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Adam Samosh
   PGY-2 Family Medicine
 Schulich School of Medicine
University of Western Ontario



                                1
A learning resource for Residents in Family Medicine
Residency Programs

Online Learning Module




                                                       2
๏‚— Definitions
๏‚— Family Medicine
๏‚— Assessment
๏‚— Investigations
๏‚— Screening
๏‚— Risk Assessment
๏‚— Treatment
๏‚— Summary
๏‚— References

                    3
๏‚— Review the basics of what osteoporosis is
๏‚— Review key aspects of history taking and physical exam
  related to osteoporosis
๏‚— Be able to determine appropriate screening and
  fracture risk stratification for different patient
  demographics
๏‚— Become familiar with basic management options for
  osteoporosis (note: thorough discussion of
  pharmacological management of osteoporosis is
  beyond the scope of this learning module)

                                                           4
Skeletal disorder characterized by compromised bone
       strength predisposing to an increased risk of fractures
       (1)

       WHO Definition:
       BMD value at the spine, hip, or forearm of 2.5 or more
       standard deviations below the young adult mean (i.e.
       t-score โ‰ค-2.5), with or without the presence of a
       fragility fracture (2)

       Fragility Fracture: no, or low trauma fracture (3)
1. Kanis JA, Melton LJ, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. Journal of Bone and Mineral
   Research. 1994, 9:1137.
2. Kanis JA. Osteoporosis and osteopenia. J Bone Miner Res. 1990, 5:209-11.
                                                                                                                              5
3. Kanis JA, Oden A, Johnell O, Jonsson B, de Laet C, Dawson A. The burden of osteoporotic fractures: a method for setting
   intervention thresholds. Osteoporosis International. 2002, 12:417โ€“24.
Normal: t-score โ‰ฅ -1

        Osteopenia: -1 > t-score > -2.5

        Osteoporosis: t-score < -2.5




3. Kanis JA, Oden A, Johnell O, Jonsson B, de Laet C, Dawson A. The burden of osteoporotic fractures: a method for setting
intervention thresholds. Osteoporosis International. 2002, 12:417โ€“24.                                                        6
๏‚— Primary care physicians are often responsible for screening
       and initiating management in patients with osteoporosis
   ๏‚—   Canada: 1 in 3 women and 1 in 5 men will experience a
       fracture from osteoporosis
   ๏‚—   Approximately 80% of fractures in Canadians over 50 years
       old are due to osteoporosis
   ๏‚—   The annual cost to the health care system from
       Osteoporosis is estimated at $2.3 billion each year
   ๏‚—   Guidelines for management have changed several times
       over the last few decades - most notably in 2002, 2004,
       2010, 2011 and 2012(4)
4. Osteoporosis Canada. Osteoporosis Facts & Statistics [Internet]. Toronto, Ontario. Osteoporosis Canada. 2012 March.
Available from: http://www.osteoporosis.ca/osteoporosis-and-you/osteoporosis-facts-and-statistics/.                      7
๏‚— Osteoporosis Guidelines can be found from several
 different sources:
  ๏‚— Canadian Task Force on LTC
  ๏‚— SOGC/JOGC
  ๏‚— CMA
  ๏‚— Osteoporosis Canada


๏‚— One of the main purposes of this online learning
 module is to combine these guidelines into one
 resource for use in Family Medicine practice

                                                      8
๏‚— Fall Risk Assessment โ€“ Topics to ask patients about(5):
       ๏‚— Previous history of falls
       ๏‚— Alcohol intake (โ‰ฅ 3 drinks per day)
       ๏‚— Poor strength
       ๏‚— Balance or gait issues
       ๏‚— Dizziness
       ๏‚— Poor vision




5.Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and
Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct   9
1];[about 2 screens].
๏‚— Main Risks for Developing Osteoporosis (5):
       ๏‚—   History of fragility fracture
       ๏‚—   Parent with a hip fracture
       ๏‚—   Rheumatoid Arthritis
       ๏‚—   Chronic (โ‰ฅ3 months) glucocorticoid use
       ๏‚—   Smoking (any amount has the potential to be
           detrimental to bone health)
       ๏‚—   Chronic Liver/Kidney disease
       ๏‚—   Early Menopause (before age 45 years old โ€“ including
           surgically induced menopause)
       ๏‚—   Caffeine intake (โ‰ฅ4 cups/day)
       ๏‚—   Androgen Deficiency (in men)
5.Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and
Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct   10
1];[about 2 screens].
๏‚— Physical Exam:
         ๏‚— Check occiput-to-wall distance (look for >5cm)


         ๏‚— Serial heights of patient โ€“ looking for >2cm loss of
             height, or >6cm loss of height based on patient history
             (6)




6. Brown JP, Josse RG. 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada.
CMAJ 2002; 167(10 Suppl):S1-34.                                                                                        11
Confirm Diagnosis with Dual-energy X-ray Absorptiometry
          (DXA or DEXA) scan to determine BMD of the patient

          In Ontario, OHIP (Ontario Health Insurance) will cover DEXA
          scans:

          -For patients at high risk for osteoporosis and future fractures,
          annual scans are covered

          -For patients at low/intermediate risk for osteoporosis and future
          fractures, initial BMD testing is covered. A second test can be
          ordered 3 years after the baseline (i.e. first) test. After those two
          tests, OHIP will cover any further BMD testing up to every 5
          years
7. Ontario Ministry of Health and Long-Term Care. BMD Testing [Internet]. Toronto, Ontario. Queenโ€™s Printer for Ontario. July
2010 [updated June 28, 2012; cited 2013 March 2]. Available from:
http://www.health.gov.on.ca/en/public/publications/ohip/bone.aspx                                                               12
๏‚— Bloodwork is indicated to rule out secondary causes of
       osteoporosis (8)
        ๏‚— CBC โ€“ malabsorption or bone marrow malignancy
        ๏‚— Creatinine โ€“ chronic renal disease
        ๏‚— Calcium (+ Albumin) โ€“ hyperparathyroidism
        ๏‚— TSH - hyperthyroidism
        ๏‚— Alkaline Phosphatase โ€“ chronic liver disease
        ๏‚— Vitamin D โ€“ malabsorption
        ๏‚— Serum protein electrophoresis โ€“ multiple myeloma



