It Covers different aspects of Pain and Inflammation.
Including their:
Types, Different initiators, Related Diseases and Drugs used for PAIN and INFLAMMATION
Pain and inflamation + drugs use for pain and inflamationNouman Minhas
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This document discusses pain, inflammation, and the drugs used to treat them. It describes the types of pain as acute or chronic, and the signs of inflammation as pain, heat, redness, swelling and loss of function. Prostaglandins are fatty acids produced during inflammation via the COX enzymes. COX-1 produces prostaglandins for normal functions while COX-2 produces pain-causing prostaglandins during inflammation. Diseases associated with pain and inflammation include arthritis, rheumatoid arthritis, and ankylosing spondylitis. Non-narcotic analgesics and narcotic analgesics are used to treat pain, while NSAIDs and selective COX-2 inhibitors are used to treat inflammation and pain
The document discusses pain physiology and assessment. It defines pain and describes the fast and slow pain fiber pathways. It discusses gate control theory and different classifications of pain including nociceptive, inflammatory, and pathological pain. The document also covers parameters for understanding a patient's pain like intensity, duration, frequency, relieving/aggravating factors. It provides guidance on assessing characteristics of pain from different tissues.
Autologous Plasma and Regenerative Techniques (Prolotherapy, PRP, and Proloz...Megan Hughes
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Dr John Hughes DO Discusses Autologous Plasma and Regenerative Techniques (Prolotherapy, PRP, and Prolozone) for Chronic Pain Due to Musculoskeletal Conditions, Neuropathy, and Scar Tissue.
This document discusses drugs used to treat pain and inflammation. It defines acute and chronic pain, as well as neuropathic and inflammatory pain. Nociceptors detect painful stimuli. NSAIDs like aspirin and ibuprofen work by inhibiting prostaglandin synthesis to reduce pain and inflammation. Steroidal anti-inflammatory drugs also reduce inflammation. NSAIDs can cause side effects like ulcers, bleeding, and kidney damage, so should be used carefully.
The muscular system allows vertebrates to move through skeletal, cardiac, and smooth muscles. Skeletal muscles contract through the sliding filament model where myosin heads attach to and pull actin fibers. Muscles produce ATP aerobically or anaerobically depending on intensity and duration of exercise. Cardiac muscle fibers are laterally connected while smooth muscles are involuntary. Motor neurons control muscle contraction through acetylcholine release and calcium-mediated muscle twitches. Diseases cause symptoms like pain, weakness, stiffness or inability to move from mechanical injury, neurological problems, infection or muscular dystrophy.
The document outlines numerous benefits of massage therapy such as alleviating back pain, assisting with easier childbirth and shorter hospital stays for expectant mothers, easing medication dependence, enhancing immunity, improving circulation, reducing stress and anxiety, relaxing tense muscles, and releasing the body's natural painkillers.
The charcoal memory foam mattress is firm enough to support your neck, back, and body, while still offering plenty of cushioning comfort. Besides ensuring restful comfort, the mattress helps in maintaining the perfect temperature for a nice sleep experience.
This document provides an outline and overview of the neurophysiology of pain. It begins with definitions of pain and discusses the dual nature of pain perception and reaction. It describes the types of pain receptors and the chemical mediators involved in pain signaling. The theories of pain perception including specificity theory, central summation theory, and the gate control theory are summarized. The physiology of pain processing from transduction to transmission and modulation is explained. Assessment scales for pain are also mentioned. The document provides references for further reading on the topic.
Pain and inflamation + drugs use for pain and inflamationNouman Minhas
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This document discusses pain, inflammation, and the drugs used to treat them. It describes the types of pain as acute or chronic, and the signs of inflammation as pain, heat, redness, swelling and loss of function. Prostaglandins are fatty acids produced during inflammation via the COX enzymes. COX-1 produces prostaglandins for normal functions while COX-2 produces pain-causing prostaglandins during inflammation. Diseases associated with pain and inflammation include arthritis, rheumatoid arthritis, and ankylosing spondylitis. Non-narcotic analgesics and narcotic analgesics are used to treat pain, while NSAIDs and selective COX-2 inhibitors are used to treat inflammation and pain
The document discusses pain physiology and assessment. It defines pain and describes the fast and slow pain fiber pathways. It discusses gate control theory and different classifications of pain including nociceptive, inflammatory, and pathological pain. The document also covers parameters for understanding a patient's pain like intensity, duration, frequency, relieving/aggravating factors. It provides guidance on assessing characteristics of pain from different tissues.
