1. Optho Times | Vol. IV May. 2016 to July. 2016
Eyes are undoubtedly the windows to the world
www.opthoremedies.com
Serving Humanity Since 1973
OPTHO
R
From The Desk of Director - Sales
It gives me a sense of pride, as I release this annual issue of Optho times. As it is establishing our brand
image.
Director's speech on Annual Sales Meeting (2015-2016)
It gives me a great pleasure to welcome you all to this year's Annual Meeting, celebrating not only our last
year's accomplishments, but also 43 years' worth of Optho Remedies Pvt. Ltd achievements.
Such occasions & meetings builds more strong connections among us, after all-that's what it's all about for
us:. successful community inclusion. I want to start by thanking you for joining us today; your support and
presence here, is indicative of the steps we've made in the right direction.
This event is a key step towards a collective vision of integration and target achievement strategies. As it is a
deep belief that cooperation and integration will greatly strengthen our roots and bring benefits to all .
Thus, this meeting today embodies this belief.
The annual meeting was entitled as- “LAKSHYA". The Goal is self explanatory, In these two days we all have to make a giant pool of ideas,
innovations, strategies and goals, so that we can utilize these resources for achieving our LAKSHYA.
My dear team managers the achievement of your goal is assured the moment you commit yourself to it. It is imperative to have moral courage by
sticking to your beliefs: "A leader needs to pursue a course of action even in the face of overwhelming criticism and great adversity". This kind of
courage is always in short supply. Authenticity, is a key trait required in a leader. Other qualities can be picked up based on experience and
situations. As a leader it is unlikely that you will be able to inspire, arouse, excite or motivate people unless you can show what you stand for and
reveal that you are willing to learn. Be fair to colleagues and friends. The ability to judge well is often linked to an ability to mix with, and learn from,
other people.
In an organization, the value system has to percolate down to all the employees. This can only come about by demonstration, which starts at the
top. Therefore, the senior management must make it a point to interact with all employees, thereby constantly reinforcing the organizational
culture. How leaders behave will always reflect in how the rest of the employees behave.
Managers discipline is very important in sales, as we can't achieve targets without it. As, discipline on the positive side creates winners with goals
and on negative side, losers with excuses.
My team members, make your personal area wise strategies, and teach your inline people about the same. If the plan “A” doesn't work change it to
plan “B” but never change your goal.
Here, again I say that “INNOVATION” is the key to success, it is not just about doing new things, it is about doing things differently and a creative
manager is motivated by the desire to achieve, not by the desire to beat others.
Gentlemen, these are the times of historic changes. Many of you face challenges, I know too well from my own experiences, but these challenges
urge you to stay focused on your goals for more inclusion and resilience. till the goal is reached.ARISE, AWAKE and STOP NOT
Rajesh Agarwal
O-Outstanding P-People serving T-Towards H-Humanity with O-Optimism
Rakesh Agarwal
From The Desk of Director - Operations
Last year, has been challenging & coming days to be more challenging . The updation & amendment in
the Drug Laws, revised pricing and FDC screening will make the ground more competitive, but our hard
work, dedication and patience has made us successful. All this has been possible because we worked as a
team and were true to the core values of the organization. Its good to see that sales team is well versed to
adapt the changes quickly and act on it swiftly. So demand for our products is not the question, the
balance between DEMAND & SUPPLY governs the success of an organization. To concrete our supply
th
chain management, we held Distributor's meet on 17 Feb. 2016. Distributors across the country have
participated in the meeting that arrived to fruitful conclusion and the same are under implementation.
To welcome the ocular allergy season and say good bye to ocular itch, now you have in your basket one
drop once daily ODIN 0.2% ahead this summer to treat better dry, eye patients your basket will add CCS LC
& HY-5. Product diversification and new introduction is on top priorities to support the sales team in all
possible ways. To honour and give gratitude to the body fuel which you invest to materialize company's goal can't be denied, so to keep the flame
to excel, glowing year 2016-17 has updated travel allowances along with the fabulous and lucrative incentive scheme for you all. So, this year has
a lot in terms of growth and opportunities, rewards and recognition in the basket, thus, look at what you have got and make the best of it.
At the end I would like to share a few lines...“The struggle you're in today is developing the strength you need for tomorrow, therefore
overcome your barriers, intend the best, be patient & don't give up.”

2. Dear,
Optho's family Members
Summers are in full swing, with scorching heat and high
rising temperatures. Our pursuit of excellence through
consolidation and growth continues unabated, reflecting
in steadily improving readers feedback and customer
satisfaction. Your support inspires us to excel.
Honesty, Integrity and truthfulness are absolutely
essential keys for success in all areas of life. Truthfulness,
the ability to take and give, honest and well intended
feedback, strength of character and conviction in one's
principles. Integrity is feeling myself the truth. And
honesty is telling the truth to other people.
A company cannot simply list it's values in the annual
report or post them in the staff lounge and expect
employees to follow suit. Values must be lived by everyone
in the company. Otherwise they're just good intentions.
Leaders, above all, must walk the talk.
This year's AIOS conference took place in Kolkatta, "The
city of joy". Here, we are presenting you a brief insight to
th
Optho's participation in 74 Annual conference of AIOS.
Plus, March is the month dedicated to women across the
globe, read about Optho's women's day celebration across
the nation.
While we are striving hard to give you the best, always
shortcomings do surface at times. I, on my part will always
welcome your feedback at (anushri@opthoremedies.com)
on any issue that you may come across. Wishing you, your
family happy holidays.
Regards
Anushri R. Agarwal
(Editor In Chief)
2
We Value Your Feedback
It's a pleasure to read an
article titled 'What Makes a
Great Manager'. It is
welcome addition which
inspires the aspiring
younger, lot of employees
bubbling with confidence
and enthusiasm and guide
them to build their career in
better and organized way.
You are suggested to make
management related
article a permanent feature
of Optho times touching
upon various aspects the
effort will make Optho times
more purposeful.
March is the month dedicated in ophthalmic fraternity
for creating awareness and adding fuel to the fight
against Glaucoma. Optho remedies tries to contribute
the maximum to 'World Glaucoma Patient Association'
(WGPA). Optho remedies has been conducting regular
glaucoma awareness activities throughout the year on
6th of every month to symbolize the beginning of 'World
Glaucoma Week'. Glaucoma Awareness Walk &
Glaucoma OPD campaign have been done through out
the week, thousands of Glaucoma Patients were screened
in different parts of the country. We will be organizing
awareness camps round the year on 8th & 20th of every
month at leading hospitals & institutes, to mark the
beginning of “World Glaucoma Week 2017” and Optho
remedies foundation's day. Company aims to extend
campaigns for cataract and other ocular morbidities in
coming months.
Walk for Glaucoma Awareness
R. S. Tripathi
Manager
(Field Administration)
Allahabad team organized a walk to raise awareness on Glaucoma