8.Papaioannou A. Quick Reference Guide: 2010 Clinical Practice Guidelines for the Diagnosis and Management of
Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Sept]. Available from:   13
http://www.osteoporosis.ca
๏‚— The Canadian Task Force on Preventative Health Care
        made several screening recommendations in 2004(9):
         ๏‚— There is fair evidence to recommend screening
           postmenopausal women to prevent fragility fractures
           (grade B)
         ๏‚— There is no direct evidence that screening reduces fractures,
           however, there is good evidence that screening is effective in
           identifying postmenopausal women with low bone mineral
           density and that treating osteoporosis can reduce the risk of
           fractures in this population (grade A)
    ๏‚— Screening is determined based on age and presence of
      medical comorbidities
    ๏‚— The most current osteoporosis screening guidelines used in
      Ontario are from 2010 and are outlined in the following
      slides
9. Wathen CN, Feig DS, Feightner JW, Abramson BL, Cheung AM. Hormone replacement therapy for the primary prevention
of chronic diseases: recommendation statement from the Canadian Task Force on Preventive Health Care. CMAJ 2004 May,   14
170(10):1535-7.
๏‚— DXA scans (to determine BMD and fracture risk) are
       indicated for screening in all men and women over the
       age of 65 years old (8)




8.Papaioannou A. Quick Reference Guide: 2010 Clinical Practice Guidelines for the Diagnosis and Management of
Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Sept]. Available from:   15
http://www.osteoporosis.ca
๏‚— Screening is indicated in a patient between the age of
       50-64 years old if they have a risk factor for developing
       osteoporosis (discussed on slide #10)

   ๏‚— In addition to the risk factors already mentioned,
       consider screening in patients with:
        ๏‚— primary hyperparathyroidism, type 1 diabetes,
             osteogenesis imperfecta, hyperthyroidism,
             hypogonadism, Cushingโ€™s disease, malabsorption
             syndrome, IBD, COPD (8)

8.Papaioannou A. Quick Reference Guide: 2010 Clinical Practice Guidelines for the Diagnosis and Management of
Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Sept]. Available from:   16
http://www.osteoporosis.ca
๏‚— Screening is only indicated if patient has one of the
       following risk factors (8):
        ๏‚— history of fragility fracture
        ๏‚— prolonged use of glucocorticoids (>3 months)
        ๏‚— hypogonadism
        ๏‚— premature menopause (<45 years old)
        ๏‚— malabsorption syndrome
        ๏‚— primary hyperparathyroidism




8.Papaioannou A. Quick Reference Guide: 2010 Clinical Practice Guidelines for the Diagnosis and Management of
Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Sept]. Available from:   17
http://www.osteoporosis.ca
๏‚— Assess 10-year fracture risk using BMD and one of two risk
           assessment tools (available online)

            ๏‚— FRAX score (10) (developed by the WHO โ€“ has settings that
                can be set for the Canadian population specifically)
                http://www.shef.ac.uk/FRAX/tool.aspx?country=19

            ๏‚— CAROC (11) (Canadian Association of Radiologists and
                Osteoporosis Canada Risk Assessment tool)
                http://www.osteoporosis.ca/multimedia/pdf/CAROC.pdf

      ๏‚— These tools enable risk stratification
10. World Health Organization Collaborating Centre for Metabolic Bone Diseases. FRAX [Internet]. Sheffield, UK: University of
        Sheffield; 2013. Available from: http://www.shef.ac.uk/FRAX/tool.aspx?country=19.
11. Osteoporosis Canada. Assessment of 10-year Fracture Risk โ€“ Women and Men [Internet]. Canada. Canadian Association of
        Radiologists and Osteoporosis Canada (CAROC); 2013. Available from:                                                     18
        http://www.osteoporosis.ca/multimedia/pdf/CAROC.pdf.
Note โ€“ Entire Table can be found at: 12. The Foundation for Medical Practice Education. Osteoporosis: Applying the paradigm
shift from new guidelines. Practice Based Learning Program Educational Module. 2012 May;20(5)1-20.                            19
๏‚— The current 2010 guidelines recommend using the
     CAROC tool (rather than FRAX) for assessing fracture
     risk in patients in Canada
   ๏‚— The same guidelines recommend using only the BMD
     t-score for the femoral neck when calculating fracture
     risk (with CAROC being the preferred tool)




13 Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM,
Kvern B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in
Canada: summary. CMAJ. 2010 Nov 23;182(17):1-10.                                                                         20
๏‚— In previous years, guidelines focussed on treating a
     patientโ€™s BMD t-score
   ๏‚— Currently the focus has shifted to managing a patientโ€™s
     fracture risk level (rather than the t-score)
   ๏‚— The main key point of the 2010 clinical practice
     guidelines for osteoporosis in Canada states:
        ๏‚— The management of osteoporosis should be guided by
            an assessment of the patientโ€™s absolute RISK OF
            OSTEOPOROSIS RELATED FRACTURES (13)


13 Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM,
Kvern B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in
Canada: summary. CMAJ. 2010 Nov 23;182(17):1-10.                                                                         21
๏‚— Risk Categories based on 10-year fracture risk (14):
        ๏‚— Low (< 10%)
        ๏‚— Moderate (10 - 20%)
        ๏‚— High (> 20%)


   ๏‚— Risk categorization helps determine the most
       appropriate (evidence based) treatment for each
       patient



14. Lentle B, Cheung AM, Hanley DA, Leslie WD, Lyons D, Papaioannou A, Atkinson S, Brown JP, Feldman S, Hodsman AB,
Jamal AS, Josse RG, Kaiser SM, Kvern B, Morin S, Siminoski K. Osteoporosis Canada 2010 Guidelines for the Assessment of
Fracture Risk. Can Assoc Radiol J. 2011 Nov;62(4):243-50                                                                  22
๏‚— Thorough discussion of treatment options for
 osteoporosis is beyond the scope of this learning
 module but will briefly be discussed on the following
 slides to introduce the learner to commonly used
 medications for fracture reduction management




                                                         23
๏‚— No evidence for benefit (i.e. prevention of future
      fractures) from pharmacotherapy

