This document discusses the physiology and theories of olfaction (the sense of smell). It begins by describing the anatomy of the olfactory membrane and olfactory cells, which are the receptor cells for smell located in the nose. It explains how odor molecules activate these cells and cause nerve impulses. The pathways that transmit smell signals to the brain are then outlined, including both primitive and newer pathways. Several theories on the mechanisms of olfaction are briefly described. The document concludes by listing some common clinical tests used to evaluate a person's sense of smell.
Olfaction is one the major sense. In the following presentation, a brief description of the olfactory system is given. In this following topics are discussed: olfactory membrane, olfactory bulb, odor pathway, anosmia, directional smelling and plasticity. By the end of it, you will be able to describe the olfactory pathway of the nervous system.
Olfaction is one the major sense. In the following presentation, a brief description of the olfactory system is given. In this following topics are discussed: olfactory membrane, olfactory bulb, odor pathway, anosmia, directional smelling and plasticity. By the end of it, you will be able to describe the olfactory pathway of the nervous system.
- Cranial nerves are nerves that emerge directly from the brain and brain stem.
- There are twelve pairs of cranial nerves
- The olfactory nerve (CN I) is the first and shortest cranial nerve. It is a special visceral afferent nerve, which transmits information relating to smell.
- Embryologically, the olfactory nerve is derived from the olfactory placode (a thickening of the ectoderm layer), which also give rise to the glial cells which support the nerve.
- The olfactory placode eventually invaginates and forms the olfactory pit, which further develops into the nasal cavity and the olfactory epithelium, where olfactory receptor neurons reside.
Smell and taste by Pandian M. Dept of Physiology, DYPMCKOP,MHPandian M
Describe the basic features of the neural elements in the olfactory epithelium and olfactory bulb.
Describe signal transduction in odorant receptors.
Outline the pathway by which impulses generated in the olfactory epithelium reach the olfactory cortex.
Describe the location and cellular composition of taste buds.
Name the five major taste receptors and signal transduction mechanisms in these receptors.
Outline the pathways by which impulses generated in taste receptors reach the insular cortex.
Smell & Taste theory updated on 2021 BY PANDIAN M. Pandian M
10.13 & 10.14 Describe and discuss perception of smell and taste sensation
At the end of the session, the first phase MBBS student should be able to
1] Describe the location, structure, and afferent pathways of taste receptors.
2]Describe the location, structure, and afferent pathways of smell receptors.
3]Name the basic taste sensations, identify the five distinct gustatory modalities.
4] describe the cells of a taste bud.
5] explain how taste receptors are activated and explain the mechanism of taste transduction for each taste quality.
6] explain how olfactory receptors are activated and explain the mechanism of olfactory transduction.
7] identify the three cranial nerves that transmit taste information to the cerebral cortex.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
- Cranial nerves are nerves that emerge directly from the brain and brain stem.
- There are twelve pairs of cranial nerves
- The olfactory nerve (CN I) is the first and shortest cranial nerve. It is a special visceral afferent nerve, which transmits information relating to smell.
- Embryologically, the olfactory nerve is derived from the olfactory placode (a thickening of the ectoderm layer), which also give rise to the glial cells which support the nerve.
- The olfactory placode eventually invaginates and forms the olfactory pit, which further develops into the nasal cavity and the olfactory epithelium, where olfactory receptor neurons reside.
Smell and taste by Pandian M. Dept of Physiology, DYPMCKOP,MHPandian M
Describe the basic features of the neural elements in the olfactory epithelium and olfactory bulb.
Describe signal transduction in odorant receptors.
Outline the pathway by which impulses generated in the olfactory epithelium reach the olfactory cortex.
Describe the location and cellular composition of taste buds.
Name the five major taste receptors and signal transduction mechanisms in these receptors.
Outline the pathways by which impulses generated in taste receptors reach the insular cortex.
Smell & Taste theory updated on 2021 BY PANDIAN M. Pandian M
10.13 & 10.14 Describe and discuss perception of smell and taste sensation
At the end of the session, the first phase MBBS student should be able to
1] Describe the location, structure, and afferent pathways of taste receptors.
2]Describe the location, structure, and afferent pathways of smell receptors.
3]Name the basic taste sensations, identify the five distinct gustatory modalities.
4] describe the cells of a taste bud.
5] explain how taste receptors are activated and explain the mechanism of taste transduction for each taste quality.
6] explain how olfactory receptors are activated and explain the mechanism of olfactory transduction.
7] identify the three cranial nerves that transmit taste information to the cerebral cortex.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
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Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
1.4 modern child centered education - mahatma gandhi-2.pptx
Olfaction.pptx
1. Physiology of olfaction
Theories of olfaction
Tests for olfaction
Moderator : Dr. Shamsheer
Assistant professor
Presentor : Dr. M Hema Bindu
ENT PG 1st yr
2. Physiology of olfaction
• Smell is the least understood of our senses, partly because the sense of
smell is a subjective phenomenon that cannot be studied with ease in lower
animals.
