People are susceptible to biases when making decisions based on how problems are framed or presented, such as being more concerned about a 20% chance of dying during surgery versus an 80% chance of living. A study found volunteers with a certain serotonin transporter gene variant were more impacted by framing effects in a gambling task than others. While the gene explains some variability, framing biases are difficult to overcome due to activation of the emotional brain region called the amygdala across many cultures.