  ๏‚— May benefit from vitamin D and calcium
      supplementation as well as conservative treatments
      (see slide #25 and 26)

  ๏‚— BMD should be repeated in 5 years to reassess risk
      levels (5)

5.Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and
Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct   24
1];[about 2 screens].
๏‚— Recommend (13):
           ๏‚— Weight bearing exercise such as walking or weights (grade B)
           ๏‚— Balance training (such as Tai Chi ) (grade A evidence for those at
               risk of falls)
           ๏‚—   Home safety assessments (PT/OT) (grade B)
           ๏‚—   Treating poor vision (i.e. glasses, cataract removal) (grade B)
           ๏‚—   Hip-protectors (for patients in long-term care facilities) (grade B)
           ๏‚—   Smoking cessation
           ๏‚—   Limiting alcohol intake (<2 drinks/day)
     ๏‚— Consider Referral (if appropriate) to (5):
           ๏‚—   Geriatric medicine
           ๏‚—   Falls prevention program
           ๏‚—   Homecare
           ๏‚—   Occupational therapy or Physical therapy
13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern B,
Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary.
CMAJ. 2010
5.Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and Protocols   25
Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct 1];[about 2
screens].
๏‚— Daily Calcium Intake (from all sources):
           ๏‚— 1200mg (grade B) (discussed further on next slide)


      ๏‚— Daily Vitamin D Intake:
           ๏‚— <50 years old 400-1000IU (grade D)
           ๏‚— >50 years old 800-2000IU (grade C)
           ๏‚— Recheck Vitamin D levels 3 months after initiating
             supplementation (OHIP will only cover Vitamin D
             Testing for patients with Osteoporosis/Osteopenia)
           ๏‚— Daily doses up to 2000 IU is safe and does not require
             serial monitoring (grade C) (13)
13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern
B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada:   26
summary. CMAJ 2010 Nov 23;182(17):1-10.
๏‚— Recent article (June 2012) in the journal Heart suggests there
        may be increase cardiovascular risk with taking calcium
        supplements
      ๏‚— Conclusion:
            ๏‚— โ€œthis study suggests that increasing calcium intake from diet might
                not confer significant cardiovascular benefits, while calcium
                supplements, which might raise MI risk, should be taken with
                cautionโ€ (15)

      ๏‚— There has been no official change to guidelines in Canada for
        calcium supplementation since this article was published
      ๏‚— Anecdotally, many family doctors are avoiding use of calcium
        supplements (and encouraging adequate calcium intake from
        diet instead) until formal guidelines are released
15. Kuanrong Li, Rudolf Kaaks, Jakob Linseisen. Associations of dietary calcium intake and overall calcium supplementation with
myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective
Investigation into Cancer and Nutrition study (EPIC-Heidelberg). Heart 2012 98: 920-5.                                            27
๏‚— May benefit from conservative management and
     adequate supplementation of Calcium and Vitamin D
     (see slide #27 for concerns around calcium
     supplementation)
   ๏‚— Use clinical judgement in considering that individuals
     at increase risk for falls or fracture in particular may
     benefit from treatment (5)




5. Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and
Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct
1];[about 2 screens]. Available from: http://www.bcguidelines.ca/guideline_osteoporosis.html                             28
๏‚— Evidence for benefit from pharmacotherapy (5)


   ๏‚— The following pharmacologic treatment options are
       briefly discussed on the following slides:
        ๏‚— Bisphosphonates
        ๏‚— Selective Estrogen Receptor Modulators (SERMs)
        ๏‚— Hormone Replacement Therapy (HRT)
        ๏‚— Calcitonin
        ๏‚— Miscellaneous


5. Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and
Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct
1];[about 2 screens]. Available from: http://www.bcguidelines.ca/guideline_osteoporosis.html                             29
๏‚— Generally a bisphosphonate is used as first line treatments
          for prevention of fracture for both men and women (Grade
          A for women, Grade D for men) (13)




      ๏‚— However, there are other first line options (with evidence in
          post-menopausal women) for fracture prevention

13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern
B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada:   30
summary. CMAJ 2010 Nov 23;182(17):1-10.
๏‚— Raloxifene can be used as a first line therapy for
          prevention of vertebral fractures in menopausal
          women with osteoporosis (grade A) (13)

        Raloxifene (Evistaยฎ)                        60 mg daily




13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern
B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada:   31
summary. CMAJ 2010 Nov 23;182(17):1-10.
๏‚— Monoclonal Antibody

       Denosumab (Proliaยฎ)                          60 mg subcutaneous injection every six months


      ๏‚— Parathyroid Hormone (PTH) Analog

       Teriparatide (Forteoยฎ)                       20 ฮผg subcutaneously daily



      ๏‚— In menopausal women with vasomotor symptoms and
        osteoporosis, Hormone Replacement Therapy (HRT) can be
        used to treat both
      ๏‚— HRT is available as oral medication, patches applied to skin or as
        a topical cream (13)
16. Papaioannou A. 2010 Clinical Practice Guidelines for the Diagnosis and Management of Osteoporosis in Canada [Internet].
Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Oct]. Available from: http://www.osteoporosis.ca/health-care-
professionals/clinical-tools-and-resources/2010-clinical-guidelines-slideset/. Select Slide Deck 05 (Strategies for Fracture
Prevention).
13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern       32
B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada:
summary. CMAJ 2010 Nov 23;182(17):1-10.
๏‚— Second line therapies include calcitonin, and etidronate
        (Grade B)
      ๏‚— Calcitonin

        Calcitonin (Miacalcinยฎ)                     200 IU intranasally daily


      ๏‚— Etidronate
                                                    Cyclical therapy of daily 200 mg for 14 days
        Etidronate (Didrocalยฎ)                      followed by calcium supplements for 10
                                                    weeks

      ๏‚— Testosterone is not recommended as a treatment in men
          (Grade B)
13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern
B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada:   33
summary. CMAJ 2010 Nov 23;182(17):1-10.
๏‚— Consider referral to a specialist in patients who meet
          one of the following criteria:
           ๏‚— decrease in bone density while on therapy
           ๏‚— new fracture while on therapy
           ๏‚— poor drug tolerance to several first line agents
           ๏‚— rare drug therapy complications such as osteonecrosis of
               the jaw or atypical femoral fractures (13)




