Node.js is a JavaScript runtime built on Chrome's V8 JavaScript engine that allows for asynchronous and non-blocking code execution. It is well-suited for real-time applications due to its event-driven and scalable nature. The document compares Node.js to other web servers like Nginx and PHP, showing that Node.js has faster performance for simple tasks and handling concurrent requests. Examples of real-world Node.js applications include chat sites, multiplayer games, and push notification services. Resources for learning more about Node.js are provided.