Autologous Plasma and Regenerative Techniques (Prolotherapy, PRP, and Proloz...Megan Hughes
Â
Dr John Hughes DO Discusses Autologous Plasma and Regenerative Techniques (Prolotherapy, PRP, and Prolozone) for Chronic Pain Due to Musculoskeletal Conditions, Neuropathy, and Scar Tissue.
This document discusses drugs used to treat pain and inflammation. It defines acute and chronic pain, as well as neuropathic and inflammatory pain. Nociceptors detect painful stimuli. NSAIDs like aspirin and ibuprofen work by inhibiting prostaglandin synthesis to reduce pain and inflammation. Steroidal anti-inflammatory drugs also reduce inflammation. NSAIDs can cause side effects like ulcers, bleeding, and kidney damage, so should be used carefully.
The muscular system allows vertebrates to move through skeletal, cardiac, and smooth muscles. Skeletal muscles contract through the sliding filament model where myosin heads attach to and pull actin fibers. Muscles produce ATP aerobically or anaerobically depending on intensity and duration of exercise. Cardiac muscle fibers are laterally connected while smooth muscles are involuntary. Motor neurons control muscle contraction through acetylcholine release and calcium-mediated muscle twitches. Diseases cause symptoms like pain, weakness, stiffness or inability to move from mechanical injury, neurological problems, infection or muscular dystrophy.
The document outlines numerous benefits of massage therapy such as alleviating back pain, assisting with easier childbirth and shorter hospital stays for expectant mothers, easing medication dependence, enhancing immunity, improving circulation, reducing stress and anxiety, relaxing tense muscles, and releasing the body's natural painkillers.
The charcoal memory foam mattress is firm enough to support your neck, back, and body, while still offering plenty of cushioning comfort. Besides ensuring restful comfort, the mattress helps in maintaining the perfect temperature for a nice sleep experience.
This document provides an outline and overview of the neurophysiology of pain. It begins with definitions of pain and discusses the dual nature of pain perception and reaction. It describes the types of pain receptors and the chemical mediators involved in pain signaling. The theories of pain perception including specificity theory, central summation theory, and the gate control theory are summarized. The physiology of pain processing from transduction to transmission and modulation is explained. Assessment scales for pain are also mentioned. The document provides references for further reading on the topic.
The document provides information on non-steroidal anti-inflammatory drugs (NSAIDs) including their classification, mechanisms of action, and major effects. NSAIDs are chemically diverse drugs that reduce pain, fever, and inflammation by inhibiting cyclooxygenase (COX) enzymes and subsequent prostaglandin synthesis. They are classified based on their selectivity for COX-1 versus COX-2 isoenzymes. The major effects of inhibiting prostaglandin synthesis include analgesia, antipyresis, anti-inflammatory action, antiplatelet aggregation, and closure of the ductus arteriosus in newborns. NSAIDs produce gastric mucosal damage by inhibiting protective prostaglandins in
The document discusses inflammation and the mechanisms by which nonsteroidal anti-inflammatory drugs (NSAIDs) work to reduce inflammation. It describes how NSAIDs inhibit the cyclooxygenase (COX) enzymes that produce prostaglandins, leading to their analgesic, antipyretic, and anti-inflammatory effects. However, it also notes that NSAID inhibition of prostaglandin production can cause gastric mucosal damage and bleeding risks as side effects. The document provides details on the classification and mechanisms of different types of NSAIDs including selective and non-selective COX inhibitors.
This document provides biographical information about Rachmat Gunadi Wachjudi in Indonesian. It includes his date and place of birth, his educational background obtaining degrees in general medicine and internal medicine, and his work in rheumatology. It lists his current position at Dr. Hasan Sadikin Hospital and his involvement in several professional organizations related to medicine and rheumatology.