13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern
B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada:   34
summary. CMAJ 2010 Nov 23;182(17):1-10.
๏‚— Osteoporosis corresponds to a BMD t-score < -2.5
๏‚— Review falls risks and risk of developing osteoporosis when
    concerned about a patientโ€™s future risk of fracture
๏‚—   Screening for osteoporosis is appropriate in individuals over the
    age of 65 years old, or younger patients at risk of developing
    osteoporosis
๏‚—   Screening generally involves using a DEXA scan to determine
    BMD, which is then used by a risk-assessment tool (CAROC is
    preferred) to determine a patientโ€™s fracture risk
๏‚—   Fracture risk level (low, intermediate or high) will determine
    what type of management is appropriate to prevent future
    fractures
๏‚—   Ultimately, the goal of osteoporosis management is fracture
    risk reduction


                                                                        35
1.   Kanis JA, Melton LJ, Christiansen C, Johnston CC, Khaltaev N. The
     diagnosis of osteoporosis. Journal of Bone and Mineral Research.
     1994, 9:1137.
2.   Kanis JA. Osteoporosis and osteopenia. J Bone Miner Res. 1990, 5:209-11.
3.   Kanis JA, Oden A, Johnell O, Jonsson B, de Laet C, Dawson A. The
     burden of osteoporotic fractures: a method for setting intervention
     thresholds. Osteoporosis International. 2002, 12:417โ€“24.
4.   Osteoporosis Canada. Osteoporosis Facts & Statistics [Internet].
     Toronto, Ontario. Osteoporosis Canada. 2012 March. Available from:
     http://www.osteoporosis.ca/osteoporosis-and-you/osteoporosis-
     facts-and-statistics/.
5.   Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British
     Columbia Medical Association. Guidelines and Protocols Advisory
     Committee. Osteoporosis: Diagnosis, Treatment and Fracture
     Prevention. 2011 May 1 [updated 2012 Oct 1];[about 2 screens].
     Available from:
     http://www.bcguidelines.ca/guideline_osteoporosis.html

                                                                                36
6.    Brown JP, Josse RG. 2002 clinical practice guidelines for the diagnosis and
      management of osteoporosis in Canada. CMAJ 2002; 167(10 Suppl):S1-34.
7.    Ontario Ministry of Health and Long-Term Care. BMD Testing [Internet]. Toronto,
      Ontario. Queenโ€™s Printer for Ontario. July 2010 [updated June 28, 2012; cited 2013
      March 2]. Available from:
      http://www.health.gov.on.ca/en/public/publications/ohip/bone.aspx
8.    Papaioannou A. Quick Reference Guide: 2010 Clinical Practice Guidelines for the Diagnosis
      and Management of Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis
      Canada. 2010 Oct [updated 2011 Sept]. Available from:
      http://www.osteoporosis.ca/multimedia/pdf/Quick_Reference_Guide_October_2010.pdf.
9.    Wathen CN, Feig DS, Feightner JW, Abramson BL, Cheung AM. Hormone replacement
      therapy for the primary prevention of chronic diseases: recommendation statement from
      the Canadian Task Force on Preventive Health Care. CMAJ 2004 May, 170(10):1535-7.
10.   World Health Organization Collaborating Centre for Metabolic Bone Diseases. FRAX
      [Internet]. Sheffield, UK: University of Sheffield; 2013. Available from:
      http://www.shef.ac.uk/FRAX/tool.aspx?country=19.



                                                                                                  37
11.   Osteoporosis Canada. Assessment of 10-year Fracture Risk โ€“ Women and Men [Internet]. Canada.
      Canadian Association of Radiologists and Osteoporosis Canada (CAROC); 2013. Available from:
      http://www.osteoporosis.ca/multimedia/pdf/CAROC.pdf.
12.   The Foundation for Medical Practice Education. Osteoporosis: Applying the paradigm shift from new
      guidelines. Practice Based Learning Program Educational Module. 2012 May;20(5)1-20.
13.   Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal
      SA, Kaiser SM, Kvern B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and
      management of osteoporosis in Canada: summary. CMAJ. 2010 Nov 23;182(17):1-10.
14.   Lentle B, Cheung AM, Hanley DA, Leslie WD, Lyons D, Papaioannou A, Atkinson S, Brown JP,
      Feldman S, Hodsman AB, Jamal AS, Josse RG, Kaiser SM, Kvern B, Morin S, Siminoski K.
      Osteoporosis Canada 2010 Guidelines for the Assessment of Fracture Risk. Can Assoc Radiol J. 2011
      Nov;62(4):243-50
15.   Kuanrong L, Rudolf K, Jakob L. Associations of dietary calcium intake and overall calcium
      supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the
      Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-
      Heidelberg). Heart 2012 98: 920-5.
16.   Papaioannou A. 2010 Clinical Practice Guidelines for the Diagnosis and Management of
      Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct
      [updated 2011 Oct]. Available from: http://www.osteoporosis.ca/health-care-
      professionals/clinical-tools-and-resources/2010-clinical-guidelines-slideset/. Select Slide
      Deck 05 (Strategies for Fracture Prevention).



