to all updated on Atomoxetine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Vildagliptin Tablets 50mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Vildagliptin Dosage & Rx Info | Vildagliptin Uses, Side Effects Vildagliptin: Indications, Side Effects, Warnings, Vildagliptin -Drug Information –Taj Pharma, Vildagliptin dose Taj pharmaceuticals Vildagliptin interactions, Taj Pharmaceutical Vildagliptin contraindications, Vildagliptin price, Vildagliptin Taj Pharma Vildagliptin SmPC-Taj Pharma Stay connected to all updated on Vildagliptin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
1. Papaverine Hydrochloride Injection BP 60mg/2ml Taj Pharma : U ses, Side Effects, Interactions, Pictures, Warnings, Papaverine Hydrochloride Injection BP 60mg/2ml Dosage & Rx Info | Papaverine Hydrochlor ide Injection BP 60mg/2ml Uses, Side Effects , Papaverine Hydrochloride Injection BP 60mg/2ml : Indications, Side Effects, Warnings, Papaverine Hydrochloride Injection BP 60mg/2ml - Drug Information – Taj Pharma, Papaverine Hydrochloride Injection BP 60mg/2ml dose Taj pharmaceuticals Papaverine Hydrochloride Injection BP 60mg/2ml interactions, Taj Pharmaceutical Papaverine Hydr ochloride Injection BP 60mg/2ml contraindications, Papaverine Hydrochloride Injection BP 60mg/2ml price, Papaverine Hydrochloride Injection BP 60mg/2ml Taj Pharma Papaverine Hydrochloride Injection BP 60mg/2ml PIL- Taj Pharma Stay connected to all updated on Papaverine Hydrochloride Injec tion BP 60mg/2ml Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
Papaverine Hydrochloride Injection BP 30mg/ml,
60mg/2ml
1. NAME OF PRODUCT
Papaverine Hydrochloride 30mg/ml Solution for injection Taj Pharma
Papaverine Hydrochloride 60mg/2ml Solution for injection Taj Pharma
2. QUALITATIVE AND QUANTITATIVECOMPOSITION
Each ml contains
Papaverine hydrochloride BP 30mg
Each 2ml contains
Papaverine hydrochloride BP 60mg
For the full list of excipients, see section 6.1.
3. PHARMACEUTICAL FORM
Solution for injection
Papaverine Hydrochloride Injection is a sterile, clear, colourless to pale-
yellow solution. The pH of the injection ranges between 3.0 and 5.0.
4. CLINICALPARTICULARS
4.1Therapeutic indications
Papaverine Hydrochloride Injection is indicated for the treatment of erectile
dysfunction.
3.2 Dose and method of administration
Papaverine Hydrochloride Injection should only be prescribed, and
treatment should be supervised, by prescribers having expertise in the
management of erectile dysfunction using a range of treatment modalities.
The 300mg/10 mL ampoule of Papaverine Hydrochloride Injection must only
be used for treatment of a single patient, on one occasion only.
The use of Papaverine Hydrochloride Injection in combination with other
agents, including phentolamine and alprostadil is not recommended (see
section 4.4).
Papaverine Hydrochloride Injection should be administered by
intracavernosal injection.
Before initiation of treatment with Papaverine Hydrochloride Injection,
patients should be carefully assessed by a specialist practitioner in erectile
dysfunction with appropriate training in the use of this drug. The dose should
be titrated carefully according to individual need. The first injection of
Papaverine Hydrochloride Injection must be done by medically trained
personnel. After proper training and instruction, Papaverine Hydrochloride
Injection may be injected at home. If self-administration isplanned, the
specialist should make an assessment of the patient's (or as appropriate, the
partner's) skill and competence with the procedure. While on self-injection
treatment, it isrecommended that the patient visit the specialist's office at
periodic intervals. At that time, the efficacy and safety of the therapy
should be assessed, and the dose of Papaverine Hydrochloride Injection
should be adjusted, ifneeded.
Dosage
The lowest effective dose should be determined for each patient. In general
most patients respond to doses in the range of 2.5 to 60mg of papaverine
hydrochloride.
