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osteoarthritis
Learning
objectives
Objectives:
Definition
Causes
Types
Signs and symptoms
Diagnosis
Treatment
definition
EPIDEMIOLOGY:
Causes of OA:
ANATOMY
PATHOPHYSIOLOGY
PATHOPHYSIOLOGY
formerly considered to be simply a degenerative "wear and tear" process and
therefore often misnamed as degenerative joint disease
Pathogenesis of OA is much more complex
"-itis" is indicative of an inflammatory process is actually correct
Destruction and loss of the articular cartilage is a central component of OA, all joint tissues
are affected in some way
PATHOGENESI
S
PATHOGENESIS
HISTOLOGY OF OA
OA
GRADES OF OA:
1RY. VS
2RY.
CLINICAL PICTURE
CLINICAL
PICTURE;
OA CLINICAL
PICTURES
X-RAYS;
XR
Differential
Diagnosis
Rheumatoid arthritis (symmetric, atrophic rather than hypertrophic
arthritis)
Psoriatic arthritis (may be in one finger as dactylitis, and characteristic
nail changes are usually present)
Avascular necrosis (articular cartilage loss precedes bone destruction in
OA)
Crystalline arthritis (urate or CPP crystals in synovial fluid, tophi on
imaging in gout)
Hemochromatosis (targets the MCP joints and wrists, predominates in
men, squared-off bone ends and hook-like osteophytes in the MCP joints)
SYNOVIAL CHONDROMATOSIS
Infectious arthritis : (inflammatory signs effusion, increased
warmth, erythema), culturing the pathogen from the synovial fluid or from
the blood
Diffuse Idiopathic Skeletal Hyperostosis (bony spurs in pelvic apophyses
and vertebral column, usually
asymptomatic)
Soft tissue abnormalities (bursitis, tendinitis, enthesitis, etc.)
TREATMENT
OF OA:
HIGH TIBIAL OSTEOTOMY
ARTHROSCOPIC
DEBRIDEMENT
ARTHRODESIS = JOINT
FUSION
ARTHROPLASTY
THANKS
REFERENCES
ØSolomon L, Warwick D, Nayagam S. Apley’s system of orthopedics and fractures, 9th edition
ØLeticia Alle Deveza et al., Overview of the management of osteoarthritis, https://www.uptodate.com/contents/overview-of-themanagement-
of-osteoarthritis
ØMichael Doherty et al., Clinical manifestations and diagnosis of osteoarthritis, https://www.uptodate.com/contents/clinicalmanifestations-
and-diagnosis-of-osteoarthritis
ØLeticia Alle Deveza et al., Management of knee osteoarthritis, https://www.uptodate.com/contents/management-of-knee-osteoarthritis
ØLyn March, AM et al., Epidemiology and risk factors for osteoarthritis, https://www.uptodate.com/contents/epidemiology-and-riskfactors-
for-osteoarthritis
ØLisa A Mandl et al., Overview of surgical therapy of knee and hip osteoarthritis, https://www.uptodate.com/contents/overview-ofsurgical-
therapy-of-knee-and-hip-osteoarthritis
ØKarine Louati et al., Comorbidities that impact management of osteoarthritis, https://www.uptodate.com/contents/comorbidities-thatimpact-
management-of-osteoarthritis

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osteoarthritis.pptx

  • 9. PATHOPHYSIOLOGY formerly considered to be simply a degenerative "wear and tear" process and therefore often misnamed as degenerative joint disease Pathogenesis of OA is much more complex "-itis" is indicative of an inflammatory process is actually correct Destruction and loss of the articular cartilage is a central component of OA, all joint tissues are affected in some way
  • 13. OA
  • 14.
  • 16.
  • 19.
  • 22.
  • 24. XR
  • 25. Differential Diagnosis Rheumatoid arthritis (symmetric, atrophic rather than hypertrophic arthritis) Psoriatic arthritis (may be in one finger as dactylitis, and characteristic nail changes are usually present) Avascular necrosis (articular cartilage loss precedes bone destruction in OA) Crystalline arthritis (urate or CPP crystals in synovial fluid, tophi on imaging in gout) Hemochromatosis (targets the MCP joints and wrists, predominates in men, squared-off bone ends and hook-like osteophytes in the MCP joints) SYNOVIAL CHONDROMATOSIS Infectious arthritis : (inflammatory signs effusion, increased warmth, erythema), culturing the pathogen from the synovial fluid or from the blood Diffuse Idiopathic Skeletal Hyperostosis (bony spurs in pelvic apophyses and vertebral column, usually asymptomatic) Soft tissue abnormalities (bursitis, tendinitis, enthesitis, etc.)
  • 26.
  • 28.
  • 29.
  • 30.
  • 31.
  • 37. REFERENCES ØSolomon L, Warwick D, Nayagam S. Apley’s system of orthopedics and fractures, 9th edition ØLeticia Alle Deveza et al., Overview of the management of osteoarthritis, https://www.uptodate.com/contents/overview-of-themanagement- of-osteoarthritis ØMichael Doherty et al., Clinical manifestations and diagnosis of osteoarthritis, https://www.uptodate.com/contents/clinicalmanifestations- and-diagnosis-of-osteoarthritis ØLeticia Alle Deveza et al., Management of knee osteoarthritis, https://www.uptodate.com/contents/management-of-knee-osteoarthritis ØLyn March, AM et al., Epidemiology and risk factors for osteoarthritis, https://www.uptodate.com/contents/epidemiology-and-riskfactors- for-osteoarthritis ØLisa A Mandl et al., Overview of surgical therapy of knee and hip osteoarthritis, https://www.uptodate.com/contents/overview-ofsurgical- therapy-of-knee-and-hip-osteoarthritis ØKarine Louati et al., Comorbidities that impact management of osteoarthritis, https://www.uptodate.com/contents/comorbidities-thatimpact- management-of-osteoarthritis