                                                                                                                38

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  • 1. Adam Samosh PGY-2 Family Medicine Schulich School of Medicine University of Western Ontario 1
  • 2. A learning resource for Residents in Family Medicine Residency Programs Online Learning Module 2
  • 3. ๏‚— Definitions ๏‚— Family Medicine ๏‚— Assessment ๏‚— Investigations ๏‚— Screening ๏‚— Risk Assessment ๏‚— Treatment ๏‚— Summary ๏‚— References 3
  • 4. ๏‚— Review the basics of what osteoporosis is ๏‚— Review key aspects of history taking and physical exam related to osteoporosis ๏‚— Be able to determine appropriate screening and fracture risk stratification for different patient demographics ๏‚— Become familiar with basic management options for osteoporosis (note: thorough discussion of pharmacological management of osteoporosis is beyond the scope of this learning module) 4
  • 5. Skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fractures (1) WHO Definition: BMD value at the spine, hip, or forearm of 2.5 or more standard deviations below the young adult mean (i.e. t-score โ‰ค-2.5), with or without the presence of a fragility fracture (2) Fragility Fracture: no, or low trauma fracture (3) 1. Kanis JA, Melton LJ, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. Journal of Bone and Mineral Research. 1994, 9:1137. 2. Kanis JA. Osteoporosis and osteopenia. J Bone Miner Res. 1990, 5:209-11. 5 3. Kanis JA, Oden A, Johnell O, Jonsson B, de Laet C, Dawson A. The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporosis International. 2002, 12:417โ€“24.
  • 6. Normal: t-score โ‰ฅ -1 Osteopenia: -1 > t-score > -2.5 Osteoporosis: t-score < -2.5 3. Kanis JA, Oden A, Johnell O, Jonsson B, de Laet C, Dawson A. The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporosis International. 2002, 12:417โ€“24. 6
  • 7. ๏‚— Primary care physicians are often responsible for screening and initiating management in patients with osteoporosis ๏‚— Canada: 1 in 3 women and 1 in 5 men will experience a fracture from osteoporosis ๏‚— Approximately 80% of fractures in Canadians over 50 years old are due to osteoporosis ๏‚— The annual cost to the health care system from Osteoporosis is estimated at $2.3 billion each year ๏‚— Guidelines for management have changed several times over the last few decades - most notably in 2002, 2004, 2010, 2011 and 2012(4) 4. Osteoporosis Canada. Osteoporosis Facts & Statistics [Internet]. Toronto, Ontario. Osteoporosis Canada. 2012 March. Available from: http://www.osteoporosis.ca/osteoporosis-and-you/osteoporosis-facts-and-statistics/. 7
  • 8. ๏‚— Osteoporosis Guidelines can be found from several different sources: ๏‚— Canadian Task Force on LTC ๏‚— SOGC/JOGC ๏‚— CMA ๏‚— Osteoporosis Canada ๏‚— One of the main purposes of this online learning module is to combine these guidelines into one resource for use in Family Medicine practice 8
  • 9. ๏‚— Fall Risk Assessment โ€“ Topics to ask patients about(5): ๏‚— Previous history of falls ๏‚— Alcohol intake (โ‰ฅ 3 drinks per day) ๏‚— Poor strength ๏‚— Balance or gait issues ๏‚— Dizziness ๏‚— Poor vision 5.Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct 9 1];[about 2 screens].
  • 10. ๏‚— Main Risks for Developing Osteoporosis (5): ๏‚— History of fragility fracture ๏‚— Parent with a hip fracture ๏‚— Rheumatoid Arthritis ๏‚— Chronic (โ‰ฅ3 months) glucocorticoid use ๏‚— Smoking (any amount has the potential to be detrimental to bone health) ๏‚— Chronic Liver/Kidney disease ๏‚— Early Menopause (before age 45 years old โ€“ including surgically induced menopause) ๏‚— Caffeine intake (โ‰ฅ4 cups/day) ๏‚— Androgen Deficiency (in men) 5.Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct 10 1];[about 2 screens].
  • 11. ๏‚— Physical Exam: ๏‚— Check occiput-to-wall distance (look for >5cm) ๏‚— Serial heights of patient โ€“ looking for >2cm loss of height, or >6cm loss of height based on patient history (6) 6. Brown JP, Josse RG. 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ 2002; 167(10 Suppl):S1-34. 11
  • 12. Confirm Diagnosis with Dual-energy X-ray Absorptiometry (DXA or DEXA) scan to determine BMD of the patient In Ontario, OHIP (Ontario Health Insurance) will cover DEXA scans: -For patients at high risk for osteoporosis and future fractures, annual scans are covered -For patients at low/intermediate risk for osteoporosis and future fractures, initial BMD testing is covered. A second test can be ordered 3 years after the baseline (i.e. first) test. After those two tests, OHIP will cover any further BMD testing up to every 5 years 7. Ontario Ministry of Health and Long-Term Care. BMD Testing [Internet]. Toronto, Ontario. Queenโ€™s Printer for Ontario. July 2010 [updated June 28, 2012; cited 2013 March 2]. Available from: http://www.health.gov.on.ca/en/public/publications/ohip/bone.aspx 12
  • 13. ๏‚— Bloodwork is indicated to rule out secondary causes of osteoporosis (8) ๏‚— CBC โ€“ malabsorption or bone marrow malignancy ๏‚— Creatinine โ€“ chronic renal disease ๏‚— Calcium (+ Albumin) โ€“ hyperparathyroidism ๏‚— TSH - hyperthyroidism ๏‚— Alkaline Phosphatase โ€“ chronic liver disease ๏‚— Vitamin D โ€“ malabsorption ๏‚— Serum protein electrophoresis โ€“ multiple myeloma 8.Papaioannou A. Quick Reference Guide: 2010 Clinical Practice Guidelines for the Diagnosis and Management of Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Sept]. Available from: 13 http://www.osteoporosis.ca
  • 14. ๏‚— The Canadian Task Force on Preventative Health Care made several screening recommendations in 2004(9): ๏‚— There is fair evidence to recommend screening postmenopausal women to prevent fragility fractures (grade B) ๏‚— There is no direct evidence that screening reduces fractures, however, there is good evidence that screening is effective in identifying postmenopausal women with low bone mineral density and that treating osteoporosis can reduce the risk of fractures in this population (grade A) ๏‚— Screening is determined based on age and presence of medical comorbidities ๏‚— The most current osteoporosis screening guidelines used in Ontario are from 2010 and are outlined in the following slides 9. Wathen CN, Feig DS, Feightner JW, Abramson BL, Cheung AM. Hormone replacement therapy for the primary prevention of chronic diseases: recommendation statement from the Canadian Task Force on Preventive Health Care. CMAJ 2004 May, 14 170(10):1535-7.
  • 15. ๏‚— DXA scans (to determine BMD and fracture risk) are indicated for screening in all men and women over the age of 65 years old (8) 8.Papaioannou A. Quick Reference Guide: 2010 Clinical Practice Guidelines for the Diagnosis and Management of Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Sept]. Available from: 15 http://www.osteoporosis.ca