This document discusses nonsteroidal anti-inflammatory drugs (NSAIDs) in 3 paragraphs or less:
NSAIDs are a chemically diverse group of drugs that are grouped together because they have common analgesic and antipyretic effects and anti-inflammatory effects at higher doses. They act primarily on peripheral pain mechanisms and in the central nervous system. All NSAIDs inhibit prostaglandin synthesis by blocking the cyclooxygenase enzymes.
NSAIDs were developed from white willow bark and include aspirin, ibuprofen, naproxen, and others. They are classified based on their chemical structure and selectivity for the COX-1 and COX-2 enzymes. Traditional NSAIDs
This document provides an overview of analgesics, with a focus on non-steroidal anti-inflammatory drugs (NSAIDs). It defines pain and discusses the classification, mechanism of action, and history of analgesics. NSAIDs are introduced as a class of drugs that relieve pain and inflammation by inhibiting cyclooxygenase (COX) enzymes and subsequent prostaglandin synthesis. The document outlines the role of prostaglandins in inflammation and bone resorption, as well as the beneficial and harmful actions of NSAIDs through COX inhibition. Host modulation is discussed as a treatment concept in periodontics where NSAIDs may reduce tissue destruction by modulating the host inflammatory response.
COX inhibitors like NSAIDs work as nonopioid analgesics and anti-inflammatory drugs. They function by inhibiting the COX enzymes and thereby decreasing the production of prostaglandins and other inflammatory mediators derived from arachidonic acid. This leads to their analgesic, antipyretic, and anti-inflammatory effects but also side effects involving the gastrointestinal tract and kidney function. Aspirin is a prototypical NSAID that was first isolated from willow bark and introduced in 1899, demonstrating the clinical usefulness of this class of drugs.
This document summarizes information about pain, inflammation, and fever. It defines pain and classifies pain based on duration, location, intensity, and etiology. It also discusses the management of pain through pharmacological and non-pharmacological interventions. Inflammation is described as the body's response to harmful stimuli and signs of inflammation include heat, redness, swelling, pain, and loss of function. Both acute and chronic inflammation are summarized. Common inflammatory mediators are also listed. Fever is defined as an elevated body temperature regulated by the hypothalamus in response to infection or other stimuli. Management of fever includes conservative measures as well as medications like NSAIDs.
A PowerPoint presentation on "NSAIDS" suitable for reading by UG and PG Medical/Paramedical students of Pharmacology and Pharmacy sciences. This Ppt. is prepared for academic purpose only and already presented to my students in one of the theory classes of mine.
Rheumatoid arthritis is a chronic inflammatory disease that affects the joints, characterized by progressive destruction of symmetric joints. It is caused by a combination of genetic and environmental factors that lead to an immune system attack on the joints. The disease causes pain, swelling, stiffness, and loss of function in the affected joints. Treatment involves medications to reduce inflammation and prevent further joint damage, including NSAIDs, steroids, DMARDs, and biologic DMARDs. Lifestyle changes and surgery may also be used to treat rheumatoid arthritis and improve quality of life.
This document discusses pain pathways and pharmacotherapy for pain management. It describes how pain is transmitted through three pathways - neospinothalamic, paleospinothalamic, and archispinothalamic tracts. It also outlines different types of pain including nociceptive, neuropathic, inflammatory, acute, chronic, and referred pain. The document further discusses inflammatory processes and mediators involved in pain signaling like eicosanoids, cytokines, and biological oxidants. It concludes by covering recommendations for pharmacotherapy of acute and chronic pain.
for education purpose of MBBS, BHMS and BAMS students.
Rheumatoid Arthritis is a quite common and troublesome disease in the society. Plenty of patients present with RA in our clinics as well as family.
This brief presentation tends to cover the basic pathology behind RA, easy to identify signs and symptoms and prompt management of the disease before the deformities set in.
In case of doubts or feedbacks, feel free to contact me on WhatsApp 9409012212 or Email- dr.aakashnandu@gmail.com
Complex regional pain syndrome (CRPS) is an abnormal response to injury characterized by prolonged pain, vasomotor disturbances, delayed recovery, and trophic changes. It has two types: type 1 has no identifiable nerve injury while type 2 follows a nerve injury. It progresses through three stages - acute, dystrophic, and atrophic. Treatment involves sympathetic blocks, drugs like antidepressants and anticonvulsants, physiotherapy, and electroacupuncture which may help reduce sympathetic drive, inflammation, and pain.