A starting dose of 15mg is recommended for patients with erectile dysfunction
due to most causes. Patients with psychogenic erectile dysfunction are likely
2. Papaverine Hydrochloride Injection BP 60mg/2ml Taj Pharma : U ses, Side Effects, Interactions, Pictures, Warnings, Papaverine Hydrochloride Injection BP 60mg/2ml Dosage & Rx Info | Papaverine Hydrochlor ide Injection BP 60mg/2ml Uses, Side Effects , Papaverine Hydrochloride Injection BP 60mg/2ml : Indications, Side Effects, Warnings, Papaverine Hydrochloride Injection BP 60mg/2ml - Drug Information – Taj Pharma, Papaverine Hydrochloride Injection BP 60mg/2ml dose Taj pharmaceuticals Papaverine Hydrochloride Injection BP 60mg/2ml interactions, Taj Pharmaceutical Papaverine Hydr ochloride Injection BP 60mg/2ml contraindications, Papaverine Hydrochloride Injection BP 60mg/2ml price, Papaverine Hydrochloride Injection BP 60mg/2ml Taj Pharma Papaverine Hydrochloride Injection BP 60mg/2ml PIL- Taj Pharma Stay connected to all updated on Papaverine Hydrochloride Injec tion BP 60mg/2ml Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
to respond to lower doses, while those with vasculogenic erectile dysfunction
are likely to require higher doses. Patients who do not respond to a dose of
60mg should be changed to alternative therapy.
A starting dose of 5mg is recommended for men with erectile dysfunction
due to spinal cord injury.
Erection usually occurs within 10 minutes of injection of the drug and may
persist for one to several hours. Tolerance to papaverine hydrochloride may
occur during long-term use and may require an increase in dosage.
The dose should be reduced if erections persist for longer than four hours.
Early studies using doses of up to 80mg papaverine hydrochloride resulted in
high proportion patients requiring assisted detumescence.
Dosage adjustment should be made carefully, based on the degree and
duration of tumescence achieved with the previous dose.
General procedure for injection
Ampoules of Papaverine Hydrochloride Injection are intended for single use
only and should be discarded after use. The 300mg/10 mL ampoule is for
use in one patient only, on one occasion only.
Intracavernosal papaverine hydrochloride may be self-administered by
patients, but only after careful training in the technique to reduce the
incidence of inadvertent subcutaneous administration, ecchymosis and
urethral injury.
The patient should be instructed to use a new syringe and needle for each
injection and in the appropriate disposal of the syringe and the needle. Needle
breakage, with a portion of the needle remaining in the penis, has been
reported and in some cases, required hospitalisation and surgical removal.
The patient should be cautioned against using bent needles, to inject
Papaverine Hydrochloride Injection or attempting to straighten a bent needle
prior to injecting.
Following is the general procedure for injection.
1. Prior to administration, visually inspect Papaverine Hydrochloride
Injection for particulate matter and discolouration.
2. Using a needle, withdraw the required dosage. A 13 mm, 27 to 30 gauge
needle is recommended.
3. Stretch the penis out across the thigh, with the foreskin retracted in
uncircumcised men. Clean the site with an alcohol swab. Do not
inject along the midline. Do not inject through any of the superficial
veins that are clearly visible under the skin. Inject over one to two
minutes into either of the two corpora cavernosa. Inject at 90 degrees to
the skin; the needle should be inserted up to the needle hub to ensure that
the corpus is injected. Note: Subsequent injections should be
alternated between the two cavernosa. The injection site should be
varied from the base of the penis to just proximal to the glans avoiding
the midlineand any veins. Injections should not be made into the
underside of the penis.
4. After injecting, remove the needle and apply pressure to the injection site
with the alcohol swab until any bleeding stops. The entire length of the
corpus cavernosum should be squeezed firmly to distribute medication,
followed by the same procedure on the other side. The penis should
then be pinched transversely in several places to distribute medication to
both ends of the corpus cavernosum. This procedure should result in an
erection that is adequate for intercourse.
3.3 Contraindications
Papaverine Hydrochloride Injection is contraindicated in patients with
complete atrioventricular block.