  • 16. ๏‚— Screening is indicated in a patient between the age of 50-64 years old if they have a risk factor for developing osteoporosis (discussed on slide #10) ๏‚— In addition to the risk factors already mentioned, consider screening in patients with: ๏‚— primary hyperparathyroidism, type 1 diabetes, osteogenesis imperfecta, hyperthyroidism, hypogonadism, Cushingโ€™s disease, malabsorption syndrome, IBD, COPD (8) 8.Papaioannou A. Quick Reference Guide: 2010 Clinical Practice Guidelines for the Diagnosis and Management of Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Sept]. Available from: 16 http://www.osteoporosis.ca
  • 17. ๏‚— Screening is only indicated if patient has one of the following risk factors (8): ๏‚— history of fragility fracture ๏‚— prolonged use of glucocorticoids (>3 months) ๏‚— hypogonadism ๏‚— premature menopause (<45 years old) ๏‚— malabsorption syndrome ๏‚— primary hyperparathyroidism 8.Papaioannou A. Quick Reference Guide: 2010 Clinical Practice Guidelines for the Diagnosis and Management of Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Sept]. Available from: 17 http://www.osteoporosis.ca
  • 18. ๏‚— Assess 10-year fracture risk using BMD and one of two risk assessment tools (available online) ๏‚— FRAX score (10) (developed by the WHO โ€“ has settings that can be set for the Canadian population specifically) http://www.shef.ac.uk/FRAX/tool.aspx?country=19 ๏‚— CAROC (11) (Canadian Association of Radiologists and Osteoporosis Canada Risk Assessment tool) http://www.osteoporosis.ca/multimedia/pdf/CAROC.pdf ๏‚— These tools enable risk stratification 10. World Health Organization Collaborating Centre for Metabolic Bone Diseases. FRAX [Internet]. Sheffield, UK: University of Sheffield; 2013. Available from: http://www.shef.ac.uk/FRAX/tool.aspx?country=19. 11. Osteoporosis Canada. Assessment of 10-year Fracture Risk โ€“ Women and Men [Internet]. Canada. Canadian Association of Radiologists and Osteoporosis Canada (CAROC); 2013. Available from: 18 http://www.osteoporosis.ca/multimedia/pdf/CAROC.pdf.
  • 19. Note โ€“ Entire Table can be found at: 12. The Foundation for Medical Practice Education. Osteoporosis: Applying the paradigm shift from new guidelines. Practice Based Learning Program Educational Module. 2012 May;20(5)1-20. 19
  • 20. ๏‚— The current 2010 guidelines recommend using the CAROC tool (rather than FRAX) for assessing fracture risk in patients in Canada ๏‚— The same guidelines recommend using only the BMD t-score for the femoral neck when calculating fracture risk (with CAROC being the preferred tool) 13 Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ. 2010 Nov 23;182(17):1-10. 20
  • 21. ๏‚— In previous years, guidelines focussed on treating a patientโ€™s BMD t-score ๏‚— Currently the focus has shifted to managing a patientโ€™s fracture risk level (rather than the t-score) ๏‚— The main key point of the 2010 clinical practice guidelines for osteoporosis in Canada states: ๏‚— The management of osteoporosis should be guided by an assessment of the patientโ€™s absolute RISK OF OSTEOPOROSIS RELATED FRACTURES (13) 13 Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ. 2010 Nov 23;182(17):1-10. 21
  • 22. ๏‚— Risk Categories based on 10-year fracture risk (14): ๏‚— Low (< 10%) ๏‚— Moderate (10 - 20%) ๏‚— High (> 20%) ๏‚— Risk categorization helps determine the most appropriate (evidence based) treatment for each patient 14. Lentle B, Cheung AM, Hanley DA, Leslie WD, Lyons D, Papaioannou A, Atkinson S, Brown JP, Feldman S, Hodsman AB, Jamal AS, Josse RG, Kaiser SM, Kvern B, Morin S, Siminoski K. Osteoporosis Canada 2010 Guidelines for the Assessment of Fracture Risk. Can Assoc Radiol J. 2011 Nov;62(4):243-50 22
  • 23. ๏‚— Thorough discussion of treatment options for osteoporosis is beyond the scope of this learning module but will briefly be discussed on the following slides to introduce the learner to commonly used medications for fracture reduction management 23
  • 24. ๏‚— No evidence for benefit (i.e. prevention of future fractures) from pharmacotherapy ๏‚— May benefit from vitamin D and calcium supplementation as well as conservative treatments (see slide #25 and 26) ๏‚— BMD should be repeated in 5 years to reassess risk levels (5) 5.Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct 24 1];[about 2 screens].
  • 25. ๏‚— Recommend (13): ๏‚— Weight bearing exercise such as walking or weights (grade B) ๏‚— Balance training (such as Tai Chi ) (grade A evidence for those at risk of falls) ๏‚— Home safety assessments (PT/OT) (grade B) ๏‚— Treating poor vision (i.e. glasses, cataract removal) (grade B) ๏‚— Hip-protectors (for patients in long-term care facilities) (grade B) ๏‚— Smoking cessation ๏‚— Limiting alcohol intake (<2 drinks/day) ๏‚— Consider Referral (if appropriate) to (5): ๏‚— Geriatric medicine ๏‚— Falls prevention program ๏‚— Homecare ๏‚— Occupational therapy or Physical therapy 13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ. 2010 5.Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and Protocols 25 Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct 1];[about 2 screens].
  • 26. ๏‚— Daily Calcium Intake (from all sources): ๏‚— 1200mg (grade B) (discussed further on next slide) ๏‚— Daily Vitamin D Intake: ๏‚— <50 years old 400-1000IU (grade D) ๏‚— >50 years old 800-2000IU (grade C) ๏‚— Recheck Vitamin D levels 3 months after initiating supplementation (OHIP will only cover Vitamin D Testing for patients with Osteoporosis/Osteopenia) ๏‚— Daily doses up to 2000 IU is safe and does not require serial monitoring (grade C) (13) 13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: 26 summary. CMAJ 2010 Nov 23;182(17):1-10.
  • 27. ๏‚— Recent article (June 2012) in the journal Heart suggests there may be increase cardiovascular risk with taking calcium supplements ๏‚— Conclusion: ๏‚— โ€œthis study suggests that increasing calcium intake from diet might not confer significant cardiovascular benefits, while calcium supplements, which might raise MI risk, should be taken with cautionโ€ (15) ๏‚— There has been no official change to guidelines in Canada for calcium supplementation since this article was published ๏‚— Anecdotally, many family doctors are avoiding use of calcium supplements (and encouraging adequate calcium intake from diet instead) until formal guidelines are released 15. Kuanrong Li, Rudolf Kaaks, Jakob Linseisen. Associations of dietary calcium intake and overall calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-Heidelberg). Heart 2012 98: 920-5. 27
  • 28. ๏‚— May benefit from conservative management and adequate supplementation of Calcium and Vitamin D (see slide #27 for concerns around calcium supplementation) ๏‚— Use clinical judgement in considering that individuals at increase risk for falls or fracture in particular may benefit from treatment (5) 5. Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct 1];[about 2 screens]. Available from: http://www.bcguidelines.ca/guideline_osteoporosis.html 28