Osteoarthritis is a common joint disease involving the breakdown of cartilage. It often affects weight-bearing joints like the knees and hips and risk factors include age, obesity, and joint injuries. Symptoms include pain, stiffness, and limited movement in the joints. Treatment focuses on pain management through medications, physical therapy, weight loss, and sometimes surgery like joint replacement for severe cases.
Rheumatology deals with diseases of the joints, muscles, bones and tendons. The document discusses various types of arthritis including osteoarthritis, rheumatoid arthritis, pseudogout, gout and spondyloarthropathies. It covers the causes, risk factors, symptoms, investigations and treatment options for these conditions. Connective tissue diseases are also described which affect tissues between structures of the body. Management of arthritis in the elderly focuses on exercise, medications, assistive devices and lifestyle modifications.
10 year old child presented with body weakness,dysphagia newZahid Jamil
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The document describes a case of a 10-year old boy presenting with muscle weakness, difficulty swallowing, and toe walking. After examination and testing, he was diagnosed with polymyositis based on proximal muscle weakness without skin lesions. Polymyositis is a rare inflammatory muscle disease in children characterized by muscle inflammation and weakness. Treatment involves high-dose steroids initially along with immunosuppressants if needed to control symptoms and improve muscle strength.
The eicosanoids are oxygenation products of polyunsaturated
long-chain fatty acids. They are ubiquitous in the animal kingdom
and are also foundâtogether with their precursorsâin a variety
of plants. They constitute a very large family of compounds that
are highly potent and display an extraordinarily wide spectrum of
biologic activity. Because of their biologic activity, the eicosanoids,
their specific receptor antagonists and enzyme inhibitors, and
their plant and fish oil precursors have great therapeutic potential.
This document discusses emerging pharmacological and non-pharmacological aspects in pain management. It notes that multimodal analgesia using combinations of drugs targeting different pain pathways can provide improved pain relief with reduced side effects compared to single drugs. Newer drugs targeting specific receptor subtypes are emerging. Non-invasive options such as topical agents, exercise, and interventional techniques are increasingly utilized before more invasive options. Interventional pain management techniques discussed include injections, neurolysis, and spinal cord stimulation.
The document provides information on non-steroidal anti-inflammatory drugs (NSAIDs) including their classification, mechanisms of action, and major effects. NSAIDs are chemically diverse drugs that reduce pain, fever, and inflammation by inhibiting cyclooxygenase (COX) enzymes and subsequent prostaglandin synthesis. They are classified based on their selectivity for COX-1 versus COX-2 isoenzymes. The major effects of inhibiting prostaglandin synthesis include analgesia, antipyresis, anti-inflammatory action, antiplatelet aggregation, and closure of the ductus arteriosus in newborns. NSAIDs produce gastric mucosal damage by inhibiting protective prostaglandins in
The document discusses inflammation and the mechanisms by which nonsteroidal anti-inflammatory drugs (NSAIDs) work to reduce inflammation. It describes how NSAIDs inhibit the cyclooxygenase (COX) enzymes that produce prostaglandins, leading to their analgesic, antipyretic, and anti-inflammatory effects. However, it also notes that NSAID inhibition of prostaglandin production can cause gastric mucosal damage and bleeding risks as side effects. The document provides details on the classification and mechanisms of different types of NSAIDs including selective and non-selective COX inhibitors.
This document provides biographical information about Rachmat Gunadi Wachjudi in Indonesian. It includes his date and place of birth, his educational background obtaining degrees in general medicine and internal medicine, and his work in rheumatology. It lists his current position at Dr. Hasan Sadikin Hospital and his involvement in several professional organizations related to medicine and rheumatology.
This document discusses nonsteroidal anti-inflammatory drugs (NSAIDs) in 3 paragraphs or less:
NSAIDs are a chemically diverse group of drugs that are grouped together because they have common analgesic and antipyretic effects and anti-inflammatory effects at higher doses. They act primarily on peripheral pain mechanisms and in the central nervous system. All NSAIDs inhibit prostaglandin synthesis by blocking the cyclooxygenase enzymes.