3. Dr. Rohit Saxena Dr. Ashok Km Nanda
Dr. Raj Km Srivastav &
Dr. Ulka Srivastav
Dr Vinay Gupta &
Dr. Mandal Pranad
Dr. Shrikant Tiwari &
Dr. Ramesh Kumar Singh
Dr. Shrikant Tiwari &
Dr. Ramesh Kumar Singh
th
74 All India Ophthalmology Conference . Kolkatta
Dr. V. Panner Selvam Dr. HP Jain Dr Ramesh Ch. Gupta &
Dr. Lalit Verma
Manoj Kumar &
Dr. Ramesh Ch. Gupta
Dr. Ahuja Arjun Sadhuram
& Dr. Rohit
Dr. Rishi Mohan
Dr Ramesh Mahar &
Dr. Ashok Bajaj Dr. B.P Jain Optho Remedies Team
th
The 74 . AIOC, 2016 was held at Kolkota from 25th-28th.Feb., 2016.The conference was organised by
All India Ophthalmic Society.The conference took place at Science City & Milan Mela ground . More
than 150 companies participated including surgical companies and publication houses. The event
witnessed the presence of more than six thousand delegates, including trade people.
Honourable Mr. Somnath Chatterjee, former speaker of parliament was the chief guest of the
conference. Prof. Priya Abraham of Christian Medical college and Hospital, Vellore, India and Prof.
Arunaloke Chakrabarti PGIMER, Chandigarh were the key speakers of the conference. The conference touched and focused on all
spheres like Eye Surgeries, Ophthalmology and Eye Health.
Highlight of the event: Medical session are common phenomenon to every conference, as management lesion has touched all
discipline of study so as medical science too.
Mr. Tourbo of Germany conducted a session on skill management for the doctors at AIOS, Kolkota has tied up with IIM, Kolkota to
conduct a session on skill management.
Optho was present at Trade Hall No.-2 ,Semi Pavilion Stall No. A, elegant stall right at the entrance to greet & welcome all
the delegates. All eminent doctor's left their footprint at our stall. Budding ophthalmologists enjoyed the casino game at
our counter. We unveiled our entire ophthalmic products range by means of product collage, displayed at the stall and we
have also distributed the AIOS interesting facts card among the delegates. Optho remedies is turning out to be curiosity
corner by the showcase. As a tradition we offered the best of best hospitality services to the doctor's fraternity.
3

4. Welcome on Board
*Previously associated with.
Shashi Kant Mishra
Sale Admin Exe.-HO
Sudhir Rajbhar
RM Mumbai
(*Cipla Akumentis)
North Delhi
Ranchi
Amritsar
Guntur
Sambalpur
Bareilly
Gorakhpur
Ghaziabad
Nagpur
Rohtak
Gorakhpur
Bikaner
Chennai
Chennai
North Delhi
Tirupati
Bolpur
Madurai
Ahmednagar
Hyderabad
Burdwan
Name of Staff Designation Headquarter
MR
MR
MR
MR
MR
MR
MR
MR
MR
SO
MR
MR
MR
MR
MR
MR
MR
MR
MR
MR
MR
Bhoop Singh
Anusha Thapa
Pankaj Sharma
Srinivas. Ballam
Utkala Keshari Mahapatra
Rahul Mishra
Ritesh Kumar
Manoj Kumar Sharma
Yogesh Dhok
Pawan Sharma
Abhay Shankar Tripathi
Tejaram Kumawat
Mr. R. Manikandan
B. Dasthageer
Aman
K Ramakrishana
Pemranjan Ghosh
Paramasivan Allais Saravanan
Tukaram Devrao Garje
Ramesh Chukka
Asish Rudra
Top Product Performer
SOC (Stabilized Oxychloro Complex)
SOC is biodegradable polymer and it is an oxidative-
type preservative.
SOC dissipates by converting into components normally
found in tears, such as sodium ions, chloride ions, oxy-
gen, and water. This unique quality makes SOC an
unusually gentle preservative that is ideal for chronic
use. For this reason, products containing SOC may have
an improved tolerability profile, reduced toxicity,
and, ultimately, better patient compliance.
SOC consists of an equilibrium mixture of oxychloro
species: 99.5% chlorite (ClO 0.5% chlorate (ClO), and
trace amounts of chlorine dioxide (ClO which have
bactericidal, fungicidal, and virucidal activity.
Thus SOC has preservative action in bottle and product
becomes virtually preservative free on ocular tissues,
which provides better tolerability.
Preservative-free approach in ocular lubricants
*Based on sales data till March. 2016
Products BrandsProducts Brands HeadquarterHeadquarter Hq. RepresentativeHq. Representative
Lubrinac Jamshedpur
Muzaffarpur
Nikesh Km Singh
Amit km Ranjan
IMEG-3 Gorakhpur
Hyderabad
Patna
Yugal Dubey
OP Mishra
Amar Singh & Om Mishra
Sachin Chandel
Raman Kumar
Shekhar Kothari
Muzaffarnagar
Darbhanga
Dehradun
Moxifax
Products Brands Headquarter Hq. Representative
Kanpur Sanjeev Mishra
Products Brands Headquarter Hq. Representative
4