  • 29. ๏‚— Evidence for benefit from pharmacotherapy (5) ๏‚— The following pharmacologic treatment options are briefly discussed on the following slides: ๏‚— Bisphosphonates ๏‚— Selective Estrogen Receptor Modulators (SERMs) ๏‚— Hormone Replacement Therapy (HRT) ๏‚— Calcitonin ๏‚— Miscellaneous 5. Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct 1];[about 2 screens]. Available from: http://www.bcguidelines.ca/guideline_osteoporosis.html 29
  • 30. ๏‚— Generally a bisphosphonate is used as first line treatments for prevention of fracture for both men and women (Grade A for women, Grade D for men) (13) ๏‚— However, there are other first line options (with evidence in post-menopausal women) for fracture prevention 13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: 30 summary. CMAJ 2010 Nov 23;182(17):1-10.
  • 31. ๏‚— Raloxifene can be used as a first line therapy for prevention of vertebral fractures in menopausal women with osteoporosis (grade A) (13) Raloxifene (Evistaยฎ) 60 mg daily 13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: 31 summary. CMAJ 2010 Nov 23;182(17):1-10.
  • 32. ๏‚— Monoclonal Antibody Denosumab (Proliaยฎ) 60 mg subcutaneous injection every six months ๏‚— Parathyroid Hormone (PTH) Analog Teriparatide (Forteoยฎ) 20 ฮผg subcutaneously daily ๏‚— In menopausal women with vasomotor symptoms and osteoporosis, Hormone Replacement Therapy (HRT) can be used to treat both ๏‚— HRT is available as oral medication, patches applied to skin or as a topical cream (13) 16. Papaioannou A. 2010 Clinical Practice Guidelines for the Diagnosis and Management of Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Oct]. Available from: http://www.osteoporosis.ca/health-care- professionals/clinical-tools-and-resources/2010-clinical-guidelines-slideset/. Select Slide Deck 05 (Strategies for Fracture Prevention). 13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern 32 B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ 2010 Nov 23;182(17):1-10.
  • 33. ๏‚— Second line therapies include calcitonin, and etidronate (Grade B) ๏‚— Calcitonin Calcitonin (Miacalcinยฎ) 200 IU intranasally daily ๏‚— Etidronate Cyclical therapy of daily 200 mg for 14 days Etidronate (Didrocalยฎ) followed by calcium supplements for 10 weeks ๏‚— Testosterone is not recommended as a treatment in men (Grade B) 13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: 33 summary. CMAJ 2010 Nov 23;182(17):1-10.
  • 34. ๏‚— Consider referral to a specialist in patients who meet one of the following criteria: ๏‚— decrease in bone density while on therapy ๏‚— new fracture while on therapy ๏‚— poor drug tolerance to several first line agents ๏‚— rare drug therapy complications such as osteonecrosis of the jaw or atypical femoral fractures (13) 13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: 34 summary. CMAJ 2010 Nov 23;182(17):1-10.
  • 35. ๏‚— Osteoporosis corresponds to a BMD t-score < -2.5 ๏‚— Review falls risks and risk of developing osteoporosis when concerned about a patientโ€™s future risk of fracture ๏‚— Screening for osteoporosis is appropriate in individuals over the age of 65 years old, or younger patients at risk of developing osteoporosis ๏‚— Screening generally involves using a DEXA scan to determine BMD, which is then used by a risk-assessment tool (CAROC is preferred) to determine a patientโ€™s fracture risk ๏‚— Fracture risk level (low, intermediate or high) will determine what type of management is appropriate to prevent future fractures ๏‚— Ultimately, the goal of osteoporosis management is fracture risk reduction 35
  • 36. 1. Kanis JA, Melton LJ, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. Journal of Bone and Mineral Research. 1994, 9:1137. 2. Kanis JA. Osteoporosis and osteopenia. J Bone Miner Res. 1990, 5:209-11. 3. Kanis JA, Oden A, Johnell O, Jonsson B, de Laet C, Dawson A. The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporosis International. 2002, 12:417โ€“24. 4. Osteoporosis Canada. Osteoporosis Facts & Statistics [Internet]. Toronto, Ontario. Osteoporosis Canada. 2012 March. Available from: http://www.osteoporosis.ca/osteoporosis-and-you/osteoporosis- facts-and-statistics/. 5. Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct 1];[about 2 screens]. Available from: http://www.bcguidelines.ca/guideline_osteoporosis.html 36
  • 37. 6. Brown JP, Josse RG. 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ 2002; 167(10 Suppl):S1-34. 7. Ontario Ministry of Health and Long-Term Care. BMD Testing [Internet]. Toronto, Ontario. Queenโ€™s Printer for Ontario. July 2010 [updated June 28, 2012; cited 2013 March 2]. Available from: http://www.health.gov.on.ca/en/public/publications/ohip/bone.aspx 8. Papaioannou A. Quick Reference Guide: 2010 Clinical Practice Guidelines for the Diagnosis and Management of Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Sept]. Available from: http://www.osteoporosis.ca/multimedia/pdf/Quick_Reference_Guide_October_2010.pdf. 9. Wathen CN, Feig DS, Feightner JW, Abramson BL, Cheung AM. Hormone replacement therapy for the primary prevention of chronic diseases: recommendation statement from the Canadian Task Force on Preventive Health Care. CMAJ 2004 May, 170(10):1535-7. 10. World Health Organization Collaborating Centre for Metabolic Bone Diseases. FRAX [Internet]. Sheffield, UK: University of Sheffield; 2013. Available from: http://www.shef.ac.uk/FRAX/tool.aspx?country=19. 37
  • 38. 11. Osteoporosis Canada. Assessment of 10-year Fracture Risk โ€“ Women and Men [Internet]. Canada. Canadian Association of Radiologists and Osteoporosis Canada (CAROC); 2013. Available from: http://www.osteoporosis.ca/multimedia/pdf/CAROC.pdf. 12. The Foundation for Medical Practice Education. Osteoporosis: Applying the paradigm shift from new guidelines. Practice Based Learning Program Educational Module. 2012 May;20(5)1-20. 13. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ. 2010 Nov 23;182(17):1-10. 14. Lentle B, Cheung AM, Hanley DA, Leslie WD, Lyons D, Papaioannou A, Atkinson S, Brown JP, Feldman S, Hodsman AB, Jamal AS, Josse RG, Kaiser SM, Kvern B, Morin S, Siminoski K. Osteoporosis Canada 2010 Guidelines for the Assessment of Fracture Risk. Can Assoc Radiol J. 2011 Nov;62(4):243-50 15. Kuanrong L, Rudolf K, Jakob L. Associations of dietary calcium intake and overall calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC- Heidelberg). Heart 2012 98: 920-5. 16. Papaioannou A. 2010 Clinical Practice Guidelines for the Diagnosis and Management of Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Oct]. Available from: http://www.osteoporosis.ca/health-care- professionals/clinical-tools-and-resources/2010-clinical-guidelines-slideset/. Select Slide Deck 05 (Strategies for Fracture Prevention). 38