NSAIDs were developed from white willow bark and include aspirin, ibuprofen, naproxen, and others. They are classified based on their chemical structure and selectivity for the COX-1 and COX-2 enzymes. Traditional NSAIDs
This document provides an overview of analgesics, with a focus on non-steroidal anti-inflammatory drugs (NSAIDs). It defines pain and discusses the classification, mechanism of action, and history of analgesics. NSAIDs are introduced as a class of drugs that relieve pain and inflammation by inhibiting cyclooxygenase (COX) enzymes and subsequent prostaglandin synthesis. The document outlines the role of prostaglandins in inflammation and bone resorption, as well as the beneficial and harmful actions of NSAIDs through COX inhibition. Host modulation is discussed as a treatment concept in periodontics where NSAIDs may reduce tissue destruction by modulating the host inflammatory response.
COX inhibitors like NSAIDs work as nonopioid analgesics and anti-inflammatory drugs. They function by inhibiting the COX enzymes and thereby decreasing the production of prostaglandins and other inflammatory mediators derived from arachidonic acid. This leads to their analgesic, antipyretic, and anti-inflammatory effects but also side effects involving the gastrointestinal tract and kidney function. Aspirin is a prototypical NSAID that was first isolated from willow bark and introduced in 1899, demonstrating the clinical usefulness of this class of drugs.
This document summarizes information about pain, inflammation, and fever. It defines pain and classifies pain based on duration, location, intensity, and etiology. It also discusses the management of pain through pharmacological and non-pharmacological interventions. Inflammation is described as the body's response to harmful stimuli and signs of inflammation include heat, redness, swelling, pain, and loss of function. Both acute and chronic inflammation are summarized. Common inflammatory mediators are also listed. Fever is defined as an elevated body temperature regulated by the hypothalamus in response to infection or other stimuli. Management of fever includes conservative measures as well as medications like NSAIDs.
A PowerPoint presentation on "NSAIDS" suitable for reading by UG and PG Medical/Paramedical students of Pharmacology and Pharmacy sciences. This Ppt. is prepared for academic purpose only and already presented to my students in one of the theory classes of mine.
Rheumatoid arthritis is a chronic inflammatory disease that affects the joints, characterized by progressive destruction of symmetric joints. It is caused by a combination of genetic and environmental factors that lead to an immune system attack on the joints. The disease causes pain, swelling, stiffness, and loss of function in the affected joints. Treatment involves medications to reduce inflammation and prevent further joint damage, including NSAIDs, steroids, DMARDs, and biologic DMARDs. Lifestyle changes and surgery may also be used to treat rheumatoid arthritis and improve quality of life.
This document discusses pain pathways and pharmacotherapy for pain management. It describes how pain is transmitted through three pathways - neospinothalamic, paleospinothalamic, and archispinothalamic tracts. It also outlines different types of pain including nociceptive, neuropathic, inflammatory, acute, chronic, and referred pain. The document further discusses inflammatory processes and mediators involved in pain signaling like eicosanoids, cytokines, and biological oxidants. It concludes by covering recommendations for pharmacotherapy of acute and chronic pain.
for education purpose of MBBS, BHMS and BAMS students.
Rheumatoid Arthritis is a quite common and troublesome disease in the society. Plenty of patients present with RA in our clinics as well as family.
This brief presentation tends to cover the basic pathology behind RA, easy to identify signs and symptoms and prompt management of the disease before the deformities set in.
In case of doubts or feedbacks, feel free to contact me on WhatsApp 9409012212 or Email- dr.aakashnandu@gmail.com
Complex regional pain syndrome (CRPS) is an abnormal response to injury characterized by prolonged pain, vasomotor disturbances, delayed recovery, and trophic changes. It has two types: type 1 has no identifiable nerve injury while type 2 follows a nerve injury. It progresses through three stages - acute, dystrophic, and atrophic. Treatment involves sympathetic blocks, drugs like antidepressants and anticonvulsants, physiotherapy, and electroacupuncture which may help reduce sympathetic drive, inflammation, and pain.
Osteoarthritis is a common joint disease involving the breakdown of cartilage. It often affects weight-bearing joints like the knees and hips and risk factors include age, obesity, and joint injuries. Symptoms include pain, stiffness, and limited movement in the joints. Treatment focuses on pain management through medications, physical therapy, weight loss, and sometimes surgery like joint replacement for severe cases.