Papaverine Hydrochloride Injection is contraindicated inpatients who have
conditions that might predispose them to priapism such as sickle cell anaemia,
multiplemyeloma or leukaemia. Patients with pre-existing penile fibrosis
3. Papaverine Hydrochloride Injection BP 60mg/2ml Taj Pharma : U ses, Side Effects, Interactions, Pictures, Warnings, Papaverine Hydrochloride Injection BP 60mg/2ml Dosage & Rx Info | Papaverine Hydrochlor ide Injection BP 60mg/2ml Uses, Side Effects , Papaverine Hydrochloride Injection BP 60mg/2ml : Indications, Side Effects, Warnings, Papaverine Hydrochloride Injection BP 60mg/2ml - Drug Information – Taj Pharma, Papaverine Hydrochloride Injection BP 60mg/2ml dose Taj pharmaceuticals Papaverine Hydrochloride Injection BP 60mg/2ml interactions, Taj Pharmaceutical Papaverine Hydr ochloride Injection BP 60mg/2ml contraindications, Papaverine Hydrochloride Injection BP 60mg/2ml price, Papaverine Hydrochloride Injection BP 60mg/2ml Taj Pharma Papaverine Hydrochloride Injection BP 60mg/2ml PIL- Taj Pharma Stay connected to all updated on Papaverine Hydrochloride Injec tion BP 60mg/2ml Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
should not be accepted into intracavernosal self-injection therapy.
Papaverine Hydrochloride Injection should not be used in patients with
anatomical deformation of the penis, such as angulation, cavernosal fibrosis or
Peyronie’s disease.
Papaverine Hydrochloride Injection should not be used in men for whom
sexual activity is inadvisable or contraindicated.
Papaverine Hydrochloride Injection should not be used in patients with
penileimplants.
3.4 Special warnings and precautions for use
Priapism
Intracavernosal injection of Papaverine Hydrochloride Injection has caused
priapism. Treatment of priapism should not be delayed. Patie nts should
be instructe d to seek urge nt me dical atte ntion if an erection lasts for
more than four hours. Priapism has been managed by aspiration of
cavernosal blood and/or intracavernosal injection of small doses of an α-
adrenergic agonist. Parenteral administration of high doses may cause
cardiac arrhythmia and fatal apnoea; a slow rate of intravenous
administration is recommended (over a 1 to 2 minute period) to avoid serious
adverseeffects.
Penile Fibrosis
Patients should be carefully assessed for pre-existing penile fibrosis before
initiation of treatment with intracavernosal Papaverine Hydrochloride
Injection. If pre-existing penile fibrosis is found, the patient should not be
accepted into intracavernosal self-injection therapy. This assessment should
be made during pharmacologically-induced erection. At regular visits, the
physician must examine the penis carefully, preferably in the erect state, for
potential development of fibrotic changes. If there are signs of fibrotic
complications, treatment with Papaverine Hydrochloride Injection must be
stopped immediately. Development of penile fibrosis appears to be related to
the injection volume being in excess of 1 mL. During self-injection therapy,
the patient must be instructed to report to the physician any unusual new
adverse effects such as increased or new penile pain, penile bending and/or
nodule formation in the penile shaft.
Other Precautions
Caution is also advised in the presence of cardiac conduction disorders or
unstable cardiovascular disease. Extreme care should be taken when
conduction is depressed since the drug may produce transient ectopic rhythms
of ventricular origin, either premature beats or paroxysmal tachycardia.
Elderly patients should undertake an ECG before being prescribed this
product to eliminate the existence of cardiac conductiondisorders.
Patients on anticoagulants such as warfarin or heparin may have an
increased propensity for bleeding after the intracavernosal injection.
The injection of papaverine hydrochloride can induce a small amount of
bleeding at the site of injection. In patients infected with blood-borne
diseases, this could increase the transmission of such diseases to the
partner.
Patients should be advised to take care when getting up from a lying or
sitting position or when climbing stairs because of the possibility of postural
hypotension.