5. 5
Products of the
Spring/Summer Season
Falling leaves, flowers, blossoming all
around and bright sunlight is the
announcement of the arrival of the most
beautiful spring season. It is the most
pleasant and enjoyable season , the
whole of the environment is filled with
pollen grains lingering everywhere
making the life of inhabitants miserable
. Pollen grains are the main cause of
ocular allergy. Thus, the beginning of the
spring season in beginning of the ocular
allergy. Optho is marketing various
formulations to cover the allergic sign &
symptoms. Odin eye drop is one of the
formulation which cures the ocular
allergy miraculously.
Odin Eye drops :
This is not a new product for all of you have been promoting it
successfully since long . But now odin has arrived in the new look. As
the concentration of the main effective ingredient olopatadine
concentration has been raised to 0.2% as compared to 0.1% . The
enhancement of our odin makes more efficacious and more
convenient to use.
Odin eye drop is clear ophthalmic solution to control the seasonal
and perennial allergic conjunctivitis, and intense itching caused due
to change of season (like spring ) and various allergens.
Odin contains olopatadine in higher concentration of 0.2%..
Olopatadine is a white coloured powder, which is freely soluble in
water to provide a clear and shining solution. Odin eye drop is
especially designed to cure allergic conjunctivitis, associated with
intense ocular itch and tearing from the eye. Which may caused due
to change season or allergen such as pollen mould or animal danger .
These are foreign body which is also known as allergens.
The ocular allergic conjunctivitis is caused when allergen or antigen
such as pollen grain mold binds with antibody on the surface of mast
cells to induce degranulation which releases a content of granules or
mixture of components (hiscamine, cycokine etc.) Thus, histamines
releases in eyes and further causes the vascular response which is
manifested in the form of redness, itching ,watery discharge & mucus
discharge.
Dual Activity of Odin :- The drug which counteracts in more than
one component ,always play a better role ,Like wise Olopatadine , on
the one hand blocks H1 activity and on the other hand it inhibits
the release of histamines, tryptase PGE2 from human conjunctiva
mast cells. The dual action of ODIN 0.2% makes it a unique anti
allergic conjunctivitis drug.
Duration of Action : Most of the anti allergic preparation require
frequent dosing and thus are inconvenient to use. ODIN 0.2% drop is
unique wipes out itch immediately after the instillation of first drop
and effective for 24 hrs, thus it once daily. Thus its most convenient for
the use by patient.
Dosage & Administration: 2 drop in affected eye one daily.
ODIN is comfortable :- Odin provides minimum ocular discomfort
after application.
ODIN VS KETOROLAC
Both the drugs are for similar kind of use i.e . allergic conjunctivitis
and ocular itch. Odin has faster onset of action as compared to
Ketorolac (KT) KT requires frequent dosing every 2 hourly.
KT (ketorolac) irritant nature, where ODIN has no ocular discomfort,
thus great patient acceptance.
It starts its action within half an hour
and patients are relived from ocular
itch after 1-2 hours of instillation.
Its action starts instantaneously &
ocular itch is relived from 1st drop.
Half life not less than 7
Frequent Instillation is required
Irritant
Longer half life
OD dosing
Non Irritant
Our range of products possess a versatile preparation which is
equally efficacious in treating ocular infections and inflammation in
pre & post operative state and for ocular allergy associated with
secondary infection .This is our Tocin - F eye drops . Tocin - F is anti
bacterial & anti inflammatory preparation as it contains Tobramycin
0.3% w/v & Fluoromethalone 0.1% w/v in the form of microfine
aqueous suspension.
TOCIN-F Eye drops
Tobramycin sulphate:
1. It is a white coloured powder which is
freely soluble in water and gives a
clear solution.
2. It is broad spectrum antibiotic active
against gram positive & gram
negative microorganism. But unlike
other antimicrobial its spectrum
for gram-negative organism is very
broad as compared to any other anti
microbial. Due to its unique spectrum
it is the most preferred antibiotic .
3. S i n c e To b r a m y c i n i s n e v e r
recommended as Oral or
systemically hence resistance has never been reported.
4. Tobramycin has minimal protein binding , a such it
penetrates deeper in the corneal layer ensuring deeper
penetration.
5. Tobramycin is safest and well tolerated antibiotic for
children and elderly patients.
6. It belongs to aminoglycoside group of antimicrobial.
7. Tobramycin is choice for treating the infection in pre &
post operative state , corneal ulcer & ophthalmia
neonatrum. The infection which occurs in eye of new born
kids.
Fluoromethalone:
1. This is a white coloured powder and is insoluble in water
to provide a suspension .
2. It belongs to corticosteroid family .But it is considered to
very safe drug as it does not raise the IOP .
Reason for Safety: Fluoromethalone is very poorly absorbed
by the cornea. Whatever quantity is absorbed by the
cornea is very rapidly eliminated . Therefore this can be
used for longer period of time without any steroidal side
effect.
3. Being a corticosteroid fluoromethalone is anti-inflammatory
and anti allergic. Especially in chronic conjunctivitis which
persist for longer period , fluoromethalone can be used to
eradicate the same very safely.
4. Offcoure fluoromethalone being a corticosteroid is strictly
contraindicated in Glaucoma & corneal ulcer .
Both the molecules in TOCIN–F eye drop are safe for the use of
prolonged therapy . The formulation safe & well tolerated in
(babies/kids)* .
Therefore whenever the patients coming with allergic conjunctivitis
and secondary infection, or in chronic allergic conjunctivitis
persisting for long time .TOCIN – F is a drug of choice .It can also be
prescribed, when the patient are not responding to other
antimicrobial drugs and have developed resistance.
* It is suggested to promote Tocin-F among paediatric doctor's too.

6. 6
Doctor’s Speak
Causes of Red Eye :
Conjunctivitis is the most common cause of red eye and is one
of the leading indications for antibiotics. Causes of
conjunctivitis may be infectious (e.g., viral, bacterial,
chlamydial) or noninfectious (e.g., allergies, irritants). Most
cases of viral and bacterial conjunctivitis are self-limiting.
Other common causes of red eye include:
1. Blepharitis
2. Corneal abrasion.
3. Foreign body.
4. Subconjunctival hemorrhage.
5. Keratitis.
6. Iritis.
7. Glaucoma.
8. Chemical burn.
9. Scleritis.
A thorough patient history and eye examination may provide
clues to the etiology of red eye. The history should include
questions about unilateral or bilateral eye involvement,
duration of symptoms, type and amount of discharge, visual
changes, severity of pain, photophobia, previous treatments,
presence of allergies or systemic disease, and the use of
contact lenses. The eye examination should include the
eyelids, lacrimal sac, pupil size and reaction to light, corneal
involvement, and the pattern and location of hyperemia.
Preauricular lymph node involvement and visual acuity must
also be assessed. Common causes of red eye and their clinical
presentations are summarized under:
RedEyeRedEyeRedEye
Red eye is one of the most
common ophthalmologic
conditions in the primary care
setting. Inflammation of almost
any part of the eye, including the
lacrimal glands and eyelids, or
faulty tear film can lead to red
eye. Primary care physicians
often effectively manage red
eye, although knowing when to refer patients to an
ophthalmologist is crucial.
Dr. Rohit Agarwal
Diagnosis and Management of Red Eye in Primary Care
Diagnosis of the Underlying Cause of Red Eye
Patient presents with red eye
Pain*
Mild or no pain, with mild
blurring or normal vision
Moderate to severe pain
Hyperemia
Vision loss, distorted pupil,
corneal invelvement
Focal Diffuse
Episcleritis Discharge?
No Yes
Emergency ophthalmology referral
Subconjunctival
hemorrhage
Intermittent Continuous
Dry eye
Watery
or serous
Mucopurulent
to purulent
Itching
Chlamydial
conjunctivitis
Acute
bacterial
conjunctivitis
Mild to
none
Moderate
to severe
Viral
conjunctivitis
Allergic
conjunctivitis
Note : Blepharitis, hordeolum, and chalzaion are associated with a localized red, swol-
len, tender eyelid; other symptoms are rare.
*—Patients with corneal abrasion may present with severe pain, but can be treated
by a primary care physician.
+—Paradoxical tearing of the eye
Vesicular rash (herpetic keratitis),
severe mucopurulent discharge
(hyperacute bacterial conjunctivitis),
keratitis, corneal ulcer, acte angle
glaucoma, iritis, traumatic eye
injury, chemical burn, scleritis
Causes of Red Eye