Rheumatology deals with diseases of the joints, muscles, bones and tendons. The document discusses various types of arthritis including osteoarthritis, rheumatoid arthritis, pseudogout, gout and spondyloarthropathies. It covers the causes, risk factors, symptoms, investigations and treatment options for these conditions. Connective tissue diseases are also described which affect tissues between structures of the body. Management of arthritis in the elderly focuses on exercise, medications, assistive devices and lifestyle modifications.
10 year old child presented with body weakness,dysphagia newZahid Jamil
Â
The document describes a case of a 10-year old boy presenting with muscle weakness, difficulty swallowing, and toe walking. After examination and testing, he was diagnosed with polymyositis based on proximal muscle weakness without skin lesions. Polymyositis is a rare inflammatory muscle disease in children characterized by muscle inflammation and weakness. Treatment involves high-dose steroids initially along with immunosuppressants if needed to control symptoms and improve muscle strength.
The eicosanoids are oxygenation products of polyunsaturated
long-chain fatty acids. They are ubiquitous in the animal kingdom
and are also foundâtogether with their precursorsâin a variety
of plants. They constitute a very large family of compounds that
are highly potent and display an extraordinarily wide spectrum of
biologic activity. Because of their biologic activity, the eicosanoids,
their specific receptor antagonists and enzyme inhibitors, and
their plant and fish oil precursors have great therapeutic potential.
This document discusses emerging pharmacological and non-pharmacological aspects in pain management. It notes that multimodal analgesia using combinations of drugs targeting different pain pathways can provide improved pain relief with reduced side effects compared to single drugs. Newer drugs targeting specific receptor subtypes are emerging. Non-invasive options such as topical agents, exercise, and interventional techniques are increasingly utilized before more invasive options. Interventional pain management techniques discussed include injections, neurolysis, and spinal cord stimulation.
Similar to Pain and inflammation + drugs use for pain and inflammation (20)
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
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There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganongâs Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
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In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
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Weâre talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Recomendaçþes da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS â Objetivos do Desenvolvimento SustentĂĄvel e a EstratĂŠgia Global para a SaĂşde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pĂłs-natais devem expandir-se para alĂŠm da cobertura e da simples sobrevivĂŞncia, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pĂłs-natais essenciais e de rotina prestados Ă s mulheres e aos recĂŠm-nascidos, com o objetivo final de melhorar a saĂşde e o bem-estar materno e neonatal.
Uma âexperiĂŞncia pĂłs-natal positivaâ ĂŠ um resultado importante para todas as mulheres que dĂŁo Ă luz e para os seus recĂŠm-nascidos, estabelecendo as bases para a melhoria da saĂşde e do bem-estar a curto e longo prazo. Uma experiĂŞncia pĂłs-natal positiva ĂŠ definida como aquela em que as mulheres, pessoas que gestam, os recĂŠm-nascidos, os casais, os pais, os cuidadores e as famĂlias recebem informação consistente, garantia e apoio de profissionais de saĂşde motivados; e onde um sistema de saĂşde flexĂvel e com recursos reconheça as necessidades das mulheres e dos bebĂŞs e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendaçþes novas e jĂĄ bem fundamentadas sobre cuidados pĂłs-natais de rotina para mulheres e neonatos que recebem cuidados no pĂłs-parto em unidades de saĂşde ou na comunidade, independentemente dos recursos disponĂveis.
Ă fornecido um conjunto abrangente de recomendaçþes para cuidados durante o perĂodo puerperal, com ĂŞnfase nos cuidados essenciais que todas as mulheres e recĂŠm-nascidos devem receber, e com a devida atenção Ă qualidade dos cuidados; isto ĂŠ, a entrega e a experiĂŞncia do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendaçþes da OMS de 2014 sobre cuidados pĂłs-natais da mĂŁe e do recĂŠm-nascido e complementam as atuais diretrizes da OMS sobre a gestĂŁo de complicaçþes pĂłs-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências Ê contemplada.
Recomendamos muito.
