Oral complications in bone marrow transplantation patients recent advances. heb

1. 14.4.2020 Oral complications in bone marrow transplantation patients: recent advances. - PubMed - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/8138387 1/1
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Isr J Med Sci. 1994 Jan;30(1):120-4.
Oral complications in bone marrow transplantation patients:
recent advances.
Garfunkel AA , Tager N, Chausu S, Chausu G, Haze C, Galili D.
Department of Hospital Oral Medicine, Hebrew University-Hadassah School of Dental Medicine,
Jerusalem, Israel.
Abstract
This paper presents some of the oral aspects encountered in bone marrow transplant
(BMT) patients, as reflected in recent research conducted in the Department
of Oral Medicine. Oralinfections caused by Enterobacteriaceae were found to be responsible for
a large proportion of positive cultures, during different stages of the transplantation process.
Mucositis was constantly detected concomitant with the infections. It correlated with
granulocytopenia and fever. The mucositis improved together with the immune system
reconstitution. Immunoglobulins in saliva of BMT patients showed a drastic reduction following
the patients' conditioning protocol and a return to normal levels soon after the transplantation.
IgA, IgM and IgG were studied. Saliva was also shown to play an important role in the fibrinolytic
system, through its plasminogen activator inhibitory contents. It seems that the active molecules
are contained in the oral epithelial cells.
PMID: 8138387
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