7. DRUGS USED IN ALLERGIC DISEASES OF THE EYE
Sr.
No.
Name
2
3
Vasoconstrictor
Mast Cell Stabiliser
4 Multiple Action Drugs
Effect Examples Indication Dosage Adverse Effect
Decongestion
Used for
prophylaxis
Oxymetazoline,
Nephazoline,
Tetrahydrozoline,
Phenylephrine
Sodium cromoglycate,
Lodoxamine
Burning, Stinging,
Mydriasis, rebound
hyperaemia
conjunctivitsmedicamentosa
with chronic use
Requires loading period
before exposure to antigen
hence requires very good
compliance
PAC,
SAC
PAC,
SAC
1 Antihistamines
Relieves
Itching &
Redness
Antazoline,
Pheniramine,
Levocabastine
(0.5%)
Irritation especially on
prolonged use
PAC,
SAC
Tds to
qid
Tds
Tds
5
NSAID
(Non Steroidal
Anti-inflammatory Drugs)
Reduces the
Conjunctival
hyperaemia &
the pruritus
caused by
Ketorolac (0.5%),
Pranoprofen,
Fluribiprofen,
Diclofenac
Burning, StingingSAC, VKC Tds
Relieves
itching,
redness,
edema with
immediate
effect
Olopatadine (0.1%)
Ketotifen (0.025%),
Nedocromil,
Azelastine,
Epinastine (0.05%)
Blurred vision,
buming& stinging
PAC,
SAC,
VKC,
AKC
BD
1
2
3
4
5
6
7
8
9
11
12
13
14
History of
atopy
Age
Gender
Seasonal Springs SpringsPerennial Perennial
Common Common Possible Possible PossibleConstnt
Children / Adults Children / AdultsChildren / Adults Children / Adults Adults
Adolescent /
Adults
No predilection No predilection No predilection No predilectionMales Males
Perennial /
Summer
No
NoNoYesYesNoNoCornea
Vision Minimal Minimal MinimalMild Severe Minimal
Papillary
hypertrophy No No No<1 >1
Edema Edema Edema Edema
7-8 mm Limbus
Affected
NoNo No No No Yes
Exposure to
drugs
Periocular skin
involvement
Dermatiris Dermatiris
Serum IgE Elevated Elevated Variable Variable VariableGreatly Elevated
Variable
Variable
Variable
Variable
No Frequent No FrequentFrequent Very Frequent Characteristic Characteristic
Eosinophils in
conjunctival
swab
Globeled Cells Increased Increased Increased Decreased
Skin Test Positive Positive PositiveNon Specific
16 NoYes Yes Low Low Variable
Response to Anti
Allergic Drugs
18
Immuno-
supressives
Burning Ocular
Pain
TDSAKC VKC
Cyclosprine (1%,
2%) Tacrolimus
(0.003%)
Decreases steriod
dosage
& tracolimus is
useful in steroid
resistant cases
Cyclosprine inhibits
eosinophil infiltration
by affecting type IV
hypersensitivity reaction.
Tarcolimus acts
by inhibiting the action
of T-Cells
Sr.
No.
Features SAC PAC VKC AKC GPC CDC
19
Oral
Antihistamines
Dry eye especially
with second
generation
antihistamines
Od ; bd
Severe Allergic
Conditions Od ; bd
Cetirizine,
Loratadine,
Ebastine,
Levocetirizine,
Fexofenadine
These block H 1
receptors some have anti
inflammatory properties
by inhibiting ICAM 1
& PGF
Reduces itching,
edema
vasodilatation
in severe allergic
conjunctivitis
7

8. 8
Discipline is important in every sphere of life. So as in office
where we spend 1/3rd of our day. Adherence to discipline &
etiquette are mandatory at work place .With this
questionnaire self analyze whether, you are a good employee
or not ......???
How is your conduct at office?
Work excellence supports to get jobs , whereas right code of
conduct helps you to survive and sustain in an organization.
This can affect employee's ratings and credibility in an
organization. Answer the below given questions and analyze
your personality.
1. Do you obey the rules and regulation?
A Fully
B Sometime its practically not possible
C Whatever is possible, stick to same
D Don't believe in following rules
2. How is your office outfit?
As per given dress codeA
Love to wear casualB
Wear whatever is there in wardrobeC
Follow the fashion trend.D
3. How is your behavior towards office colleague.
Do you support /help them?
Always ready to supportA
Helps those who help meB
Says straightly noC
Minds my own business.D
4. What is your reaction towards a subordinate's
mistake?
Call him/her and discuss the mistake.A
Hide the mistakeB
Complain to the bossC
Tell it to other staffD
5. What do you do if urgent important work creeps
in on an off day/post office hours?
A Give importance to the work
B Place your problems before boss with
reason of inability to attend.
C Make excuse and walk away.
Give excuse that work hour are over.D
6. You take steps to make sure that there no noise at
work station?
A Keep the cellphone in silent mode .
B Talk politely over phone
C Walkaway from desk and talk so that others
are not disturbed.
D Bit of noise should be there in office
7. How much you are conscious of self &
colleague's privacy?
A Don't use any one system phone or pc
without permission
B Talk about there personal lives
C No question of privacy among office
colleagues
D Knock before entering anyones cabin.
8. How organized is your work & work station?
A Keep the desk clean and remove
unnecessary paper time to time.
B Organize your file before leaving the office.
C Peon will do his duty
D Some degree of unorganization is part of
office.
9. How much conscious you are about office
cleanliness & organization etc?
A Check cleanliness as you arrive to office
B Throw waste paper and other things in
dustbin.
C Hygiene dept. is there to maintain.
D Stop people from doing wrong things.
10. Deadlines means to you?
A Always complete the work on time.
B Always reach office on time.
C Love to postpone work.
D Work as per your convenience.
KNOW YOUR SCORE
Answer all question and sum-up your score.
Option A – 4
Option B - 3
Option C - 2
Option D - 1
If your score is between 30-35 you are an excellent employee.
If your score is between 25-30 you are disciplined, but you
can improve your skills.
If your score is below 20 you need to work on your behavior,
a lot of improvement is needed.