Vamos discutir essas recomendaçþes no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação sĂł estĂĄ disponĂvel em inglĂŞs atĂŠ o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
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Overall life span (LS) was 1671.7Âą1721.6 days and cumulative 5YS reached 62.4%, 10 years â 50.4%, 20 years â 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6Âą1723.6 days), 22 â more than 10 years (LS=5571Âą1841.8 days). 67 LCP died because of LC (LS=471.9Âą344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
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The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 â 3649 E-mail : sales@trinexpharmacy.com
5. ď An unpleasant sensation occurring in varying
degrees of severity as a consequences of injury,
disease, or emotional disorder.
ď Suffering or distress.
ď Pain is a feeling or a perception it varies from
person to person and its intensity depends upon
individual response to stimuli.
ď Informal a source of annoyance; A nuisance.
7. ďHaving a rapid onset and following a short
but severe course.
ďAfflicted by a disease exhibiting a rapid
onset followed by short, severe course.
8. ď Lasting for a long period of time or marked
by frequent recurrence, as certain disease.
11. PROSTGLANDINS Basic Facts
ď Prostaglandins are unsaturated fatty acids.
ď PG are of nine types, A,B,C,D,E,F,G,H and I.
ď PG are formed on demand.
12.
13. ďReaction of living tissue to all forms of
injury.
ďThe bodyâs major defenses against injury
and infection in an attempt to localize and
heal it.
ďIt may vary in timing and intensity ,
depending on its cause & the type of tissue.
14. Agents Causing
Can broadly classify into four major types:
1) Biological
2) Chemical
3) Physical
4) Immunological
15. Types Of
ďAn inflammation that lasts for a few
minutes, several hours or one to two days.
ďAn inflammation that persists for months or
years.
17. TISSUE INJURY
MAST CELL RELEASE HISTAMINE,KININS,SEROTININ & PROSTAGLANDINS
INCREASED PERMEABILITY
EXDUATE PASSES THROUGH
CAPILLART WALL TO INJURED AREA
MIGRATION OF LEUKOCYTES
INCREASED BLOOD FLOW
SWELLINGHEAT AND REDNESS
18. ⢠Enzyme that catalyze the synthesis of PGs
⢠Purified in 1976 and cloned in 1988.
⢠A second COX-2 was discovered in 1991.
⢠The two known COX forms are similar in
size and kinetics but vary in their
a) Expression
b) Distribution
COX ( Cycloxygenase )
19. COX-1 ( The Good COX )
⢠Cox-1 is present in most cells throughout
the body and produce PGs which involved
in the physiological processes known as
âhousekeeping functionâ also called Good
COX.
20. COX-2 âThe Bad COXâ
⢠Inducible form, found in inflammatory and
immune cells.
⢠At the sight of inflammation, COX-2 is
responsible for the generation of the
hyperalgesic (pain causing) and pro-
inflammatory PGs.
⢠COX-2 is also present in the CNS, where it
involved in fever and Neuro-transmission of
pain.
21. ⢠The drug concentration that inhibits the
activity of the enzyme by 50%.
⢠The lower the IC-50 the stronger is the
drug.
⢠Cox-1/Cox-2 are determined in ratio.
⢠Ratio more than 1 = Cox1 selective
⢠Ratio less than 1 = Cox2 selective
Concept Of IC-50
23. Arthritis
⢠Any type of joint pain or inflammation is
called arthritis.
⢠Multiple Etiology.
⢠Treatment options includes NSAID and
selective And specific COX inhibitors.
⢠If untreated will lead to complications.
24. Rheumatoid Arthritis
⢠A systemic connective tissue disorder.
⢠Involving multiple joints.
⢠Usually Small joints.
⢠Symmetrical joints.
⢠Morning stiffness.
⢠Positive RA factor.
25. Osteoarthritis is a disease of joint
characterized by cartilage loss with
an accompanying periarticular
bone response.
29. ⢠Inflammatory disease of back especially
effecting young.
⢠There is white cells infiltration.
⢠Erosion of bone at the place of ligament
attachment.
30. Symptoms of
⢠Episodic sacroiliac pain.
⢠Buttock Pain.
⢠Stiffness in morning.
⢠Low stiffness after exercise.
⢠Para spinal muscle wasting.
34. This is a group of medicine which are used
for the treatment of pain and inflamation.
These medicines are also used in
osteoarthritis, rheumatoid arthritis and other
conditions associated with pain.