• Another complicating problem is that the sense of smell is poorly developed
in human beings compared with the sense of smell in many other mammals.
3. OLFACTORY MEMBRANE:
• The olfactory membrane, lies in the superior part of the nasal cavity.
• Medially, the olfactory membrane folds downward along the surface of
the superior septum
• Laterally, it folds over the superior turbinate and even over a small
portion of the upper surface of the middle turbinate.
• The olfactory membrane has a total surface area of about 5 square cms
in humans.
4.
5. • Olfactory Cells Are the Receptor Cells for Smell Sensation.
• The olfactory cells are actually bipolar nerve cells derived originally from
the central nervous system.
• There are about 100 million of these cells in the olfactory epithelium
interspersed among sustentacular cells.
• The mucosal end of the olfactory cell forms a knob from which 4 to 25
olfactory hairs (also called olfactory cilia), measuring 0.3 micrometer in
diameter and up to 200 micrometers in length, project into the mucus
that coats the inner surface of the nasal cavity.
6.
7. • These projecting olfactory cilia form a dense mat in the mucus, and it is
these cilia that react to odors in the air and stimulate the olfactory cells.
• Spaced among the olfactory cells in the olfactory membrane are many
small Bowman glands that secrete mucus onto the surface of the
olfactory membrane.
9. • The portion of each olfactory cell that responds to the olfactory
chemical stimuli is the olfactory cilia.
• Activation of the receptor protein by the odorant substance activates
the G-protein complex.
• Activates multiple molecules of adenylyl cyclase inside the olfactory
cell membrane.
• Causes the formation of many times more molecules of cAMP
• The cAMP opens still many times more sodium ion channels.
10. • Therefore, even a minute concentration of a specific odorant initiates a
cascading effect that opens extremely large numbers of sodium
channels.
• This process accounts for the exquisite sensitivity of the olfactory
neurons to even the slightest amount of odorant
• In addition to the basic chemical mechanism whereby the olfactory cells
are stimulated, several physical factors affect the degree of stimulation.
11. First, only volatile substances that can be sniffed into the nasal cavity
can be smelled.
Second, the stimulating substance must be at least slightly water-soluble
so that it can pass through the mucus to reach the olfactory cilia.
Third, it is helpful for the substance to be at least slightly lipid-soluble,
presumably because lipid constituents of the cilium are a weak barrier to
non–lipid soluble odorants.
12. Membrane Potentials and Action Potentials in Olfactory Cells:
• The membrane potential inside unstimulated olfactory cells, as
measured by microelectrodes, averages about −55 millivolts.
• At this potential, most of the cells generate continuous action potentials
at a very slow rate, varying from once every 20 seconds up to two or
three per second.
• Most odorants cause depolarization of the olfactory cell membrane,
decreasing the negative potential in the cell from the normal level of −55
millivolts to −30 millivolts or less.
13. • Along with this, the number of action potentials increases to 20 to 30
per second, which is a high rate for the minute olfactory nerve fibers.
• Over a wide range, the rate of olfactory nerve impulses changes
approximately in proportion to the logarithm the stimulus strength,
which demonstrates that the olfactory receptors obey principles of
transduction similar to those of other sensory receptors.
14. TRANSMISSION OF SMELL SIGNALS INTO THE CENTRAL NERVOUS
SYSTEM:
• The olfactory nerve fibers leading backward from the bulb are called
cranial nerve I, or the olfactory tract.
• In reality, both the tract and the bulb are an anterior outgrowth of brain
tissue from the base of the brain; the bulbous enlargement at its end,
the olfactory bulb, lies over the cribriform plate, separating the brain
cavity from the upper reaches of the nasal cavity.
15. • The cribriform plate has multiple small perforations through which an
equal number of small nerves pass upward from the olfactory
membrane in the nasal cavity to enter the olfactory bulb in the cranial
cavity
• The olfactory cells in the olfactory membrane and the olfactory bulb,
showing short axons from the olfactory cell terminating in multiple
globular structures in the olfactory bulb called glomeruli.
• Each bulb has several thousand such glomeruli, each of which is the
terminus for about 25,000 axons from olfactory cells.
16. • Each glomerulus also is the terminus for dendrites from about 25 large
mitral cells and about 60 smaller tufted cells, the cell bodies of which lie
in the olfactory bulb superior to the glomeruli.
• These dendrites receive synapses from the olfactory cell neurons; the
mitral and tufted cells send axons through the olfactory tract to transmit
olfactory signals to higher levels in the central nervous system.
17.
18. Primitive and Newer Olfactory Pathways Into the Central Nervous
System:
• The olfactory tract enters the brain at the anterior junction between the
mesencephalon and cerebrum; there, the tract divides into two pathways
• one passing medially into the medial olfactory area of the brain stem
and the other passing laterally into the lateral olfactory area.