9. 1. ---------------- Also known as conjunctivitis.
2. Combination reduces aqueous humor production by
35%.
3. Choice of drug for corneal edema.
Recommended for opthalmia neonatrum.
4. Gold standard therapy for IOP & Open Angle Glaucoma.
5. Prolonged exposure to visual screen causes.
6. Anti Allergic preparation that require adminstration after
every 2 hours.
7. Cold Compression is recommended primary treatment for
………………………..
8. Choice of drug for Chronic Alleric conjunctivitis.
9. Lubricant recommended for Post LASIK surgery.
Note: Mail the correct answers at opthotimes@opthoremedies.com
Winners will be rewarded in the next issue.
CROSSWORD
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Volume 4 Quiz:
Amazing Picturesque Facts in Ophthalmology
*Search for the suitable answers from the given grid of cross word puzzle,
, Horizontally & Vertically.
9
Ankur Sharma
MR (Amritsar)
Sandeep Yogi
AM (Jalandhar)
Optho Times Vol. 3 Quiz Answers:
Ocular disease:
1. Dry eye
2. Ocular allergy
3. Glaucoma
4. Pink eye
5. Conjunctivitis
Competitor brands:
1. Refresh
2. Olopat
3. Olap
4. Iotim
Our brands:
1. Brimotim
2. Moxifax
3. Gatifax
4. Lotemox
5. Glutim
6. Odin
7. CCS
8. Tocin
Volume 3 Quiz Winners

10. Women's Day Celebration
I am a Woman.I bend.
I don't break
Gandhiji said, “ Intellectually, mentally and spiritually, woman is equivalent to a man.” Also Article No 14 of the constitution accords equality for both gender. Only in India, women is worshipped as "Shakti" (Strength), "Saraswati" (Knowledge) and "Lakshmi" (Prosperity). Pages of
history have numerous stories of women, from Sita in Ramayana to Kannagi in Silapathikaram to Rani of Jhansi are not only celebrated women but also their contribution to social change & awareness had been held immense. Women in India have always been honored &
respected . Women are the most beautiful creation of God. They have left their footprints in all fields, surpassed the mount everest & stepped in space. Women have great adaptability, they fit in all roles, plus surpassed different phases of life. Women have proved to be great
leader like men too, women are leaders everywhere you look -- from the CEO who runs a million dollar company to the housewife who raises her children and heads her household. “Women are the largest untapped reservoir of talent in the world”.
International Women's Day Celebration started long back in 1911 but efforts took proved to be small enough to provide equal platform. International women's day 2016 appeals & takes the Pledge for Parity. Optho Remedies acknowledged & honoured all the women working
for optho Remedies at HO/BO and sales staff on the behalf of women's day. To align with the International Women's Day, optho has also saluted and greeted all leading women ophthalmologist/optometrist and other staffs of all leading Institutions/Hospital & Clinics.
Women's Day Special
10 11

11. 12
Mr. Baldev
(Baldev Medical Agencies - 'KARNAL' (HARYANA)
Mr. Mukesh Agarwal
(Medichem Distributor's - 'JABALPUR' (M.P.)
Our Valuable
Distributors
Q. 1: How did your journey as a distributor start?
I started my journey as salesman in 1970-1975 from Prakash
medicine agencies, under the supervision of Om Prakash Shareen.
After 1975, we had overtaken the business of shareen distributors
and named as baldev distributors in Karnal (Haryana).
Q. 2: Share with us some experience from your growing
years?
An association with Optho remedies since last 40 years, I
remember the many important events which really happened.
Such close interactions with the founder of Optho remedies
during the events praise me a lot because his dedication towards
the work always inspire me and often suffused me with emotions
& grief.
Q. 3: How is your relationship with company's director/NSM?
The director/NSM of Optho remedies both has a potential to
intentionally cultivate and maintain connections with vendors &
distributors and this quality builds a healthy & friendly relations
with them and also with the company, such a strong business
relations can promote customer loyalty, customer retention and
collaboration between businesses in the supply chain.
Q. 4: Name our manager who introduced you to Optho?
The capabilities of the affected individuals are not limited to
recalling specific events from their personal experience, thus, I
remember the words of Late Mr R.K. Agarwal “Never get tired until
you achieve the success & dignity for what you are paying since
last years.”
This statement of him really boost me a lot and maybe this is the
only reason of my success and long term relations with Optho
family.
Q. 5: What does Optho do for its dealers that no other brand
does?
Optho's deal & requisition are much more unique & different than
others. This company is a great idea driven along with strong
focus and working with such a friendly & cooperative
environment enforce us to be the part of this firm as longer as we
can.
Q. 6: Is your family also involved in the business with you? If
yes, how does the young generation take the association with
Optho?
Yes!! Me & my children are involved in the business of pharma
distributors; therefore, I can assure you that the young generation
of Baldev distributors will also carry their candidature with Optho
family because they are also very fond of the friendly environment
of the company.
At last, Baldev said that “In such a long tenure with Optho our
relationship builds stronger & healthier, we find that the company
is growing in an ophthalmic market”.
Q. 1: How did your journey as a distributor start?
My journey as Pharma Distributor started since long back from
1972. In those days supply chain/distributions business was on
rise, therefore we have started our business in a pharma
distribution.
Q. 2: Share with us some experience from your growing
years?
In growing years with Optho Remedies, we have experience a lot
of changes, but let me share one thing over here that commitment
is the biggest word in the business and Optho always stand by its
statement and this is the major part of their success in the market.
Q. 3: How is your relationship with company's director/NSM?
Successful businesses don't just communicate with prospects and
customers for special sales. They need to build a healthy
relationship with their distributors, vendors or any kind of supply
chain. We have found that Director/NSM of the Optho Remedies
has a quality to develop such strategies to build a strong
relationship with us, this quality of Optho Remedies transform
into a valuable resource.
Q. 4: Name our manager who introduced you to Optho?
Memories are not always good; we remember the day when Late
R.K. Agarwal (Founder of Optho) has passed away, but the way his
two sons carry away his business this is really quiet appreciable
and prideful.
Q. 5: What does Optho do for its dealers that no other brand
does?
Chuckles.... “Deals & benefits are the major part of us, we are the
dealers and we need the best deal in every aspect.”
So, Yes! Optho is the company which provide us the valuable deal
in acceptable price and we get the evident benefit from the Optho
goods.
Q. 6: Is your family also involved in the business with you? If
yes, how does the young generation take the association with
Optho?
Yes! My entire family is involved in the same business along with
my son. Optho has supported us, not only in the term of business
but also solely, thus, our next generation will also like to carry the
same bond as we are in with.