Combination Therapy
The physical compatibility and stability of papaverine hydrochloride with
alprostadil and/or phentolamine in mixed preparations has not been
established. Co-administration of papaverine hydrochloride with alprostadil
and/or phentolamine was associated with an increased risk of adverse
events including dizziness and syncope in evaluated trials. The safety and
efficacy of combination therapy with papaverine hydrochloride and
4. Papaverine Hydrochloride Injection BP 60mg/2ml Taj Pharma : U ses, Side Effects, Interactions, Pictures, Warnings, Papaverine Hydrochloride Injection BP 60mg/2ml Dosage & Rx Info | Papaverine Hydrochlor ide Injection BP 60mg/2ml Uses, Side Effects , Papaverine Hydrochloride Injection BP 60mg/2ml : Indications, Side Effects, Warnings, Papaverine Hydrochloride Injection BP 60mg/2ml - Drug Information – Taj Pharma, Papaverine Hydrochloride Injection BP 60mg/2ml dose Taj pharmaceuticals Papaverine Hydrochloride Injection BP 60mg/2ml interactions, Taj Pharmaceutical Papaverine Hydr ochloride Injection BP 60mg/2ml contraindications, Papaverine Hydrochloride Injection BP 60mg/2ml price, Papaverine Hydrochloride Injection BP 60mg/2ml Taj Pharma Papaverine Hydrochloride Injection BP 60mg/2ml PIL- Taj Pharma Stay connected to all updated on Papaverine Hydrochloride Injec tion BP 60mg/2ml Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
phentolamine and/or alprostadil has not been established.
The use of papaverine hydrochloride in combination with oral agents for
erectile dysfunction has not beenestablished.
Use in Hepatically Impaired Patients
Papaverine Hydrochloride Injection should be used with caution in patients
with pre- existing hepatic impairment (liver disease) because of the potential
for exacerbation (see below). If signs or symptoms of exacerbated hepatic
impairment occur during papaverine hydrochloride therapy, the drug should be
discontinued.
Liver Function Abnormalities
Elevations of hepatic enzymes and bilirubinhave been reported during use of
papaverine hydrochloride. Most of the affected patients were also consuming
alcohol and a causal relationship to papaverine hydrochloride has not been
proven. Routine monitoring of hepatic function during papaverine
hydrochloride therapy is not required. However, patients with a history of
alcohol abuse or liver disease should be followed more closely with liver
function tests obtained before initiating treatment and at 6-monthly intervals.
Effect on Laboratory Tests
Liver function test results (serum ALT, AST and bilirubin concentrations as
well as eosinophil count) may be altered during intravenous papaverine
hydrochloride therapy.
3.5 Interaction with other medicines and other forms of interaction
The effects of Papaverine hydrochloride may be slightly potentiated by
CNS depressants and a synergism may result from combination with
morphine.
Papaverine hydrochloride may interfere with the therapeutic effects of
levodopa in patients with Parkinson’s disease when the drugs are
administered concomitantly. Several Parkinsonian patients maintained on
levodopa have developed worsening of their Parkinsonism following
Papaverine hydrochloride administration. The therapeutic response to
levodopa returned 5 to 10 days after the papaverine was stopped. The use of
papaverine hydrochloride in these patients should be avoided.
Patients on anticoagulants such as warfarin or heparin may have an
increased propensity for bleeding after the intracavernosal injection.
Ioxaglate can form a paste-like precipitate with Papaverine hydrochloride,
and this could have serious consequences should precipitation occur in the
penis.
3.6 Fertility, pregnancy and lactation
Fe rtility
There are no adequate human or animal studies addressing the effect of
papaverine hydrochloride on fertility or reproductive performance.
Pregnancy
Category B3
Papaverine Hydrochloride Injection is not intended for use by women.
In animal studies, a single 140mg/kg subcutaneous dose of papaverine
hydrochloride to mice on gestation day 9 (timed to coincide with neural tube
closure) caused increased foetal mortality and retardation, spinal cord
kinking and dilation of the fourth brain ventricle. Neither neural anomaly
was observed in control foetuses. Neural tube defects were also observed in
explanted mouse and chick embryos exposed to 50-75 microgram/mL
papaverine hydrochloride during neurulation in vitro.The relevance of these
5. Papaverine Hydrochloride Injection BP 60mg/2ml Taj Pharma : U ses, Side Effects, Interactions, Pictures, Warnings, Papaverine Hydrochloride Injection BP 60mg/2ml Dosage & Rx Info | Papaverine Hydrochlor ide Injection BP 60mg/2ml Uses, Side Effects , Papaverine Hydrochloride Injection BP 60mg/2ml : Indications, Side Effects, Warnings, Papaverine Hydrochloride Injection BP 60mg/2ml - Drug Information – Taj Pharma, Papaverine Hydrochloride Injection BP 60mg/2ml dose Taj pharmaceuticals Papaverine Hydrochloride Injection BP 60mg/2ml interactions, Taj Pharmaceutical Papaverine Hydr ochloride Injection BP 60mg/2ml contraindications, Papaverine Hydrochloride Injection BP 60mg/2ml price, Papaverine Hydrochloride Injection BP 60mg/2ml Taj Pharma Papaverine Hydrochloride Injection BP 60mg/2ml PIL- Taj Pharma Stay connected to all updated on Papaverine Hydrochloride Injec tion BP 60mg/2ml Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
animal findings to humans is currently unknown.