• The medial olfactory area represents a very primitive olfactory system,
whereas the lateral olfactory area is the input to the following: (1) a less
old olfactory system; and (2) a newer system.
19.
20. The Primitive Olfactory System—The Medial Olfactory Area:
• The medial olfactory area consists of a group of nuclei located in the
midbasal portions of the brain immediately anterior to the hypothalamus.
• Most conspicuous are the septal nuclei, which are midline nuclei that feed
into the hypothalamus and other primitive portions of the brain’s limbic
system.
• The removal of these areas hardly affects the more basic responses to
olfaction, such as licking the lips, salivation, and other feeding responses
caused by the smell of food or by basic emotional drives associated with
smell.
21. The Less Old Olfactory System—The Lateral Olfactory Area:
• The lateral olfactory area is composed mainly of the prepyriform and
pyriform cortex plus the cortical portion of the amygdaloid nuclei.
• From these areas, signal pathways pass into almost all portions of the
limbic system, especially into less primitive portions such as the
hippocampus, which seem to be most important for learning to like or
dislike certain foods depending on one’s experiences with them.
• An important feature of the lateral olfactory area is that many signal
pathways from this area also feed directly into an older part of the cerebral
cortex called the paleocortex in the anteromedial portion of the temporal
lobe.
22. The Newer Pathway:
• A newer olfactory pathway that passes through the thalamus, passing
to the dorsomedial thalamic nucleus and then to the lateroposterior
quadrant of the orbitofrontale cortex, has been found.
23.
24.
25. Centrifugal Control of Activity in the Olfactory Bulb by the Central
Nervous System:
• Many nerve fibers that originate in the olfactory portions of the brain
pass from the brain in the outward direction into the olfactory tract to the
olfactory bulb (i.e., centrifugally from the brain to the periphery)
• These nerve fibers terminate on a large number of small granule cells
located among the mitral and tufted cells in the olfactory bulb.
• The granule cells send inhibitory signals to the mitral and tufted cells.
• This inhibitory feedback may be a means for sharpening a person’s
specific ability to distinguish one odor from another.
26. THEORIES OF OLFACTION
1. Vibration theory
2. Olfactory pigment theory
3. Enzyme theory
4. Penetrating and puncturing theory
5. Corpuscular theory
27. Vibration or Wave Theory:
• If one considers that visual/auditory stimulation is the result of particular
vibration, then olfactory vibration has been suggested for many years.
• Randerbrock (1968) suggested that the olfactory perceptors are peptide
chains vibrating in an alpha helix.
• An odorant molecule forms a band with the peptide chain and thus
modulating the vibration.
• At the other end of the helix, the vibration is transmitted to nerves.
28. Olfactory Pigment Theory:
• Rosenberg (1968) has suggested that odorant molecules form a
complex with certain olfactory pigment giving them an increased
electrical conductivity
EnzymesTheory:
• It suggests that the activity of certain enzymes can be altered by
adsorption of odorant molecules. No valid evidence in favour.
29. Penetrating or Puncturing Theory:
• Davies suggested that odorant molecule is able to penetrate the
membrane of the olfactory receptor cell and diffuse through, leaving a
hole.
• Through this hole, leakage of ions such as sodium and potassium
occurs and initiates the nerve impulse.
30. The Corpuscular Theory:
• It is proposed that the olfactory region of the nose is stimulated by
odorants, which are carried in the air in a particular form, some sort of
chemical reaction taking place on contact with the sensory surface.
• According to stereochemical theory of olfaction, each of the seven
primary odours or modalities of sense possess a molecule of unique size
and shape.
• The olfacory epithelium is presumed to possess receptor sites that have
definite shape and dimensions, so that a specific odour molecule is
required for a particular receptor.
31. Tests for olfaction
• Small bottles are required containing essences of familiar odours.
Coffee, almonds, chocolate, oil of lemon and peppermint are among
those available.
• The patient must compress each nostril in turn and by sniffing through
the other, show that the airway is clear.
• The test odour is then placed under one nostril while the other is
compressed and the patient told to take good sniffs.
• He is asked if he is able to smell anything and can identity the odour.
32. • The test is repeated using the other nostril and he is asked the same
question. After an interval to allow the odour to disperse, the test is then
repeated with other odours
Electro-olfactogram:
• Electrode, which is placed on the olfactory epithelium, records a slow,
negative and monophasic potential in response to odorants. Electro-
olfactogram (EOG) represents a “generator potential”.
33. Others tests :
• University of Pennsylvania Smell Identification Test (UPSIT)
• Sniffin’ Sticks (SS) test
• Scandinavian odour-identification test (SOIT)
• Sniff Magnitude test (SMT)
• Cross-Cultural Smell Identification Test (CC- SIT)
• Pocket Smell Test (PST).