12. 413
Distribution & market channel are important part of any organization to deliver their products & services to consumer properly.
Distribution channel & distributors play a pivotal role in the success of healthcare industry. We at Optho have strong distribution
system to cater our quality products to the consumers through the distribution channel. Our dignified distributors have been doing
a commendable job and have delivered services at par excellence. We at Optho strongly believe in WIN-WIN principle, thus we
ensure that everyone in the business cycle wins whether its Distributor-Whole seller-Retailer. Our distributors have been the
connecting link between stockist & company. Our quality products pass through our distributors to stockists and so on. To
recognize and acknowledge the efforts of our distributors we held a meeting on 17th Feb. 2016. The meet was confluence of
distributors all across the nation. In a cordial environment a round table conference took place that witnessed exchange of ideas
towards further strengthening the distribution system & make it error free. Company's vision and forthcoming plans for the new
fiscal year were share. The journey to Allahabad is incomplete without the holy dip at Sangam, thus the same was arranged for our
distributors. At last, such more meetings we will be organized in the future to build a strong bonding within us.
Annual Distributor's Meet at H.O.
National Conferences
Disclaimer : Information provided in conference calendar is meant for general information. Publication does not hold any
responsibility in-case of change or discrepancy. Kindly confirm respective official body.
Inter-National Conferences
Title of Conference City Date Venue
st
1 May-2016
th th
17 - 19 June 2016
nd rd
2 - 3 July 2016
th th
19 - 20 Aug. 2016
th th
03 - 04 Sep. 2016
th th
14 - 16 Oct. 2016
th th
15 - 17 Oct. 2016
th th
4 - 6 Nov. 2016
th th
30 - 4 Dec. 2016
nd th
2 - 4 Dec. 2016
Hotel Hyson Heritage, Calicut
Renaissance Mumbai Convection
Center Hotel
Hotel IITC Grand Chola
ITC Maratha, Hyatt Regency &
Hilton, Mumbai
Hotel ITC Grand Chola Chennai
CIDCO Exhibition Centre, Vashi
Chennai Trade Centre, Chennai
Palampur, Kangra, H.P.
Hotel Hyatt Regency
Jaipur Marriott Hotel
Calicut
Mumbai
Chennai
Mumbai
Chennai
Navi-Mumbai
Chennai
Palampur
Chandigarh
Jaipur
Opthalmology Update
2016 (KSOS)
Eye Advance 2016
IIRSI 2016
Boa-focus 2016
WCOA 2016
Moscon-2016
India International Optical
& Ophthalmology Expo 2016
Galucoma Society Of
India 26th Annual
Meeting -2016
Vitreoretinal Society Of India
Annual Conference 2016
(VRSI 2016)
AAPOS | SPOSI Joint
Meeting- 2016
Title of Conference City Date Venue
th th
27 - -30 July
th th
25 - 29 Sep. 2016
th st
29 Sep. – 1 Oct. 2016
Bali Nusa Dua Convention
Center
Keio Plaza Hotel
Shangrila Hotel, JAKARTA
Bali, Indonesia
Shinjuku-KU,
Tokyo, JAPAN
Jakarta, Indonesia
th
26 APCRAS
nd
22 Biennial Meeting Of
The International Society For
Eye Research 2016
th
14 National Congress And
The 41st Annual Scientific
Meeting Of The Indonesian
Ophthalmologists Association
2016
Media Gallery
CME on Occuplasty & Ocular Oncology at IGIMS Patna
Dr. Santosh G Honavar
AIOS Conference 2016 DOS Conference 2016

13. Medical Humors
Annual Sales Meeting-2016
Doctor to Medical student- Where is
the eye located???
Medical student replied- Between
the 'H' & the 'J'.
Doctor to Medical student- What
music do ophthalmologists listen to?
Medical student replied- I tunes.
A w o r r i e d p a t i e n t t e l l s a n
opthalmologist (eye doctor): "Doc, I am
very scared about the outcome of the
operation on my left eye. What are my
chances?" Grinning doctor to the
patient: "Hey don't worry, you won't be
able to see the difference."
14
20th April 2016 will be marked in the history of Optho Remedies as a 'Remarkable Day'
An annual sales meeting is integral to the success of the year's sales performance. It's a one-time opportunity to recognize
past performances and inspire achievement for the next twelve months. It brings all the companys sales people together to look
at new products and learn from each other what is working or not working in each other's territories.
The day witnessed a meet with new vision, self analysis & zeal towards reformation. Highlights of the day were the annual
sales achievement, discussion on quarterly revenue, awarding ceremony of our annual sales achievers and at last the
motivational speech reflects the strength of bonding between the company & its employees. The unending devotions &
indispensable contributions of our managers towards the organization will unequivocally helps us to accomplishing company's
set goals.
So, as we step into a new phase of vitality, we continue to rely on this support and confidence that- “Setting goals is the first step
in turning the invisible into the visible."
Managers team with Directors Head office team with Directors

15. 16
(Sodium Hyaluronate 0.1%)
4-Muco-adhesive and Muco-mimetic properties -
Long staying
5-Anti-oxidant and Anti-inflammatory properties-
Epithelium cyto-protection
HY-5 is a balanced hypotonic solution (149 mOsmol/l)
along with an excellent topical tolerance, due to
physiological pH 7.4.
How the corneal epithelial wounds develop and which
mechanisms are involved in the resurfacing of the cells??
Damage to the corneal epithelium caused by chemical,
physical or microbial insults results in swelling of the stroma,
activation of stromal fibroblasts and infiltration of various
inflammatory cells, leading to the loss of corneal transparency
and integrity. Therefore, it is important to repair corneal
epithelial damage as rapidly as possible. Most corneal
epithelial wounds are indeed repaired promptly. However,
under certain clinical conditions, resurfacing of the corneal
epithelium is delayed. Knowledge of the mechanisms that
underlie the healing of corneal epithelial wounds is crucial for
the development of new treatments. Resurfacing of corneal
epithelial defects occurs in three phases:
1) Immediately after the wound or injury of epithelial cells, the
neighbouring intact epithelial cells begin to migrate over the
affected area until they cover it with a cell monolayer.
2) This is followed by the proliferation of the migrated
epithelial cells, resulting in the restoration of the normal
epithelial thickness.
3) A few weeks after the wounding occurred, the epithelial
cells begin to differentiate, the surface of the healed region
becomes smooth and a well-layered structure is restored.
The three phases of corneal epithelial wound healing are thus
characterized by migration, cell proliferation, and cell
differentiation, respectively. Two different types of epithelial
movement during the covering process of the exposed area of
the cornea have been observed as shown in figure 1: epithelial
abrasion (upper panel) is followed by an initial sheet-like
movement of individual epithelial cells (middle panel) and a
subsequent landslide-like movement of the remaining
epithelium enmasse (lower panel).
For patients seeking relief from a variety of
eye conditions ranging from dry eye to
recovery from LASIK eye surgery, HY-5
which can be used as part of a continuum
of care with their existing Lubricant eye
drops to personalise the treatment
regime around patient need.
HY-5 eye drops contain Sodium
hyaluronate 0.1%, an effective lubricant
that can replenish the tear film and
provide enduring relief from dry
1
e y e . S o d i u m h y l a u r o n a t e i s a
biocompatible, non-immunogenic, high
range molecular weight polymer with a
unique physical characteristics; Hy-5 has been designed to
give a high level of ocular protection, viscosity, and hydration
over an extended period of time which prolonged the contact
2
time to the ocular surface. It is also indicated for the
medication of wounds and abrasions of the ocular surface
caused by traumatic events and following surgery associated
with lachrymal film alterations.
HY-5 (sodium hyaluronate 0.1%) has five unique
properties:
1-Re-epithelialisation properties -
Promotes healing and protection
2-Viscoelastic and Pseudoplastic properties -
good ocular retention time
3-Water retaining and wetting properties -
Long lasting lubrication.