There are no formal studies of papaverine hydrochloride in pregnant women.
Lactation
Papaverine hydrochloride Injection is not intended for use by women.
It is not known whether papaverine hydrochloride is excreted in breast milk.
Because many drugs are excreted in breast milk,caution should be
exercised when Papaverine hydrochloride is administered to a nursing
woman.
3.7 Effects on ability to drive and use machinery
No data available.
3.8 Undesirable effects
Intracavernosal injection of papaverine hydrochloride may cause mild
discomfort in the penis during injection, ecchymosis at the injection site,
urethral bleeding, paraesthesia of the glans, difficulty in reaching orgasm
and ejaculation, and priapism. Treatment of priapism should not be
delayed. Patients should be instructed to seek urgent medical attention
if an erection lasts for more than four hours.
Following is a listing of local and systemic adverse effects from clinical
studies and case reports in which papaverine hydrochloride was used.
Local Adverse Events
• Prolonged erection/priapism
• Penile fibrosis, manifested as subcutaneous nodules, plaques,
cavernosal fibrosis, scarring, deformity, curvature (Peyronie’s disease)
and calcification
• Pain/ discomfort/ burning sensations during the injection
• Injection site bruising/ haematoma
• Injection site blister/ ulcer
• Penile/ foreskin oedema
• Loss of penile sensation
• Misplaced injections, sometimes leading to urethral bleeding
• Pain during erection
• Infection/ cavernositis/ pyogenic granuloma
• Thrombophlebitis/ lymphangitis
• Intracorporal needle breakage
• Fixed drug eruption
• Penile fracture
Systemic Adverse Events
▪ Liver function abnormalities
▪ Symptoms/ signs resulting from vasodilation including headache,
flushing, a sensation of heat in the pelvis, dizziness, photopsia,
tachycardia, hypotension and syncope.
▪ Vasovagal reactions
▪ Cardiac events
▪ Allergic reactions, urticaria
▪ Impaired ejaculation
▪ Death (one report)
Re porting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicine is
important. It allows continued monitoring of the benefit/risk balance of the
medicine.
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3.9 Overdose
Symptoms
The symptoms of toxicity from papaverine hydrochloride often result from
vasomotor instability and include nausea, vomiting, weakness, central nervous
system depression, nystagmus, diplopia, diaphoresis, flushing, dizziness, and
sinus tachycardia. In large overdoses, papaverine hydrochloride is a potent
inhibitorof cellular respiration and a weak calcium antagonist. Following an
oral overdose of 15 g, metabolic acidosis with hyperventilation,
hyperglycaemia, and hypokalemia have been reported. No information on
toxic serum concentrations is available.
Overdose of papaverine hydrochloride via the intracavernosal route is likely to
result in priapism. Patie nts should be instructed to seek urgent me dical
atte ntion if an erection lasts for more than four hours.
Patients should be instructed to seek medical help immediately if they have
self-administered an overdose of papaverine hydrochloride.
Treatment
In managing overdosage, a physician must consider the possibility of
multiple drug overdoses, interaction among drugs, and unusual drug kinetics.
The patient’s airway must be protected, and ventilation and perfusion
supported. Vital signs, blood gases, blood chemistry values and other
variables need to be monitored.
In the event of convulsions, administration of diazepam or phenytoin needs
to be considered. If seizures are refractory, general anaesthesia with
thiopentone or halothane and paralysis with a neuromuscular blocking agent
may benecessary.
For hypotension, intravenous fluids, elevation of legs and administration of an
inotropic vasopressor, such as dopamine, need to be considered.
Theoretically, calcium gluconate may be helpful in treating some of the toxic
cardiovascular effects of Papaverine hydrochloride; the ECG and plasma
calcium concentrations need to bemonitored.