Editor's Notes

  1. Kanis JA, Melton LJ, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. Journal of bone and mineral research. 1994, 9:1137.Kanis JA. Osteoporosis and osteopenia. J Bone Miner Res. 1990, 5:209-11.
  2. 3. Kanis JA, Oden A, Johnell O, Jonsson B, de Laet C, Dawson A. The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporosis International. 2002, 12:417โ€“24.
  3. 15. Osteoporosis Canada. Osteoporosis Facts &amp; Statistics [Internet]. Toronto, Ontario. Osteoporosis Canada. 2012 March. Available from: http://www.osteoporosis.ca/osteoporosis-and-you/osteoporosis-facts-and-statistics/.
  4. 5. Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct 1];[about 2 screens]. Available from: http://www.bcguidelines.ca/guideline_osteoporosis.html
  5. 5. Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct 1];[about 2 screens]. Available from: http://www.bcguidelines.ca/guideline_osteoporosis.html
  6. 6. Papaioannou A. Quick Reference Guide: 2010 Clinical Practice Guidelines for the Diagnosis and Management of Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Sept]. Available from: http://www.osteoporosis.ca/multimedia/pdf/Quick_Reference_Guide_October_2010.pdf.
  7. 6. Papaioannou A. Quick Reference Guide: 2010 Clinical Practice Guidelines for the Diagnosis and Management of Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Sept]. Available from: http://www.osteoporosis.ca/multimedia/pdf/Quick_Reference_Guide_October_2010.pdf.
  8. 6. Papaioannou A. Quick Reference Guide: 2010 Clinical Practice Guidelines for the Diagnosis and Management of Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Sept]. Available from: http://www.osteoporosis.ca/multimedia/pdf/Quick_Reference_Guide_October_2010.pdf.
  9. 6. Papaioannou A. Quick Reference Guide: 2010 Clinical Practice Guidelines for the Diagnosis and Management of Osteoporosis in Canada [Internet]. Toronto, Ontario. Osteoporosis Canada. 2010 Oct [updated 2011 Sept]. Available from: http://www.osteoporosis.ca/multimedia/pdf/Quick_Reference_Guide_October_2010.pdf.
  10. 8. World Health Organization Collaborating Centre for Metabolic Bone Diseases. FRAX [Internet]. Sheffield, UK: University of Sheffield; 2013. Available from: http://www.shef.ac.uk/FRAX/tool.aspx?country=19.9. Osteoporosis Canada. Assessment of 10-year Fracture Risk โ€“ Women and Men [Internet]. Canada. Canadian Association of Radiologists and Osteoporosis Canada (CAROC); 2013. Available from: http://www.osteoporosis.ca/multimedia/pdf/CAROC.pdf.
  11. 10. The Foundation for Medical Practice Education. Osteoporosis: Applying the paradigm shift from new guidelines. Practice Based Learning Program Educational Module. 2012 May;20(5)1-20.
  12. 11.Lentle B, Cheung AM, Hanley DA, Leslie WD, Lyons D, Papaioannou A, Atkinson S, Brown JP, Feldman S, Hodsman AB, Jamal AS, Josse RG, Kaiser SM, Kvern B, Morin S, Siminoski K. Osteoporosis Canada 2010 Guidelines for the Assessment of Fracture Risk. Can Assoc Radiol J. 2011 Nov;62(4):243-50.
  13. 5. Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct 1];[about 2 screens]. Available from: http://www.bcguidelines.ca/guideline_osteoporosis.html
  14. 12. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ. 2010 Nov 23;182(17):1-10.5. Ministry of Health: BC Guidelines [Internet]. Victoria, BC. British Columbia Medical Association. Guidelines and Protocols Advisory Committee. Osteoporosis: Diagnosis, Treatment and Fracture Prevention. 2011 May 1 [updated 2012 Oct 1];[about 2 screens]. Available from: http://www.bcguidelines.ca/guideline_osteoporosis.html
  15. 12. Papaioannou A, Morin S, Cheung AM, Atkinson S, Brown JP, Feldman S, Hanley DA, Hodsman A, Jamal SA, Kaiser SM, Kvern B, Siminoski K, Leslie WD. 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ. 2010 Nov 23;182(17):1-10.
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