New generation fungicides with novel modes of action have been developed since 2001 that are more targeted and safer for non-target sites. These include fungicides that affect respiration, cell membranes, protein synthesis, signal transduction, and cell mitosis. Many important plant diseases that were previously not well-controlled can now be managed by these new systemic fungicides. The discovery process for fungicides has changed over time from broad-spectrum to more targeted site-specific and novel action chemistries. These new fungicides are more eco-friendly as they can be used at lower doses than earlier compounds.

2. New generation fungicides with
novel modes of action
• It includes systemic as well as contact
fungicides with novel mode of action
developed from 2001 to till date
• Technical feature of new generation fungicides
are target specific action and safer to non
target sites

3. • Several truly novel compounds have been launched
commercially and have reached an advanced stage of
development which effects on respiration, cell
membrane components, protein synthesis, signal
transduction, and cell mitosis
• Many of the important plant diseases, which were not
controlled satisfactorily by the previous traditional
fungicides , can now well managed by the new
compounds which are mostly systemic in nature

4. • The process of fungicides discovery has
undergone a noteworthy change over the
period of time.
• After the era of broad spectrum multisite and
site specific systemic fungicides, several novel
action fungicides of different chemical classes
have been developed in the past two decades.

5. • These are more eco- friendly as these are used
at much lower doses as compared to the
earlier compounds.
• Most important among these are the
strobilurins (QoIs), derived from Strobilurus
tenacellus, a wild mushroom

6. Other important fungicides
• Oxazolidinediones
• Phenoxyquinolines
• Anilinopyrimidines
• Valinamides
• Benzamides
• Thiocarbamates and
• Imidazoles
• Benzamides

7. New generation fungicide Disease crop
Strobilurins powdery mildew,
downy mildew
grapevine and
cucurbits
Valinamides Oomycere diseases grapevine, potato,
tomato and cucurbits
Oxazolidinediones potato late blight potato
Phenyl-ureas black scurf of potato potato
Mandelamides late blight of potato
downy mildew
Potato
grapevine

8. Mode of action Target site of action Active ingredient common
name
Respiration Complex I: NADH
oxidoreductase inhibitors
Diflumetorim
Complex II: Succinate
dehydrogenase
Boscalid
Complex III: cytochrome
bc1 (ubiquinol oxidase) at
Quinone outside site (cyt b
gene)
Azoxystrobin
(Strobilurins )

9. Mode of action Target site of action Active ingredient common
name
Protein synthesis
Signal transduction
Methionine biosynthesis Cyprodinil
Pyrimethanil
Sterol biosynthesis in
membranes
C-14demethylase in sterol
biosynthesis
Cyproconazole
Difenoconazole
Mitosis and cell division Delocalization of spectrin
like proteins
Fluopicolide