16. 17
Fig. 2 : MMPs in Corneal Wound Healing
Sodium hyaluronate and provides
superficial healing of keratitis
Fig. 1 : Epithelial Movement
The matrix metalloproteinases (MMPs) are a family of
proteolytic enzymes whose function is to maintain and
remodel the tissue architecture. They have been implicated in a
wide range of processes and diseases and their substrates
comprise a variety of extracellular matrix components,
secreted cytokines and cell surface molecules. MMPs including
MMP-9 (gelatinase B), -2 (gelatinase A), and -1 (collagenase)
have been reported to be involved in the pathogenesis of
2
ulceration and pterygia of the cornea.
Role of CD44 in regeneration of corneal cells with the help
of sodium hyaluronate:
CD44: The CD44 antigen, a type 1 transmembrane
glycoprotein, is the main receptor for hyaluronan. It is present
on cell membranes of almost all human cells. A specific
function of CD44 is the capability to bind and internalize HA;
however, it can interact with other ligands, such as fibronectin,
collagens, osteopontin, and matrix metalloproteinases
(MMPs). It has proven to work as a docking agent for MMP9 and
5
as a growth factor reservoir. In a wound environment, CD44 is
responsible for cellular internalization of HA degradation
products. The other role of CD44 signalling in the wound
environment is to induce fibroblast migration from
surrounding tissue into the wounded area. It is noteworthy
that neither CD44 nor HA alone can induce cell migration and
promote wound healing; an interaction between HA and CD44
5,6
is essential to activate this process. . the ability of hyaluronan
particles to bind with the CD44 receptor depends on its
molecular size.
CD44 (receptor) are involved in cell- cell interaction and that
they provide tensile strength for healing epithelial cells,
whereas the others may serve as an adhesion molecule that is
required in cell-matrix interactions for effective cell migration,
including the lateral movement observed during wound
closure and the upward movement seen during epithelial cell
hyper proliferation.
1 . R E - E P I T H E L I S AT I O N P R O P E R T Y O F H Y - 5 :
(PROLIFERATION & MIGRATION OF CELLS)
How Cell Regenrates With Sodium Hyaluronate (hy-5 Eye
Drops) And Provides Wound Healing??
Hyaluronan is a natural polymer and its concentration
increases in response to ocular damage and during corneal
wound healing.
Hyaluronate promotes cell migration and can stabilise ocular
surface epithelial barrier, suggesting that it may be directly
involved in the process of epithelial repair by activation of the
CD44 (the hyaluronate receptor). Moreover, binding of
6,7,
hyaluronate to CD44 may stimulate cell proliferation
N OT E : S o d i u m
hyaluronate has
been shown to
foster the cell
m i g r a t i o n o f
corneal epithelial
cells, ability for
s t i m u l a t i n g
e p i t h e l i a l c e l l
proliferation and
which promotes
corneal wound
healing. This may
be facilitated by
t h e a d h e s i o n
between CD44 on
t h e c e l l s a n d
hyaluronic acid,
which coats the
surface of the denuded cornea. It was concluded that Sodium
Hyaluronate may effectively improve ocular surface damage
6,7,8.
associated with dry eye syndrome
CLINICAL STUDIES
Sodium hyaluronate (hyaluronic acid) promotes migration of
human corneal epithelial cells in vitro.
J A P Gomes1, R Amankwah2, A Powell-Richards2, H S Dua2
Abstract
Purpose: Sodium hyaluronate (hyaluronic acid) is known to
promote corneal epithelial wound healing in vivo and in vitro,
in animal experiments. Sodium hyaluronate is the ligand for
CD44, a cell surface adhesion molecule which has been found
on normal human corneal epithelial cells. The purpose of this
study was to investigate the effect of sodium hyaluronate on
human corneal epithelial cell migration, proliferation, and
CD44 receptor expression.

17. 18
Between blinking:
HA forms long
lasting protective
coating
A
During blinking:
HA molecules
align & spreads easily
over the cornea.
B
A) Between blinks SH forms a long- lasting protective coating.
B) While blinking, SH molecules align and spread easily over the
cornea.
Representation of Sodium Hyaluronate Pseudoplastic
behaviour during blinking
The low angle of contact and high surface tension is highly
4,5
effective in coating the cornea .
Clinical Studies
Ocular surface residence times of artificial tear solutions.
Snibson GR1, Greaves JL, Soper ND, Tiffany JM, Wilson CG,
Bron AJ. Cornea, 1992 Jul; 11(4):288-93.
Case Study
Re-epithelialisation propperties
In a clinical study comppleted by P. Aragona et al, the effects of
longer term treatment with 0.15%Sodium Hyaluronate
(preservative-free) compared with 0.9% Sodium Chloride
(Saline), on the ocular surface of patients with dry eye syndrome
was investigated. After 3 month treatment in patent with
medium to severer dry eye, sodium hyaluronate improved the
impression cytology score with a statistically significant
difference compared to the baseline significant difference
compared to the baseline value (p=0.024 v baseline). At the
same time the difference compared to 3 months treatment with
0.9% Sodium Chloride was also statistically significant (p=0036
v Sodium Chloride 0.9%). After 3 months treatment with 0.15%
Sodium Hyaluronate the main cytological further of impressions
made against the temporal interppalpebral bulbar conjunctiva
were the presences of smaller cells with both polygonal and
round shape and the presence of goblet cells. This was
compared to the 0.9% Sodium Chloride treated group where
cytological features were presence of polygonal cells with
keratinised, basophilic cytophlasm, markedly reduced
nucleus/cytoplasm ratio and an absence of globlet cells. It was
concluded that 0.15% Sodium Hyaluronate may effectively
improve ocular surface damage associated with dry eye
6
syndrome .
Methods: Human corneal epithelial cell cultures were
established from 32 donor corneoscleral rims and maintained
separately in three different culture conditions: (1) culture
medium only, (2) sodium hyaluronate enriched (0.6 mg/ml)
medium, and (3) hydroxypropylmethylcellulose enriched (2.5
mg/ml) medium. The total area of migrating epithelial cell
sheets in each case was measured by planimetry on days 4, 8,
12, and 16. Cytospin preparations of cells cultured in the
different culture conditions were examined immune-
histochemically for proliferation and CD44 receptor
expression using antibodies directed against Ki67 and CD44
respectively.
Results: Cells cultured in the presence of sodium hyaluronate
showed significantly increased migration at days 12 and 16
(Friedmen test: p = 0.0012, day 16; p = <0.001, day 12)
compared with cells cultured in the other media. There was no
difference in cell proliferation (Ki67) or CD44 expression on
cells cultured in the different culture conditions.
Conclusions: Sodium hyaluronate promotes migration but
not proliferation or CD44 expression on human corneal
epithelial cells in vitro. The beneficial effect of sodium
hyaluronate in corneal wound healing is likely to be related to
rapid migration of cells leading to rapid wound closure. This
may be facilitated by the adhesion between CD44 on the cells
and hyaluronic acid, which coats the surface of the denuded
cornea.
EVIDENCE OF CORNEAL RE-EPITHELISATION & CORNEAL
REPAIR
P. Aragona et al., Long term treatment with Sodium
Hyaluronate- containing artificial tears reduces ocular surface
damage in patients with dry eye. Br J Ophthalmology 2002;
(86): 181-184.
2. VISCO ELASTIC PROPERTY OF HY-5:
The most important property of HA solutions is their viscoelasticity,
which combines the viscous properties of a liquid with the elastic
properties of a solid, depending on the shear stress applied.
When used as an ocular lubricant, the unique viscoelastic properties
of HA increase the stability of the pre-corneal tear film and maximize
.4,5
tear film residence time .
During blinking, Sodium Hyaluronate fluidity increases so
enabling it to coat the entire surface of the eye. At rest in the
non- blinking eye, Sodium Hyaluronate recovers its initial
viscosity, granting it one of the longest retention times on the
3
ocular surface compared to other artificial tears.
This characteristic of Sodium Hyaluronate is described as
pseudoplastic behaviour. The pseudo plastic properties of
Sodium Hyaluronate enable it to be a sufficiently viscous and
static substance when at rest and to transform to a more fluid
and mobile substance when a stress force is applied. This
behaviour ensures a high lachrymal viscosity when the eye lids
are open which contributes to enhanced tear film stability and
a reduction in tear film evaporation. This should also equate to
a reduced requirement on the frequency of instillation of
Sodium Hyaluronate for the treatment of dry eye. In addition
during increased blinking and subsequent increased shear
stress on the tear film, the progressive reduction in viscosity of
sodium hyaluronate helps to reduce any friction of movement
between the eye lids and the ocular surface.