5. PHARMACOLOGICAL PROPERTIES
5.1 Pharmacodynamic properties
Mechanism of action
Papaverine hydrochloride is the hydrochloride of an alkaloid obtained from
opium or prepared synthetically. It belongs to the benzylisoquinoline group of
alkaloids. The principal therapeutic action of papaverine hydrochloride is its
relaxant effect on smooth muscles, which leads to penile erection. It may
induce erections by arteriolar relaxation, increased blood flow and volume
due to relaxation of the sinusoidal wall of the corpora cavernosa and
subsequent compression of venous channels between the sinusoids and the
tunica albuginea.
The spasmolytic effect of papaverine hydrochloride is most pronounced on
the vascular system, including coronary, cerebral, pulmonary and peripheral
vasodilation; it also relaxes the bronchial, gastrointestinal, biliary and urinary
tract smooth muscles. Papaverine hydrochloride has also been reported to
have direct cardiac inotropic effects, leading to increased myocardial oxygen
consumption, which can outstrip the effect of increased coronary blood
flow if hypotension is also present. It can depress myocardial excitability,
prolong the refractory period and depress myocardial conduction. In the
presence of depressed conduction due to other causes (eg AV block),
Papaverine hydrochloride may produce transient ventricular arrhythmias.
Papaverine hydrochloride can mildlystimulate respiration via action on the
carotid and aortic body chemoreceptors.
Papaverine hydrochloride has minimal Central Nervous System (CNS)
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actions, although large doses may have a depressant effect in some patients.
The drug also exhibits weak calcium-channel blocking activity at high doses.
Papaverine hydrochloride has been reported to have antiviral activity
against respiratory syncytial virus, cytomegalovirus, measles and HIV. It
may inhibitmitochondrial oxidative reactions, which can lead to severe
lactic acidosis following large doses, especially overdose.
5.2 Pharmacokinetic properties
The extent and time-course of papaverine hydrochloride absorption have
not been documented. In theory, systemic absorption following
intracavernosal injection would initiallybe rapid, until the local effect of
papaverine hydrochloride led to occlusion of the venous outflow from the
penis. Absorption would then be slow, but would pick up again as
detumescence occurred and the sequestered blood was returned to the
systemic circulation.
Papaverine hydrochloride has a relatively short plasma half-life (1-2 hours)
and is rapidly metabolised by the liver and excreted in the urine, chiefly as the
glucuronide conjugates of phenolic metabolites. The drug is excreted in the
urine in an inactive form. Approximately 90% of the drug is bound to
plasma proteins. After intracavernosal injection, the peak plasma
concentration is several times lower than after extracavernosalinjection.
5.3 Preclinical safety data
Genotoxicity
In an Ames test, papaverine hydrochloride was weakly mutagenic to the
TA100 but not the TA98 strain of Salmonella typhimurium, only in the
presence of metabolic activation.
Carcinoge nicity
No long-term animal studies on the carcinogenic potential of papaverine
hydrochloride have been performed.
Re productive and de velopme ntal toxicity
There are no adequate human or animal studies addressing the effect of
papaverine hydrochloride on fertility or reproductive performance.
6. PHARMACEUTICAL PARTICUALRS
6.1 List of excipients
Water for injection
6.2 Incompatibilities
A precipitate results when Papaverine Hydrochloride Injection is added to
lactated Ringer’s Injection.
6.3 Shelf life
36 months
6.4 Special precautions for storage
Papaverine Hydrochloride Injection should be stored below 25°C and
protected from light.
6.5 Nature and contents of container
Papaverine Hydrochloride Injection is supplied in clear glass ampoules in
the following presentations and packsizes:
Papaverine hydrochloride Injection 30mg/1 mL 5 x 1 mL ampoules
7. Manufactured in India by:
TAJ PHARMACEUTICALS LTD.
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Mumbai, India
Unit No. 214.Old Bake House,
Maharashtra chambers of Commerce Lane,
Fort, Mumbai - 400001
at:Gujarat, INDIA.
Customer Service and Product Inquiries:
1-800-TRY-FIRST (1-800-222-434 & 1-800-222-825)
Monday through Saturday 9:00 a.m. to 7:00 p.m. EST
E-mail: tajgroup@tajpharma.com