18. 19
Fluorophotometric measurement of the precorneal resisdence
time of topically applied hyaluronic acid.
1 1 2
H Mochizuki, M Yamada, S Hato1, T Nishida
Abstract
Purpose: This study was performed to separately assess the
aqueous flow applied with hyaluronic acid, and the behavior of
hyaluronic acid itself on the ocular surface.
Methods : Two different fluorescent dyes, fluorescein sodium
dissolved in 0.1% fluorescein conjugated with hyaluronic acid
(F-HA) dissolved in saline, were used. A volum of 20 ul of tested
solution was applied to teh eye of 10 healthy volunteers.
Fluorescein sodium dissolved in saline served as a control. The
fluorescent intensity of the precorneal tear film was measured
at eh central cornea every minute for 10 min. The turnover rate
was calculated using the equation that plots fluorescent
intensity against time the equation that plots and expressed as
% min.
Case Study
Viscoelastic properties
Esto,ates of the ocular surface residence times of 0.3%
Hydroxpropylmethylcellulose (Hypromellose), 1.4%
Plolyvinyl Alcohol and 0.2% Sodium Hyalyronate were
made using quantitative gamma scinitigraphy in six
patients with keratoconjunctivitis sicca. Sodium
Hyaluronate hacl a mean half life on the ocular surface of
321 seconds, which was significantly longer than
Hydroxproplymenthylcellulose 44 sconds; p=0.012 and
Polyvinyl Alcohol 39 seconds; p=0.013. Given its
prolonged residence time, favourable rheology, and
emerging clinical support, Sodium Hyaluronate may
3
come to pay a greater part in the treatment of dry eyes .
Conclusion : Our results indicate that the bulk aqueous flow
applied with HA and the turnover of HA itself are different. HA
molecules may adhere to the ocular surface by surface-
chemical and/or the ocular surface may explain the
mechanism in which hyaluronic acid has been show to
enhance tear film stability for a few hours.
References:
1.2007 Report of the International Dry Eye Workshop (DEWS),The Ocular
Surface, April 2007, Volume 5, No.2.
2.Snibson G. R. et al., Ocular surface residence times of artificial tear solutions.
Cornea 1992; 11(4): 288-293.
3.Saettone MF et al. Int J Pharm 1989; 51: 203–12
4.P. Aragona et al., Long term treatment with Sodium Hyaluronate- containing
artificial tears reduces ocular surface damage in patients with dry eye. Br J
Ophthalmology 2002; (86): 181-184.
5.Condon PI, McEwen CG, Wright M, et al. Double blind, randomized,
placebo controlled, crossover, multicentre study to determine the efficacy of a
0.1% (w/v) sodium hyaluronate solution (Fermavisc) in the treatment of dry
eye syndrome.Br J Ophthalmol 1999;83:1121–4.
6.Gomes JAP, Amankwah R, Powell-Richards A, et al. Sodium hyaluronate
promotes migration of human corneal epithelial cells in vitro. Br J Ophthalmol;
2004;88:821–5
7.Nokazaki Y et al. Jpn Pharmacol Ther: 1993; 21: 87–102.
Results: Turnover rates of topically applied 0.1% F-HA, 0.1%
HA and saline were 8.1 (SD 3.6)% min, 21.6 (2.8)%, min 31.0
(3.7)%min, respectively. The turnover rate of F-HA was
significantly lower than those of HA and saline (p=0.00012 adn
p =0.00000022, respectively; Mann-Whitney test). The
turnover rate of HA was significantly lower than that of saline
(p=0.00001; Mann-Whitney test).
Abstract
Solutions of hydroxypropylmethylcellulose (HPMC) and
polyvinyl alcohol (PVA) are widely used as artificial tears.
However, their usefulness is limited by the short duration of
their effect. Dilute sodium hyaluronate (SH) solutions exhibit
non-Newtonian rheology with high viscosities at low shear
rates, which would be expected to enhance their ocular surface
residence time. Using quantitative gamma scintigraphy,
estimates of the ocular surface residence times of 0.3% HPMC,
1.4% PVA, and 0.2% SH were made in six patients with
keratoconjunctivitis sicca. The sodium hyaluronate solution
had a mean half-life on the ocular surface of 321 s,
significantly longer than hydroxypropylmethylcellulose
(44 s; p = 0.012) and polyvinyl alcohol (39 s; p = 0.013).

19. Patron
Mr. Rajesh Agarwal & Mr. Rakesh Agarwal
Editor in Chief
Mrs. Anushri R. Agarwal
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Mr. D. K. Srivastava, Mr. Satyendra Verma
& Ms. Manjari Mishra
Special Thanks to
Dr. Rohit Agarwal & Mr. Ridim Agarwal
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